KR102737329B1 - Cosmetic composition for total scalp care, including scalp soothing, pore improvement, and dandruff improvement - Google Patents
Cosmetic composition for total scalp care, including scalp soothing, pore improvement, and dandruff improvement Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
본 발명은 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하여 두피 진정 효과, 모공 개선 효과 및 비듬 개선 효과를 갖도록 한 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition containing awapuhi extract, mung bean extract, radish root extract, flaxseed extract and white willow bark extract as active ingredients, and having a scalp soothing effect, pore improvement effect and dandruff improvement effect.
Description
본 발명은 화장료 조성물에 관한 것으로, 더 자세하게는 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하여 두피 진정 효과, 모공 개선 효과 및 비듬 개선 효과를 갖도록 한, 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물에 관한 것이다. The present invention relates to a cosmetic composition, and more specifically, to a cosmetic composition for soothing the scalp, improving pores and improving dandruff, which contains awapuhi extract, mung bean extract, mushu extract, flaxseed extract and white willow bark extract as active ingredients and has a scalp soothing effect, a pore improving effect and a dandruff improving effect.
두피 표면에서 자연히 떨어져 나오는 각질(角質)에 지방이나 먼지가 묻어서 생기는 비듬은 염증을 수반하지 않으면서 두피에 각질이 과하게 일어나는 것을 특징으로 하는 비정상적인 두피 상태로서, 이러한 비듬 현상의 심화는 두피의 혈행 불량에 의해 모근에 충분한 영양이 공급되지 않아 비강성 탈모(枇糠性脫毛)의 원인이 되기도 한다. Dandruff, which is caused by oil or dust sticking to the keratin that naturally falls off from the scalp surface, is an abnormal scalp condition characterized by excessive keratin on the scalp without inflammation. If this dandruff phenomenon worsens, it can cause anaplastic alopecia due to insufficient nutrition supplied to the hair roots due to poor blood circulation in the scalp.
이러한 비듬의 원인으로는 비듬균인 피티로스포름 오발레 등이 지목되어 왔고, 대부분의 비듬 치료제들은 피티로스포름 오발레를 억제하는 아연 피리치온이나 피록톤올아민 등을 사용하여 왔으나, 이러한 종래의 항비듬제들을 사용하여 목적하는 효과를 얻기 위해서는 이들을 과량 사용하여야 하는데, 이 경우 인체에 유해하기 때문에 그 사용에 제한이 있었다.The cause of dandruff has been identified as the dandruff fungus Pityrosform ovale, and most dandruff treatments have used zinc pyrithione or piroctone olamine, which inhibit Pityrosform ovale. However, in order to achieve the desired effect using these conventional anti-dandruff agents, they must be used in excessive amounts, which is harmful to the human body, so their use has been limited.
또한, 최근에는 미용을 위한 염모제나 펌제 등 화학제의 빈번한 사용에 따른 두피 및 모발의 손상이 심각한 상황이고, 스트레스, 영양분 결핍 및 기타 환경적 영향에 의해 두피의 모근에 혈액량을 감소시켜 두피의 영양이 결핍되므로, 두피가 점점 얇아져 모근이 부실해지고 모발을 가늘게 만든다.In addition, the frequent use of chemical agents such as hair dyes and perms for cosmetic purposes has recently caused serious damage to the scalp and hair, and stress, nutrient deficiencies, and other environmental influences have reduced the amount of blood in the hair roots of the scalp, causing the scalp to become nutrient deficient, which in turn causes the scalp to become thinner, weakening the hair roots and making the hair thinner.
이에 따라, 상기와 같은 두피 진정 효과, 모공 개선 효과 및 비듬 개선 효과를 갖는 화장료 조성물에 대한 연구가 거듭되고 있는 실정이다. Accordingly, research is being conducted repeatedly on cosmetic compositions that have the scalp soothing effect, pore improvement effect, and dandruff improvement effect as described above.
상기와 같은 문제점을 해결하기 위하여 본 발명은 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하여 두피 진정 효과, 모공 개선 효과 및 비듬 개선 효과를 갖도록 한, 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물에 관한 것이다.In order to solve the above problems, the present invention relates to a cosmetic composition for scalp soothing, pore improvement and dandruff improvement, which contains awapuhi extract, mung bean extract, muscat extract, flaxseed extract and white willow bark extract as active ingredients and has a scalp soothing effect, pore improvement effect and dandruff improvement effect.
상기와 같은 목적을 달성하기 위하여 본 발명은 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물의 혼합물을 유효성분으로 포함하는 두피진정, 모공개선, 비듬개선 등 두피토탈케어용 화장료 조성물을 제공한다. In order to achieve the above-mentioned purpose, the present invention provides a cosmetic composition for total scalp care, including scalp soothing, pore improvement, and dandruff improvement, which contains a mixture of awapuhi extract, mung bean extract, radish root extract, flaxseed extract, and white willow bark extract as effective ingredients.
이때, 상기 혼합물은 아와푸히추출물이 0.01 ~ 99.96중량%, 녹두추출물이 0.01 ~ 99.96중량%, 무환자추출물이 0.01 ~ 99.96중량%, 아마씨추출물이 0.01 ~ 99.96중량%, 흰버드나무껍질추출물이 0.01 ~ 99.96중량%로 포함되는 것을 특징으로 한다. At this time, the mixture is characterized in that it contains 0.01 to 99.96 wt% of awapuhi extract, 0.01 to 99.96 wt% of mung bean extract, 0.01 to 99.96 wt% of muhuai extract, 0.01 to 99.96 wt% of flaxseed extract, and 0.01 to 99.96 wt% of white willow bark extract.
이때, 상기 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물은 물, 탄소수 1 내지 4의 알콜, 프로판다이올, 메틸프로판다이올, 글리세린, 부틸렌글라이콜, 펜틸렌글라이콜, 프로필렌글라이콜, 에틸헥실글리세린 및 헥산디올로 이루어진 군에서 선택된 어느 하나 이상의 추출용매로 추출된 것을 특징으로 한다. At this time, the above-mentioned awapuhi extract, mung bean extract, radish root extract, flaxseed extract and white willow bark extract are characterized in that they are extracted with at least one extraction solvent selected from the group consisting of water, alcohols having 1 to 4 carbon atoms, propanediol, methylpropanediol, glycerin, butylene glycol, pentylene glycol, propylene glycol, ethylhexylglycerin and hexanediol.
이때, 상기 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물의 혼합물을 유효성분으로 포함하여 두피 진정 효과, 모공 개선 효과 및 비듬 개선 효과를 갖는 것을 특징으로 한다. At this time, it is characterized by having a scalp soothing effect, pore improvement effect, and dandruff improvement effect by including a mixture of the above awapuhi extract, mung bean extract, muhuash extract, flaxseed extract, and white willow bark extract as effective ingredients.
또한, 본 발명은 상기 혼합물을 이용하여 헤어 컨디셔너, 헤어 트리트먼트, 헤어팩, 헤어 토닉, 헤어 에센스, 헤어 그루밍 에이드, 포마드, 헤어 스프레이, 무스, 왁스, 젤, 헤어 크림, 헤어 로션 헤어 오일 샴푸, 린스, 퍼머넌트 웨이브, 헤어 스트레이트너, 흑채 그 밖의 두발용 제품류로 이루어지는 군에서 어느 하나의 제형으로 제형화되는 것을 특징으로 하는 화장료 조성물을 제공한다. In addition, the present invention provides a cosmetic composition characterized in that it is formulated into any one formulation from the group consisting of hair conditioner, hair treatment, hair pack, hair tonic, hair essence, hair grooming aid, pomade, hair spray, mousse, wax, gel, hair cream, hair lotion, hair oil, shampoo, rinse, permanent wave, hair straightener, black hair, and other hair products using the mixture.
