KR102114633B1 - Functional food composition with improved palatability for cadmium emission by grub and Lycium Chinense - Google Patents
Functional food composition with improved palatability for cadmium emission by grub and Lycium Chinense Download PDFInfo
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- KR102114633B1 KR102114633B1 KR1020180155035A KR20180155035A KR102114633B1 KR 102114633 B1 KR102114633 B1 KR 102114633B1 KR 1020180155035 A KR1020180155035 A KR 1020180155035A KR 20180155035 A KR20180155035 A KR 20180155035A KR 102114633 B1 KR102114633 B1 KR 102114633B1
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- cadmium
- functional food
- food composition
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L35/00—Food or foodstuffs not provided for in groups A23L5/00 – A23L33/00; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/334—Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/204—Animal extracts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
본 발명은 굼벵이의 건조 분말의 제조 시에 굼벵이 맛을 개선시켜 복용하는 사람의 순응성을 향상시킨 굼벵이를 이용하여 제조되는 카드뮴 배출 효과가 우수한 기능성 식품 조성물에 관한 것으로서, 그 구성 성분은 구기자 나무의 잎을 달인 물로 절식시킨 굼벵이를 5 내지 20초 동안 데친 후 40 ~ 60℃에서 건조하여 분말로 제조한 굼벵이 건조 분말, 메티오닌(methionine), 시스테인(Cysteine) 및 시스틴(cystine)으로 이루어진 군에서 선택되는 어느 하나 이상의 황 함유 아미노산, 토코페롤, 피리독신, 아스코르빈산. 칼슘, 마그네슘, 아연 및 셀레늄 함유 건조 효모이다.The present invention relates to a functional food composition having excellent cadmium discharge effect, which is manufactured using slugs that improve the adherence of a person taking them by improving the taste of slugs at the time of preparing dry powder of slugs, the component of which is a leaf of wolfberry Boiled slugs fastened with decoction water for 5 to 20 seconds, and then dried at 40 to 60 ° C. to form slugs dried powder, methionine, cysteine, and cystine. One or more sulfur-containing amino acids, tocopherol, pyridoxine, ascorbic acid. It is a dry yeast containing calcium, magnesium, zinc and selenium.
Description
본 발명은 굼벵이와 구기자를 이용한 카드뮴 배출을 위한 기호성이 향상된 기능성 식품 조성물에 관한 것이다.The present invention relates to a functional food composition with improved palatability for cadmium discharge using slugs and goji berries.
산업사회의 발달로 생활이 편리해진 반면 이로 인한 환경오염은 인간의 생활환경에 위협이 되고 있다. 이 중 토양이나 수질의 중금속 오염은 먹이사슬을 통해 인체에 이행, 축적되어 급성 또는 만성 중독을 일으킬 수 중금속은 종류에 따라 유기 혹은 무기 화합물을 형성하면 생체 내에서 이동이 용이하게 되어 여러 가지 악영향을 미치며, 또한 미세먼지 내지 황사에 포함되어 있는 중금속은 호흡기를 통하여 인체에 흡수되어 더 큰 문제를 일으킬 수 있다.While the development of industrial society has made life easier, the environmental pollution caused by this is a threat to the human living environment. Among these, heavy metal contamination of soil or water can accumulate and accumulate in the human body through the food chain, which can cause acute or chronic poisoning. Heavy metals can easily move in vivo if they form organic or inorganic compounds depending on the type, and have various adverse effects. Crazy, and also heavy metals contained in fine dust or yellow dust can be absorbed into the human body through the respiratory system and cause more problems.
이와 같은 중금속은 생체 내로 들어가면 쉽게 배출되지 않으며 축적량이 증가할 경우 체중감소, 빈혈, 장기의 생화학 및 형태학적 변화, 뇌 손상 등의 중독현상을 일으키며 칼슘, 철분, 아연, 셀레늄 등의 필수 무기원소와 장내 흡수 단계에 경쟁적으로 작용하여 조직 내 이들 함량을 감소시킨다. 또한, 일부 유독성 금속은 비교적 낮은 농도에서도 체조직과 반응하여 체내에 서서히 독 작용을 나타내고 특히 생물학적 반감기가 길어 일단 중독이 되면 완치가 불가능하다.Such heavy metals are not easily discharged when they enter the body, and when their accumulation increases, they cause poisoning such as weight loss, anemia, organ biochemical and morphological changes, brain damage, and essential inorganic elements such as calcium, iron, zinc, and selenium. It acts competitively in the intestinal absorption stage, reducing these contents in the tissue. In addition, some toxic metals react with body tissues even at relatively low concentrations, slowly exhibiting poison action in the body, and especially, because of a long biological half-life, it is impossible to cure once poisoned.
