KR102291441B1 - Composition for skin whitening comprising plum seed extract - Google Patents
Composition for skin whitening comprising plum seed extract Download PDFInfo
- Publication number
- KR102291441B1 KR102291441B1 KR1020200020329A KR20200020329A KR102291441B1 KR 102291441 B1 KR102291441 B1 KR 102291441B1 KR 1020200020329 A KR1020200020329 A KR 1020200020329A KR 20200020329 A KR20200020329 A KR 20200020329A KR 102291441 B1 KR102291441 B1 KR 102291441B1
- Authority
- KR
- South Korea
- Prior art keywords
- seed extract
- plum seed
- composition
- skin
- present
- Prior art date
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Abstract
Description
본 발명은 자두 씨 추출물을 유효성분으로 함유하는 미백용 조성물에 관한 것이다.The present invention relates to a composition for whitening containing a plum seed extract as an active ingredient.
멜라닌(melanin)은 일정량 이상의 자외선을 흡수하여 유해한 자외선이 인체 내로 침투하는 것을 차단하여 인체를 보호하는 역할을 하나, 이에 의해 멜라닌 생성이 증가되어 피부의 색소 침착 문제가 발생하게 된다. Melanin (melanin) acts to protect the human body by absorbing more than a certain amount of ultraviolet rays and blocking harmful ultraviolet rays from penetrating into the human body.
비정상적인 피부 색소 침착 문제를 야기하는 주요 원인인 멜라닌의 합성 과정을 살펴보면, 세포 내의 티로신(tyrosine)을 기질로 하여 티로시나제(tyrosinase), TRP-1(tyrosinase related protein-1), TRP-2 등의 효소에 의해 도파(3,4-dihydroxyphenylalanine, DOPA)를 거쳐 도파퀴논(dopaquinone)을 생성시키며, 도파퀴논으로부터 자발적인 반응과 효소 반응을 거쳐 공중합체 흑색 색소인 멜라닌이 생성된다.Looking at the synthesis process of melanin, which is the main cause of abnormal skin pigmentation, enzymes such as tyrosinase, TRP-1 (tyrosinase related protein-1), TRP-2 using tyrosine as a substrate in cells Dopaquinone is produced through dopa (3,4-dihydroxyphenylalanine, DOPA), and melanin, the black pigment of the copolymer, is produced through spontaneous reaction and enzymatic reaction from dopaquinone.
비정상적인 색소 침착을 막기 위한 방법으로 멜라닌 합성 과정 중의 일부 반응을 저해함으로써 상기 멜라닌의 생성을 감소시키는 방법이 일반적으로 용이하게 행해지고 있으며, 이러한 용도로서 종래는 아스코르브산(ascorbic acid), 코지산(kojic acid), 알부틴(arbutin), 하이드로퀴논(hydroquinone) 등과 같은 각종 식물 추출물이 사용되는 경우가 많았다. As a method to prevent abnormal pigmentation, a method for reducing the production of melanin by inhibiting some reactions in the melanin synthesis process is generally easily performed, and for this purpose, conventionally ascorbic acid, kojic acid ), arbutin, and various plant extracts such as hydroquinone were often used.
하지만, 이들 중 코지산은 티로시나제 활성 부위에 존재하는 구리 이온을 킬레이트 시켜 효소 활동을 저해하는 작용을 하는 것으로, 성능이 좋으나 화장품에 배합시 안전성에 문제가 있어 사용에 제한이 가해지고 있고, 하이드로퀴논은 피부에 대한 자극성이 높으며, 아스코르브산 역시 안전성 문제를 가지고 있는 실정이다.However, among them, kojic acid inhibits enzyme activity by chelating copper ions present at the tyrosinase active site. Although it has good performance, there is a problem with safety when formulated in cosmetics. It is highly irritating to the skin, and ascorbic acid also has a safety problem.
한편, 자두(Prunus salicina L.)는 우리나라 신라 시대 때부터 재배된 과실로 장미과 벚나무 속 자두 아속에 속한다. 우리나라에서 생산되는 자두는 대부분 동양계 자두로서, 70%가 경북에서 생산되는 국내의 주요 과실 중 하나이다. 자두는 연중 수확 시기가 이른 과일로 품종과 환경에 따라 조성에 차이가 있으나 유용 성분으로 천연 페놀 화합물을 다량 함유하고 있다. 최근 연구에 따르면 페놀 화합물이 활성산소 대신 산화하여 항산화, 항암, 항균 등에 효과가 있는 것으로 연구되고 있다. On the other hand, plum ( Prunus salicina L. ) is a fruit cultivated since the Silla period in Korea and belongs to the subgenus Prunus in the family Rosaceae. Most of the plums produced in Korea are oriental plums, and 70% of them are produced in Gyeongbuk, and it is one of the main fruits in Korea. Plums are fruits with an early harvest throughout the year, and although the composition differs depending on the variety and environment, it contains a large amount of natural phenolic compounds as useful ingredients. According to a recent study, phenolic compounds are oxidized instead of free radicals and are being studied to have antioxidative, anticancer, and antibacterial effects.
자두는 주로 생식으로 섭취하거나 건자두, 잼, 넥타, 주스, 와인 등의 형태로 가공된다. 이러한 가공식품들은 주로 과육과 과피를 이용한 것으로 가공식품 제조 후 부산물인 씨가 발생하게 되며 대부분 폐기되고 있다. 최근 이러한 부산물을 활용하기 위한 여러 가지 연구가 진행되고 있으나, 피부 미백 또는 색소 질환 치료를 위한 자두 부산물에 대한 연구는 아직 미비한 실정이다.Plums are mainly consumed raw or processed into dried plums, jam, nectar, juice, and wine. These processed foods mainly use the flesh and peel, and after manufacturing the processed foods, seeds, which are by-products, are generated and most of them are discarded. Recently, various studies have been conducted to utilize these by-products, but studies on prune by-products for skin whitening or treatment of pigment diseases are still insufficient.
본 발명의 목적은 폐기되는 과실의 씨 추출물을 이용한 피부 미백용 조성물을 제공하는 데에 있다. An object of the present invention is to provide a composition for skin whitening using a seed extract of discarded fruit.
본 발명의 다른 목적은 폐기되는 과실의 씨 추출물을 이용한 멜라닌 과다 생성에 따른 피부 질환 예방 또는 치료용 조성물을 제공하는 데에 있다.Another object of the present invention is to provide a composition for preventing or treating skin diseases caused by excessive melanin production using a seed extract of discarded fruits.
상기의 목적을 달성하기 위하여, 본 발명은 자두 씨 추출물을 유효성분으로 함유하는 피부 미백용 화장료 조성물을 제공한다.In order to achieve the above object, the present invention provides a cosmetic composition for skin whitening containing a plum seed extract as an active ingredient.
