KR102855855B1 - Cosmetic Composion for Skin Whitening Comprising Fraction of Ginseng Flower Extract - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin whitening, comprising an alcohol fraction of a ginseng flower extract, prepared by a method comprising the steps of extracting ginseng flowers with an extraction solvent to prepare a ginseng flower extract, fractionating the ginseng flower extract by adding alcohol, and recovering the alcohol layer after fractionation. The alcohol fraction of the ginseng flower extract according to the present invention has an excellent melanin synthesis inhibitory effect, and thus can be usefully used as a cosmetic composition for skin whitening.

Description

{Cosmetic Composition for Skin Whitening Comprising Fraction of Ginseng Flower Extract}

The present invention relates to a cosmetic composition for skin whitening comprising a fraction of ginseng flower extract.

Skin whitening is one of the most popular cosmetic areas among women. "Skin whitening" refers to the treatment of skin discoloration caused by excessive pigment production within the skin due to environmental factors such as UV rays, stress, hormonal imbalances, and pregnancy. The most important factor in this process is melanin, the skin pigment.

Melanin is synthesized in melanocytes, pigment cells located in the basal layer of the epidermis, and transferred to surrounding keratinocytes to determine skin color. Tyrosinase is known to catalyze melanin biosynthesis. Tyrosinase hydroxylates the substrate L-tyrosine to L-DOPA (L-3,4-dihydroxyphenylalanine), which then oxidizes L-DOPA to dopaquinone. Dopaquinone is then converted into melanin under intracellular pH conditions without enzyme catalysis. Melanin is an unusually stable pigment found in living organisms. However, many aspects of its chemical properties remain unknown, and research progress has been slow.

Skin hyperpigmentation can be caused by a variety of factors, including hormonal imbalances following an inflammatory skin reaction, genetic disorders, and UV exposure. The primary cause is abnormalities in melanin synthesis and distribution. Melanin's primary function is to protect the skin from damage by scavenging oxygen radicals. Therefore, high levels of melanin indicate an effective defense system against physical and chemical toxicants.

However, excessive melanin deposition can cause pathological skin problems, such as freckles, dark spots, and age spots, and is recognized as a cosmetic concern. Therefore, interest in whitening agents that can suppress melanin formation is increasing, and extensive research is being conducted. Various whitening cosmetics have been proposed to prevent pigmentation in the skin. For example, those utilizing vitamin C and its derivatives, reducing agents such as glutathione, hydrogen peroxide, placental extract, and kojic acid, which inhibit melanin production, are known.

However, vitamin C is easily oxidized, and cosmetics containing it can become discolored and odorous. Reducing agents such as glutathione not only have an unpleasant odor but also have problems with percutaneous absorption, and hydrogen peroxide has safety and stability issues. Furthermore, animal tissue extracts such as placental extracts are not sufficiently effective and also have problems with stability, color, and odor. Kojic acid also has problems such as a small amount not being effective in preventing skin darkening, so it is difficult to say that they are all sufficient as effective ingredients in whitening cosmetics.

Therefore, the above-mentioned melanin production inhibitors are insufficiently effective when used alone, so there is a need to develop a material that has an excellent whitening effect even when used alone.

Meanwhile, ginseng ( Panax ginseng ) is a traditional Korean herbal medicine belonging to the Araliaceae family and widely used in folk remedies as well as oriental medicine. Its safety and efficacy have been proven over a long period of use as a medicinal ingredient. Ginseng has been reported to have protective effects against radiation, protect against chromosomal aberrations and micronuclei caused by alkylating agents, and reduce mutations and cell transformation in cultured cells (Patent Document 1).

Recently, with the growing consumer interest in natural cosmetics and the release of many cosmetics utilizing herbal ingredients, ginseng is being studied as a plant-based material with important skin benefits in cosmetics. However, most of these studies have only utilized extracts from ginseng roots or ginsenosides and ginseng polysaccharides from ginseng roots, and research on the benefits of ingredients from various parts of ginseng, such as ginseng flowers, is lacking. In addition, the usefulness of ginseng flowers has not been known for a long time, and they have been largely discarded in favor of ginseng seeds. Only recently have fragrance compositions utilizing the unique fresh fragrance of ginseng flowers begun to be developed (Patent Document 2).