본 발명에 따른 두피진정, 모공개선, 비듬개선 등 두피토탈케어용 화장료 조성물은 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하여 두피 진정 효과, 모공 개선 효과 및 비듬 개선 효과를 극대화 한다. The cosmetic composition for total scalp care, including scalp soothing, pore improvement, and dandruff improvement, according to the present invention contains awapuhi extract, mung bean extract, rhizome extract, flaxseed extract, and white willow bark extract as effective ingredients, thereby maximizing the scalp soothing effect, pore improvement effect, and dandruff improvement effect.
도 1은 본 발명에 따른 화장료 조성물을 제조하는 공정을 나타낸 플로우차트.
도 2는 본 발명의 실시예 1 및 비교예 1 내지 5에 따른 실험용 조성물의 세포 독성에 관한 그래프.
도 3은 본 발명의 실시예 1 및 비교예 1 내지 5에 따른 실험용 조성물의 두피 진정 효과에 관한 그래프.
도 4는 본 발명의 실시예 1 및 비교예 1 내지 5에 따른 실험용 조성물의 모공 개선 효과에 관한 그래프.
도 5는 본 발명의 실시예 1 및 비교예 1 내지 5에 따른 실험용 조성물의 비듬 감소 효과에 관한 그래프.
도 6은 본 발명의 실시예 1 및 비교예 1 내지 5에 따른 실험용 조성물의 항균 효과에 관한 그래프. Figure 1 is a flow chart showing a process for manufacturing a cosmetic composition according to the present invention.
Figure 2 is a graph regarding the cytotoxicity of experimental compositions according to Example 1 and Comparative Examples 1 to 5 of the present invention.
Figure 3 is a graph regarding the scalp soothing effect of experimental compositions according to Example 1 and Comparative Examples 1 to 5 of the present invention.
Figure 4 is a graph regarding the pore improvement effect of experimental compositions according to Example 1 and Comparative Examples 1 to 5 of the present invention.
Figure 5 is a graph regarding the dandruff reduction effect of experimental compositions according to Example 1 and Comparative Examples 1 to 5 of the present invention.
Figure 6 is a graph regarding the antibacterial effect of experimental compositions according to Example 1 and Comparative Examples 1 to 5 of the present invention.
이하의 본 발명에 관한 상세한 설명들은 본 발명이 실시될 수 있는 실시 예이고 해당 실시 예의 예시로써 도시된 첨부 도면을 참조한다. 이들 실시 예는 당 업자가 본 발명의 실시에 충분하도록 상세히 설명된다. 본 발명의 다양한 실시 예는 서로 다르지만 상호 배타적일 필요는 없음이 이해되어야 한다. 예를 들어, 여기에 기재되어 있는 특정 형상, 구조 및 특성은 일 실시 예에 관련하여 본 발명의 사상 및 범위를 벗어나지 않으면서 다른 실시 예로 구현될 수 있다. 또한, 각각의 기재된 실시예 내의 개별 구성요소의 위치 또는 배치는 본 발명의 사상 및 범위를 벗어나지 않으면서 변경될 수 있음이 이해되어야 한다. The following detailed description of the present invention is made with reference to the accompanying drawings, which are exemplary of embodiments in which the present invention may be practiced. These embodiments are described in sufficient detail to enable those skilled in the art to practice the present invention. It should be understood that the various embodiments of the present invention, while different from each other, are not necessarily mutually exclusive. For example, specific shapes, structures, and characteristics described herein may be implemented in other embodiments without departing from the spirit and scope of the present invention with respect to one embodiment. In addition, it should be understood that the positions or arrangements of individual components within each described embodiment may be changed without departing from the spirit and scope of the present invention.
따라서 후술되는 상세한 설명은 한정적인 의미로서 취하려는 것이 아니며, 본 발명의 범위는 적절하게 설명된다면 그 청구항들이 주장하는 것과 균등한 모든 범위와 더불어 첨부된 청구항에 의해서만 한정된다. 도면에서 유사한 참조부호는 여러 측면에 걸쳐서 동일하거나 유사한 기능을 지칭한다. Accordingly, the detailed description set forth below is not intended to be taken in a limiting sense, and the scope of the present invention is defined only by the appended claims, along with the full scope equivalents to which such claims are entitled, if properly described. Like reference numerals in the drawings designate the same or similar features throughout the several aspects.
본 발명에서 사용되는 용어는 본 발명에서의 기능을 고려하면서 가능한 현재 널리 사용되는 일반적인 용어들을 선택하였으나, 이는 당 분야에 종사하는 기술자의 의도 또는 판례, 새로운 기술의 출현 등에 따라 달라질 수 있다. 또한, 특정한 경우는 출원인이 임의로 선정한 용어도 있으며, 이 경우 해당되는 발명의 설명 부분에서 상세히 그 의미를 기재할 것이다. 따라서 본 발명에서 사용되는 용어는 단순한 용어의 명칭이 아닌, 그 용어가 가지는 의미와 본 발명의 전반에 걸친 내용을 토대로 정의되어야 한다. The terms used in the present invention are selected from the most widely used general terms possible while considering the functions of the present invention, but they may vary depending on the intention of engineers working in the field, precedents, the emergence of new technologies, etc. In addition, in certain cases, there are terms arbitrarily selected by the applicant, and in this case, the meanings thereof will be described in detail in the description of the relevant invention. Therefore, the terms used in the present invention should be defined based on the meanings of the terms and the overall contents of the present invention, rather than simply the names of the terms.
본 발명에서 어떤 부분이 어떤 구성요소를 “포함”한다고 할 때, 이는 특별히 반대되는 기재가 없는 한, 다른 구성요소를 제외하는 것이 아니라 다른 구성요소를 더 포함할 수 있음을 의미한다. When it is said that a part of the present invention “includes” a certain component, this does not exclude other components, but rather may include other components, unless otherwise specifically stated.
본 발명에 따른 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물은, 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하는 것을 특징으로 한다. The cosmetic composition for scalp soothing, pore improvement and dandruff improvement according to the present invention is characterized by containing awapuhi extract, mung bean extract, rhizome extract, flaxseed extract and white willow bark extract as effective ingredients.
상기 아와푸히추출물(Zingiber Zerumbet Extract)은 아와푸히(Zingiber Zerumbet)로부터 추출한 추출물을 지칭한다. The above Awapuhi Extract (Zingiber Zerumbet Extract) refers to an extract extracted from Awapuhi ( Zingiber Zerumbet ).
상기 녹두추출물(Vigna Radiata Seed Extract)은 녹두(Vigna Radiata)로부터 추출한 추출물을 지칭한다. The above mung bean extract (Vigna Radiata Seed Extract) is mung bean ( Vigna It refers to an extract extracted from the plant ( Radiata ).
상기 무환자추출물(Sapindus Mukorossi Fruit Extract)은 무환자(Sapindus Mukorossi)의 과실로부터 추출한 추출물을 지칭한다. The above Sapindus Mukorossi Fruit Extract refers to an extract extracted from the fruit of Sapindus Mukorossi .
상기 아마씨추출물(Linum Usitatissimum (Linseed) Seed Extract)은 아마(Linum Usitatissimum (Linseed))의 씨로부터 추출한 추출물을 지칭한다. The above flaxseed extract (Linum Usitatissimum (Linseed) Seed Extract) refers to an extract extracted from the seeds of flax (Linum Usitatissimum (Linseed)).
상기 흰버드나무껍질추출물(Salix Alba (Willow) Bark Extract)은 흰버드나무(Salix Alba (Willow))의 껍질로부터 추출한 추출물을 지칭한다. The above Salix Alba (Willow) Bark Extract refers to an extract extracted from the bark of the white willow tree ( Salix Alba (Willow) ).