본 발명은 자두 씨 추출물을 유효성분으로 함유하는 피부 미백용 건강식품 조성물을 제공한다.The present invention provides a health food composition for skin whitening containing a plum seed extract as an active ingredient.
본 발명은 자두 씨 추출물을 유효성분으로 함유하는 멜라닌 과다 생성에 따른 피부 질환 예방 또는 치료용 약학 조성물을 제공한다.The present invention provides a pharmaceutical composition for preventing or treating skin diseases caused by excessive melanin production, comprising a plum seed extract as an active ingredient.
또한, 본 발명은 자두 씨 추출물을 유효성분으로 함유하는 멜라닌 과다 생성에 따른 피부 질환 예방 또는 개선용 건강식품 조성물을 제공한다.In addition, the present invention provides a health food composition for preventing or improving skin diseases caused by excessive production of melanin containing the plum seed extract as an active ingredient.
본 발명에 따른 자두 씨 추출물, 특히 피자두 씨 추출물은 기존 미백 원료로 사용되는 아스코르브산과 비교하여 안정되고 우수한 티로시나제 저해 활성을 나타내므로, 피부 미백을 위한 화장료 조성물, 건강식품 조성물 등으로 활용할 수 있다.The plum seed extract, particularly the pizza bean seed extract, according to the present invention is stable and exhibits superior tyrosinase inhibitory activity compared to ascorbic acid used as a conventional whitening raw material, and thus can be used as a cosmetic composition for skin whitening, a health food composition, and the like.
또한, 상기 자두 씨 추출물을 멜라닌 과다 생성에 따른 피부 질환 예방 또는 치료용 조성물로 이용함으로써, 과도한 멜라닌 생성으로 발생되는 기미, 주근깨, 검버섯 등의 비정상적 피부 색소 침착 질환들을 효과적으로 예방 또는 치료할 수 있다.In addition, by using the plum seed extract as a composition for preventing or treating skin diseases caused by excessive melanin production, abnormal skin pigmentation diseases such as spots, freckles, and age spots caused by excessive melanin production can be effectively prevented or treated.
본 발명에 따른 조성물은 과실의 부산물인 자두의 씨를 유효성분으로 이용함으로써, 폐기되는 자원을 효율적으로 활용하여 환경 보호 및 자원 절약에 도움을 줄 수 있다.The composition according to the present invention uses the seeds of plums, which are by-products of fruits, as an active ingredient, thereby efficiently utilizing wasted resources, thereby helping to protect the environment and save resources.
도 1은 본 발명의 일 실시예에 사용된 자두의 3가지 품종, 후무사(Prunus salicina Formosa), 피자두(Prunus salicina Lindl. cv. Soldam) 및 도담(Prunus salicina Dodam)의 단면 이미지이다.
도 2는 본 발명의 일 실시예에 따른 자두 씨 추출물 제조방법을 나타낸 순서도이다.
도 3은 본 발명의 일 실험예에 따른 자두 품종별 티로시나제 저해 활성을 확인한 그래프이다.
도 4는 본 발명의 일 실험예에 따른 피자두 씨 추출물의 농도에 따른 티로시나제 저해 활성을 확인한 그래프이다.
도 5는 본 발명의 일 실험예에 따른 피자두 씨 추출물의 상온 보관 기간에 따른 티로시나제 저해 활성의 변화를 나타낸 그래프이다.
도 6은 본 발명의 일 실험예에 따른 아스코르브산의 상온 보관 기간에 따른 티로시나제 저해 활성의 변화를 나타낸 그래프이다.1 is a cross-sectional image of three varieties of plums used in an embodiment of the present invention, Prunus salicina Formosa , Prunus salicina Lindl. cv. Soldam , and Prunus salicina Dodam.
2 is a flowchart illustrating a method for preparing a plum seed extract according to an embodiment of the present invention.
3 is a graph confirming the tyrosinase inhibitory activity for each plum variety according to an experimental example of the present invention.
4 is a graph confirming the tyrosinase inhibitory activity according to the concentration of the pizza bean seed extract according to an experimental example of the present invention.
5 is a graph showing the change in tyrosinase inhibitory activity according to the storage period at room temperature of the pizza bean seed extract according to an experimental example of the present invention.
6 is a graph showing the change in tyrosinase inhibitory activity according to the storage period at room temperature of ascorbic acid according to an experimental example of the present invention.
이하, 본 발명을 상세하게 설명하기로 한다.Hereinafter, the present invention will be described in detail.
본 발명자는 우리나라에서 주로 재배되는 자두인 후무사(Formosa), 피자두(Soldam), 도담(Dodam) 씨의 추출물을 제조하여, 이들의 티로시나제 저해 활성 등을 확인함으로써, 본 발명을 완성하였다.The inventors have after the plums are mainly grown in the country to prepare a safe (Formosa), two pizzas (Soldam), Dodam extract of (Dodam) seed, by checking the like thereof tyrosinase inhibitory activity, and completed the present invention.
본 발명은 자두 씨 추출물을 유효성분으로 함유하는 피부 미백용 화장료 조성물을 제공한다.The present invention provides a cosmetic composition for skin whitening containing a plum seed extract as an active ingredient.
본 명세서에서, 상기 "자두 씨"는 자두(Plum)에서 과육 및 과피를 제거한 종자 부분으로, 피자두, 후무사, 도담, 대석, 홍로센, 홍자두, 대왕자두, 자봉자두, 게루시 및 추희로 이루어진 군에서 선택된 하나 이상의 자두의 씨일 수 있으나, 이에 제한되는 것은 아니다.In the present specification, the "plum seed" is a part of the seed from which the flesh and skin are removed from the plum (Plum). It may be one or more plum seeds selected from the group consisting of, but is not limited thereto.
바람직하게는 피자두(Prunus salicina Lindl. cv. Soldam), 후무사(Prunus salicina Formosa) 및 도담(Prunus salicina Dodam)으로 이루어진 군에서 선택된 하나 이상의 자두의 씨일 수 있고, 보다 바람직하게는 피자두(Prunus salicina Lindl. cv. Soldam)의 씨일 수 있다.Preferably pizza two (Prunus salicina Lindl. Cv. Soldam), and then okay (Prunus salicina Formosa) and Dodam (Prunus salicina Dodam) of which may seal the one or more plum selected from the group consisting of, and more preferably pizza two (Prunus salicina Lindl. cv. Soldam ).
상기 자두 씨는 자연에서 채취 또는 재배된 자두에서 수득한 것일 수 있고, 상업적으로 판매되는 것을 구입한 것일 수 있다.The plum seeds may be obtained from plums harvested or grown in nature, or purchased commercially.