예를 들어, 카드뮴(Cd)은 중금속 중에서 가장 독성이 높은 물질 중의 하나이며 환경 중금속으로, 인체에 암을 유발하는 발암물질로 분류된다(Satoh, M., et al., Tohoku J. Exp. Med., 196, pp23-32, 2002). 역학 조사에 따르면 소량의 카드뮴일지라도 장기간 섭취되면 카드뮴이 표적 장기에 축적되어 결과적으로 건강에 악영향을 끼치게 된다.For example, cadmium (Cd) is one of the most toxic substances among heavy metals and is an environmental heavy metal and is classified as a carcinogen causing cancer in the human body (Satoh, M., et al., Tohoku J. Exp. Med ., 196, pp23-32, 2002). According to epidemiological studies, even a small amount of cadmium, when ingested for a long time, accumulates in the target organs, resulting in adverse health effects.
인간이 평생 섭취하는 총 카드뮴의 양은 대략 2000 mg(Klaassen, C.D., Casarett and Doull'sToxociology, McGraw-Hill Medical Publishing Division, New York, pp822-826, 2001) 정도이며, 음식이나 작업실 공기 중에 존재하는 카드뮴을 만성적으로 섭취할 경우, 카드뮴이 축적된 조직의 세포를 사멸시켜 기관(organ)이상을 야기할 수 있다(Falck, F.Y.Jr., et al., Am. J. Ind. Med., 4, pp541-549, 1983). 카드뮴은 주로 간과 신장에 축적되고, 낮은 용량일지라도 만성적으로 축적된 카드뮴은 폐, 간, 신 세뇨관 질환을 야기한다.The total amount of cadmium consumed by humans for a lifetime is approximately 2000 mg (Klaassen, CD, Casarett and Doull's Toxociology, McGraw-Hill Medical Publishing Division, New York, pp822-826, 2001), and cadmium present in food or studio air When chronically consumed, cadmium-accumulated tissue cells can kill cells and cause organ abnormalities (Falck, FYJr., Et al., Am. J. Ind. Med., 4, pp541 -549, 1983). Cadmium mainly accumulates in the liver and kidneys, and even at low doses, chronically accumulated cadmium causes lung, liver and renal tubular diseases.
카드뮴 노출에 의해 유도된 세포의 형태적인 변형은 세포퇴화, 염증성 반응, 섬유화를 포함한다. 카드뮴에 의해 유도된 조직손상의 병리적 기전은 세포 괴사 및 높은 세포교체율과 관련된다(Sauer, J.M., et al., Toxicology, 121, pp155-164, 1997).Morphological modifications of cells induced by cadmium exposure include cell degeneration, inflammatory responses, and fibrosis. The pathological mechanism of tissue damage induced by cadmium is associated with cell necrosis and high cell replacement rates (Sauer, J.M., et al., Toxicology, 121, pp155-164, 1997).
일반적으로, 저용량의 독성물질은 세포자멸사(apoptosis)를 야기하는 경향이 있지만, 높은 수준의 독성물질노출은 나중에 세포괴사를 일으킨다(Raffray, M., et al., Pharmacol. Ther., 75, 153-177, 1997). 세포사멸자극에 의한 단백질의 분해는 단백질에 결합되어 있는 배드(Bad)를 방출하고, 배드의 미토콘드리아로의 전위를 촉진하며 배드는 미토콘드리아 내의 BclXL와 상호작용하여 세포사를 증가시킨다(Nomura, M., et al., J. Biol. Chem.,278, pp2058-2065, 2003).In general, low doses of toxic substances tend to cause apoptosis, but high levels of toxic exposure later cause cell necrosis (Raffray, M., et al., Pharmacol. Ther., 75, 153 -177, 1997). Decomposition of proteins by apoptosis stimulates the release of the protein-bound bad, promotes the potential of the bed to mitochondria, and increases the cell death by interacting with BclXL in the mitochondria (Nomura, M., et al., J. Biol. Chem., 278, pp2058-2065, 2003).
이러한 사회적 배경으로 최근에 납과 카드뮴 중독 증상을 완화하기 위한 연구의 일환으로 섬유소, 단백질, 셀레늄 및 미량 원소들의 효능이 연구되고 있으며 홍차 및 녹차 카테킨이 카드뮴 중독으로 인한 신기능 장애를 개선하고 혈압을 정상화시켰다는 연구 등이 보고되고 있다.Against this background, the efficacy of fibrin, protein, selenium and trace elements has been studied as part of research to alleviate the symptoms of lead and cadmium poisoning, and black tea and green tea catechin improve renal dysfunction caused by cadmium poisoning and normalize blood pressure. Research has been reported.