상기 혼합물은 아와푸히추출물이 0.01 ~ 99.96중량%, 녹두추출물이 0.01 ~ 99.96중량%, 무환자추출물이 0.01 ~ 99.96중량%, 아마씨추출물이 0.01 ~ 99.96중량%, 흰버드나무껍질추출물이 0.01 ~ 99.96중량%되는 것이 바람직하다. It is preferable that the above mixture contains 0.01 to 99.96 wt% of awapuhi extract, 0.01 to 99.96 wt% of mung bean extract, 0.01 to 99.96 wt% of muhuai extract, 0.01 to 99.96 wt% of flaxseed extract, and 0.01 to 99.96 wt% of white willow bark extract.
더 적절하게는 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물이 동량으로 혼합되는 것이 가장 바람직할 것이다.More appropriately, it would be most desirable to mix equal amounts of awapuhi extract, mung bean extract, turmeric extract, flaxseed extract, and white willow bark extract.
본 발명에 따른 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물은 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물를 혼합한 혼합물을 포함하며, 혼합 과정에서 각 원물의 핵심 성분 간의 상호 반응에 의해 예기치 못한 효과를 갖게 된다.The cosmetic composition for scalp soothing, pore improvement and dandruff improvement according to the present invention comprises a mixture of awapuhi extract, mung bean extract, rhizome extract, flaxseed extract and white willow bark extract, and has an unexpected effect due to the mutual reaction between the core components of each raw material during the mixing process.
상기 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물은 40 ~ 150℃의 온도에서 8 ~ 24시간 동안 추출하는 것이 바람직하다. It is preferable to extract the above awapuhi extract, mung bean extract, radish root extract, flaxseed extract and white willow bark extract at a temperature of 40 to 150°C for 8 to 24 hours.
이때, 상기 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물은, 아와푸히, 녹두, 무환자, 아마씨 및 흰버드나무껍질을 물, 탄소수 1 내지 4의 알콜, 프로판다이올, 메틸프로판다이올, 글리세린, 부틸렌글라이콜, 펜틸렌글라이콜, 프로필렌글라이콜, 에틸헥실글리세린 및 헥산디올로 이루어진 군에서 선택된 어느 하나 이상의 추출용매로 추출하여얻어진 것이 적절하다. 가장 적절하게 상기 추출용매는 부틸렌글라이콜 및 헥산디올을 혼합한 추출용매일 수 있다. At this time, the above awapuhi extract, mung bean extract, radish root extract, flaxseed extract and white willow bark extract are suitably obtained by extracting awapuhi, mung bean, radish root, flaxseed and white willow bark with at least one extraction solvent selected from the group consisting of water, alcohols having 1 to 4 carbon atoms, propanediol, methylpropanediol, glycerin, butylene glycol, pentylene glycol, propylene glycol, ethylhexylglycerin and hexanediol. Most suitably, the extraction solvent may be an extraction solvent mixed with butylene glycol and hexanediol.
한편, 상기 혼합물은 10 ~ 40℃의 온도에서 1 내지 7일 동안 숙성기간을 거칠 수도 있다. 상기 혼합물을 숙성하면, 본 발명의 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물의 핵심 성분 간의 상호 반응에 의해 두피 진정 효과, 모공 개선 효과 및 비듬 개선 효과가 증대된다. Meanwhile, the mixture may be aged for 1 to 7 days at a temperature of 10 to 40°C. When the mixture is aged, the scalp soothing effect, pore improvement effect, and dandruff improvement effect are enhanced by the mutual reaction between the core components of the awapuhi extract, mung bean extract, mulberry extract, flaxseed extract, and white willow bark extract of the present invention.
이하, 본 발명에 따른 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하는 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물의 제조과정에 대하여 간단히 설명한다.Hereinafter, a process for manufacturing a cosmetic composition for scalp soothing, pore improvement and dandruff improvement containing awapuhi extract, mung bean extract, radish root extract, flaxseed extract and white willow bark extract as active ingredients according to the present invention will be briefly described.
본 발명에 따른 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하는 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물의 제조과정은 세척 및 건조 단계(S10), 추출 단계(S20), 혼합 단계(S30), 숙성 단계(S40)를 포함할 수 있다. The manufacturing process of a cosmetic composition for scalp soothing, pore improvement and dandruff improvement containing an awapuhi extract, a mung bean extract, a rhizome extract, a flaxseed extract and a white willow bark extract as active ingredients according to the present invention may include a washing and drying step (S10), an extraction step (S20), a mixing step (S30), and a maturing step (S40).
상기 세척 및 건조 단계(S10)에서는 아와푸히, 녹두, 무환자, 아마씨 및 흰버드나무껍질을 준비하여, 필요에 따라 1 × 1cm 크기의 절편으로 절단한 다음, 세척하고 건조하는 과정을 수행한다.In the above washing and drying step (S10), awapuhi, mung beans, sesame seeds, flax seeds, and white willow bark are prepared, cut into 1 × 1 cm pieces as needed, and then washed and dried.
그 다음, 상기 추출 단계(S20)에서는 상기 세척 및 건조 단계(S10)에서 준비된 아와푸히, 녹두, 무환자, 아마씨 및 흰버드나무껍질에 물, 탄소수 1 내지 4의 알콜, 프로판다이올, 메틸프로판다이올, 글리세린, 부틸렌글라이콜, 펜틸렌글라이콜, 프로필렌글라이콜, 에틸헥실글리세린 및 헥산디올로 이루어진 군에서 선택된 어느 하나 이상의 추출용매를 가하고 40 ~ 150℃의 온도에서 8 ~ 24시간 동안 추출하여, 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 제조한다.Next, in the extraction step (S20), at least one extraction solvent selected from the group consisting of water, alcohols having 1 to 4 carbon atoms, propanediol, methylpropanediol, glycerin, butylene glycol, pentylene glycol, propylene glycol, ethylhexylglycerin, and hexanediol is added to the awapuhi, mung bean, muhuani, flaxseed, and white willow bark prepared in the washing and drying step (S10), and extraction is performed at a temperature of 40 to 150°C for 8 to 24 hours, thereby producing an awapuhi extract, a mung bean extract, a muhuani extract, a flaxseed extract, and a white willow bark extract.
다음으로, 상기 혼합 단계(S30)에서는 상기 추출 단계(S20)에서 준비한 아와푸히추출물이 0.01 ~ 99.96중량%, 녹두추출물이 0.01 ~ 99.96중량%, 무환자추출물이 0.01 ~ 99.96중량%, 아마씨추출물이 0.01 ~ 99.96중량%, 흰버드나무껍질추출물이 0.01 ~ 99.96중량%로 포함되도록 혼합하여 혼합물을 제조한다.Next, in the mixing step (S30), a mixture is prepared by mixing the awapuhi extract prepared in the extraction step (S20) at 0.01 to 99.96 wt%, the mung bean extract at 0.01 to 99.96 wt%, the mung bean extract at 0.01 to 99.96 wt%, the flaxseed extract at 0.01 to 99.96 wt%, and the white willow bark extract at 0.01 to 99.96 wt%.
마지막으로, 상기 숙성 단계(S40)에서는 상기 혼합단계(S30)에서 제조된 혼합물을 10 ~ 40℃의 온도에서 1 내지 7일 동안 숙성해 준다.Finally, in the maturing step (S40), the mixture prepared in the mixing step (S30) is matured at a temperature of 10 to 40°C for 1 to 7 days.
상기 과정을 거쳐 완성된 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하는 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물은 두피 진정 효과, 모공 개선 효과 및 비듬 개선 효과를 갖는다. A cosmetic composition for scalp soothing, pore improvement and dandruff improvement containing as active ingredients awapuhi extract, mung bean extract, radish root extract, flaxseed extract and white willow bark extract completed through the above process has a scalp soothing effect, a pore improvement effect and a dandruff improvement effect.