본 명세서에서, "추출물"이란, 추출 방법, 추출 용매, 추출된 성분 또는 추출물의 형태를 불문하고 천연물의 성분을 뽑아냄으로써 얻어진 물질을 의미하는 것으로, 천연물의 성분을 뽑아내어 얻어진 물질을 추출 후 다른 방법으로 가공 또는 처리하여 얻어질 수 있는 물질을 모두 포함할 수 있다.As used herein, the term "extract" refers to a material obtained by extracting a component of a natural product regardless of an extraction method, an extraction solvent, an extracted component, or the form of an extract, and the material obtained by extracting the component of a natural product is extracted It may include any material obtainable by processing or processing by the method.
상기 자두 씨 추출물은 물, C1 내지 C4의 알코올 또는 이들의 혼합 용매로 추출된 것일 수 있고, 바람직하게는 60 내지 80중량% 에탄올 수용액 또는 프레타놀 수용액 추출물일 수 있으며, 보다 바람직하게는 70중량%의 식물성 에탄올인 프레타놀(prethanol) 추출물일 수 있다.The plum seed extract may be extracted with water, C1 to C4 alcohol, or a mixed solvent thereof, preferably 60 to 80% by weight of an aqueous ethanol solution or an aqueous pretanol solution, more preferably 70% by weight It may be a vegetable ethanol extract of pretanol (prethanol).
상기 자두 씨 추출물은 당해 기술 분야에서 통상적으로 사용하는 방법에 따라 추출될 수 있고, 예를 들어, 열수 추출, 초음파 추출법, 여과법, 환류 추출법 등이 있으며, 이들은 단독으로 수행되거나 2종 이상의 방법을 병용하여 수행될 수 있다.The plum seed extract may be extracted according to a method commonly used in the art, for example, hot water extraction, ultrasonic extraction, filtration, reflux extraction, etc., which are performed alone or in combination of two or more methods can be performed.
본 명세서에서, "미백"은 멜라닌 색소 등의 과다 침착을 억제, 저해, 또는 완화시켜, 상기 색소 침착으로 야기되는 피부의 흑화를 방지하여 피부 트러블을 개선하는 작용을 의미한다. As used herein, "whitening" refers to an action of improving skin troubles by inhibiting, inhibiting, or alleviating excessive deposition of melanin pigment, etc., to prevent blackening of the skin caused by the pigmentation.
본 명세서에서, "화장료"란, 피부 색소 침착 등의 예방 또는 개선의 효과를 가지는 기능성 화장료를 포함할 수 있고, 상기 기능성 화장료는 일반 화장료와 달리 생리활성적인 효능, 효과가 강조된 전문적인 기능성을 갖는 것으로, 화장품법에 정의된 바에 따라 피부 미백 등 특정 효능과 효과가 강조된 화장료를 의미한다.In the present specification, the term "cosmetics" may include functional cosmetics having an effect of preventing or improving skin pigmentation, etc., and the functional cosmetics have specialized functionalities that emphasize physiologically active efficacy and effects, unlike general cosmetics. As defined by the Cosmetics Act, it refers to cosmetics emphasizing specific efficacy and effects such as skin whitening.
본 발명에 따른 피부 미백용 화장료 조성물에 있어서, 상기 자두 씨 추출물은 우수한 티로시나제(tyrosinase) 저해 활성을 가질 수 있다. 상술한 바와 같이, 티로시나제는 멜라닌 합성 과정에 이용되는 효소로, 이의 활성을 저해함으로써 멜라닌 생성을 억제하여 미백 효과를 부여할 수 있다.In the cosmetic composition for skin whitening according to the present invention, the plum seed extract may have excellent tyrosinase inhibitory activity. As described above, tyrosinase is an enzyme used in the melanin synthesis process, and by inhibiting its activity, it can inhibit melanin production to impart a whitening effect.
본 발명의 일 실험예에 따르면, 상기 자두 씨 추출물은 티로시나제 저해 활성을 가지는 것으로 나타났고, 특히, 피자두 씨 추출물에서 우수한 티로시나제 저해 활성이 나타남을 확인할 수 있었다.According to an experimental example of the present invention, the plum seed extract was found to have tyrosinase inhibitory activity, and in particular, it was confirmed that the pizza bean seed extract exhibited excellent tyrosinase inhibitory activity.
또한, 상기 자두 씨 추출물은 기존 미백 원료로 사용되는 아스코르브산에 비해 티로시나제 저해 활성에 대한 안정성이 현저히 우수한 것으로 나타나, 보다 안정적이고 효과적인 피부 미백용 화장료 조성물로 사용될 수 있다.In addition, the plum seed extract showed significantly superior stability to tyrosinase inhibitory activity compared to ascorbic acid used as a conventional whitening raw material, and thus can be used as a more stable and effective cosmetic composition for skin whitening.
본 발명에 따른 피부 미백용 화장료 조성물에 있어서, 상기 자두 씨 추출물은 전체 화장료 100 중량부에 대하여 0.001 내지 50 중량부로 포함될 수 있으나, 이에 제한되는 것은 아니다.In the cosmetic composition for skin whitening according to the present invention, the plum seed extract may be included in an amount of 0.001 to 50 parts by weight based on 100 parts by weight of the total cosmetic, but is not limited thereto.
본 발명에 따른 화장료 조성물은 식품 의약품 안전청에 등록된 화장품 원료 리스트 및 ICID(국제화장품 원료집)에 등재되어 있는 성분 중에서 1종 이상을 더 포함할 수 있다. 예를 들어, 상기 화장료 조성물은 유기 용매, 용해제, 농축제, 겔화제, 연화제, 항산화제, 현탁화제, 안정화제, 방향제, 계면활성제, 유화제, 충전제, 금속이온 봉쇄제, 방부제, 비타민, 차단제, 습윤화제, 염료 및 안료, 친수성 또는 친유성 활성제, 또는 화장품에 통상적으로 사용되는 임의의 다른 성분과 같은 화장품 분야에서 통상적으로 사용되는 보조제를 하나 이상 더 포함할 수 있다.The cosmetic composition according to the present invention may further include one or more of the ingredients listed in the list of cosmetic raw materials registered with the Food and Drug Administration and ICID (International Cosmetic Ingredients). For example, the cosmetic composition may include an organic solvent, a solubilizer, a thickener, a gelling agent, an emollient, an antioxidant, a suspending agent, a stabilizer, a fragrance, a surfactant, an emulsifier, a filler, a sequestering agent, a preservative, a vitamin, a blocking agent, It may further comprise one or more adjuvants commonly used in the cosmetic field, such as wetting agents, dyes and pigments, hydrophilic or lipophilic actives, or any other ingredients commonly used in cosmetics.