또한, 유해물질이 체내 유입되면 체내에서 유해물질을 빠르게 배설하기 위해 생물학적 변형작용 (biotransformation)이 진행되고 결국 이러한 작용을 통해 유해물질은 체외로 배설되게 된다. 이러한 대사과정은 크게 두 개의 단계로 나누어 설명되는데, 즉 체내로 흡수되는 환경오염물질이나 약물과 같은 이물질은 간 조직에서 phase 1 반응 또는 phase 2 반응에 의하거나 두 단계를 모두 통해 체외로 배설된다. phase1 효소는 cytochrom P450을 포함하며 소수성 화합물의 산화, 환원, 가수분해 반응을 통해 반응성 전자를 갖도록 변화시켜 반응성이 높은 화합물로 전환한다. phase 2 효소는 glutathion S-transferase, UDP-glucuronosyl transferase, guinone reductase가 있는데 이들은 대사성이 높은 물질을 안정한 물질로 전환시켜 쉽게 배설되도록 돕는다(Liska DJ. Alter med rev 3: 187 -198,1998).In addition, when a harmful substance enters the body, biotransformation proceeds to quickly excrete the harmful substance from the body, and through this action, the harmful substance is excreted outside the body. This metabolic process is largely described in two stages, that is, foreign substances such as environmental pollutants or drugs absorbed into the body are excreted in the liver tissue by a phase 1 reaction or a phase 2 reaction, or excreted through both phases. The phase1 enzyme contains cytochrom P450 and is converted to a highly reactive compound by changing to have reactive electrons through oxidation, reduction, and hydrolysis reactions of hydrophobic compounds. Phase 2 enzymes include glutathion S-transferase, UDP-glucuronosyl transferase, and guinone reductase, which help to convert highly metabolizable substances into stable substances and facilitate excretion (Liska DJ. Alter med rev 3: 187 -198,1998).
최근 잠재적 암예방 물질로서 콜리플라워, 양배추, 케일, 브로콜리와 같은 십자화과 채소류의 황함유물질인 gulcosinolates와 암과의 상관관계에 대한 연구가 많이 수행되고 있으며, 그 결과 gulcosinolates는 biotransformation enzyme 발현을 변화시킴으로써 항암작용을 갖는 것으로 보고되었다.Recently, many studies have been conducted on the correlation between gulcosinolates, which are sulfur-containing substances of cruciferous vegetables, such as cauliflower, cabbage, kale, and broccoli, as cancers, and cancer as a potential cancer prevention substance. It has been reported to have action.
이와 같이 phase 1 반응 또는 phase 2의 효소 활성의 유도와 관련된 항암작용에 관한 연구는 활발하지만 이에 비해 중금속 물질에 대한 해독작용에 관한 연구와 과학적 자료는 미흡하며, 중금속 체내 축적 및 배출을 유도할 수 있는 기능성 식품에 관한 연구는 아직 미약한 실정이다.As such, studies on anticancer activity related to the induction of phase 1 reaction or phase 2 enzymatic activity are active, but on the other hand, studies on detoxification of heavy metals and scientific data are insufficient, and heavy metals can induce accumulation and discharge in the body. The research on functional foods is still weak.
또한 체내 미네랄 균형을 유지하는 것이 면역 기능의 유지, 세포 활성 유지, 질병 예방에 매우 중요한데, 파괴된 균형을 바로잡아 주면서 동시에 그 균형을 유지하여 주는 식품에 관한 연구 역시 미약한 실정이다.In addition, maintaining the mineral balance in the body is very important for the maintenance of immune function, maintenance of cell activity, and disease prevention. Research on foods that correct the destroyed balance and maintain the balance at the same time is also weak.
이에, 본 발명은 체내 미네랄 균형 유지, 유해 중금속인 납과 카드뮴 독성에 대한 피해를 완화할 수 있는 조성물에 대한 연구를 수행하던 중 굼벵이를 이용하는 경우에 카드뮴 배출에 유의할 만한 효과를 가지는 건강식품으로 사용될 수 있음을 확인하였으며, 이와 함께 굼벵이 건조 분말의 맛을 개선하여 굼벵이가 주는 불쾌함을 없애는 방법을 완성하게 되어 본 발명이 이르게 되었다.Accordingly, the present invention is to be used as a health food having a significant effect on cadmium discharge when using slugs while conducting research on a composition capable of maintaining the balance of minerals in the body and alleviating damage to harmful heavy metals, lead and cadmium toxicity It has been confirmed that the present invention has been accomplished by improving the taste of dried powdery slugs and completing a method of removing the discomfort from slugs.
따라서, 굼벵이의 건조 분말의 제조 시에 굼벵이 맛을 개선시켜 복용하는 사람의 순응성을 향상시킨 굼벵이와 구기자를 이용한 카드뮴 배출을 위한 기호성이 향상된 기능성 식품 조성물을 제공하는 것이다. Therefore, it is to provide a functional food composition with improved palatability for cadmium discharge using slugs and goji berries, which improves the taste of slugs when improving the taste of slugs when preparing dry powders of slugs.
상기 기술적 과제를 달성하기 위하여 본 발명은In order to achieve the above technical problem, the present invention
구기자 나무의 잎을 달인 물로 절식시킨 굼벵이를 5 내지 20초 동안 데친 후 40 ~ 60℃에서 건조하여 분말로 제조한 굼벵이 건조 분말 600 mg,600 mg of slug dry powder prepared from powder by boiling the leaves of wolfberry tree with decoction water for 5 to 20 seconds and then drying at 40 to 60 ° C.