보다 구체적으로, 본 발명에 따른 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물은 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물의 혼합물을 동시에 포함하여, 일부 원물을 배제한 경우에 비해, 두피 진정 효과, 모공 개선 효과 및 비듬 개선 효과가 증대된다. More specifically, the cosmetic composition for scalp soothing, pore improvement and dandruff improvement according to the present invention simultaneously contains a mixture of awapuhi extract, mung bean extract, muscat extract, flaxseed extract and white willow bark extract, thereby enhancing the scalp soothing effect, pore improvement effect and dandruff improvement effect compared to a case where some of the raw materials are excluded.
한편, 본 발명에 따른 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하는 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물은 상기 혼합물을 이용하여 헤어 컨디셔너, 헤어 트리트먼트, 헤어팩, 헤어 토닉, 헤어 에센스, 헤어 그루밍 에이드, 포마드, 헤어 스프레이, 무스, 왁스, 젤, 헤어 크림, 헤어 로션 헤어 오일 샴푸, 린스, 퍼머넌트 웨이브, 헤어 스트레이트너, 흑채 그 밖의 두발용 제품류로 이루어지는 군에서 어느 하나의 제형으로 제형화될 수 있을 것이다.Meanwhile, the cosmetic composition for scalp soothing, pore improvement and dandruff improvement containing the awapuhi extract, mung bean extract, rhizome extract, flaxseed extract and white willow bark extract according to the present invention as active ingredients may be formulated into any one formulation from the group consisting of hair conditioner, hair treatment, hair pack, hair tonic, hair essence, hair grooming aid, pomade, hair spray, mousse, wax, gel, hair cream, hair lotion, hair oil, shampoo, rinse, permanent wave, hair straightener, black hair and other hair products using the mixture.
이하, 하기의 실시예, 비교예, 실험예를 통하여, 본 발명에 따른 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하는 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물이 갖는 효과에 대해 자세히 알아본다.Hereinafter, through the following examples, comparative examples, and experimental examples, the effects of a cosmetic composition for scalp soothing, pore improvement, and dandruff improvement containing as active ingredients an awapuhi extract, a mung bean extract, a rhizome extract, a flaxseed extract, and a white willow bark extract according to the present invention will be examined in detail.
실시예Example 1. 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하는 실험용 조성물의 제조 1. Preparation of an experimental composition containing awapuhi extract, mung bean extract, radish root extract, flaxseed extract and white willow bark extract as active ingredients
하기의 제조과정에 따라, 실시예 1의 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하는 실험용 조성물을 제조하였다.According to the manufacturing process described below, an experimental composition containing the awapuhi extract, mung bean extract, radish root extract, flaxseed extract, and white willow bark extract of Example 1 as effective ingredients was manufactured.
세척 및 건조 단계(S10): 아와푸히, 녹두, 무환자, 아마씨 및 흰버드나무껍질을 준비하여, 필요에 따라 1 × 1cm 크기의 절편으로 절단한 다음, 세척하고 통풍이 잘되는 그늘에서 건조하였다.Washing and drying step (S10): Awapuhi, mung beans, sesame seeds, flax seeds and white willow bark were prepared, cut into 1 × 1 cm pieces as needed, washed and dried in a well-ventilated shade.
추출 단계(S20): 상기 세척 및 건조 단계(S10)에서 준비된 아와푸히, 녹두, 무환자, 아마씨 및 흰버드나무껍질에 부틸렌글라이콜 및 헥산디올이 혼합된 추출용매를 가하고 60℃의 온도에서 12시간 동안 추출하여, 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 제조하였다. Extraction step (S20): An extraction solvent mixed with butylene glycol and hexanediol was added to the awapuhi, mung bean, muhuani, flaxseed and white willow bark prepared in the washing and drying step (S10), and extraction was performed at a temperature of 60°C for 12 hours, thereby producing an awapuhi extract, a mung bean extract, a muhuani extract, a flaxseed extract and a white willow bark extract.
혼합 단계(S30): 상기 추출 단계(S20)에서 준비한 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 동량으로 혼합하여 혼합물을 제조하였다. Mixing step (S30): A mixture was prepared by mixing equal amounts of the awapuhi extract, mung bean extract, radish root extract, flaxseed extract, and white willow bark extract prepared in the above extraction step (S20).
숙성 단계(S40): 상기 혼합단계(S30)에서 제조된 혼합물을 15℃의 온도에서 3일 동안 숙성하였다.Maturation step (S40): The mixture prepared in the mixing step (S30) was matured at a temperature of 15°C for 3 days.
비교예Comparative example 1. 1. 아와푸히추출물이Awapuhi extract 배제된 실험용 조성물의 제조Preparation of the excluded experimental composition
하기의 제조과정에 따라, 비교예 1의 아와푸히추출물이 배제된 실험용 조성물을 제조하였다.According to the manufacturing process below, an experimental composition excluding the awapuhi extract of Comparative Example 1 was manufactured.
세척 및 건조 단계(S10): 녹두, 무환자, 아마씨 및 흰버드나무껍질을 준비하여, 필요에 따라 1 × 1cm 크기의 절편으로 절단한 다음, 세척하고 통풍이 잘되는 그늘에서 건조하였다.Washing and drying step (S10): Prepare mung beans, sesame seeds, flax seeds and white willow bark, cut into 1 × 1 cm pieces as needed, and then wash and dry in a well-ventilated shade.
추출 단계(S20): 상기 세척 및 건조 단계(S10)에서 준비된 녹두, 무환자, 아마씨 및 흰버드나무껍질에 부틸렌글라이콜 및 헥산디올이 혼합된 추출용매를 가하고 60℃의 온도에서 12시간 동안 추출하여, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 제조하였다. Extraction step (S20): An extraction solvent mixed with butylene glycol and hexanediol was added to the mung bean, radish green tea, flaxseed and white willow bark prepared in the washing and drying step (S10), and extraction was performed at a temperature of 60°C for 12 hours, thereby producing a mung bean extract, a radish green tea extract, a flaxseed extract and a white willow bark extract.
혼합 단계(S30): 상기 추출 단계(S20)에서 준비한 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 동량으로 혼합하여 혼합물을 제조하였다. Mixing step (S30): A mixture was prepared by mixing equal amounts of the mung bean extract, the neem extract, the flaxseed extract, and the white willow bark extract prepared in the above extraction step (S20).
숙성 단계(S40): 상기 혼합단계(S30)에서 제조된 혼합물을 15℃의 온도에서 3일 동안 숙성하였다.Maturation step (S40): The mixture prepared in the mixing step (S30) was matured at a temperature of 15°C for 3 days.
비교예Comparative example 2. 녹두2. Green beans 추출물이The extract 배제된 실험용 조성물의 제조Preparation of the excluded experimental composition
하기의 제조과정에 따라, 비교예 2의 녹두추출물이 배제된 실험용 조성물을 제조하였다.According to the manufacturing process below, an experimental composition excluding the mung bean extract of Comparative Example 2 was manufactured.
세척 및 건조 단계(S10): 아와푸히, 무환자, 아마씨 및 흰버드나무껍질을 준비하여, 필요에 따라 1 × 1cm 크기의 절편으로 절단한 다음, 세척하고 통풍이 잘되는 그늘에서 건조하였다.Washing and drying step (S10): Awapuhi, muscat, flax seed and white willow bark were prepared, cut into 1 × 1 cm pieces as needed, washed and dried in a well-ventilated shade.
