KR102423025B1 - Food composition and health functional food containing Lactobacillus rhamnosus IDCC 3201 with proteolytic ability - Google Patents
Food composition and health functional food containing Lactobacillus rhamnosus IDCC 3201 with proteolytic ability Download PDFInfo
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- KR102423025B1 KR102423025B1 KR1020210123132A KR20210123132A KR102423025B1 KR 102423025 B1 KR102423025 B1 KR 102423025B1 KR 1020210123132 A KR1020210123132 A KR 1020210123132A KR 20210123132 A KR20210123132 A KR 20210123132A KR 102423025 B1 KR102423025 B1 KR 102423025B1
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
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- A23Y2220/73—
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Abstract
Description
본 발명은 단백질 분해능을 가지는 락토바실러스 람노서스 IDCC 3201을 포함하는 식품 조성물 및 건강기능식품에 관한 것이다.The present invention relates to a food composition and health functional food comprising Lactobacillus rhamnosus IDCC 3201 having proteolytic ability.
단백질은 평균 에너지 섭취의 11~14%를 구성하며, 체내의 모든 대사 과정에 이용된다. 식이 단백질은 동물 및 식물 원료로부터 얻어지며, 섭취한 단백질이 체내에서 이용되기 위해서는 펩타이드(peptide)를 거쳐 아미노산(amino acid)으로 분해되어야 한다. Proteins make up 11-14% of average energy intake and are used for all metabolic processes in the body. Dietary protein is obtained from animal and plant raw materials, and in order for the ingested protein to be used in the body, it must be decomposed into amino acids through peptides.
단백질의 분해에는 단백질을 가수분해하여 펩타이드 결합(peptide bond)을 끊는 프로테아제(protease) 등이 관여한다. 최근에는 동물성 단백질과 식물성 단백질의 균형 잡힌 섭취뿐 아니라 단백질 분해를 통해 혈중 아미노산 농도를 높여 체내 흡수율을 증가시키려는 노력이 지속되고 있다.In the degradation of proteins, a protease, which hydrolyzes the protein to break a peptide bond, and the like are involved. In recent years, efforts to increase the absorption rate in the body by increasing the concentration of amino acids in the blood through protein breakdown as well as a balanced intake of animal protein and vegetable protein are continuing.
본 발명은 유산균을 포함하는 단백질 분해능을 가지는 락토바실러스 람노서스 IDCC 3201을 포함하는 식품 조성물 및 건강기능식품을 제공하는 것을 목적으로 한다.An object of the present invention is to provide a food composition and health functional food containing Lactobacillus rhamnosus IDCC 3201 having proteolytic ability including lactic acid bacteria.
본 발명의 목적은 단백질 분해능을 가지는 식품 조성물에 있어서, 락토바실러스 람노서스 IDCC 3201 [기탁번호: ATCC BAA-2836]을 포함하는 것에 의해 달성된다.An object of the present invention is achieved by including Lactobacillus rhamnosus IDCC 3201 [Accession No.: ATCC BAA-2836] in a food composition having proteolytic ability.
상기 식품 조성물은 상기 락토바실러스 람노서스 IDCC 3201을 0.01 중량% 내지 50중량% 포함할 수 있다.The food composition may include 0.01 wt% to 50 wt% of the Lactobacillus rhamnosus IDCC 3201.
본 발명의 목적은 단백질 분해능을 가지는 건강기능식품에 있어서, 락토바실러스 람노서스 IDCC 3201 [기탁번호: ATCC BAA-2836]을 유효성분으로 포함하는 것에 의해 달성된다.An object of the present invention is achieved by including Lactobacillus rhamnosus IDCC 3201 [Accession No.: ATCC BAA-2836] as an active ingredient in a health functional food having proteolytic ability.
상기 건강기능식품은 상기 락토바실러스 람노서스 IDCC 3201을 0.1 중량% 내지 100중량% 포함할 수 있다.The health functional food may include 0.1 wt% to 100 wt% of the Lactobacillus rhamnosus IDCC 3201.