메티오닌(methionine), 시스테인(Cysteine) 및 시스틴(cystine)으로 이루어진 군에서 선택되는 어느 하나 이상의 황 함유 아미노산 1500 mg,1500 mg of any one or more sulfur-containing amino acids selected from the group consisting of methionine, cysteine and cystine,
토코페롤 25 mg, Tocopherol 25 mg,
피리독신 17 mg, Pyridoxine 17 mg,
아스코르빈산 85 mg,85 mg ascorbic acid,
칼슘 40 mg,40 mg calcium,
마그네슘 20 mg, Magnesium 20 mg,
아연 10 mg, 및Zinc 10 mg, and
셀레늄 함유 건조 효모 79 mgSelenium-containing dry yeast 79 mg
포함하는 것을 특징으로 하는 체내 미네랄 균형 유지, 중금속의 생체 내 흡수 방지 및 체외 배출을 위한 기능성 식품 조성물을 제공한다.It provides a functional food composition for maintaining the balance of minerals in the body, preventing the absorption of heavy metals in vivo and discharging the body, characterized in that it comprises.
본 발명의 기능성 식품은 카드뮴 배출 효과가 우수한 기능성 식품으로서 사용될 수 있으며, 더더욱 굼벵이 주는 불쾌한 맛을 개선하여 환자의 순응성을 향상시켜 유용성을 더욱 증대시킬 수 있다.The functional food of the present invention can be used as a functional food having an excellent cadmium discharge effect, and further improving the patient's compliance by improving the unpleasant taste of the slug, thereby further increasing the usability.
이하, 본 발명에 대하여 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 상세히 설명한다.Hereinafter, the present invention will be described in detail so that those skilled in the art to which the present invention pertains can easily practice it.
본 발명에 따른 기능성 식품 조성물은 Functional food composition according to the invention
구기자 나무의 잎을 달인 물로 절식시킨 굼벵이를 5 내지 20초 동안 데친 후 40 ~ 60℃에서 건조하여 분말로 제조한 굼벵이 건조 분말 600 mg,600 mg of slug dry powder prepared from powder by boiling the leaves of wolfberry tree with decoction water for 5 to 20 seconds and then drying at 40 to 60 ° C.
메티오닌(methionine), 시스테인(Cysteine) 및 시스틴(cystine)으로 이루어진 군에서 선택되는 어느 하나 이상의 황 함유 아미노산 1500 mg,1500 mg of any one or more sulfur-containing amino acids selected from the group consisting of methionine, cysteine and cystine,
토코페롤 25 mg, Tocopherol 25 mg,
피리독신 17 mg, Pyridoxine 17 mg,
아스코르빈산 85 mg,85 mg ascorbic acid,
칼슘 40 mg,40 mg calcium,
마그네슘 20 mg, Magnesium 20 mg,
아연 10 mg, 및Zinc 10 mg, and
셀레늄 함유 건조 효모 79 mg을79 mg dry yeast containing selenium
포함하여 체내 미네랄 균형 유지, 중금속의 생체 내 흡수 방지 및 체외 배출를 발휘하는 것을 특징으로 한다.It is characterized by maintaining the balance of minerals in the body, preventing absorption of heavy metals in vivo, and excreted outside the body.
본 발명에서 사용되는 굼벵이는 한방으로부터 오랫동안 다양한 질환에 약으로 사용돼 왔으며 현재 농가에서 널리 사육돼 한방이나 민간요법에 사용되고 있으며 딱정벌레목(Coleopteran), 꽃무지과(Etonian) 곤충인 흰점박이꽃무지(Protaetia brevitarsis)의 유충으로 이를 건조하여 분말화 하는 방법은 본 발명이 속하는 기술 분야에 널리 알려진 것이라면 특별한 제한 없이 이용가능하다.The slug used in the present invention has been used as a medicine for various diseases for a long time from oriental medicine and is currently widely used in farming and is used for herbal medicine or folk remedies, and white beetle (Protaetia) which is an insect of Coleopteran and Etonian. brevitarsis), a method for drying and pulverizing it into larvae can be used without particular limitation as long as it is well known in the art.
이와 같은 굼벵이의 일반 성분은 단백질 58% 정도 매우 높으며, 또한 불포화 지방산을 다량 함유하고 있는데 특히 혈압강하작용 등이 알려져 있는 올레인산(oleic acid) 가 전체 지방산 중에서 60%를 차지하는 것으로 서 알려져 있습니다. 그리고 무기질 중 인과 칼륨, 비타민은 B3와 B9이 포함되어 있어 독소를 없애주고 혈액순환을 원활하게 하는 효능이 있으며, 알레르기 중상을 완화시키며 혈액 생성을 돕는 유아기 필수 아미노산인 히스티딘(histidine), 인지능력 개선 및 기억력 향상에 도움이 되는 글루탐산(glutamic acid) 및 콜라겐 형성에 도움을 주어 연골형성을 돕는 프롤린(proline)이 이 다량 함유되어 있다.The general component of these slugs is about 58% very high in protein, and also contains a large amount of unsaturated fatty acids. Especially, it is known that oleic acid, which is known to lower blood pressure, accounts for 60% of all fatty acids. In addition, phosphorus, potassium, and vitamins in the minerals include B3 and B9, which have the effect of eliminating toxins and smoothing blood circulation, alleviating serious injuries and helping blood production. Histidine, an essential amino acid in childhood, improves cognitive ability And it contains a large amount of proline (proline) that helps to form cartilage by helping to form glutamic acid and collagen, which help improve memory.