추출 단계(S20): 상기 세척 및 건조 단계(S10)에서 준비된 아와푸히, 무환자, 아마씨 및 흰버드나무껍질에 부틸렌글라이콜 및 헥산디올이 혼합된 추출용매를 가하고 60℃의 온도에서 12시간 동안 추출하여, 아와푸히추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 제조하였다. Extraction step (S20): An extraction solvent mixed with butylene glycol and hexanediol was added to the awapuhi, muhuashi, flaxseed and white willow bark prepared in the washing and drying step (S10), and extraction was performed at a temperature of 60°C for 12 hours, thereby producing an awapuhi extract, a muhuashi extract, a flaxseed extract and a white willow bark extract.
혼합 단계(S30): 상기 추출 단계(S20)에서 준비한 아와푸히추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 동량으로 혼합하여 혼합물을 제조하였다. Mixing step (S30): A mixture was prepared by mixing equal amounts of the awapuhi extract, the muhuashi extract, the flaxseed extract, and the white willow bark extract prepared in the above extraction step (S20).
숙성 단계(S40): 상기 혼합단계(S30)에서 제조된 혼합물을 15℃의 온도에서 3일 동안 숙성하였다.Maturation step (S40): The mixture prepared in the mixing step (S30) was matured at a temperature of 15°C for 3 days.
비교예Comparative example 3. 무환자추출물이 배제된 실험용 조성물의 제조3. Preparation of experimental compositions excluding patient-free extracts
하기의 제조과정에 따라, 비교예 3의 무환자추출물이 배제된 실험용 조성물을 제조하였다.According to the manufacturing process below, an experimental composition was prepared from which the patient-free extract of Comparative Example 3 was excluded.
세척 및 건조 단계(S10): 아와푸히, 녹두, 아마씨 및 흰버드나무껍질을 준비하여, 필요에 따라 1 × 1cm 크기의 절편으로 절단한 다음, 세척하고 통풍이 잘되는 그늘에서 건조하였다.Washing and drying step (S10): Awapuhi, mung beans, flax seeds and white willow bark were prepared, cut into 1 × 1 cm pieces as needed, washed and dried in a well-ventilated shade.
추출 단계(S20): 상기 세척 및 건조 단계(S10)에서 준비된 아와푸히, 녹두, 아마씨 및 흰버드나무껍질에 부틸렌글라이콜 및 헥산디올이 혼합된 추출용매를 가하고 60℃의 온도에서 12시간 동안 추출하여, 아와푸히추출물, 녹두추출물, 아마씨추출물 및 흰버드나무껍질추출물을 제조하였다. Extraction step (S20): An extraction solvent mixed with butylene glycol and hexanediol was added to the awapuhi, mung bean, flaxseed, and white willow bark prepared in the washing and drying step (S10), and extraction was performed at a temperature of 60°C for 12 hours, thereby producing an awapuhi extract, a mung bean extract, a flaxseed extract, and a white willow bark extract.
혼합 단계(S30): 상기 추출 단계(S20)에서 준비한 아와푸히추출물, 녹두추출물, 아마씨추출물 및 흰버드나무껍질추출물을 동량으로 혼합하여 혼합물을 제조하였다. Mixing step (S30): A mixture was prepared by mixing equal amounts of the awapuhi extract, mung bean extract, flaxseed extract, and white willow bark extract prepared in the above extraction step (S20).
숙성 단계(S40): 상기 혼합단계(S30)에서 제조된 혼합물을 15℃의 온도에서 3일 동안 숙성하였다.Maturation step (S40): The mixture prepared in the mixing step (S30) was matured at a temperature of 15°C for 3 days.
비교예Comparative example 4. 아마씨4. Flaxseed 추출물이The extract 배제된 실험용 조성물의 제조Preparation of the excluded experimental composition
하기의 제조과정에 따라, 비교예 4의 아마씨추출물이 배제된 실험용 조성물을 제조하였다.According to the manufacturing process below, an experimental composition excluding the flaxseed extract of Comparative Example 4 was manufactured.
세척 및 건조 단계(S10): 아와푸히, 녹두, 무환자, 및 흰버드나무껍질을 준비하여, 필요에 따라 1 × 1cm 크기의 절편으로 절단한 다음, 세척하고 통풍이 잘되는 그늘에서 건조하였다.Washing and drying step (S10): Awapuhi, mung bean, muhusha, and white willow bark were prepared, cut into 1 × 1 cm pieces as needed, washed, and dried in a well-ventilated shade.
추출 단계(S20): 상기 세척 및 건조 단계(S10)에서 준비된 아와푸히, 녹두, 무환자 및 흰버드나무껍질에 부틸렌글라이콜 및 헥산디올이 혼합된 추출용매를 가하고 60℃의 온도에서 12시간 동안 추출하여, 아와푸히추출물, 녹두추출물, 무환자추출물 및 흰버드나무껍질추출물을 제조하였다. Extraction step (S20): An extraction solvent mixed with butylene glycol and hexanediol was added to the awapuhi, mung bean, muhuani and white willow bark prepared in the washing and drying step (S10), and extraction was performed at a temperature of 60°C for 12 hours, thereby producing an awapuhi extract, a mung bean extract, a muhuani extract and a white willow bark extract.
혼합 단계(S30): 상기 추출 단계(S20)에서 준비한 아와푸히추출물, 녹두추출물, 무환자추출물 및 흰버드나무껍질추출물을 동량으로 혼합하여 혼합물을 제조하였다. Mixing step (S30): A mixture was prepared by mixing equal amounts of the awapuhi extract, mung bean extract, radish root extract, and white willow bark extract prepared in the above extraction step (S20).
숙성 단계(S40): 상기 혼합단계(S30)에서 제조된 혼합물을 15℃의 온도에서 3일 동안 숙성하였다.Maturation step (S40): The mixture prepared in the mixing step (S30) was matured at a temperature of 15°C for 3 days.
비교예Comparative example 5. 흰버드나무껍질5. White willow bark 추출물이The extract 배제된 실험용 조성물의 제조Preparation of the excluded experimental composition
하기의 제조과정에 따라, 비교예 5의 흰버드나무껍질추출물이 배제된 실험용 조성물을 제조하였다.According to the manufacturing process below, an experimental composition excluding the white willow bark extract of Comparative Example 5 was manufactured.
세척 및 건조 단계(S10): 아와푸히, 녹두, 무환자 및 아마씨를 준비하여, 필요에 따라 1 × 1cm 크기의 절편으로 절단한 다음, 세척하고 통풍이 잘되는 그늘에서 건조하였다.Washing and drying step (S10): Awapuhi, mung beans, sesame seeds and flax seeds were prepared, cut into 1 × 1 cm pieces as needed, washed and dried in a well-ventilated shade.
추출 단계(S20): 상기 세척 및 건조 단계(S10)에서 준비된 아와푸히, 녹두, 무환자 및 아마씨에 부틸렌글라이콜 및 헥산디올이 혼합된 추출용매를 가하고 60℃의 온도에서 12시간 동안 추출하여, 아와푸히추출물, 녹두추출물, 무환자추출물 및 아마씨추출물을 제조하였다. Extraction step (S20): An extraction solvent containing a mixture of butylene glycol and hexanediol was added to the awapuhi, mung bean, mushu root, and flax seed prepared in the washing and drying step (S10), and extraction was performed at a temperature of 60°C for 12 hours, thereby producing an awapuhi extract, a mung bean extract, a mushu root extract, and a flax seed extract.
혼합 단계(S30): 상기 추출 단계(S20)에서 준비한 아와푸히추출물, 녹두추출물, 무환자추출물 및 아마씨추출물을 동량으로 혼합하여 혼합물을 제조하였다. Mixing step (S30): A mixture was prepared by mixing equal amounts of the awapuhi extract, mung bean extract, neem extract, and flaxseed extract prepared in the extraction step (S20).
숙성 단계(S40): 상기 혼합단계(S30)에서 제조된 혼합물을 15℃의 온도에서 3일 동안 숙성하였다.Maturation step (S40): The mixture prepared in the mixing step (S30) was matured at a temperature of 15°C for 3 days.