본 발명은 단백질 분해능을 갖는 락토바실러스 람노서스 IDCC 3201 [기탁번호: ATCC BAA-2836]에 관한 것이다.The present invention relates to Lactobacillus rhamnosus IDCC 3201 [Accession No.: ATCC BAA-2836] having proteolytic ability.
본 발명에 따르면 단백질 분해능을 가지는 락토바실러스 람노서스 IDCC 3201을 포함하는 식품 조성물 및 건강기능식품이 제공된다. According to the present invention, there is provided a food composition and health functional food comprising Lactobacillus rhamnosus IDCC 3201 having protein-degrading ability.
도 1은 pea protein과 skim milk 배지에 각 균주를 배양하였을 때 프로테아제 활성으로 나타난 clear zone을 보여주는 것이고,
도 2는 pea protein과 skim milk 배지에 각 균주를 배양하였을 때 프로테아제 활성을 비교한 그래프이다.Figure 1 shows the clear zone shown by protease activity when each strain is cultured in pea protein and skim milk medium,
Figure 2 is a graph comparing protease activity when each strain is cultured in pea protein and skim milk medium.
이하 도면을 참조하여 본 발명을 더욱 상세히 설명한다.Hereinafter, the present invention will be described in more detail with reference to the drawings.
첨부된 도면은 본 발명의 기술적 사상을 더욱 구체적으로 설명하기 위하여 도시한 일 예에 불과하므로 본 발명의 사상이 첨부된 도면에 한정되는 것은 아니다. 또한 첨부된 도면은 각 구성요소 간의 관계를 설명하기 위해 크기와 간격 등이 실제와 달리 과장되어 있을 수 있다.Since the accompanying drawings are only an example shown in order to explain the technical idea of the present invention in more detail, the spirit of the present invention is not limited to the accompanying drawings. In addition, in the accompanying drawings, the size and spacing may be exaggerated differently from reality in order to explain the relationship between each component.
프로바이오틱스는 충분히 섭취했을 때 숙주에게 유익한 건강 효과를 제공하는 살아있는 미생물로써, 영양소 흡수와 이용에 영향을 미친다. 프로바이오틱스는 단백질 분해 효소인 프로테아제와 펩티다아제(peptidase) 활성을 유도하며, 단백질 소화에 관여하는 효소를 방출할 수 있다. 또한 프로바이오틱스는 대장상피의 흡수 및 운반력을 높여 펩타이드와 아미노산의 흡수를 향상시킬 수 있다.Probiotics are living microorganisms that, when consumed in sufficient amounts, provide beneficial health effects to the host, affecting the absorption and utilization of nutrients. Probiotics induce the activity of protease and peptidase, which are proteolytic enzymes, and can release enzymes involved in protein digestion. In addition, probiotics can enhance the absorption and transport capacity of the colonic epithelium to improve the absorption of peptides and amino acids.
본 발명은 락토바실러스(Lactoacillus), 락토코커스(Lactococcus) 속 균주 중에서 단백질 분해능이 뛰어난 균주에 관한 것이다.The present invention relates to a strain having excellent proteolytic ability among Lactobacillus and Lactococcus genus strains.
본 발명의 락토바실러스 람노서스 IDCC 3201 [기탁번호: ATCC BAA-2836]은 프로테아제 활성이 우수하다.Lactobacillus rhamnosus IDCC 3201 [Accession No.: ATCC BAA-2836] of the present invention is excellent in protease activity.
본 발명의 락토바실러스 람노서스 IDCC 3201은 배양물 형태일 수 있다.Lactobacillus rhamnosus IDCC 3201 of the present invention may be in the form of a culture.
본 발명의 락토바실러스 람노서스 IDCC 3201은 단백질 분해를 돕는 프로바이오틱스 제제에 사용될 수 있다.Lactobacillus rhamnosus IDCC 3201 of the present invention can be used in a probiotic preparation to help protein degradation.
본 발명의 락토바실러스 람노서스 IDCC 3201은 단백질 분해능을 가져 단백질의 소화 및 아미노산 흡수를 도울 수 있으며, 특히 단백질 섭취 시 소화에 어려움을 겪는 섭취자의 아미노산 흡수를 도울 수 있다.Lactobacillus rhamnosus IDCC 3201 of the present invention can help protein digestion and amino acid absorption by having proteolytic ability, and in particular, it can help the amino acid absorption of ingestors who have difficulty in digestion when ingesting protein.
