KR101970998B1 - The composition of poultry red mite control product for oral, and method for manufacturing thereof - Google Patents

The composition of poultry red mite control product for oral, and method for manufacturing thereof Download PDF

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KR101970998B1
KR101970998B1 KR1020170114371A KR20170114371A KR101970998B1 KR 101970998 B1 KR101970998 B1 KR 101970998B1 KR 1020170114371 A KR1020170114371 A KR 1020170114371A KR 20170114371 A KR20170114371 A KR 20170114371A KR 101970998 B1 KR101970998 B1 KR 101970998B1
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weight
composition
cinnamon extract
powder
oral
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KR20190027512A (en
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이종석
정은용
장희주
최형규
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(주)이엘티사이언스
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87—Re-use of by-products of food processing for fodder production
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S426/00—Food or edible material: processes, compositions, and products
    • Y10S426/807—Poultry or ruminant feed

Abstract

본 발명은 안전성이 입증된 천연물질을 경구적으로 급여하여 닭에 기생하고 있는 와구모를 효과적으로 구제함과 동시에 농약성분 잔류문제 걱정이 없는 안전한 계란 생산이 가능한 경구용 닭 와구모 구제제 조성물 및 그 제조방법을 제공하고자 한다.
상기 목적을 달성하기 위해 본 발명은 천연물질인 계피추출물 분말, 법제유황 분산체 및 구운 왕겨분말을 일정 비율로 혼합하여 제조된 조성물을 특징으로 한다.
또한, 본 발명은 계피추출물 분말을 형성하는 제1단계와; 법제유황 분산체를 형성하는 제2단계; 및 상기 계피추출물 분말 6 ~ 14중량%와 법제유황 분산체 30 ~ 70중량% 및 구운 왕겨분말 16 ~ 64중량%를 각각 혼합기에 투입한 후 120rpm 속도로 10 ~ 30분간 혼합하여 조성물을 형성하는 제3단계;를 포함하여서 된 것을 특징으로 한다.The present invention relates to a composition for oral chicken vaccine composition capable of producing a safe egg without having to worry about the residual problem of pesticide ingredients while effectively relieving Wagumo which is parasitic on chicken by feeding a proven natural substance safely, .
In order to achieve the above object, the present invention is characterized by a composition prepared by mixing natural extracts of cinnamon extract powder, legal sulfur dispersal agent and baked rice hull powder at a certain ratio.
The present invention also provides a method for producing a cinnamon extract, comprising: a first step of forming a cinnamon extract powder; A second step of forming a legal sulfur dispersant; And 6 to 14% by weight of the cinnamon extract powder, 30 to 70% by weight of the formal sulfur dispersion, and 16 to 64% by weight of the baked rice hull powder, respectively, and mixing the mixture at a rate of 120 rpm for 10 to 30 minutes to form a composition 3 < / RTI >

Description

경구용 닭 와구모 구제제 조성물의 제조방법{The composition of poultry red mite control product for oral, and method for manufacturing thereof}Technical Field [0001] The present invention relates to a method for preparing a composition for oral administration,

본 발명은 경구용 닭 와구모 구제제 조성물의 제조방법에 관한 것으로, 보다 상세하게는 가금이 섭취하는 사료에 본 조성물을 첨가하여 경구로 급여함으로써 가금류에 서식하는 와구모를 친환경적으로 구제하여 가금의 생산성 저하를 방지하고 농약성분의 잔류 위험이 없는 인체에 안전한 계란을 생산할 수 있도록 하는 경구용 닭 와구모 구제제 조성물의 제조방법에 관한 것이다.More particularly, the present invention relates to a method for producing an oral chicken wax extract composition, and more particularly, to a method for producing an oral chicken wax extract composition, which comprises the step of adding the composition to a feed for poultry, And to produce a safe egg for a human being free from the risk of residual pesticidal components. BACKGROUND OF THE INVENTION