실험예Experimental example 1. 세포독성 확인1. Confirmation of cytotoxicity
상기 실시예 1 및 비교예 1 내지 5에서 제조된 실험용 조성물에 대하여 세포독성을 확인하였다. 실험은 공지된 방법을 통해 수행되었다. Cytotoxicity was confirmed for the experimental compositions prepared in Example 1 and Comparative Examples 1 to 5. The experiments were performed using a known method.
세포독성 실험은 실시예 1 및 비교예 1 내지 5에서 제조된 실험용 조성물의 HaCaT 세포 생존율에 미치는 정도를 측정하여 파악하였다. 상기 실시예 1 및 비교예 1 내지 5에서 제조된 실험용 조성물을 정제수에 현탁하여 농도별(0.5%, 1%. 5%, 10%)로 조성한 후, 하기의 방법을 통해 세포 생존율을 측정하였다. Cytotoxicity experiments were conducted by measuring the extent to which the experimental compositions prepared in Example 1 and Comparative Examples 1 to 5 affected the HaCaT cell viability. The experimental compositions prepared in Example 1 and Comparative Examples 1 to 5 were suspended in purified water to prepare concentrations (0.5%, 1%, 5%, 10%), and then the cell viability was measured using the following method.
세포 독성 및 증식 실험을 다음과 같은 방법으로 실시하였다. 배양하고 있는 각질형성세포주 HaCaT 세포를 96 웰 마이크로플레이트에 5,000세포/웰로 분주하여 30분간 항온조에서 배양하고, 실시예 1 및 비교예 1 내지 5에서 제조된 실험용 조성물을 농도별(0.5%, 1%. 5%, 10%)로 투여하여 72시간 동안 배양하였다. 그리고 티아졸린 블루(Thiazoline blue)를 투여하고 4시간 동안 추가 배양을 하였다. 배양액을 모두 버리고 마이크로플레이트의 각 웰에 반응 정지액을 가하고 5분간 교반한 후, 570 nm에서 흡광도를 측정하였다. 대조군으로 시료 주입량만큼 농도별(0.5%, 1%. 5%, 10%) 우태아혈청(Fetal Bovine Serum, FBS)을 투여하여 세포 성장의 최적 조건으로 동시배양을 하였으며, 대조군의 세포증식을 100%로 하고 시료투입 실험군의 세포 증식률을 계산하였다(세포증식률(%)=(추출물처리시의흡광도-대조군의흡광도)/대조군의흡광도×100)). Cytotoxicity and proliferation experiments were performed as follows. HaCaT cells, a keratinocyte cell line, were seeded at 5,000 cells/well in a 96-well microplate and cultured in a constant temperature bath for 30 minutes. The experimental compositions prepared in Example 1 and Comparative Examples 1 to 5 were administered at various concentrations (0.5%, 1%, 5%, 10%) and cultured for 72 hours. Thiazoline blue was administered and additional culture was performed for 4 hours. All culture solution was discarded, and a reaction stop solution was added to each well of the microplate, stirred for 5 minutes, and then the absorbance was measured at 570 nm. As a control group, fetal bovine serum (FBS) was administered at concentrations (0.5%, 1%, 5%, 10%) equivalent to the sample injection amount, and co-culture was performed under optimal conditions for cell growth. The cell proliferation of the control group was set to 100%, and the cell proliferation rate of the sample injection experimental group was calculated (Cell proliferation rate (%) = (absorbance at the time of extract treatment - absorbance of control group) / absorbance of control group × 100)).
실험결과, 표 1에 나타낸 바와 같이 실시예 1 및 비교예 1 내지 5의 실험용 조성물을 처리하는 경우, 피부각질형성 세포인 HaCaT 세포에 대한 유의미한 독성은 확인되지 않아, 피부 적용시에 안전한 것으로 나타났다. As a result of the experiment, as shown in Table 1, when the experimental compositions of Example 1 and Comparative Examples 1 to 5 were treated, no significant toxicity was observed for HaCaT cells, which are keratinocyte cells, indicating that they are safe when applied to the skin.
실험예Experimental example 2. 2. 실시예Example 1 및 1 and 비교예Comparative example 1 내지 5의 조성물에 대한 두피 진정 효과 확인 Confirmation of scalp soothing effect for compositions 1 to 5
실시예 1 및 비교예 1 내지 5의 조성물에 대하여 두피 진정효과를 확인하였다.The scalp soothing effect was confirmed for the compositions of Example 1 and Comparative Examples 1 to 5.
비듬이 많이 생기거나 혹은 두피 가려움증을 느끼는 20대 ~ 60대의 남녀를 무작위로 20명 선정하여 상이한 농도(5.0%, 10.0%)를 갖는 실시예 1 및 비교예 1 내지 5의 조성물을 샴푸 사용 후 1일에 1회씩 8주 동안 사용하게 한 후, 두피 진정 효과를 관찰하였다. 양성대조군으로는 징크피리치온(1.0%)을 이용하였다. Twenty men and women in their 20s to 60s who suffered from a lot of dandruff or an itchy scalp were randomly selected and used the compositions of Example 1 and Comparative Examples 1 to 5 having different concentrations (5.0%, 10.0%) once a day after using shampoo for 8 weeks, and the scalp soothing effect was observed. Zinc pyrithione (1.0%) was used as a positive control group.
상기 가려움증 감소 효과는 하기의 평가기준에 따라, 5점 척도법(효과 없음 (1점), 효과가 약간 있음 (2점), 효과 보통 (3점), 효과가 좋음 (4점), 효과가 매우 좋음(5점))을 기준으로 측정하고 평균을 내었다. The above itching reduction effect was measured and averaged using a 5-point scale (no effect (1 point), slightly effective (2 points), moderately effective (3 points), good effective (4 points), very good effective (5 points)) according to the evaluation criteria below.
결과는 하기 표 2에 평균점수로 나타내었다.The results are presented as average scores in Table 2 below.
그 결과, 실시예 1의 조성물이 비교예 1 내지 5의 조성물에 비해 우수한 효과를 갖는 것을 확인할 수 있었으며, 특히 실시예 1의 조성물이 두피 진정 효과가 우수한 것을 확인할 수 있었다. 이에 따라, 본 발명에 따른 조합을 통해 두피 진정 효과가 증진됨을 확인할 수 있었다. As a result, it was confirmed that the composition of Example 1 had a superior effect compared to the compositions of Comparative Examples 1 to 5, and in particular, it was confirmed that the composition of Example 1 had a superior scalp soothing effect. Accordingly, it was confirmed that the scalp soothing effect was enhanced through the combination according to the present invention.
실험예Experimental example 3. 3. 실시예Example 1 및 1 and 비교예Comparative example 1 내지 5의 조성물에 대한 모공 개선 효과 확인 Confirmation of pore improvement effect for compositions 1 to 5
두피의 모공이 막히는 등 이와 관련한 문제로 두피 트러블을 겪고 있는 20대 ~ 60대의 남녀를 무작위로 20명 선정하여 상이한 농도(5.0%, 10.0%)를 갖는 실시예 1 및 비교예 1 내지 5의 조성물을 샴푸 사용 후 1일에 1회씩 8주 동안 사용하게 한 후, 두피 모공 개선 효과를 관찰하였다. 양성대조군으로는 징크피리치온(1.0%)을 이용하였다. Twenty men and women in their 20s to 60s who were suffering from scalp trouble such as clogged pores were randomly selected and used the compositions of Example 1 and Comparative Examples 1 to 5 having different concentrations (5.0%, 10.0%) once a day after using shampoo for 8 weeks, and the effect of improving scalp pores was observed. Zinc pyrithione (1.0%) was used as a positive control group.