상기 비타민은 수용성 또는 유용성 비타민을 포함할 수 있고, 상기 수용성 비타민은 수용성 비타민으로서 화장품에 배합 가능한 것으로, 바람직하게는 비타민 B1, 비타민 B2, 비타민 B6, 피리독신, 염산피리독신, 비타민 B12, 판토텐산, 니코틴산, 니코틴산아미드, 엽산, 비타민C, 비타민 H 등을 들 수 있으며, 보다 바람직하게는 콜라겐 합성이 도움을 주는 비타민 C를 포함할 수 있다. 또한, 그들의 염 (티아민염산염, 아스코르빈산나트륨염 등)이나 유도체(아스코르빈산-2-인산나트륨염, 아스코르빈산-2-인산마그네슘염 등)도 포함될 수 있고, 상기 수용성 비타민은 미생물 변환법, 미생물의 배양물로부터의 정제법, 효소법 또는 화학 합성법 등의 통상의 방법에 의해 수득될 수 있다.The vitamin may include a water-soluble or oil-soluble vitamin, and the water-soluble vitamin is a water-soluble vitamin that can be formulated in cosmetics, preferably vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, and nicotinic acid amide, folic acid, vitamin C, vitamin H, and the like, and more preferably, vitamin C that helps collagen synthesis. In addition, salts thereof (thiamine hydrochloride, sodium ascorbate salt, etc.) or derivatives (ascorbic acid-2-phosphate sodium salt, ascorbic acid-2-phosphate magnesium salt, etc.) may be included, and the water-soluble vitamin is a microorganism transformation method , can be obtained by a conventional method such as purification from a culture of microorganisms, enzymatic method or chemical synthesis method.
본 발명에 따른 화장료 조성물은 본 발명이 속하는 기술 분야에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있다. 예를 들어, 화장수, 유액, 로션, 크림, 페이스트, 젤, 용액, 현탁액, 오일, 왁스, 팩, 파우더, 파운데이션, 스프레이, 계면활성제-함유 클렌징 등으로 제형화 될 수 있으나, 이에 제한되는 것은 아니다. The cosmetic composition according to the present invention may be prepared in any formulation conventionally prepared in the technical field to which the present invention pertains. For example, it may be formulated as a lotion, emulsion, lotion, cream, paste, gel, solution, suspension, oil, wax, pack, powder, foundation, spray, surfactant-containing cleansing, etc., but is not limited thereto. .
더욱 상세하게는, 유연 화장수, 영양 화장수, 수렴 화장수, 영양 크림, 마사지 크림, 밀크 로션, 파우더, 에센스, 아이 크림, 선로션, 선크림, 메이크업 프라이머, 메이크업 베이스, 비비크림, 분말 파운데이션, 유탁액 파운데이션, 클렌징크림, 클렌징폼, 클렌징 워터, 비누, 팩, 스틱상 제품, 밤(Balm) 타입 제품, 스프레이 또는 파우더의 제형으로 제조될 수 있다.More specifically, flexible lotion, nourishing lotion, astringent lotion, nourishing cream, massage cream, milk lotion, powder, essence, eye cream, sun lotion, sun cream, makeup primer, makeup base, BB cream, powder foundation, emulsion foundation , cleansing cream, cleansing foam, cleansing water, soap, pack, stick type product, balm type product, spray or powder formulation.
본 발명에 따른 화장료 조성물이 크림 또는 젤 제형인 경우에는 담체 성분으로 동물성유, 식물성유, 왁스, 파라핀, 전분, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등을 더 포함할 수 있다.When the cosmetic composition according to the present invention is a cream or gel formulation, animal oil, vegetable oil, wax, paraffin, starch, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be further included as a carrier component. can
상기 화장료 조성물이 용액 또는 유탁액 제형인 경우에는 용매, 용매화제 또는 유탁화제로, 물, 에탄올, 이소프로판올, 에틸카보네이트, 에틸아세테이트, 벤질알코올, 프로필렌글리콜, 글리세롤 지방족 에스테르, 폴리에틸렌글리콜 또는 소르비탄의 지방산 에스테르 등을 더 포함할 수 있다.When the cosmetic composition is a solution or emulsion formulation, a solvent, a solvating agent or an emulsifying agent, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, propylene glycol, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid It may further include esters and the like.
상기 화장료 조성물이 현탁액 제형인 경우에는 담체 성분으로 물, 에탄올 또는 프로필렌 글리콜과 같은 액상 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등을 더 포함할 수 있다.When the cosmetic composition is a suspension formulation, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be further included.
상기 화장료 조성물이 파우더 또는 스프레이 제형인 경우에는 담체 성분으로 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더를 더 포함할 수 있고, 특히 스프레이 제형인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸에테르와 같은 추진체를 더 포함할 수 있다.When the cosmetic composition is in a powder or spray formulation, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be further included as a carrier component, and in particular, in the case of a spray formulation, additional chlorofluorohydrocarbon , may further include a propellant such as propane/butane or dimethyl ether.
상기 화장료 조성물이 계면활성제-함유 클렌징 제형인 경우에는 담체 성분으로 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성유, 리놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등을 더 포함할 수 있다.When the cosmetic composition is a surfactant-containing cleansing formulation, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide as carrier components It may further include ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linolin derivative or ethoxylated glycerol fatty acid ester.
본 발명에 따른 화장료 조성물은 단독 또는 중복으로 도포하여 사용하거나, 본 발명 이외의 다른 화장료 조성물과 중복 도포하여 사용할 수 있다. 또한, 본 발명에 따른 화장료 조성물은 통상적인 사용방법에 따라 사용될 수 있으며, 사용자의 피부 상태 또는 취향에 따라 그 사용횟수를 달리할 수 있다.The cosmetic composition according to the present invention may be used alone or by being applied in duplicate, or may be used by overlapping with other cosmetic compositions other than the present invention. In addition, the cosmetic composition according to the present invention can be used according to a conventional method of use, and the number of times of use can be varied according to the skin condition or taste of the user.
본 발명은 자두 씨 추출물을 유효성분으로 함유하는 피부 미백용 건강식품 조성물을 제공한다.The present invention provides a health food composition for skin whitening containing a plum seed extract as an active ingredient.
상기 자두 씨 추출물은 우수한 티로시나제 저해 활성을 가짐으로써, 멜라닌 생성을 억제하여 미백 효과를 부여할 수 있다. 본 발명의 일 실험예에 따르면, 상기 자두 씨 추출물은 티로시나제 저해 활성을 가지며, 특히, 피자두 씨 추출물에서 우수한 티로시나제 저해 활성이 나타남을 확인할 수 있었다. The plum seed extract has an excellent tyrosinase inhibitory activity, thereby inhibiting melanin production to impart a whitening effect. According to an experimental example of the present invention, it was confirmed that the plum seed extract had tyrosinase inhibitory activity, and in particular, the pizza bean seed extract showed excellent tyrosinase inhibitory activity.
또한, 상기 자두 씨 추출물은 기존 미백 원료로 사용되는 아스코르브산에 비해 티로시나제 저해 활성에 대한 안정성이 현저히 우수한 것으로 나타나, 보다 안정적이고 효과적인 피부 미백용 건강식품 조성물로 사용될 수 있다.In addition, the plum seed extract showed significantly superior stability to tyrosinase inhibitory activity compared to ascorbic acid used as a conventional whitening raw material, and thus can be used as a more stable and effective health food composition for skin whitening.