또한 굼벵이는 민간에서 간질환 치료제로 애용된 생약으로, 국내에서 굼벵)의 간보호 효과가 과학적으로 검증되었다. 굼벵이 추출물의 간 보호 효과는 사염화탄소 유발 급성 간염에서 GOT, GPT, 담즙산, 빌리루빈 수치가 조사하여 국립농업과학원 농업생물부에서 실험용 쥐에 굼벵이 추출액을 투여한 결과 간경화 예방 효과가 있다는 사실이 확인하였다. 간경화가 진행 중인 쥐에서 간섬유화를 억제하는 현상이 나타나 치료제로서도 효과가 있을 것으로 보고 있다. In addition, slug is a herbal medicine favored as a remedy for liver disease in the private sector. The liver protective effect of the slug extract was examined for the levels of GOT, GPT, bile acids, and bilirubin in acute hepatitis induced by carbon tetrachloride. The liver cirrhosis inhibits liver fibrosis in mice in progress, and is expected to be effective as a therapeutic agent.
특히 굼벵이 건조 분말을 제조하기 위한 바람직한 방법은 제조하기 전에 굼벵이를 절식시켜, 바람직하게는 4일 정도 절식시켜 굼벵이의 내장 속에 남아 있는 노폐물을 완전히 제거한 후에 구기자 나무의 잎을 달인 물을 끓여 약 5 내지 20초간 데쳐 굼벵이를 죽이면서 표면에 대한 살균 효과 및 잡내를 제거한 다음에 40 ~ 60℃에서 건조(열풍 건조 또는 히터에 의한 건조 모두 가능)하여 분말로 제조하는 방법에 의해 제조하는 것이다. In particular, a preferred method for preparing dried slugs is to fasten slugs before preparation, preferably fasting for about 4 days to completely remove the residue remaining in the slug's intestines, then boil water with the leaves of wolfberry trees to boil about 5 to 5 It is produced by a method of manufacturing a powder by killing slugs for 20 seconds, removing the sterilizing effect and stains on the surface, and then drying at 40 to 60 ° C (both hot air drying or drying by a heater).
본 발명에서의 구기자 나무는 학명이 Lycium chinense로서 가지과에 속하는 낙엽성 활엽관목으로서 고춧잎 같이 생긴 어린잎은 식용하며 관상용으로도 심으며 한국 중국, 일본에 분포한다. 열매는 구기자(拘杞子)라 하며 약용으로 사용하는데, 성분은 베타인, 베아크산틴, 카로텐, 티아민, 비타민A, B1, B2, C 등이 함유되어 있으며, 만성간염, 간경변증, 강장제, 해열제로 허리요통에 쓰이고, 뿌리 껍질은 지골피(地骨皮)라 하여 한방에서 소갈, 오한 등의 해열제로 이용된다. The wolfberry tree in the present invention has the scientific name Lycium As a chinense , it is a deciduous broad-leaved shrub belonging to the family Asteraceae. Young leaves that look like red pepper are edible and planted for ornamental purposes, and are distributed in Korea, China, and Japan. The fruit is called wolfberry, and is used for medicinal purposes. Its ingredients include betaine, beaxanthin, carotene, thiamine, vitamin A, B1, B2, C, etc., chronic hepatitis, cirrhosis, tonic, antipyretic It is used for low back pain, and the root bark is called golgolpi (地骨皮) and is used as an antipyretic agent for sogal and chills in oriental medicine.