상기 모공 개선 효과는 하기의 평가기준에 따라, 5점 척도법(효과 없음 (1점), 효과가 약간 있음 (2점), 효과 보통 (3점), 효과가 좋음 (4점), 효과가 매우 좋음(5점))을 기준으로 측정하고 평균을 내었다. The above pore improvement effect was measured and averaged using a 5-point scale (no effect (1 point), slightly effective (2 points), moderate effective (3 points), good effective (4 points), very good effective (5 points)) based on the evaluation criteria below.
결과는 하기 표 3에 평균점수로 나타내었다. The results are presented as average scores in Table 3 below.
그 결과, 실시예 1의 조성물이 비교예 1 내지 5의 조성물에 비해 우수한 효과를 갖는 것을 확인할 수 있었으며, 특히 실시예 1의 조성물이 모공 개선 효과가 우수한 것을 확인할 수 있었다. 이에 따라, 본 발명에 따른 조합을 통해 모공 개선 효과가 증진됨을 확인할 수 있었다. As a result, it was confirmed that the composition of Example 1 had a superior effect compared to the compositions of Comparative Examples 1 to 5, and in particular, it was confirmed that the composition of Example 1 had a superior pore improvement effect. Accordingly, it was confirmed that the pore improvement effect was enhanced through the combination according to the present invention.
실험예Experimental example 4. 4. 실시예Example 1 및 1 and 비교예Comparative example 1 내지 5의 조성물에 대한 비듬 개선 효과 확인 Confirmation of dandruff improvement effect for compositions 1 to 5
비듬이 비교적 많은 20대 ~ 60대의 남녀를 선정하여 상기 실시예 1 및 비교예 1 내지 5의 조성물을 10명의 사람으로 하여금 1개월 동안 실험하였다. 시험 개시 전에 동일한 통상의 샴푸로 세발하고 3일간 누적된 비듬을 채집하여 채집된 비듬의 중량과, 상이한 농도(5.0%, 10.0%)를 갖는 실시예 1 및 비교예 1 내지 5의 조성물로 매일 한번 씩 세발하여 시험 종료 후 3일간 누적된 비듬의 중량을 비교 평가하였다. 양성대조군으로는 케토코나졸(2.0%)을 이용하였다. Men and women in their 20s to 60s with relatively heavy dandruff were selected, and the compositions of Example 1 and Comparative Examples 1 to 5 were tested on 10 people for 1 month. Before the start of the test, the subjects washed their hair with the same regular shampoo, and the accumulated dandruff for 3 days was collected. The weight of the collected dandruff was compared with the weight of the accumulated dandruff for 3 days after the end of the test by washing their hair once a day with the compositions of Example 1 and Comparative Examples 1 to 5 having different concentrations (5.0%, 10.0%). Ketoconazole (2.0%) was used as a positive control group.
비듬 감소율(%) = [(시험개시전 비듬의 중량(㎎) - 시험개시 1개월 후 비듬의 중량(㎎)) / 시험개시전 비듬의 중량(㎎)]×100Dandruff reduction rate (%) = [(Dandruff weight before test (mg) - Dandruff weight 1 month after test (mg)) / Dandruff weight before test (mg)] × 100
그 결과, 실시예 1의 조성물이 비교예 1 내지 5의 조성물에 비해 우수한 효과를 갖는 것을 확인할 수 있었으며, 특히 실시예 1의 조성물이 비듬 감소 효과가 우수한 것을 확인할 수 있었다. 이에 따라, 본 발명에 따른 조합을 통해 비듬 감소 효과가 증진됨을 확인할 수 있었다. As a result, it was confirmed that the composition of Example 1 had a superior effect compared to the compositions of Comparative Examples 1 to 5, and in particular, it was confirmed that the composition of Example 1 had a superior dandruff reduction effect. Accordingly, it was confirmed that the dandruff reduction effect was enhanced through the combination according to the present invention.
실험예Experimental example 5. 항균 효과 확인5. Confirm antibacterial effect
항균효과는 2배 희석법(two fold dilution method)을 이용하여 피부 상재균에 대한 최소억제농도(MIC, Minimum Inhibitory Concentration)를 측정하여 항균력을 평가하였다. The antibacterial effect was evaluated by measuring the minimum inhibitory concentration (MIC) against skin flora using the two-fold dilution method.
시험균주로는 대장균(Escherichia coli), 황색포도상구균(Staphylococcus aureus), 말라세지아 퍼퍼(Malassezia furfur), 플라스모디움 오발레(Plasmodium ovale), 피티로스포름 오발레(Pityrosporum ovale), 프로피오니박테리움 아크네스(Propionibacterium acnes)를 대상으로 시험하였다. The test strains tested were Escherichia coli, Staphylococcus aureus, Malassezia furfur, Plasmodium ovale, Pityrosporum ovale, and Propionibacterium acnes.
상기 MIC 측정방법에서는 각각 5%, 10% 농도로 희석한 실시예 1 내지 2 및 비교예 1 내지 5의 시료를 액상배지에 일정농도 간격으로 희석하거나 멸균된 고체 배지 내에 일정농도 간격으로 첨가하여 고형화시킨 다음, 전배양된 시험균액을 도말한 뒤, 37℃에서 24시간 배양한 후 시료 균체의 성장 정도를 관찰하였다. 음성대조군으로는 동일 양의 증류수를 사용하였으며, 양성대조군으로는 TCH(1.0%)를 사용하였다. 항균력 평가 결과를 하기 표에 나타내었으며, 단위는 ppm이며, 수치가 낮을수록 균주에 대한 항균력이 우수함을 나타낸다. In the above MIC measurement method, the samples of Examples 1 to 2 and Comparative Examples 1 to 5, which were diluted to 5% and 10% concentrations, respectively, were diluted at regular intervals in a liquid medium or added at regular intervals in a sterilized solid medium to solidify, and then the pre-cultured test bacterial solution was smeared, followed by incubation at 37°C for 24 hours and observation of the growth of the sample bacterial cells. The same amount of distilled water was used as a negative control group, and TCH (1.0%) was used as a positive control group. The results of the antibacterial activity evaluation are shown in the table below. The unit is ppm, and a lower value indicates a better antibacterial activity against the strain.
(증류수)Voice control group
(distilled water)
(TCH 1.0%)Positive control group
(TCH 1.0%)
그 결과 실시예 1의 조성물이 비교예 1 내지 5의 조성물에 비해 항균 효과가 우수함을 확인할 수 있었다. 실험군 중에서 실시예 1이 가장 우수한 효과를 갖는 것 역시 확인할 수 있었다. 이에 따라, 본 발명에 따른 조합을 통해 모발 손상 개선 효과가 증진됨을 확인할 수 있었다. 한편, 비듬균(Malassezia furfur, Pityrosporum ovale), 여드름균(Propionibacterium acnes) 등에 대하여 높은 항균 효과를 갖는 바, 본 발명에 따른 조성물이 비듬 내지는 두피 트러블에 효과를 가짐을 확인할 수 있었다. As a result, it was confirmed that the composition of Example 1 had a superior antibacterial effect compared to the compositions of Comparative Examples 1 to 5. It was also confirmed that Example 1 had the best effect among the experimental groups. Accordingly, it was confirmed that the hair damage improvement effect was enhanced through the combination according to the present invention. On the other hand, it was confirmed that the composition according to the present invention was effective for dandruff and scalp troubles since it had a high antibacterial effect against Malassezia furfur, Pityrosporum ovale, and acne bacteria (Propionibacterium acnes).
결론. conclusion.
상기 실시예 1 및 비교예 1 내지 5를 통해 진행된 실험예 1 내지 4를 통하여 본 발명에 따른 조성물이 갖는 효과에 대해 살펴보았다. The effects of the composition according to the present invention were examined through Experimental Examples 1 to 4 conducted through the above Example 1 and Comparative Examples 1 to 5.