최근 유럽뿐만 아니라 우리나라에서도 살충제 계란으로 인하여 엄청난 사회적 경제적 파장을 일으킨바 있다. 최초로 살충제가 잔류된 계란이 확인된 네덜란드는 식품 및 계란산업이 초토화 되었으며 세계 각국의 식량 안보에 대한 위협으로 대두되고 있다. 우리나라에서도 2017년 8월 경기도 남양주에 소재한 친환경 인증을 받은 양계장에서 생산된 계란에서 맹독성 살충제인 피프로닐이 검출되면서 전국 산란계농장 전수검사 결과 49개 양계장에서 살충제가 잔류된 계란이 확인되어 커다란 사회적 문제가 대두된바 있다.Recently, not only in Europe but also in Korea, pesticide eggs have caused a tremendous social and economic wave. The Netherlands, where eggs were first found to contain insecticides, have been devastated by the food and egg industry and are emerging as threats to food security around the world. In Korea, fecundil, a fungicidal insecticide, was found in eggs produced in poultry farms in Korea in August 2017 in Namyangju, Gyeonggi province. As a result of whole plantation farming tests in Korea, 49 poultry eggs were found in 49 poultry farms, Has emerged.

닭 와구모는 닭 진드기라고도 부르며, 닭 등 가금류에 기생하는 거미강 진드기목의 외부기생충으로서 성충이 흡혈 후 피를 소화한 다음 4-8개의 알을 낳고 알이 부화하여 2-3일 후 유충이 되고 유충이 성장하여 흡혈이 가능한 약충이 되고 약충이 성장하여 흡혈 능력이 왕성한 성충이 되는 생활환을 가지고 있다.The chicken wiggum is also called a chicken mite. It is an external parasite of the spider mite tick which is parasitic on the poultry such as chickens. The adult catches blood after blood-sucking and then lays 4-8 eggs. The larva grows and becomes a vulture capable of vomiting. The vulture grows and has a vital circle that becomes vigorous adult.

특히, 닭 와구모는 야행성으로 햇빛이 있는 주간에는 바닥이나 벽면 틈새 등 어두운 곳에서 쉬다가 밤이 되면 닭 피부 및 깃털로 이동하여 혈액이나 림프를 빨아먹고 살아간다. 라이프사이클은 6-9일이며 한 마리가 2달 후에는 1억마리 이상으로 증식하여 가금티푸스 등 질병을 전파하며 흡혈 스트레스로 산란율 및 계란품질 저하, 사료효율 감소 및 수명단축 등 막대한 경제적 피해를 유발한다. 농림축산식품부 발표에 의하면 국내 산란계 농장의 94%가 닭 와구모에 감염되어 있으며 이로 인해 경제적으로 엄청난 피해를 입고 있지만 마땅한 대책이나 구제제가 없어 안타까운 실정이다.Especially, chicken wiggle is nocturnal and in the day when there is sunlight, it rests in dark place such as floor or wall gap, and when it is night, it moves to chicken skin and feather and sucks blood and lymph. The life cycle is 6-9 days. One month after two months, it grows to more than 100 million, spreading disease such as poultice typhus, and the blood-sucking stress causes enormous economic damages such as low egg production, do. According to the Ministry of Agriculture, Forestry, Livestock and Livestock Foods, 94% of domestic farms are infected with chicken worms, which causes huge economic damage, but it is unfortunate that we do not have adequate measures or remedies.

현재 국내에는 닭 와구모를 구제하기 위하여 동물약품으로 허가된 카바메이트계, 유기인계 또는 유기염소계 살충제가 있지만 독성이 강하여 빈 계사에만 사용을 허가하고 닭에는 사용을 금지하고 있으며 이마저도 내성이 생겨 효과가 미흡하기 때문에 대부분의 농장주들은 닭에 감염된 와구모를 구제하기 위하여 살충력이 강력한 피닐피라졸계 화합물인 피프로닐(fipronil)등 양계장 및 닭에 사용하여서는 안 될 살충제 농약을 불법적으로 사용하여 사회적인 문제를 일으킨바 있다.At present, there are carbamate, organophosphorus or organochlorine insecticides approved as animal drugs for relieving chicken worms, but they are toxic only, allowing them to be used only for empty houses, and they are prohibited to be used for chickens. , Most of the farmers have caused social problems by illegally using pesticide pesticides, which should not be used in poultry and chickens, such as fipronil, which is a powerful pyrophylazine-based compound, to kill chicken worms .