이에 상응하는 특징들은 상술된 부분에서 대신할 수 있다.Corresponding features may be substituted for the above-mentioned parts.
본 발명에 따른 건강식품 조성물에 있어서, 상기 건강식품은 분말, 과립, 정제, 캡슐, 시럽 또는 음료 등으로 제조될 수 있고, 상기 건강식품이 취할 수 있는 형태에는 제한이 없으며, 통상적인 의미의 식품을 모두 포함할 수 있다. 예를 들어, 음료 및 각종 드링크, 과실 및 그의 가공식품(과일통조림, 잼 등), 어류, 육류 및 그 가공식품(햄, 베이컨 등), 빵류 및 면류, 쿠키 및 스낵류, 유제품(버터, 치즈 등) 등이 가능하며, 통상적인 의미에서의 기능성 식품을 모두 포함할 수 있다. 또한, 동물을 위한 사료로 이용되는 식품도 포함할 수 있다.In the health food composition according to the present invention, the health food may be prepared in powder, granule, tablet, capsule, syrup or beverage, etc. may include all of them. For example, beverages and various drinks, fruits and their processed foods (canned fruit, jam, etc.), fish, meat and their processed foods (ham, bacon, etc.), breads and noodles, cookies and snacks, dairy products (butter, cheese, etc.) ), etc. are possible, and may include all functional foods in a conventional sense. It may also include food used as feed for animals.
본 발명에 따른 건강식품 조성물은 당업계에서 통상적으로 사용되는 식품학적으로 허용 가능한 식품 첨가제 및 적절한 기타 보조 성분을 더 포함하여 제조될 수 있다. 예를 들어, 향미제, 천연 탄수화물, 감미제, 비타민, 전해질, 착색제, 펙트산, 알긴산, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산화제 등을 추가로 함유할 수 있다. The health food composition according to the present invention may be prepared by further including pharmaceutically acceptable food additives and other suitable auxiliary ingredients commonly used in the art. For example, flavoring agents, natural carbohydrates, sweetening agents, vitamins, electrolytes, coloring agents, pectic acid, alginic acid, organic acids, protective colloidal thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonating agents, etc. can
특히, 상기 천연 탄수화물로는 포도당, 과당과 같은 모노사카라이드, 말토스, 수크로오스와 같은 디사카라이드, 및 덱스트린, 사이클로덱스트린과 같은 폴리사카라이드, 자일리톨, 소르비톨, 에리트리톨 등의 당알콜을 사용할 수 있으며, 감미제로서는 타우마틴, 스테비아 추출물과 같은 천연 감미제나 사카린, 아스파르탐과 같은 합성 감미제 등을 사용할 수 있다.In particular, as the natural carbohydrate, monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol can be used. , as the sweetener, natural sweeteners such as taumatine and stevia extract or synthetic sweeteners such as saccharin and aspartame may be used.
본 발명에 따른 건강식품에 함유된 자두 씨 추출물의 유효 용량은 피부 미백 목적에 따라 적절하게 조절될 수 있다. 상기 조성물은 천연물 및 식품을 원료로 하여 일반 약품의 장기 복용 시 발생할 수 있는 부작용 등이 없는 장점이 있고, 휴대성이 뛰어나, 피부 미백을 위한 보조제로 섭취될 수 있다.The effective dose of the plum seed extract contained in the health food according to the present invention may be appropriately adjusted according to the purpose of skin whitening. The composition has the advantage of not having side effects that may occur during long-term use of general drugs by using natural products and food as raw materials, and has excellent portability and can be taken as an auxiliary for skin whitening.
본 발명은 자두 씨 추출물을 유효성분으로 함유하는 멜라닌 과다 생성에 따른 피부 질환 예방 또는 치료용 약학 조성물을 제공한다.The present invention provides a pharmaceutical composition for preventing or treating skin diseases caused by excessive melanin production, comprising a plum seed extract as an active ingredient.
상기 자두 씨 추출물은 우수한 티로시나제 저해 활성을 가짐으로써, 멜라닌 생성을 억제할 수 있고, 이를 이용하여 멜라닌 과다 생성에 따른 피부 질환을 예방 또는 치료할 수 있다. Since the plum seed extract has excellent tyrosinase inhibitory activity, it is possible to inhibit melanin production, and by using it, it is possible to prevent or treat skin diseases caused by excessive melanin production.
또한, 상기 자두 씨 추출물은 기존 미백 원료로 사용되는 아스코르브산에 비해 티로시나제 저해 활성에 대한 안정성이 현저히 우수한 것으로 나타나, 보다 안정적이고 효과적인 상기 피부 질환의 치료 조성물로 사용될 수 있다.In addition, the plum seed extract showed significantly superior stability to tyrosinase inhibitory activity compared to ascorbic acid used as a conventional whitening raw material, and thus can be used as a more stable and effective composition for treating the skin disease.
이에 상응하는 특징들은 상술된 부분에서 대신할 수 있다.Corresponding features may be substituted for the above-mentioned parts.
본 발명에 따른 약학 조성물에 있어서, 상기 멜라닌 과다 생성에 따른 피부 질환은 기미, 주근깨, 잡티, 검버섯 및 오타모반으로 이루어진 군에서 선택되는 하나 이상의 색소 질환일 수 있으나, 이에 제한되는 것은 아니다. In the pharmaceutical composition according to the present invention, the skin disease caused by the excessive production of melanin may be one or more pigment diseases selected from the group consisting of melasma, freckles, blemishes, age spots and nevus Ota, but is not limited thereto.
본 명세서에서, "기미(melasma)"는 불규칙한 모양, 다양한 크기의 갈색 점이 노출부위, 특히 얼굴에 발생하는 색소성 질환으로, 태양 광선에 대한 노출 등에 의해 악화될 수 있다. 주로 좌우 대칭적으로 뺨과 이마, 눈 밑에 멜라닌 색소가 침착된다.As used herein, "melasma" is a pigmented disease in which brown spots of irregular shape and various sizes occur on exposed areas, especially on the face, and may be exacerbated by exposure to sunlight or the like. Melanin pigment is deposited mainly on the cheeks, forehead, and under the eyes symmetrically.
본 명세서에서, "주근깨(freckle)"는 햇빛에 노출된 부위의 피부에 주로 생기는 황갈색의 작은 색소성 반점으로, 원인은 정확하게 밝혀져 있지 않으나, 멜라노코르틴-1-수용체(melanocortin-1-receptor)의 유전자 변이와 관련이 있으며, 자외선에 의해 피부 멜라닌 세포가 자극을 받아 멜라닌 색소의 합성이 증가하여 발생할 수 있는 것으로 알려져 있다. As used herein, "freckle" is a small, yellowish-brown, pigmented spot that occurs mainly on the skin in areas exposed to sunlight, the cause of which is unknown, but melanocortin-1-receptor (melanocortin-1-receptor) It is related to the genetic mutation of , and it is known that it can occur because the synthesis of melanin pigment is increased by stimulation of skin melanocytes by ultraviolet rays.