The present inventors confirmed the skin whitening effect of a fraction obtained by fractionating an extract derived from ginseng flower using a specific organic solvent, and completed the present invention by confirming that an alcohol fraction of ginseng flower extract has an excellent skin whitening effect.

Republic of Korea Patent Publication No. 10-2017-0016725 Republic of Korea Patent Publication No. 10-2018-0088226

The purpose of the present invention is to provide a skin whitening cosmetic composition comprising an alcohol fraction of ginseng flower extract.

In order to achieve the above object, one aspect of the present invention provides a skin whitening cosmetic composition comprising an alcohol fraction of a ginseng flower extract, which is prepared by a method including the steps of extracting ginseng flowers with an extraction solvent to prepare a ginseng flower extract, fractionating the ginseng flower extract by adding alcohol, and recovering the alcohol layer after fractionation.

In one embodiment, the extraction solvent may be water or a base.

In other embodiments, the base may be, but is not limited to, sodium hydroxide (NaOH), calcium hydroxide (Ca(OH) ₂ ), sodium bicarbonate (NaHCO ₃ ), or sodium carbonate (Na ₂ CO ₃ ).

In one embodiment, the extraction solvent may be a 0.1 to 20% (w/v) NaOH aqueous solution, preferably, the extraction solvent may be a 2.5 to 7% (w/v) NaOH aqueous solution, but is not limited thereto.

In another embodiment, the alcohol may be a lower alcohol having a carbon number of C ₁ to C ₄ , and preferably, the alcohol may be, but is not limited to, saturated butanol.

In one embodiment, the cosmetic composition of the present invention can prevent, treat, or improve symptoms of brown spots, freckles, skin cracks, photoaging, wrinkle formation on the skin surface, or loss of skin elasticity.

In another embodiment, the alcohol fraction of the ginseng flower extract may be included in the cosmetic composition of the present invention in an amount of 0.01 to 30 wt%, but is not limited thereto.

The alcohol fraction of the ginseng flower extract according to the present invention has an excellent melanin synthesis inhibitory effect, and therefore can be usefully used as a cosmetic composition for skin whitening.

Figure 1 schematically illustrates the manufacturing process of Samples 1 to 5 manufactured in Examples 1 to 5 of the present invention.
Figure 2 is a graph showing the melanin synthesis inhibition effect of samples 1 to 5 prepared in examples 1 to 5 of the present invention.
Figure 3 is a table showing the ginsenoside content of aqueous extracts of ginseng leaves, stems, and red ginseng, and aqueous extracts of ginseng flowers and alcohol fractions of aqueous extracts of ginseng flowers of Samples 1 and 2 prepared in Examples 1 and 2.

Hereinafter, the present invention will be described in detail.

The present invention

(1) A step of producing a ginseng flower extract by extracting ginseng flowers with an extraction solvent;

(2) A step of fractionating by adding alcohol to the ginseng flower extract; and

(3) A skin whitening cosmetic composition comprising an alcohol fraction of a ginseng flower extract manufactured by a method including a step of recovering an alcohol layer after fractionation is provided.

In the present invention, "extract" means a substance extracted from a raw material by any method, and is used to mean, without limitation, an extract obtained in this way, a concentrate obtained therefrom, a dried product of the concentrate, and a powder thereof. In addition, a ginseng flower extract can be obtained by extraction from a raw material or a dried product thereof, and the raw material for the extract can be used without limitation, such as cultivated or commercially available products.

When the above extract is obtained by extraction from a raw material, all conventional extraction methods known in the art, such as solvent extraction, ultrasonic extraction, filtration, and reflux extraction, can be used as the extraction method, and preferably, the extract can be produced by using a solvent extraction method or a reflux extraction method. The above extraction process can be repeated several times, and additional steps such as concentration or freeze-drying can be performed thereafter. Specifically, the obtained extract can be concentrated under reduced pressure to obtain a concentrate, and the concentrate can be freeze-dried, and then a high-concentration extract powder can be produced using a grinder.

In the present invention, ginseng is used to mean, but is not limited to, commonly used ginseng, and preferably includes ginseng such as Panax ginseng C.A. Meyer, Panax quinquefolium, Panax notoginseng, Panax japonicum, Panax trifolium, or Panax pseudoginseng.

In the present invention, water or a base may be used as the extraction solvent in step (1), but is not limited thereto.