특허출원 제10-2011-0001048(축사 및 양계 소독용 살충제 조성물 및 이의 제조방법)에서는 닭에 직접 살포하더라도 안전하고 살충성분의 지속력이 뛰어난 닭 진드기 구충용 살충제 조성물을 게시하고 있으나 정부에서는 살충성분의 독성으로 말미암아 빈 축사에만 사용하고 닭에는 적용하지 못하도록 허가하고 있으며, 금 번 살충제 계란 사태시 계란에서 잔류 허용농도 이상으로 살충성분이 검출되어 사회적 문제를 야기한바 있어 닭에 서식하고 있는 닭 와구모를 구제하는 것은 현실적으로 매우 어려운 실정이다. 또한 작업자가 살충제를 분무시 방독면을 착용해야 하는 등 사용상에 불편함도 있다.Patent Application No. 10-2011-0001048 (Insecticidal composition for disinfection of poultry and poultry) and a method for producing the insecticide composition for poultry disinfection have disclosed a composition for insecticidal insecticidal action against chick mite which is safe even when sprayed directly on a chicken, Because it is toxic, it is used only for empty stall and it is not allowed to apply to chicken. In case of egg insecticide egg insecticide in poultry eggs, This is a very difficult situation in reality. In addition, there is also the inconvenience of using the respirator when workers spray the pesticide.

따라서, 닭 피부 및 깃털에 감염된 와구모를 효과적으로 구제함과 동시에 작업자나 닭에게 안전하고 사용이 편리하며 계란에 잔류되지 않아 공중 위생상 문제가 없는 와구모 구제제 개발이 긴급하게 요구되고 있다.
Therefore, it is urgently required to develop a vaccine remedy that does not cause public health problems because it effectively restores chicken wings and feathers infected with wagome, and is safe and easy to use for workers and chickens and does not remain in eggs.

1, 한국특허등록번호 제10-1295228호(2013.08.05 등록)1, Korean Patent Registration No. 10-1295228 (Registered on Mar. 08, 2013)

따라서, 상기와 같은 문제점을 해소하고자 본 발명은 안전성이 입증된 천연물질을 경구적으로 급여하여 닭에 기생하고 있는 와구모를 효과적으로 구제함과 동시에 농약성분 잔류문제 걱정이 없는 안전한 계란 생산이 가능한 경구용 닭 와구모 구제제 조성물의 제조방법을 제공하고자 안출된 목적이 있다.
Therefore, in order to solve the above-mentioned problems, the present invention provides a method for producing a safe egg without the worry of residual pesticide residues by effectively feeding the proven natural substance to the chicken, There is provided a method for producing a composition for chicken and egg exfoliating composition.

상기와 같은 목적을 달성하기 위해 본 발명은 70% 에탄올 100중량%에 대하여 20중량%의 건조된 계피를 세절하여 넣고 4중량%의 완두콩 크기 맥반석과 1중량%의 아스코르브산을 투입하여 3 ~ 7일간 실온에서 추출, 숙성한 후 20매쉬 체로 여과, 농축한 다음 이산화규소에 흡착하여 70% 에탄올 100중량%에 대하여 20중량%의 계피추출물 분말을 형성하는 제1단계와; 통상의 법제유황을 혼합기에 넣고 40rpm속도를 유지하면서 법제유황 100중량%에 대하여 5 ~ 20중량%의 200메쉬 내외 고운 제올라이트를 서서히 가하면서 10 내지 30분간 혼합하여 법제유황 분산체를 형성하는 제2단계; 및 상기 계피추출물 분말 6 ~ 14중량%와 법제유황 분산체 30 ~ 70중량% 및 구운 왕겨분말 16 ~ 64중량%를 각각 혼합기에 투입한 후 120rpm 속도로 10 ~ 30분간 혼합하여 조성물을 형성하는 제3단계;를 포함하되, 상기 계피추출물 분말과 법제유황 분산체의 혼합비는 1:4 ~ 1:6 인 것을 특징으로 한다.
In order to achieve the above object, the present invention relates to a method for producing a soybean sauce comprising 20% by weight of dried cinnamon by weight of 100% by weight of 70% ethanol, 4% by weight of pea size quartz and 1% by weight of ascorbic acid, Extracting and aging at a room temperature for a day, filtering and concentrating the mixture in a 20-mesh sieve, and adsorbing it on silicon dioxide to form a 20% by weight cinnamon extract powder in an amount of 100% by weight of 70% ethanol; A normal process sulfur was charged into a mixer and mixed at a speed of 40 rpm for 10 to 30 minutes while slowly adding 5 to 20% by weight of a 200 mesh inner and outer fine zeolite to 100% step; And 6 to 14% by weight of the cinnamon extract powder, 30 to 70% by weight of the formal sulfur dispersion, and 16 to 64% by weight of the baked rice hull powder, respectively, and mixing the mixture at a rate of 120 rpm for 10 to 30 minutes to form a composition Wherein the mixing ratio of the cinnamon extract powder to the legal sulfur dispersant is 1: 4 to 1: 6.