본 명세서에서, "검버섯(liver spot, age spot)"은 노화 및 햇빛의 자외선 노출에 의해 형성된 피부 상의 얼룩으로, 일광흑색점(햇빛흑색점, 일광흑자, solar lentigo) 또는 간반이라고도 한다. As used herein, "liver spot, age spot" is a stain on the skin formed by aging and exposure to ultraviolet rays of sunlight, and is also referred to as sun melanoma (sunlight spot, solar lentigo) or ganban.
본 명세서에서, "오타모반(nevus of Ota)"은 눈 주위의 피부와 눈, 점막 등에 잘 발생하는 갈색 내지 푸른 색조를 띠는 반점을 말한다.As used herein, "nevus of Ota" refers to a spot having a brown or blue color that occurs well on the skin around the eyes, eyes, mucous membranes, and the like.
본 발명에 따른 약학 조성물은 약학적 분야의 통상적인 방법에 따라 제조될 수 있다. 상기 약학 조성물은 제형에 따라 약학적으로 허용가능한 적절한 담체와 배합될 수 있고, 필요에 따라, 부형제, 희석제, 분산제, 유화제, 완충제, 안정제, 결합제, 붕해제, 용제 등을 더 포함하여 제조될 수 있다. 상기 적절한 담체 등은 본 발명에 따른 자두 씨 추출물의 활성 또는 특성을 저해하지 않는 것으로, 투여 형태 및 제형에 따라 달리 선택될 수 있다.The pharmaceutical composition according to the present invention may be prepared according to a conventional method in the pharmaceutical field. The pharmaceutical composition may be combined with an appropriate pharmaceutically acceptable carrier according to the formulation, and if necessary, excipients, diluents, dispersants, emulsifiers, buffers, stabilizers, binders, disintegrants, solvents, etc. may be prepared have. The appropriate carrier and the like do not inhibit the activity or properties of the plum seed extract according to the present invention, and may be selected differently depending on the dosage form and formulation.
본 발명에 따른 약학 조성물은 어떠한 제형으로도 적용될 수 있고, 보다 상세하게는 통상의 방법에 따라 경구형 제형, 외용제, 좌제 및 멸균 주사용액의 비경구형 제형으로 제형화하여 사용될 수 있다.The pharmaceutical composition according to the present invention can be applied in any dosage form, and more specifically, it can be used by formulating oral dosage forms, external preparations, suppositories, and parenteral dosage forms of sterile injection solutions according to conventional methods.
상기 경구형 제형 중 고형 제형은 정제, 환제, 산제, 과립제, 캡슐제 등의 형태로, 적어도 하나 이상의 부형제, 예를 들면, 전분, 칼슘카보네이트, 수크로스, 락토오스, 솔비톨, 만니톨, 셀룰로오스, 젤라틴 등을 섞어 조제할 수 있고, 단순한 부형제 이외에 마그네슘 스테아레이트, 탈크 같은 윤활제들도 포함될 수 있다. 또한, 캡술제형의 경우 상기 언급한 물질 외에도 지방유와 같은 액체 담체를 더 포함할 수 있다.The solid dosage form among the oral dosage forms is in the form of tablets, pills, powders, granules, capsules, etc., and at least one or more excipients, for example, starch, calcium carbonate, sucrose, lactose, sorbitol, mannitol, cellulose, gelatin, etc. In addition to simple excipients, lubricants such as magnesium stearate and talc may be included. In addition, the capsule formulation may further include a liquid carrier such as fatty oil in addition to the above-mentioned substances.
상기 경구형 제형 중 액상 제형은 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데 흔히 사용되는 단순 희석제인 물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등이 포함될 수 있다.Among the oral dosage forms, liquid formulations include suspensions, solutions, emulsions, syrups, etc. In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients, for example, wetting agents, sweeteners, fragrances, preservatives, etc. may be included. have.
상기 비경구 제형은 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조 제제, 좌제가 포함될 수 있다. 비수성용제, 현탁제로는 프로필렌글리콜, 폴리에틸렌 글리콜, 올리브 오일과 같은 식물성 기름, 에틸올레이트와 같은 주사 가능한 에스테르 등이 사용될 수 있다. 좌제의 기제로는 위텝솔(witepsol), 마크로골, 트윈 61, 카카오지, 라우린지, 글리세로제라틴 등이 사용될 수 있다. 이에 제한되지 않고, 당해 기술 분야에 알려진 적합한 제제를 모두 사용 가능하다.The parenteral formulation may include a sterile aqueous solution, a non-aqueous solution, a suspension, an emulsion, a freeze-dried formulation, and a suppository. Non-aqueous solvents and suspending agents include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. As the base of the suppository, witepsol, macrogol, Tween 61, cacao butter, laurin fat, glycerogelatin, and the like can be used. Without being limited thereto, any suitable agent known in the art may be used.
또한, 본 발명에 따른 약학 조성물은 치료 효능의 증진을 위해 칼슘이나 비타민 D3 등을 더 첨가할 수 있다.In addition, the pharmaceutical composition according to the present invention may further add calcium, vitamin D3, or the like to enhance therapeutic efficacy.
본 발명에 따른 약학 조성물은 약학적으로 유효한 양으로 투여될 수 있다. The pharmaceutical composition according to the present invention may be administered in a pharmaceutically effective amount.
본 명세서에서, "약학적으로 유효한 양"이란, 의학적 치료에 적용 가능한 합리적인 수혜/위험 비율로 질환을 치료하기에 충분하며 부작용을 일으키지 않을 정도의 양을 의미한다.As used herein, "pharmaceutically effective amount" means an amount sufficient to treat a disease at a reasonable benefit/risk ratio applicable to medical treatment and not to cause side effects.
상기 약학 조성물의 유효 용량 수준은 사용 목적, 환자의 연령, 성별, 체중 및 건강 상태, 질환의 종류, 중증도, 약물의 활성, 약물에 대한 민감도, 투여 방법, 투여 시간, 투여 경로 및 배출 비율, 치료기간, 배합 또는 동시 사용되는 약물을 포함한 요소 및 기타 의학 분야에 잘 알려진 요소에 따라 달리 결정될 수 있다. 예를 들어, 일정하지는 않지만 일반적으로 0.001 내지 100mg/kg으로, 바람직하게는 0.01 내지 10mg/kg을 일일 1회 내지 수회 투여될 수 있다. 상기 투여량은 어떠한 면으로든 본 발명의 범위를 한정하는 것은 아니다.The effective dose level of the pharmaceutical composition is determined by the purpose of use, the age, sex, weight and health status of the patient, the type of disease, severity, drug activity, sensitivity to drug, administration method, administration time, administration route and excretion rate, treatment It may be determined differently depending on factors including the duration, formulation or concurrent use of drugs and other factors well known in the medical field. For example, although not constant, generally 0.001 to 100 mg/kg, preferably 0.01 to 10 mg/kg, may be administered once to several times a day. The above dosage does not limit the scope of the present invention in any way.