상기 메티오닌(methionine), 시스테인(Cysteine) 및 시스틴(cystine)으로 이루어진 군에서 선택되는 어느 하나 이상의 황 함유 아미노산은 체내에 글루타치온 퍼옥시다제(Glutathione Peroxidase)와 같은 항산화 효소를 생성시켜 중금속으로 인해 생성된 체내에 산소를 함유한 유리기(free radical)를 제거시킨다. 또한 유리기가 세포 내 증가 또는 메탈로치오네인과 결합할 중금속 이온이 다량 존재할 경우 세포안으로 유입되어 메탈로치오네인과 결합하여 제거되거나 촉진인자(Metallothionein Transciprtion Factor, MTF)를 자극하게 된다. 그 결과 전사(transcription)가 진행되어 치오네인(Thionein)이 다량 합성되며, 세포내 유입될 중금속과 다시 결합하여 메탈로치오네인을 형성하게 된다. 생성된 메탈로치오네인은 대부분 아연 혹은 구리를 포함하는 메탈로치오네인이며, 이들은 다른 유해 중금속과의 친화력 차이로 인해 중금속 및 그 독성을 무력화한다. 결국 최종적으로 유해 중금속을 함유한 메탈로치오네인은 세포내의 리소좀(Lysosome)에 의해 분해 혹은 축적되거나 그 자체로 분비된다는 보고도 있다. 결국 체내에 축적된 중금속을 고분자 단백질과 결합시켜 고분자복합체인 메탈로치오네인(Metallothionein)의 생성을 유도하고 생성에 필요한 아미노산, 미네랄을 공급함으로써 유해 중금속의 독성을 무력화시킨다.Any one or more sulfur-containing amino acids selected from the group consisting of methionine, cysteine, and cystine produce antioxidant enzymes, such as glutathione peroxidase, in the body, resulting from heavy metals. Free radicals containing oxygen are removed from the body. In addition, when a large amount of heavy metal ions to bind to the metallothionein increase or free radicals in the cell is introduced into the cell, it is removed by binding to the metallothionein or stimulates the metallothionein transciprtion factor (MTF). As a result, transcription proceeds, and a large amount of thionein is synthesized, and is recombined with the heavy metal to be introduced into the cell to form a metallothionein. The resulting metallothioneins are mostly metallothioneins containing zinc or copper, which neutralize heavy metals and their toxicity due to differences in affinity with other harmful heavy metals. Eventually, there are reports that metallothionein containing harmful heavy metals is finally decomposed or accumulated by Lysosome in cells or secreted by itself. Eventually, the heavy metals accumulated in the body are combined with a polymer protein to induce the production of metallothionein, a polymer complex, and neutralize the toxicity of harmful heavy metals by supplying amino acids and minerals necessary for production.
다음으로, 본 발명의 중금속 제거용으로 비타민이 함유되는데, 비타민으로는 토코페롤, 피리독신 및 아스코르빈산이 있다. 토코페롤과 아스코르빈산은 주요 항산화제로서 글루타치온과 함께 세포에서의 산화작용을 강력하게 억제하는 것을 특징으로 하며, 토코페롤은 비타민 E로 에스테르 화합물을 포함한다. 피리독신은 글루타치온의 대사 및 합성에 보조적인 역할을 하고, 결합조직, 효소, 핵산, 면역물질의 생산을 촉진하고 뇌신경 전달물질의 생화학적 합성에 관여를 한다. 피리독신은 비타민 B6로 그의 염산염, 질산염 및 황산염을 포함한다.Next, a vitamin is included for removing heavy metals of the present invention, and the vitamins include tocopherol, pyridoxine and ascorbic acid. Tocopherol and ascorbic acid are major antioxidants and are characterized by strongly inhibiting oxidative action in cells together with glutathione, and tocopherol contains an ester compound as vitamin E. Pyridoxine plays an auxiliary role in the metabolism and synthesis of glutathione, promotes the production of connective tissue, enzymes, nucleic acids, and immune substances, and is involved in biochemical synthesis of brain neurotransmitter. Pyridoxine is vitamin B6 and includes its hydrochloride, nitrate and sulfate salts.
또한 본 발명은 각 효소의 작용을 보조하는 촉매 역할을 하며, 메탈로치오네인의 유도를 자극하는 역할을 하는 미네랄로서 함유되는 것으로는 칼슘, 마그네슘, 아연 및 셀레늄 함유 건조 효모를 포함한다. In addition, the present invention serves as a catalyst to assist the action of each enzyme, and is contained as a mineral that serves to stimulate the induction of metallothionein, and includes calcium, magnesium, zinc and selenium-containing dry yeast.
본 발명이 사용하는 셀레늄 함유 건조 효모는 여러 영양성분과 함께 셀레늄이 주성분으로 포함된 건조 효모를 셀레늄 함유 건조 효모로서 사용한다. 셀레늄은 인체에 필수적으로 요구되는 미네랄 성분으로서 산소를 소비하는 물질대사 과정에서 생성되는 자유 라디칼로부터 세포를 보호하는 항산화제로 작용할 뿐만 아니라 면역계의 기능을 강화하는 작용도 한다. The selenium-containing dry yeast used in the present invention uses dry yeast containing selenium as a main component along with various nutrients as selenium-containing dry yeast. Selenium is a mineral component that is essential for the human body and acts as an antioxidant that protects cells from free radicals generated in the process of metabolism that consumes oxygen, as well as strengthens the function of the immune system.
이어서 바람직한 실시예를 통하여 본 발명을 상세하게 설명하기로 한다. 실시예의 구체적인 예시는 본 발명을 설명하기 위한 것으로, 이에 한정되는 것이 아니고, 특허청구범위와 발명의 상세한 설명의 범위 안에서 여러 가지로 변형하여 실시하는 것이 가능하며, 이 또한 본 발명의 범위에 속하는 것은 당연하다.Next, the present invention will be described in detail through preferred embodiments. Specific examples of the embodiments are intended to illustrate the present invention, but are not limited thereto, and can be implemented in various ways within the scope of the claims and detailed description of the invention, and also belong to the scope of the present invention Of course it is.