In one embodiment, the base may be any base known to those skilled in the art, such as, but not limited to, sodium hydroxide (NaOH), calcium hydroxide (Ca(OH) ₂ ), sodium bicarbonate (NaHCO ₃ ), or sodium carbonate (Na ₂ CO ₃ ), and is preferably sodium hydroxide (NaOH).

In another embodiment, the solution used in the base treatment may be a 0.1 to 20% (w/v) NaOH aqueous solution, preferably a 0.5 to 15% (w/v) NaOH aqueous solution, more preferably a 1 to 10% (w/v) NaOH aqueous solution, and particularly preferably a 2.5 to 7% (w/v) NaOH aqueous solution, but is not limited thereto. When the NaOH aqueous solution is below the lower limit, the effective components in the ginseng flowers may not be sufficiently extracted, and there is a problem that the extraction time becomes excessively long. When the NaOH aqueous solution exceeds the upper limit, the worker producing the extract may be put at risk.

The amount of the above extraction solvent added may be 1 to 30 times the dry weight of ginseng flowers, preferably 5 to 20 times, and more preferably 7 to 15 times, but is not limited thereto.

In the present invention, the extraction of ginseng flowers can be carried out at 60°C to 100°C, preferably at 65°C to 95°C, and more preferably at 70°C to 90°C, but is not limited thereto.

In addition, the extraction may be performed for 1 to 20 hours, preferably for 2 to 16 hours, and more preferably for 3 to 12 hours, but is not limited thereto.

In addition, the above extraction may be performed 1 to 8 times, preferably 1 to 6 times, and more preferably 1 to 5 times, but is not limited thereto, and the extract may be a single extract obtained in each extraction or a mixed extract of the extracts obtained in each extraction, and is preferably a mixed extract of the extracts obtained in each extraction, but is not limited thereto.

Additionally, the alcohol in step (2) may be, but is not limited to, a lower alcohol having a carbon number of C ₁ to C _4. In one embodiment, the alcohol may be, but is not limited to, saturated butanol.

In the present invention, with respect to 1 part by weight of ginseng flower extract, the alcohol may be added in an amount of 5 to 30 parts by weight, preferably 5 to 20 parts by weight, and more preferably 5 to 15 parts by weight, but is not limited thereto. If the alcohol is added in an amount less than the lower limit, the effective components in the ginseng flower extract may not be sufficiently fractionated, and if the alcohol is added in excess of the upper limit, the time required for the subsequent concentration process excessively increases, and there are disadvantages in that reprocessing must be repeated once or several times to remove residual alcohol.

The above fractions may further undergo conventional fractionation processes to enhance their antioxidant effects. For example, active fractions obtained by passing the fractions according to the present invention through an ultrafiltration membrane having a predetermined molecular weight cut-off value, and various purification methods such as separation by various chromatographies (designed for separation by size, charge, hydrophobicity, or affinity) are also included in the fractions of the present invention. A fraction containing a mixture of various components can be separated according to the properties of the active components through concentration gradient column chromatography, etc., to produce a specific active fraction with a higher antioxidant effect.

The above column chromatography can separate and purify an active fraction by performing column chromatography using a packing material selected from the group consisting of silica gel, Sephadex, LH-20, ODS gel, RP-18, polyamide, Toyopearl, and XAD resin, and the column chromatography can be performed multiple times by selecting an appropriate packing material as needed, but is not limited thereto. In using the above chromatography, the elution solvent, elution speed, and elution time can be applied without limitation to the solvent, speed, or time generally used in the present technical field.

According to a preferred embodiment of the present invention, a fraction obtained by fractionating a ginseng flower water extract or a base extract with alcohol, such as butanol, has a superior melanin synthesis inhibition effect than an extract obtained by simply extracting ginseng flowers with water, and in particular, a fraction obtained by fractionating a ginseng flower base extract with alcohol exhibits the best melanin synthesis inhibition effect, i.e., a skin whitening effect, whereas a ginseng flower water extract fractionated with methylene chloride or a ginseng flower extracted with ethanol does not exhibit a melanin synthesis inhibition effect (see FIG. 2).

According to another preferred embodiment of the present invention, the ginseng flower water extract and its alcohol fraction exhibit a superior ginsenoside content compared to the water extracts of ginseng leaves, stems, and red ginseng, and in particular, the alcohol fraction of the ginseng flower water extract of the present invention contains even more superior ginsenoside compared to the ginseng flower water extract (see FIG. 3).