본 발명은 단백질 분해능을 가지는 락토바실러스 람노서스 IDCC 3201 [기탁번호: ATCC BAA-2836], 이를 포함하는 식품 조성물 및 이를 포함하는 건강기능식품에 관한 것이다.The present invention relates to Lactobacillus rhamnosus IDCC 3201 [Accession No.: ATCC BAA-2836] having proteolytic ability, a food composition comprising the same, and a health functional food comprising the same.
락토바실러스 람노서스 IDCC 3201은 생균 또는 용해물의 형태일 수 있다. Lactobacillus rhamnosus IDCC 3201 may be in the form of live cells or lysates.
본 발명의 식품 조성물 내지 건강기능식품은 기능성 식품(functional food), 영양 보조제(nutritional supplement), 건강식품(health food) 및 식품 첨가제(food additives) 등의 모든 형태의 식품에 대한 조성물을 포함한다. 상기 유형의 식품 조성물 내지 건강기능식품은 당업계에 공지된 통상적인 방법에 따라 다양한 형태로 제조할 수 있다. 예를 들면, 건강식품으로는 유산균이 함유된 껌, 비타민 복합체, 차, 주스 및 드링크 형태로 제조할 수 있으며, 락토바실러스 람노서스 IDCC 3201을 유효성분으로 하는 식품 조성물을 과립화, 캡슐화 또는 분말화하여 섭취할 수 있다. The food composition or health functional food of the present invention includes a composition for all types of food, such as functional food, nutritional supplement, health food, and food additives. The above type of food composition or health functional food can be prepared in various forms according to conventional methods known in the art. For example, health food can be prepared in the form of gum containing lactic acid bacteria, vitamin complex, tea, juice and drink, and a food composition containing Lactobacillus rhamnosus IDCC 3201 as an active ingredient is granulated, encapsulated or powdered. can be ingested.
본 발명의 식품 조성물 내지 건강기능식품은 식품 제조 시에 통상적으로 첨가되는 성분을 포함할 수 있으며, 예를 들어, 단백질, 탄수화물, 지방, 영양소 및 조미제를 포함할 수 있다. 예컨대, 드링크제로 제조되는 경우에는 구연산, 액상과당, 설탕, 포도당, 초산, 사과산, 과즙, 대추 추출액, 감초 추출액 등을 추가로 포함시킬 수 있다.The food composition or health functional food of the present invention may include components commonly added during food production, for example, proteins, carbohydrates, fats, nutrients and seasonings. For example, when prepared as a drink, citric acid, fructose liquid, sugar, glucose, acetic acid, malic acid, fruit juice, jujube extract, licorice extract, etc. may be additionally included.
식품 조성물 내지 건강기능식품은 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 중진제(치즈, 초콜릿 등), 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산 음료에 사용되는 탄산화제 등을 함유할 수 있다. 그밖에 천연 과일쥬스 및 과일 쥬스 음료 및 야채 음료의 제조를 위한 추출물을 함유할 수 있다. 이러한 성분은 독립적으로 또는 조합하여 사용할 수 있다.Food compositions or health functional foods are various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic and natural flavoring agents, coloring agents and thickeners (cheese, chocolate, etc.), pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. In addition, it may contain extracts for the preparation of natural fruit juices and fruit juice beverages and vegetable beverages. These components may be used independently or in combination.
다른 예로, 식품 조성물 내지 건강기능식품의 제형은 산제, 과립제, 환, 정제, 캡슐제의 형태뿐만 아니라 일반 식품 또는 음료의 형태 어느 것이나 가능하다.As another example, the formulation of the food composition or health functional food may be in the form of powders, granules, pills, tablets, capsules, as well as general foods or beverages.
식품의 종류에는 특별히 제한은 없고, 식품의 예로는 육류, 소세지, 빵, 쵸콜렛, 캔디류, 스넥류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알콜 음료 및 비타민 복합제 등이 있으며, 통상적인 의미에서의 식품을 모두 포함할 수 있다.The type of food is not particularly limited, and examples of food include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gum, dairy products including ice cream, various soups, beverages, tea, There are drinks, alcoholic beverages, vitamin complexes, and the like, and may include all foods in a conventional sense.