1. One. 실시예Example 1: 본 발명에 따른 기능성 식품 조성물 제조 1: Preparation of functional food composition according to the present invention
굼벵이 건조 분말 600 mg, 메티오닌(methionine) 1500 mg, 토코페롤 25 mg, 피리독신 17 mg, 아스코르빈산 85 mg, 칼슘 40 mg, 마그네슘 20 mg, 아연 10 mg, 및 셀레늄 함유 건조 효모 79 mg를 함유하도록 본 발명에 따른 식품 조성물을 제조하였으며, 상기 굼벵이 건조 분말을 정제수에 10초간 데친 후에 50℃의 열풍으로 건조한 후 100메쉬 정도로 분말로 제조한 것을 이용하였으며, 나머지 구성 성분들은 건강식품제조에 널리 사용되는 것을 구매하여 제조하였다. Powdered dry powder 600 mg, methionine 1500 mg, tocopherol 25 mg, pyridoxine 17 mg, ascorbic acid 85 mg, calcium 40 mg, magnesium 20 mg, zinc 10 mg, and selenium-containing dry yeast 79 mg A food composition according to the invention was prepared, and the slug dried powder was boiled in purified water for 10 seconds, then dried with a hot air at 50 ° C. and then used as a powder of about 100 mesh, and the remaining components were widely used in health food manufacturing. It was purchased and manufactured.
2. 2. 비교예Comparative example 1: 비교 식품 조성물 제조 1: Preparation of comparative food compositions
상기 실시예 1에서 굼벵이 건조 분말을 제외하고 동일하게 식품 조성물을 제조하였다.The food composition was prepared in the same manner as in Example 1 except for the slug dry powder.
3. 시험예: 동물실험을 통한 중금속 배출효능 평가3. Test Example: Evaluation of heavy metal emission efficiency through animal experiments
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상기 실시예 1의 조성물이 카드뮴을 효과적으로 배출하는지를 확인하기 위해 수컷 Sprague-Dawley 랫트(6주령, 수컷, 약 250g)를 중앙실험동물로부터 구입하여 사용하였으며, 각 군당 10마리를 배정하여 본 실험에 사용하였다. 대조군에는 카드뮴만을, 제1군은 중금속으로 카드뮴을 투여하면서 이와 함께 실시예 1의 조성물을 투여하였다. 이때 하루에 카드뮴은 3㎍/g, 실시예 조성물은 0.1mg/g을 사료와 함께 경구 투여하였으며, 투여 4주 후에 동물을 희생하여 혈액을 채취하여 중금속의 배출 정도를 확인하였다.Male Sprague-Dawley rats (6 weeks old, males, about 250 g) were purchased from central laboratory animals and used in this experiment to determine whether the composition of Example 1 effectively discharges cadmium. Did. The control group was administered only with cadmium, the first group was administered with the composition of Example 1 while administering cadmium as a heavy metal. At this time, cadmium was 3 μg / g per day, and the composition of the example was orally administered with 0.1 mg / g of feed. After 4 weeks of administration, animals were sacrificed to collect blood to confirm the degree of heavy metal discharge.
중금속 및 추출물을 4주간 투여한 다음, 마지막 투여 2시간 후에 동물을 zoletil(zoletil 50, Virbac)을 이용하여 과마취를 시킨 후에 혈액 중 납, 수은, 카드뮴의 검출을 위해서 혈청을 채취하고 또한 뇌조직, 간에서 산화적 손상 및 항산화효소의 조직 내 분포를 확인하기 위하여 조직을 채취하였다.After administration of heavy metals and extracts for 4 weeks, 2 hours after the last administration, animals were overesthetized with zoletil (zoletil 50, Virbac), and then serum was collected for detection of lead, mercury, and cadmium in the blood. , In order to confirm the oxidative damage in the liver and the distribution of antioxidant enzymes in tissues, tissues were collected.
카드뮴은 원자흡광광도-흑연로법 검사원리를 이용하여 원자에 높은 열을 가해 원자를 들뜬 상태로 만든 후 카드뮴 원자가 228.8 nm에서 광흡수가 이루어지는 것을 이용하여 정량 평가하여 그 결과를 표 1에 나타냈다.Cadmium was subjected to the atomic absorption spectroscopy-graphite method inspection principle to make the atoms excited by applying high heat, and then quantitatively evaluated using cadmium atoms absorbed at 228.8 nm, and the results are shown in Table 1.
상기 표 1 시험 결과를 보면, 통상의 정상적인 혈액에서는 0.033㎍/ℓ가 측정되나 카드뮴만을 투여한 대조군의 경우 카드뮴 농도가 급격하게 증가하여, 평균6.286 ㎍/ℓ를 확인할 수 있었다. Looking at the test results in Table 1, 0.033 μg / ℓ was measured in normal normal blood, but in the case of a control group administered with cadmium only, the cadmium concentration increased rapidly, and an average of 6.286 μg / ℓ could be confirmed.