The skin whitening cosmetic composition of the present invention provides an excellent whitening effect by fundamentally inhibiting melanin production, and can improve skin pigmentation and skin tone reduction. The skin whitening refers to any action that inhibits or prevents the deposition of melanin pigment in the skin by inhibiting melanin synthesis, and the pigmentation refers to any action or condition in which the skin color darkens due to increased melanin synthesis. In addition, the alcohol fraction of the ginseng flower extract included in the cosmetic composition of the present invention has antioxidant activity, and thus can be very useful in maintaining the quality of the composition by preventing oxidation of the cosmetic composition itself.

In the cosmetic composition of the present invention, the alcohol fraction of the ginseng flower extract may be included in the cosmetic composition in an amount of 0.01 to 30 wt%, preferably 0.01 to 20 wt%, more preferably 0.01 to 10 wt%, and particularly preferably 0.01 to 5 wt%. When the content is less than 0.01 wt%, the effect of the alcohol fraction of the ginseng flower extract may be minimal, and when it exceeds 30 wt%, the effect of the fraction may be relatively low compared to the input concentration.

The cosmetic composition of the present invention can be prepared in liquid or solid form using bases, adjuvants, and additives commonly used in the cosmetics industry. Liquid or solid cosmetics may include, but are not limited to, toners, creams, lotions, bath products, and the like.

The bases, auxiliary agents and additives commonly used in the cosmetic field are not particularly limited and include, but are not limited to, water, alcohol, propylene glycol, stearic acid, glycerol, cetyl alcohol and liquid paraffin.

The above cosmetic composition may include not only the alcohol fraction of the ginseng flower extract of the present invention, but also ingredients commonly used in cosmetic compositions, such as conventional auxiliary agents such as antioxidants, stabilizers, solubilizers, vitamins, pigments, and fragrances, and carriers.

The above cosmetic composition can be prepared in any formulation commonly manufactured in the present technical field, and for example, it can be formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, and spray, but is not limited thereto. More specifically, it can be prepared in the form of a flexible toner, a nourishing toner, a nourishing cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray, or a powder.

When the formulation of the above cosmetic composition is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component.

When the formulation of the above cosmetic composition is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, when it is a spray, a propellant such as chlorofluorohydrocarbon, propane/butane or dimethyl ether may be additionally included.

When the formulation of the above cosmetic composition is a solution or emulsion, a solvent, a solubilizer or an emulsifier is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan.

When the formulation of the above cosmetic composition is a suspension, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tragacanth may be used as a carrier component.

When the formulation of the above cosmetic composition is a surfactant-containing cleansing, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, or ethoxylated glycerol fatty acid ester may be used as a carrier component.

The above cosmetic composition may be applied alone or in combination, or in combination with other cosmetic compositions other than those of the present invention. Furthermore, the cosmetic composition according to the present invention may be used according to conventional methods, and the frequency of application may vary depending on the user's skin condition or preference.

If the above cosmetic composition is a soap, a surfactant-containing cleansing formulation, or a surfactant-free cleansing formulation, it can be applied to the skin and then wiped off, removed, or washed off with water. As specific examples, the soap may include liquid soap, powder soap, solid soap, and oil soap, the surfactant-containing cleansing formulation may include cleansing foam, cleansing water, cleansing towel, and cleansing pack, and the surfactant-free cleansing formulation may include, but is not limited to, cleansing cream, cleansing lotion, cleansing water, and cleansing gel.

Hereinafter, the present invention will be described in detail by examples.

However, the following examples are only intended to illustrate the present invention, and the content of the present invention is not limited by the following examples.

Example 1. Preparation of ginseng flower extract (sample 1)

After drying and crushing 10 g of ginseng flowers, 10 times more distilled water was added and extraction was performed at 60°C for 8 hours to prepare a ginseng flower water extract. The ginseng flower water extract was centrifuged to remove precipitates and concentrated using a vacuum rotary concentrator to remove the solvent.

Example 2. Preparation of alcohol fraction of ginseng flower extract (sample 2)

After drying and crushing 10 g of ginseng flowers, 10 times the amount of distilled water was added and extracted at 60°C for 8 hours to prepare a ginseng flower aqueous extract. 100 ml of saturated butanol was added to 100 ml of the ginseng flower aqueous extract, and after standing for 6 hours, 100 ml of a butanol fraction was obtained, which was concentrated using a vacuum rotary concentrator to remove the solvent.