식품 조성물에서 람노서스 IDCC 3201의 함량은 0.001 내지 50중량%, 0.01 내지 50중량%, 0.1 내지 50중량%, 0.1 내지 20중량% 또는 1 내지 50중량%일 수 있다. The content of Rhamnosus IDCC 3201 in the food composition may be 0.001 to 50% by weight, 0.01 to 50% by weight, 0.1 to 50% by weight, 0.1 to 20% by weight or 1 to 50% by weight.
건강기능식품에서 람노서스 IDCC 3201의 함량은 0.1 내지 100중량%, 0.1 내지 50중량%, 0.1 내지 30중량%, 0.1 내지 10중량% 또는 1 내지 10중량%일 수 있다.The content of rhamnosus IDCC 3201 in health functional food may be 0.1 to 100% by weight, 0.1 to 50% by weight, 0.1 to 30% by weight, 0.1 to 10% by weight, or 1 to 10% by weight.
일반적으로, 식품 또는 음료의 제조시에 락토바실러스 람노서스 IDCC 3201의 함량은 0.1 내지 50중량%, 0.1 내지 20중량% 또는 0.1 내지 10중량% 포함될 수 있다. 그러나, 건강 및 위생을 목적으로 하거나 또는 건강 조절을 목적으로 하는 장기간의 섭취의 경우에는 상기 양은 상기 범위 이하일 수 있다.In general, the content of Lactobacillus rhamnosus IDCC 3201 in the manufacture of food or beverage may be 0.1 to 50% by weight, 0.1 to 20% by weight, or 0.1 to 10% by weight. However, in the case of long-term ingestion for health and hygiene purposes or for health control purposes, the amount may be less than or equal to the above range.
일 구체예에 따른 식품 조성물 중 음료는 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가성분으로 함유할 수 있다. 상술한 천연 탄수화물은 포도당, 과당과 같은 모노사카라이드, 말토스, 슈크로스와 같은 디사카라이드 및 덱스트린, 사이클로덱스트린과 같은 폴리사카라이드, 자일리톨, 소르비톨, 에리트리톨 등의 당알콜일 수 있다. 감미제로서는 타우마틴, 스테비아 추출물과 같은 천연 감미제나, 사카린, 아스파르탐과 같은 합성 감미제 등을 사용할 수 있다. The beverage in the food composition according to one embodiment may contain various flavoring agents or natural carbohydrates as additional ingredients, like a conventional beverage. The above-mentioned natural carbohydrates may be monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. As the sweetener, natural sweeteners such as taumatine and stevia extract, synthetic sweeteners such as saccharin and aspartame, and the like can be used.
상기 외에 일 구체예에 따른 식품 조성물 내지 건강기능식품은 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산음료에 사용되는 탄산화제를 함유할 수 있다. 그 밖에 본 발명의 식품 조성물 내지 건강기능식품은 천연 과일쥬스, 과일쥬스 음료 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 성분은 독립적으로 또는 혼합하여 사용할 수 있다.In addition to the above, the food composition or health functional food according to one embodiment includes various nutrients, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers , preservatives, glycerin, alcohol, and carbonation agents used in carbonated beverages. In addition, the food composition or health functional food of the present invention may contain fruit for the production of natural fruit juice, fruit juice beverage, and vegetable beverage. These components may be used independently or in combination.
식품 조성물 내지 건강기능식품의 구체적 예시는 다음과 같다.Specific examples of the food composition or health functional food are as follows.