본 발명에 따른 약학 조성물은 제제 형태에 따른 적당한 투여 경로로 투여될 수 있고, 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있다. 투여 방법은 특히 한정할 필요 없이, 예를 들면, 경구, 직장 또는 정맥, 근육, 피부 도포, 피하, 호흡기내 흡입, 자궁내 경막 또는 뇌혈관내(intracere-broventricular) 주사 등의 통상적인 방법으로 투여될 수 있다.The pharmaceutical composition according to the present invention may be administered by an appropriate administration route according to the form of the formulation, and may be administered through various routes, either oral or parenteral, as long as it can reach the target tissue. The administration method does not need to be particularly limited, and for example, oral, rectal or intravenous, muscle, skin application, subcutaneous, respiratory inhalation, intrauterine dural or intracerebroventricular injection, etc. are administered in a conventional manner. can be
본 발명에 따른 약학 조성물은 멜라닌 과다 생성에 따른 피부 질환의 예방 또는 치료를 위하여 단독으로 사용될 수 있고, 수술 또는 다른 약물 치료 등과 병용하여 사용될 수 있다.The pharmaceutical composition according to the present invention may be used alone for the prevention or treatment of skin diseases caused by excessive melanin production, or may be used in combination with surgery or other drug treatment.
또한, 본 발명은 자두 씨 추출물을 유효성분으로 함유하는 멜라닌 과다 생성에 따른 피부 질환 예방 또는 개선용 건강식품 조성물을 제공한다.In addition, the present invention provides a health food composition for preventing or improving skin diseases caused by excessive production of melanin containing the plum seed extract as an active ingredient.
이에 상응하는 특징들은 상술된 부분에서 대신할 수 있다.Corresponding features may be substituted for the above-mentioned parts.
또한, 본 발명은 자두 씨 추출물을 유효성분으로 함유하는 티로시나제의 활성 저해용 시약 조성물을 제공할 수 있다.In addition, the present invention may provide a reagent composition for inhibiting the activity of tyrosinase containing a plum seed extract as an active ingredient.
이하, 본 발명의 이해를 돕기 위하여 실시예를 들어 상세하게 설명하기로 한다. 다만 하기의 실시예는 본 발명의 내용을 예시하는 것일 뿐 본 발명의 범위가 하기 실시예에 한정되는 것은 아니다. 본 발명의 실시예는 당업계에서 평균적인 지식을 가진 자에게 본 발명을 보다 완전하게 설명하기 위해 제공되는 것이다.Hereinafter, to help the understanding of the present invention, examples will be described in detail. However, the following examples are merely illustrative of the contents of the present invention, and the scope of the present invention is not limited to the following examples. The embodiments of the present invention are provided to more completely explain the present invention to those of ordinary skill in the art.
<실시예 1> 품종별 자두 씨 추출물 제조<Example 1> Preparation of Plum Seed Extracts by Varieties
본 실험에 사용된 자두는 도 1과 같이 후무사(Prunus salicina Formosa), 피자두(Prunus salicina Lindl. cv. Soldam) 및 도담(Prunus salicina Dodam) 3종으로, 각각 김천, 영천, 경산이 원산지로 온라인 및 과일가게에서 구입하여 과육으로부터 씨를 완전히 분리하여 씨만 실험에 사용하였다.As shown in FIG. 1, the plums used in this experiment are Prunus salicina Formosa , Prunus salicina Lindl. cv. Soldam , and Prunus salicina Dodam 3 types, respectively, from Gimcheon, Yeongcheon, and Gyeongsan. The seeds were completely isolated from the pulp, purchased online and at a fruit store, and only the seeds were used for the experiment.
씨를 분쇄기로 분쇄한 후, 분말 중량의 10배(v/w)의 식품 첨가용 에탄올인 70% 프레타놀 A(prethanol A, Duksan, Ansan, Gyeonggi-do, Korea)를 첨가하여 25℃, 50rpm에서 18시간씩 2회 반복 추출하였다. 추출물은 여과지(Whatman No.3, England)로 여과하여 여액은 45℃ 수욕 상에서 회전식 감압 농축기로 농축한 후 동결 건조하여 -20℃에 보관하며 실험에 사용하였다. 자세한 제조과정은 도 2와 같다.After pulverizing the seeds with a grinder, 70% pretanol A (prethanol A, Duksan, Ansan, Gyeonggi-do, Korea), which is ethanol for food addition at 10 times (v/w) of the weight of the powder, was added at 25℃, 50rpm. Extraction was repeated twice for 18 hours each. The extract was filtered through filter paper (Whatman No.3, England), and the filtrate was concentrated with a rotary vacuum concentrator on a 45°C water bath, then freeze-dried, stored at -20°C, and used in the experiment. A detailed manufacturing process is shown in FIG. 2 .
<실험예 1> 자두 씨 추출물의 티로시나제(tyrosinase) 저해 활성 확인<Experimental Example 1> Confirmation of tyrosinase inhibitory activity of plum seed extract
티로시나제(tyrosinase) 저해 활성 측정은 0.1M 인산 칼륨 완충액(potassium phosphate buffer, pH 7.0) 80μL, 0.01 M L-도파(L-Dopa) 40μL와 시료 용액 40μL의 혼합액에 버섯류 티로시나제(mushroom tyrosinase) 125U/mL를 첨가하여 37℃ 에서 3분간 반응시켜 반응액 중에 생성되는 도파크롬(dopachrome)을 475nm에서 측정하였다. Tyrosinase inhibitory activity was measured in a mixture of 80 μL of 0.1 M potassium phosphate buffer (pH 7.0), 40 μL of 0.01 M L-Dopa and 40 μL of sample solution, and 125 U/mL of mushroom tyrosinase. was added and reacted at 37° C. for 3 minutes, and the dopachrome generated in the reaction solution was measured at 475 nm.
그 결과, 품종별 자두 씨 추출물은 도 3과 같이, 피자두 씨 추출물이 가장 높은 티로시나제 저해 활성을 나타내는 것으로 나타났다.As a result, as shown in FIG. 3 for each variety of plum seed extract, the pizza bean seed extract showed the highest tyrosinase inhibitory activity.
이에, 티로시나제 저해 활성이 가장 우수한 피자두 씨 추출물의 농도별 저해 활성을 비교한 결과, 도 4와 같이, 0.25~1.5 mg/mL 농도 구간에서 농도에 의존적으로 높은 저해활성을 보였다.Accordingly, as a result of comparing the inhibitory activity by concentration of the pizza bean seed extract having the best tyrosinase inhibitory activity, as shown in FIG. 4 , the concentration-dependent high inhibitory activity was shown in the 0.25-1.5 mg/mL concentration range.