Example 3. Preparation of alcohol fraction of ginseng flower base extract (sample 3)

After drying and grinding 10 g of ginseng flowers, 10 times the volume of 5% NaOH was added and extracted at 60°C for 8 hours to prepare a ginseng flower NaOH extract. 100 ml of saturated butanol was added to 100 ml of the ginseng flower NaOH extract, and after standing for 6 hours, 100 ml of a butanol fraction was obtained, which was concentrated using a vacuum rotary concentrator to remove the solvent.

Example 4. Preparation of organic solvent fraction of ginseng flower extract (Sample 4)

After drying and grinding 10 g of ginseng flowers, 10 times the amount of distilled water was added and extracted at 60°C for 8 hours to prepare a ginseng flower water extract. 100 ml of methylene chloride was added to 100 ml of the ginseng flower water extract, allowed to stand for 6 hours, and 100 ml of a water fraction was obtained. 160 ml of ethanol was added thereto, allowed to stand for 12 hours, filtered to remove sugar, and concentrated using a vacuum rotary evaporator to remove the solvent.

Example 5. Preparation of ginseng flower alcohol extract (Sample 5)

After drying and crushing 10 g of ginseng flowers, 10 times the volume of 70% ethanol was added and extracted for 8 hours to prepare a ginseng flower ethanol extract. The ginseng flower ethanol extract was centrifuged to remove the precipitate, and concentrated using a vacuum rotary concentrator to remove the solvent.

The manufacturing process of Samples 1 to 5 described in Examples 1 to 5 above is schematically illustrated in Fig. 1.

Example 6. Skin whitening effect of alcohol fraction of ginseng flower extract

Murine melanocytes were seeded in 6-well plates at 1 × 10 ⁴ cells/well. 24 hours after seeding, the cells were treated with serially diluted samples at 100 ㎍/㎖ and 200 ㎍/㎖ and the positive control (arbutin). The negative control group was treated with IBMX (isobutylmethylxanthine), which induces melanin production. 72 hours after treatment, the cells were harvested and lysed with 1 N NaOH to detect intracellular melanin. The absorbance (OD 405 ) of the untreated group (treated with culture medium only), negative control group (treated with IBMX only), positive control group (treated with IBMX and arbutin at various concentrations), and test group (treated with IBMX and each sample at various _{concentrations} ) was measured, and the melanin production inhibition rate of each group was measured by taking the melanin production inhibition rate of the negative control group as 0 and the melanin production inhibition rate of the untreated group as 100. At this time, samples 1 to 5 prepared in Examples 1 to 5 were used by diluting them according to concentration.

As a result, Samples 1 to 3 prepared in Examples 1 to 3 showed a concentration-dependent melanin synthesis inhibition effect, and among these, Samples 2 and 3, in which ginseng flower extract was fractionated with butanol, showed a superior melanin synthesis inhibition effect than Sample 1, in which ginseng flower was simply extracted with water, and in particular, Sample 3, in which ginseng flower base extract was fractionated with butanol, showed the best skin whitening effect. In contrast, Samples 4 and 5 prepared in Examples 4 and 5, in which ginseng flower water extract was fractionated with methylene chloride or ginseng flower was extracted with ethanol, did not show a melanin synthesis inhibition effect (Fig. 2).

Example 7. Analysis of ginsenoside content in ginseng flower extracts and fractions

The ginseng flower water extract and alcohol fraction of the ginseng flower water extract prepared in Examples 1 and 2, and the ginseng leaf, ginseng stem, and red ginseng water extract prepared in the same manner as in Example 1 were each dissolved in methanol, and then analyzed by HPLC to quantify the content of ginsenoside.

As a result, the ginseng flower water extract and the alcohol fraction of the ginseng flower water extract showed a superior ginsenoside content compared to the water extracts of ginseng leaves, stems, and red ginseng, and in particular, it was confirmed that the alcohol fraction of the ginseng flower water extract of the present invention contained a more excellent ginsenoside compared to the ginseng flower water extract (Fig. 3).