미네랄 영양첨가제, 미네랄 보충제, 미네랄제, 분말형태의 과일맛 식이보충드링크믹스, 분말형태의 영양보충 드링크믹스, 비타민 및 미네랄 보충제, 비타민 및 미네랄제, 비타민 및 비타민제, 비타민제제, 비타민/ 미네랄/ 아미노산 및 미량원소 식이요법제, 비타민A제, 비타민B제, 비타민C제, 비타민D제, 비타민보충제, 비타민정제, 비타민제, 뼈질환치료용 약제, 식사대용파우더, 식이보충용영양제, 식이보충용 음료수, 식이보충음료, 식이보충제용 산화방지제, 식이섬유, 식이요법용 전분, 식이요법제 및 영양첨가제, 식품보충제 형태의 비타민제, 아연보충정제, 아연을 주성분으로 하는 영양보충제, 액상 비타민보충제, 액상 허브보충제, 약용사탕, 약용캔디, 약제용 멘톨, 에너지증진용 영양보조식 대용바, 의료용 식사대용 드링크믹스, 의료용 식 사대용 및 식이보충 드링크믹스, 의료용 식사대용 쉐이크, 의료용 식사대용 스낵, 의료용 식사대용 식이보충 드링크믹스, 의료용 식사대용 영양드링크믹스, 의료용 식사대용 드링크, 의료용 식사대용바, 의료용 식사대용 분말, 의료용 식이요법음료, 의료용 식이요법음료제조제, 의료용 식이요법제, 의료용 식이요법제품, 의료용 아 미노산, 의료용 아미노산제, 의료용 캔디, 의료용 허브스프레이, 의료용 허브제, 의료용 허브추출물, 철분을 주성분으로 하는 영양보충제, 체중감량용 의료제제, 체중감량용 캡슐, 체중감량제, 초유보충제, 칼슘 보충제, 칼슘을 주성분으로 하는 영양보충제, 혈당강하제, 난(卵)을 주원료로 하는 건강기능식품, 단백질 식이보충제, 당뇨병 환자용 식품, 드링크믹스 식이보충제, 레시틴 식이보충제, 로얄젤리 식이보충제, 마그네 슘을 주성분으로 하는 식이보충제, 맥아 식이보충제, 미네랄 보충식품, 미네랄 식이보충제, 미네랄 식품보충 제, 미네랄을 주재료로 한 건강식품보충제, 미량영양소 식이보충제, 미량영양소 식품보충제, 미용효과가 있는 식이보충제, 밀 식이보충제, 보충식품, 비타민 및 미네랄 식이보충제, 비타민 및 미네랄 식품보충제, 비타민 식이보충제, 비타민을 주재료로 한 건강식품보충제, 식이보충제, 식이보충제용 건강기능식품, 아미노산 식이보 충제, 아미노산 식품보충제, 아미노산/미네랄/미량영양소 식이보충제, 아미노산/미네랄/미량영양소 식품보충 제, 철분을 주성분으로 하는 식이보충제, 초유식이보충제, 치료용 건강기능식품, 치료용 또는 의료용 건강기 능식품, 카세인 식이보충제, 칼슘을 주성분으로 하는 식이보충제, 콜레스테롤조절용 식이보충제, 콩단백질 식 이보충제, 특수식이요법용 건강식품보조제, 포도당 식이보충제, 프로폴리스 식이보충제, 항산화 식품보충제, 환자전용 식이요법식품, 효소식이보충제Mineral nutritional additives, mineral supplements, minerals, fruit flavored dietary supplement drink mix in powder form, nutritional supplement drink mix in powder form, vitamins and mineral supplements, vitamins and minerals, vitamins and vitamins, vitamin preparations, vitamins / minerals / amino acids and trace element dietary supplements, vitamin A agents, vitamin B agents, vitamin C agents, vitamin D agents, vitamin supplements, vitamin tablets, vitamins, bone disease treatment agents, meal replacement powders, dietary supplement nutrients, dietary supplement drinks, dietary supplements Supplemental drinks, antioxidants for dietary supplements, dietary fiber, dietary starch, dietary supplements and nutritional additives, vitamins in the form of food supplements, zinc supplement tablets, zinc-based nutritional supplements, liquid vitamin supplements, liquid herbal supplements, Medicinal candy, medicinal candy, pharmaceutical menthol, energy boosting nutritional supplement bar, medical meal replacement drink mix, medical meal replacement and dietary supplement drink mix, medical meal replacement shake, medical meal replacement snack, medical meal replacement dietary supplement Drink mix, medical meal replacement nutritional drink mix, medical meal replacement drink, medical meal replacement bar, medical meal replacement powder, medical dietary beverage, medical dietary beverage preparation, medical dietary medicine, medical dietary product, medical amino acid , medical amino acids, medical candy, medical herb spray, medical herbs, medical herbal extracts, iron-based nutritional supplements, weight loss medical preparations, weight loss capsules, weight loss agents, colostrum supplements, calcium