<실험예 2> 상온(RT)에서 보관 기간에 따른 티로사나제 저해 활성 변화 비교<Experimental Example 2> Comparison of changes in tyrosanases inhibitory activity according to storage period at room temperature (RT)
피자두 씨 추출물 및 아스코르브산(ascorbic acid, Junsei Chemical Co., Ltd. Tokyo, Japan)을 농도별로 제조한 후, 상온에 방치하며, 방치 후 4일, 8일, 12일, 20일째 각각의 티로시나제 저해 활성을 측정하였다.After preparing pizza bean seed extract and ascorbic acid (ascorbic acid, Junsei Chemical Co., Ltd. Tokyo, Japan) by concentration, left at room temperature, 4 days, 8 days, 12 days, and 20 days after leaving each tyrosinase Inhibitory activity was measured.
그 결과, 도 5와 같이, 피자두 씨 추출물의 경우 8일째까지 티로시나제 저해 활성의 유의적인 변화가 없었고, 12일째 미미한 티로시나제 저해 활성 변화가 나타났으며, 20일째는 제조 첫날 시료의 티로시나제 저해 활성 대비 약 40~50%정도 상기 저해 활성이 감소된 것을 확인할 수 있었다. As a result, as shown in FIG. 5 , in the case of the Pizza bean seed extract, there was no significant change in tyrosinase inhibitory activity until the 8th day, and a slight change in tyrosinase inhibitory activity on the 12th day was observed. It was confirmed that the inhibitory activity was reduced by about 40-50%.
이에 반해, 대표적인 미백 원료로 알려진 아스코르브산은 도 6과 같이, 8일째 25μg/mL 농도에서 첫날 대비 티로시나제 저해 활성이 78%정도 감소하였으며, 20일째는 모든 농도에서 90% 가까이 저해 활성이 감소된 것을 확인할 수 있었다. On the other hand, ascorbic acid, which is known as a representative whitening raw material, decreased about 78% of the tyrosinase inhibitory activity compared to the first day at the 25 μg/mL concentration on the 8th day, as shown in FIG. could
결과적으로 티로시나제 저해 활성에 대한 안정성의 경우, 피자두 씨 추출물이 아스코르브산보다 월등히 우수한 것으로 확인되었다.As a result, in terms of stability against tyrosinase inhibitory activity, it was confirmed that the pizza bean seed extract was significantly superior to ascorbic acid.
이상으로 본 발명 내용의 특정한 부분을 상세히 기술하였는 바, 당업계의 통상의 지식을 가진 자에게 있어서, 이러한 구체적 기술은 단지 바람직한 실시양태일 뿐이며, 이에 의해 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 즉, 본 발명의 실질적인 범위는 첨부된 청구항들과 그것들의 등가물에 의하여 정의된다.As described above in detail a specific part of the content of the present invention, for those of ordinary skill in the art, it is clear that this specific description is only a preferred embodiment, and the scope of the present invention is not limited thereby. do. That is, the substantial scope of the present invention is defined by the appended claims and their equivalents.
Claims (10)
상기 자두 씨 추출물은,
물, C1 내지 C4의 알코올 또는 이들의 혼합 용매로 추출된 것을 특징으로 하는 피부 미백용 화장료 조성물.The method of claim 1,
The plum seed extract is
A cosmetic composition for skin whitening, characterized in that it is extracted with water, C1 to C4 alcohol, or a mixed solvent thereof.
상기 자두 씨 추출물은,
티로시나제(tyrosinase) 저해 활성을 가지는 것을 특징으로 하는 피부 미백용 화장료 조성물.The method of claim 1,
The plum seed extract is
A cosmetic composition for skin whitening, characterized in that it has tyrosinase inhibitory activity.
상기 자두 씨 추출물은,
전체 화장료 100 중량부에 대하여 0.001 내지 50 중량부로 포함되는 것을 특징으로 하는 피부 미백용 화장료 조성물.The method of claim 1,
The plum seed extract is
A cosmetic composition for skin whitening, characterized in that it is included in an amount of 0.001 to 50 parts by weight based on 100 parts by weight of the total cosmetic.
상기 조성물은,
유연화장수, 영양화장수, 영양크림, 에센스 또는 팩의 제형을 갖는 것을 특징으로 하는 피부 미백용 화장료 조성물.The method of claim 1,
The composition is
A cosmetic composition for skin whitening, characterized in that it has the formulation of a softening lotion, nutrient lotion, nutrient cream, essence or pack.
상기 피부 질환은,
기미, 주근깨, 잡티, 검버섯 및 오타모반으로 이루어진 군에서 선택되는 하나 이상의 색소 질환인 것을 특징으로 하는 피부 질환 예방 또는 치료용 약학 조성물.9. The method of claim 8,
The skin disease is
A pharmaceutical composition for preventing or treating skin diseases, characterized in that it is one or more pigment diseases selected from the group consisting of spots, freckles, blemishes, age spots and nevus Ota.
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| KR1020200020329A KR102291441B1 (en) | 2020-02-19 | 2020-02-19 | Composition for skin whitening comprising plum seed extract |
| PCT/KR2021/001326 WO2021167269A1 (en) | 2020-02-19 | 2021-02-02 | Whitening composition comprising plum seed extract as active ingredient |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10236969A (en) * | 1997-02-24 | 1998-09-08 | Nonogawa Shoji Kk | Antistress agent and agent for protecting disturbance due to ultraviolet ray |
| KR20120036516A (en) | 2010-10-08 | 2012-04-18 | 주식회사 바이오랜드 | Cosmetic compositions for skin whitening comprising broccoli seed extracts |
| KR20180093560A (en) * | 2017-02-14 | 2018-08-22 | (주)튜링겐코리아 | A composition for skin whitening, anti-oxidating, astringent or anti-wrinkle comprising extracts of unripe plum |
| KR20190036269A (en) * | 2017-09-27 | 2019-04-04 | 대구한의대학교산학협력단 | Japanese apricot essential oil and cosmetic composition for skin whitening containing the same |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10236969A (en) * | 1997-02-24 | 1998-09-08 | Nonogawa Shoji Kk | Antistress agent and agent for protecting disturbance due to ultraviolet ray |
| KR20120036516A (en) | 2010-10-08 | 2012-04-18 | 주식회사 바이오랜드 | Cosmetic compositions for skin whitening comprising broccoli seed extracts |
| KR20180093560A (en) * | 2017-02-14 | 2018-08-22 | (주)튜링겐코리아 | A composition for skin whitening, anti-oxidating, astringent or anti-wrinkle comprising extracts of unripe plum |
| KR20190036269A (en) * | 2017-09-27 | 2019-04-04 | 대구한의대학교산학협력단 | Japanese apricot essential oil and cosmetic composition for skin whitening containing the same |
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