실험예 1을 통하여, 본 발명에 따른 조성물은 세포에 유의미한 독성을 나타내지 않음을 확인할 수 있었다. Through Experimental Example 1, it was confirmed that the composition according to the present invention does not exhibit significant toxicity to cells.
실험예 2을 통하여, 본 발명에 따른 조성물은 두피 진정 효과를 가지며, 일부 성분이 결여되는 경우에 비해 월등히 증진되는 효과를 보여, 본 발명에 따른 조합을 통해 두피 진정 효과가 증진되는 것을 확인할 수 있었다. Through Experimental Example 2, it was confirmed that the composition according to the present invention has a scalp soothing effect and that the effect is significantly enhanced compared to when some components are missing, and that the scalp soothing effect is enhanced through the combination according to the present invention.
실험예 3를 통하여, 본 발명에 따른 조성물은 모공 개선 효과를 가지며, 일부 성분이 결여되는 경우에 비해 월등히 증진되는 효과를 보여, 본 발명에 따른 조합을 통해 모공 개선 효과가 증진되는 것을 확인할 수 있었다. Through Experimental Example 3, it was confirmed that the composition according to the present invention has a pore improvement effect and that the effect is significantly enhanced compared to when some components are missing, and that the pore improvement effect is enhanced through the combination according to the present invention.
실험예 4를 통하여, 본 발명에 따른 조성물은 비듬 감소 효과를 가지며, 일부 성분이 결여되는 경우에 비해 월등히 증진되는 효과를 보여, 본 발명에 따른 조합을 통해 비듬 감소 효과가 증진되는 것을 확인할 수 있었다. Through Experimental Example 4, it was confirmed that the composition according to the present invention has a dandruff reduction effect and that the effect is significantly enhanced compared to when some components are missing, and that the dandruff reduction effect is enhanced through the combination according to the present invention.
실험예 5를 통하여, 본 발명에 따른 조성물은 두피관련 항균효과를 가지며, 특히 비듬균, 여드름균 등에 대하여 높은 항균 효과를 갖는 바, 본 발명에 따른 조성물이 비듬 내지는 두피 트러블에 효과를 가짐을 확인할 수 있었다. Through Experimental Example 5, it was confirmed that the composition according to the present invention has an antibacterial effect related to the scalp, and in particular, has a high antibacterial effect against dandruff bacteria, acne bacteria, etc., and thus, the composition according to the present invention is effective against dandruff and scalp troubles.
이에, 본 발명은 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물을 유효성분으로 포함하여 두피 진정 효과, 모공 개선 효과 및 비듬 개선 효과를 갖도록 한, 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물을 개발하였음을 명시한다. Accordingly, the present invention states that a cosmetic composition for scalp soothing, pore improvement and dandruff improvement has been developed, which contains awapuhi extract, mung bean extract, radish root extract, flaxseed extract and white willow bark extract as effective ingredients and has a scalp soothing effect, pore improvement effect and dandruff improvement effect.
본 발명을 첨부된 도면과 함께 설명하였으나, 이는 본 발명의 요지를 포함하는 다양한 실시 형태 중의 하나의 실시 예에 불과하며, 당 업계에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 하는 데에 그 목적이 있는 것으로, 본 발명은 상기 설명된 실시예에만 국한되는 것이 아님은 명확하다. 따라서, 본 발명의 보호범위는 하기의 청구범위에 의해 해석되어야 하며, 본 발명의 요지를 벗어나지 않는 범위 내에서 변경, 치환, 대체 등에 의해 그와 동등한 범위 내에 있는 모든 기술 사상은 본 발명의 권리에 포함될 것이다. 또한, 도면의 일부 구성은 구성을 보다 명확하게 설명하기 위한 것으로 실제보다 과장되거나 축소되어 제공되는 것임을 명확히 한다.Although the present invention has been described together with the attached drawings, this is only one embodiment among various embodiments including the gist of the present invention, and the purpose is to enable a person having ordinary skill in the art to easily practice it, and it is clear that the present invention is not limited to the embodiments described above. Therefore, the protection scope of the present invention should be interpreted by the following claims, and all technical ideas within the equivalent scope by change, substitution, replacement, etc., within the scope that does not depart from the gist of the present invention shall be included in the rights of the present invention. In addition, it is clearly stated that some components of the drawings are provided exaggerated or reduced compared to the actual structure in order to more clearly explain the configuration.
(S10): 세척 및 건조 단계
(S20): 추출 단계
(S30): 혼합 단계
(S40): 숙성 단계(S10): Washing and drying step
(S20): Extraction stage
(S30): Mixing stage
(S40): Maturation stage
Claims (5)
A cosmetic composition for soothing the scalp, improving pores and improving dandruff, characterized in that it has a scalp soothing effect, a pore improving effect and a dandruff improving effect, and contains a mixture of equal amounts of awapuhi extract, mung bean extract, mung bean extract, linseed extract and white willow bark extract as an effective ingredient.
상기 상기 아와푸히추출물, 녹두추출물, 무환자추출물, 아마씨추출물 및 흰버드나무껍질추출물은 물, 탄소수 1 내지 4의 알콜, 프로판다이올, 메틸프로판다이올, 글리세린, 부틸렌글라이콜, 펜틸렌글라이콜, 프로필렌글라이콜, 에틸헥실글리세린 및 헥산디올로 이루어진 군에서 선택된 어느 하나 이상의 추출용매로 추출된 것을 특징으로 하는 두피 진정용, 모공 개선용 및 비듬 개선용 화장료 조성물.
In the first paragraph,
A cosmetic composition for scalp soothing, pore improvement and dandruff improvement, characterized in that the above-mentioned awapuhi extract, mung bean extract, radish root extract, flaxseed extract and white willow bark extract are extracted with at least one extraction solvent selected from the group consisting of water, alcohols having 1 to 4 carbon atoms, propanediol, methylpropanediol, glycerin, butylene glycol, pentylene glycol, propylene glycol, ethylhexylglycerin and hexanediol.
A cosmetic composition for scalp soothing, pore improvement and dandruff improvement, characterized in that it is formulated into any one formulation from the group consisting of hair conditioner, hair treatment, hair pack, hair tonic, hair essence, hair grooming aid, pomade, hair spray, mousse, wax, gel, hair cream, hair lotion , hair oil shampoo, rinse, permanent wave, hair straightener, hair dye and other hair products using the mixture of claim 1.
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| KR20060065196A (en) * | 2004-12-10 | 2006-06-14 | 주식회사 코리아나화장품 | Hair cosmetic composition for treating dandruff, containing mung bean extract as an active ingredient |
| KR100966836B1 (en) | 2007-12-24 | 2010-06-29 | 소망화장품주식회사 | Cosmetic composition having scalp protection and skin soothing effect |
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| KR20220092745A (en) * | 2020-12-24 | 2022-07-04 | 주식회사 비투에스컴퍼니 | A composition for stimulating growth of hairs contaning natural complex extracts |
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| KR20060065196A (en) * | 2004-12-10 | 2006-06-14 | 주식회사 코리아나화장품 | Hair cosmetic composition for treating dandruff, containing mung bean extract as an active ingredient |
| KR100966836B1 (en) | 2007-12-24 | 2010-06-29 | 소망화장품주식회사 | Cosmetic composition having scalp protection and skin soothing effect |
| KR20100077554A (en) * | 2008-12-29 | 2010-07-08 | 전라남도 | Method for purification of saponin from soapberry, dichloro methane fraction of soapberry, and cosmetic composition for hair comprising the same |
| KR20210100133A (en) * | 2018-12-06 | 2021-08-13 | 삐에르화브르데르모-코스메띠끄 | Red mouth extract for dandruff treatment |
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