supplements, calcium Nutrient supplements, hypoglycemic agents, egg-based health functional foods, protein dietary supplements, foods for diabetic patients, drink mix dietary supplements, lecithin dietary supplements, royal jelly dietary supplements, magnesium-based Dietary supplements, malt dietary supplements, mineral supplements, mineral dietary supplements, mineral food supplements, mineral-based health food supplements, micronutrient dietary supplements, micronutrient food supplements, cosmetically effective dietary supplements, wheat dietary supplements, Supplements, Vitamins and Minerals Dietary Supplements, Vitamins and Minerals Food Supplements, Vitamins and Dietary Supplements Supplement, vitamin-based health food supplement, dietary supplement, health functional food for dietary supplement, amino acid dietary supplement, amino acid food supplement, amino acid/mineral/micronutrient dietary supplement, amino acid/mineral/micronutrient food supplement, iron Dietary supplement, colostrum dietary supplement, therapeutic health functional food, therapeutic or medical health functional food, casein dietary supplement, calcium-based dietary supplement, cholesterol control dietary supplement, soy protein dietary supplement, special Dietary health food supplement, glucose dietary supplement, propolis dietary supplement, antioxidant food supplement, patient-only diet food, enzyme dietary supplement
곡물가공식품, 곡물조제품, 식용 곡물가공식품, 쌀을 주원료로 한 스낵식품, 무설탕 사탕과자, 사탕과자(캔디), 식용 캔디, 쌀과자, 양갱, 인삼과자, 인삼정과, 인삼젤리과자, 인삼캔디, 홍삼과자, 홍삼껌, 홍삼양갱, 홍삼정과, 홍삼젤리과자, 홍삼진과, 홍삼초콜릿, 홍삼캔디, 홍삼차Processed grain food, grain preparation, edible grain processed food, snack food made with rice as the main ingredient, sugar-free candy confectionery, confectionery (candy), edible candy, rice confectionery, yanggaeng, ginseng confectionery, ginseng tablet confectionery, ginseng jelly confectionery, ginseng candy , red ginseng confectionery, red ginseng gum, red ginseng yanggaeng, red ginseng tablet, red ginseng jelly confectionery, red ginseng ginseng, red ginseng chocolate, red ginseng candy, red ginseng tea
혼합양유를 주원료로 한 건강기능식품, 가공된 고기, 가공한 식육, , 부용(Bouillon), 부용제조제, 브로스(Broth), 블랙푸딩[블러드소시지], 소시지, 식용 골수, 식용 단백질, 식용 제비둥지, 식용 젤라틴, 육류가공식품, 육류내장품, 조리된 통조림고기, 통조림된 고기[통조림육], 햄, 햄버거용 고기, 가금(家禽){살아있지 않은 것}, 엽조수{살아 있지 않은 것}, 땅콩을 함유한 우유음료, 마시는 요구르트, 몰드숙성치즈, 발효유, 분유{유아용은 제외}, 빵 조각에 바르는 지방함유품, 사와(Sour), 산양유, 생크림, 숙성치즈, 식용 카세인, 신선한 미숙성치즈, 아몬드를 함유한 우유음료, 양유, 양치즈, 연유, 연질치즈, 연질하얀치즈, 요구르트, 요구르트 음료, 우유, 우유 단백질, 우유를 주성분으로한 우유음료, 우유크림, 우유크림분말, 유(乳)가공식품, 유산균음료, 유산음료, 유장(乳奬), 유제품, 응유(凝乳), 치즈, 치즈 스프레드, 치즈가루, 케피르(우유음료), 콘덴스트밀크, 쿠미스( 우유음료), 팽팽한 치즈, 하얀 치즈, 휩크림(Whipped cream), 버터, 마가린, 골유, 동물성 유지, 쇼트닝, 식용 경화유(硬化油), 식용 고래기름[식용 경지], 식용 골유, 식용 동물기름, 식용 어유(魚油), 식용 지방, 식용 우지(牛脂), 살아있지 않은 생선, 살아있지 않은 어패류{냉동 또는 염장한 것을 포함}, 소금에 절인 생선, 건제어패류, 보존처리된 생선, 보존처리한 어패류, 생선가공식품, 수산물의 통조림 및 병조림, 식용 어분(魚 粉), 어패류가공식품, 통조림된 생선, 훈제어패류, 가공처리된/냉동된/건조된/조리된 과일 및 채소, 건조된 과일[건조과일], 건조된 채소[건조채소], 과실가공식품Health functional food with mixed sheep milk as the main ingredient, processed