이와 비교하여 평균 제1군은 1.802㎍/ℓ,로 측정이 되어 본 발명에 따른 조성물의 경우에 카드뮴의 농도가 상당량 감소함을 확인할 수 있었다.Compared to this, the average first group was measured as 1.802 µg / L, and it was confirmed that the concentration of cadmium was significantly reduced in the case of the composition according to the present invention.
동일한 방법으로 하여 비교예 1의 조성물에 대하여 시험을 진행하여 그 결과를 표 2에 나타냈다.The test was conducted on the composition of Comparative Example 1 in the same manner, and the results are shown in Table 2.
상기 표 2 시험 결과를 보면, 비교예 1의 조성물의 경우에는 카드뮴 배출 효과가 없는 것으로 확인할 수 있었다.Looking at the results of Table 2, it was confirmed that the composition of Comparative Example 1 had no cadmium discharge effect.
4. 실시예 2: 본 발명에 따른 조성물 제조4. Example 2: Preparation of the composition according to the invention
실시예 1의 조성물과 동일하게 제조를 하였으나 굼벵이를 데치는 물로 정제수가 아닌 구기자 잎 달인 물을 사용한 것에 차이가 있다. 건조 구기자 잎 100g 당 물 1ℓ를 넣고 1시간 정도 끓인 물을 이용하였다.It was prepared in the same manner as in the composition of Example 1, but there is a difference in using water of decoction of goji berry instead of purified water as water for boiling slugs. 1 l of water was added per 100 g of dried goji berry leaves, and water boiled for about 1 hour was used.
5. 관능 시험5. Sensory test
실시예 1 및 실시예 2의 조성물에 대하여 남녀 20대 각 25명씩 총 50명을 선정하여 각 조성물을 섭취시킨 후에 맛이 우수한 쪽에 투표를 하게 하고 느낌을 적게 하였는데, 그 결과를 보면 50명 모두 실시예 2의 조성물에서는 구수한 맛이 느껴지며 다른 불쾌한 맛이 없어 거부감이 없이 먹을 수 있다고 하여 실시예 1보다는 우수한 것으로 평가를 하였다.With respect to the compositions of Examples 1 and 2, a total of 50 persons were selected for each of 20 men and women in their 20s, and after ingesting each composition, votes were made on the side with excellent taste and the feeling was reduced. In the composition of Example 2, it was evaluated to be superior to Example 1 because it had a savory taste and had no other unpleasant taste, so that it could be eaten without rejection.
이상에서 살펴본 바와 같은 본 발명에 따른 조성물은 본 발명의 기능성 식품은 혈중 중금속의 배출 정도를 확인한 결과, 중금속 배설효과가 탁월함을 확인하여 중금속 중독으로 인한 질환의 새로운 치료 및 예방을 위한 기능성 식품으로서 사용될 수 있으며, 또한 체내 미네랄의 균형이 파괴되었을 때 이를 정상으로 회복하여 주며, 정상의 상태일 경우에는 이를 유지하여 주슨 효과가 있어 세포 활성 유지, 면역력 강화 등에 매우 유용하다. 또한 굼벵이를 이용하였다는 거부감 없이 섭취할 수 있는 장점도 있다.As described above, the composition according to the present invention is used as a functional food for new treatment and prevention of diseases caused by heavy metal poisoning by confirming that the functional food of the present invention is excellent in excretion of heavy metals as a result of checking the discharge level of heavy metals in the blood. In addition, when the balance of minerals in the body is destroyed, it is restored to normal, and in the normal state, it is maintained, which is very useful for maintaining cell activity and strengthening immunity. It also has the advantage of being able to consume slugs without a feeling of rejection.
Claims (1)
메티오닌(methionine), 시스테인(Cysteine) 및 시스틴(cystine)으로 이루어진 군에서 선택되는 어느 하나 이상의 황 함유 아미노산 1500 mg,
토코페롤 25 mg,
피리독신 17 mg,
아스코르빈산 85 mg,
칼슘 40 mg,
마그네슘 20 mg,
아연 10 mg, 및
셀레늄 함유 건조 효모 79 mg
포함하는 것을 특징으로 하는 카드뮴 배출을 위한 기호성이 향상된 기능성 식품 조성물.
Boiled leaves of wolfberry berry fastened with water, boiled for 5 to 20 seconds, and dried at 40 to 60 ° C to improve the taste of powdery dried powder, which is improved to 600 mg,
1500 mg of any one or more sulfur-containing amino acids selected from the group consisting of methionine, cysteine and cystine,
Tocopherol 25 mg,
Pyridoxine 17 mg,
85 mg ascorbic acid,
40 mg calcium,
Magnesium 20 mg,
Zinc 10 mg, and
Selenium-containing dry yeast 79 mg
Functional food composition with improved palatability for cadmium discharge, characterized in that it comprises.
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