Manufacturing Example 1. Manufacturing of a cosmetic composition

<1-1> Essence production

An essence was prepared using the alcohol fraction (sample 2) of the ginseng flower extract of Example 2 according to the content (parts by weight) described in Table 1 below.

furtherance Content (parts by weight) triethanolamine 0.25 Carboxyvinyl polymer 0.22 glycerin 4 Butylene glycol 2 Fraction of sample 2 1.5 beeswax 0.5 Cetostearyl alcohol 1 Glyceryl monostearate 1 squalene 4 purified water Appropriate amount

<1-2> Manufacturing of flexible toner

A flexible toner containing the alcohol fraction (sample 3) of the ginseng flower base extract of Example 3 as an active ingredient was prepared as shown in Table 2 below.

raw material Content (parts by weight) 1,3-butylene glycol 1.00 Disodium EDTA 0.05 Allantoin 0.10 Dipotassium glycyrrhizate 0.05 citric acid 0.01 Sodium citrate 0.02 Glycereth-26 1.00 Arbutin 2.00 PEG-40
hydrogenated castor oil 1.00 ethanol 30.00 Fraction of sample 3 0.5 coloring agent a very small amount flavoring agent a very small amount purified water Remaining amount

<1-3> Manufacturing of nourishing cream

A nourishing cream containing the alcohol fraction (sample 2) of the ginseng flower extract of Example 2 as an active ingredient was prepared according to the composition shown in Table 3 below.

raw material Content (parts by weight) 1,3-butylene glycol 7.0 glycerin 1.0 D-panthenol 0.1 Magnesium aluminum silicate 0.3 PEG-40 stearate 1.2 Stearic acid 2.0 Polysorbate 60 1.5 glyceryl stearate 2.0 Sorbitan sesquioleate 1.5 Cetearyl alcohol 3.0 mineral oil 4.0 squalene 3.8 Fraction of sample 2 1.5 vegetable oil 1.8 Dimethicone 0.4 Dipotassium glycyrrhizate a very small amount Allantoin a very small amount Sodium hyaluronate a very small amount Tocopheryl acetate Appropriate amount triethanolamine Appropriate amount flavoring agent Appropriate amount purified water Remaining amount

<1-4> Manufacturing of lotion

A lotion containing the alcohol fraction (sample 3) of the ginseng flower base extract of Example 3 as an active ingredient was prepared according to the composition shown in Table 4 below.

raw material Content (parts by weight) Cetostearyl alcohol 1.6 Stearic acid 1.4 Glycerin monostearate 1.8 PEG-100 Stearate 2.6 Sorbital sesquioleate 0.6 squalene 4.8 Macadamia oil 2 jojoba oil 2 Tocopherol acetate 0.4 methylpolysiloxane 0.2 Tocopherol acetate 0.4 1,3-butylene glycol 4 Xanthan gum 0.1 glycerin 4 d-panthenol 0.15 Fraction of sample 3 1.0 Allantoin 0.1 Carbomer (2% aq. Sol) 4 triethanolamine 0.15 ethanol 3 purified water Appropriate amount

Claims (10)

(1) A step of producing a ginseng flower extract by extracting ginseng flowers with an aqueous solution containing a base;
(2) A step of fractionating by adding alcohol to the ginseng flower extract; and
(3) A skin whitening cosmetic composition comprising an alcohol fraction of a ginseng flower extract manufactured by a method including a step of recovering an alcohol layer after fractionation;
A skin whitening cosmetic composition wherein the base is selected from the group consisting of sodium hydroxide (NaOH), calcium hydroxide (Ca(OH) ₂ ), sodium bicarbonate (NaHCO ₃ ), and sodium carbonate (Na ₂ CO ₃ ). delete delete In claim 1,
A skin whitening cosmetic composition wherein the base is sodium hydroxide (NaOH). In claim 1,
A cosmetic composition for skin whitening wherein the above extraction solvent is a 0.1 to 20% (w/v) NaOH aqueous solution. In claim 1,
A cosmetic composition for skin whitening wherein the above extraction solvent is a 2.5 to 7% (w/v) NaOH aqueous solution. In claim 1,
A cosmetic composition for skin whitening, wherein the alcohol is a lower alcohol of C ₁ to C ₄ . In claim 1,
A cosmetic composition for skin whitening wherein the alcohol is saturated butanol. In claim 1,
A cosmetic composition for skin whitening that improves one or more symptoms selected from the group consisting of brown spots, freckles, skin cracks, photoaging, wrinkle formation on the skin surface, and decreased skin elasticity. In claim 1,
A cosmetic composition for skin whitening, wherein the alcohol fraction of the ginseng flower extract is included in the cosmetic composition in an amount of 0.01 to 30 wt%.