meat, processed meat, , bouillon, bouillon preparation, broth, black pudding [blood sausage], sausage, edible bone marrow, edible protein, edible swallow Nests, edible gelatin, meat products, meat internals, cooked canned meat, canned meat [canned meat], ham, hamburger meat, poultry {not live}, wild bird {not live} , milk drinks containing peanuts, drinking yogurt, molded cheese, fermented milk, powdered milk (except for infants), fat-containing products applied to bread slices, sour, goat's milk, fresh cream, aged cheese, edible casein, fresh unripe Milk drinks containing cheese, almonds, sheep's milk, sheep's cheese, condensed milk, soft cheese, soft white cheese, yogurt, yogurt drinks, milk, milk protein, milk drinks with milk as the main ingredient, milk cream, milk cream powder, milk (乳) Processed food, lactic acid bacteria drink, lactic acid drink, whey, dairy product, curd, cheese, cheese spread, cheese powder, kefir (milk drink), condensed milk, cumis (milk drink), Tight cheese, white cheese, whipped cream, butter, margarine, bone oil, animal fat, shortening, edible hydrogenated oil, edible whale oil [edible land], edible bone oil, edible animal oil, edible fish oil ), edible fat, edible tallow, raw fish, raw fish and shellfish (including frozen or salted), salted fish, dried shellfish, preserved fish, preserved fish and shellfish, processed fish food , canned and bottled aquatic products, edible fish meal, processed seafood, canned fish, smoked shellfish, processed/frozen/dried/cooked fruits and vegetables, dried fruit [dried fruit], dried cooked vegetables [dried vegetables], processed fruit food
발효가공된 홍삼, 인삼가공식품, 인삼잼, 인삼절편, 인삼젤리, 홍삼가공식품, 홍삼분말, 홍삼잼, 홍삼절편, 홍삼젤리, 식용 젤리, 젤리, 녹용을 주성분으로 하는 건강보조식품, 식용 우유분말, 식용 초유, 식품용 건조된 우유, 우유대용품, 유(乳)가공식품Fermented processed red ginseng, ginseng processed food, ginseng jam, ginseng slices, ginseng jelly, red ginseng processed food, red ginseng powder, red ginseng jam, red ginseng slices, red ginseng jelly, edible jelly, jelly, health supplements containing deer antler as main ingredients, edible milk Powder, edible colostrum, dried milk for food, milk substitute, milk processed food
이하 실험예를 통해 본 발명을 상세히 설명한다.Hereinafter, the present invention will be described in detail through experimental examples.
[실험예 1] 프로바이오틱스 제조 [Experimental Example 1] Preparation of probiotics
본 실험에 사용된 균주는 모유를 먹인 유아의 대변에서 분리된 락토바실러스 플란타럼(Lactobacillus rhamnosus) IDCC 3201, 엔테로코커스 페시움(Enterococcus faecium) IDCC 2102과 홈메이드 요거트에서 분리된 스트렙토코커스 써모필러스(Streptococcus thermophilus) IDCC 2201을 사용하였다.The strains used in this experiment were Lactobacillus rhamnosus IDCC 3201, Enterococcus faecium IDCC 2102, isolated from the feces of breastfed infants, and Streptococcus thermophilus isolated from homemade yogurt. (Streptococcus thermophilus) IDCC 2201 was used.
모든 프로바이오틱스 균주는 MRS 배지에서 배양하였고, 37℃에 24시간 배양된 108~109CFU/mL의 균이 실험에 사용되었다.All probiotic strains were cultured in MRS medium, and 10 8 to 10 9 CFU/mL of bacteria cultured at 37° C. for 24 hours was used for the experiment.
[실험예 2] 락토바실러스 람노서스 IDCC 3201의 프로테아제 활성 확인[Experimental Example 2] Confirmation of protease activity of Lactobacillus rhamnosus IDCC 3201
1) 프로테아제 활성 확인1) Confirmation of protease activity
단백질 분해 관련 프로테아제 활성은 다음과 같은 방법으로 측정하였다. 검사를 위한 균주는 실험예 1에서의 조건에 맞춰 배양한 균주를 사용하였다. 각 시료의 10ㅅl를 이용하여 실험하였으며 형성된 clear zone에 의해 프로테아제 활성이 구분되었다. 프로테아제 활성을 확인하기 위해 식물성 단백질인 pea protein과 동물성 단백질인 skim milk를 이용한 배양배지를 사용하였다. 각 배양배지는 protein 28g/L, tryptone 5g/L, yeast extract 2.5g/L, glucose 1g/L, agar 15g/L로 만들었으며 단백질 응고를 막기 위해 protein + 50% D.W, 나머지 조성물 + 50% D.W로 만들어 멸균 후 혼합하여 사용하였다. 단백질 배양배지에 프로바이오틱스를 10ㅅl 떨어트린 후 37℃에서 48시간 배양하였고, 배양 후 프로바이오틱스 spot 주위에 단백질이 분해되어 생겨난 clear zone의 길이를 측정하여 프로테아제 활성을 평가하였다.Proteolysis-related protease activity was measured as follows. As the strain for the test, a strain cultured according to the conditions in Experimental Example 1 was used. The experiment was conducted using 10 μl of each sample, and the protease activity was distinguished by the clear zone formed. To confirm the protease activity, a culture medium using pea protein, a vegetable protein, and skim milk, an animal protein, was used. Each culture medium was made of protein 28g/L, tryptone 5g/L, yeast extract 2.5g/L, glucose 1g/L, and agar 15g/L. To prevent protein coagulation, protein + 50% D.W, the rest of the composition + 50% D.W. It was used after sterilization and mixing. After 10 μl of probiotics was dropped into the protein culture medium, it was cultured at 37° C. for 48 hours. After culturing, the length of the clear zone generated by protein degradation around the probiotic spot was measured to evaluate protease activity.
도 1 및 도 2에 나타난 바와 같이, 락토바실러스 람노서스 IDCC 3201은 pea protein 배지에서는 다른 균들과 유사한 프로테아제 활성을 보였지만 skim milk 배지에서는 월등히 우수한 프로테아제 활성을 보였다.1 and 2,
Claims (5)
모유를 먹인 유아의 대변에서 분리되었으며 프로테아제 활성을 가지는 락토바실러스 람노서스 IDCC 3201 [기탁번호: ATCC BAA-2836]을 포함하는 식품 조성물.In the food composition having proteolytic ability,
A food composition comprising Lactobacillus rhamnosus IDCC 3201 [Accession No.: ATCC BAA-2836] isolated from the feces of breastfed infants and having protease activity.
상기 락토바실러스 람노서스 IDCC 3201을 0.01 중량% 내지 50중량% 포함하는 식품 조성물.The method of claim 1,
Food composition comprising 0.01 wt% to 50 wt% of the Lactobacillus rhamnosus IDCC 3201.
모유를 먹인 유아의 대변에서 분리되었으며 프로테아제 활성을 가지는 락토바실러스 람노서스 IDCC 3201 [기탁번호: ATCC BAA-2836]을 유효성분으로 포함하는 건강기능식품.In the health functional food having protein-degrading ability,
A health functional food containing Lactobacillus rhamnosus IDCC 3201 [Accession No.: ATCC BAA-2836] as an active ingredient isolated from the feces of breastfed infants and having protease activity.
상기 락토바실러스 람노서스 IDCC 3201을 0.1 중량% 내지 100중량% 포함하는 건강기능식품.4. The method of claim 3,
Health functional food containing 0.1% to 100% by weight of the Lactobacillus rhamnosus IDCC 3201.
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