삭제delete

상술한 바와 같이 본 발명의 경구용 닭 와구모 구제제 조성물의 제조방법을 제공함으로써, 닭에 기생하고 있는 와구모를 효과적으로 구제하고 농약성분 잔류문제 걱정이 없는 안전한 계란을 생산할 수 있으며 닭에 살포하는 기존의 방식 대신 사료에 첨가하여 경구적으로 투여하기 때문에 작업자나 닭이 안전하며 사용이 편리하다.
As described above, the present invention provides a method for producing a composition for oral and poultry chicken extract of the present invention, which is capable of effectively preventing the wormy parasitic on the chicken, producing a safe egg without worrying about the residual problem of pesticide ingredients, Because it is added orally to the feed instead of the method, the operator and the chicken are safe and convenient to use.

도 1은 본 발명에 따른 조성물의 제조공정을 도시해 보인 구성도.BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a block diagram showing a process for producing a composition according to the present invention. FIG.

이하, 첨부된 도면을 참조하여 본 발명을 구체적으로 설명한다.Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

본 발명에 따른 경구용 닭 와구모 구제제 조성물은 계피추출물 분말, 법제유황 분산체 및 구운 왕겨분말로 조성된 복합 조성물로 구성되며, 농약 성분이 계란에 잔류하여 인체에 위해를 초래할 수 있고 계사에 살포시 농약성분이 작업자에게 노출될 수 있는 위험이 있는 기존 와구모 구제제의 문제점을 해소할 수 있다.The oral chicken wax extract composition according to the present invention is composed of a composite composition composed of a cinnamon extract powder, a formal sulfur dispersion and a baked rice hull powder, and the pesticide ingredient may remain in the egg, causing harm to the human body. The problem of the existing pesticidal agent which can expose the pesticide ingredient to the worker can be solved.

즉, 상기 경구용 닭 와구모 구제제 조성물은 계피추출물 분말 6 ~ 14중량%, 법제유황 분산체 30 ~ 70중량% 및 구운 왕겨분말 16 ~ 64중량%로 이루어짐이 가장 바람직하다.That is, it is most preferable that the composition for oral use of chicken and egg whites comprises 6 to 14% by weight of a cinnamon extract powder, 30 to 70% by weight of a formal sulfur dispersion, and 16 to 64% by weight of baked rice hull powder.

계피(Cinnamomi cortex)는 녹나무과에 속한 상록교목인 육계(Cinnamomum cassia)의 나무껍질로서 혈관 확장, 혈소판 응집억제, 항응혈, 진정, 진통, 해열 및 항균작용이 우수하여 인체 분야에서는 기관지염, 요통, 건선, 담마진, 위장장애시 1일 1-2g씩 복용을 권장하고 있으며(한약약리학, 김호철, 집문당), 본 발명에서 주성분으로 사용되는 계피추출물 분말은 상기 계피를 맥반석과 아스코르빈산이 함유된 70% 에탄올로 추출, 숙성 후 여과한 액을 농축하여 이산화규소에 흡착시킨 분말로서 일반 계피추출물에 비하여 항균효과가 우수하다.Cinnamomi cortex is a bark of Cinnamomum cassia , an evergreen tree belonging to the genus Camphoraceae. It has excellent vasodilatation, inhibition of platelet aggregation, anticoagulation, sedation, analgesia, antipyretic and antimicrobial action. (Chinese herbal medicine pharmacology, Kim Ho-chul, Jeonmang Sac), the cinnamon extract powder which is used as a main component in the present invention is a powder of 70% or more, which contains cinnamon and ascorbic acid, It is extracted with ethanol, filtered after aging, concentrated and adsorbed on silicon dioxide, and is superior in antibacterial effect to general cinnamon extract.

유황(Sulfur)은 인체나 동물의 생체를 구성하고 있는 다량 광물질의 일종으로 소염작용, 진해거담작용, 살균 살충작용 및 사하작용이 있으며 인체분야에서 만성기관지염, 천식, 고혈압, 설사시 1-4g을 환으로 만들어 복용하거나 피부에 분무하여 사용을 권장하고 있다(한약약리학, 김호철, 집문당). 그러나 유황은 독성을 갖고 있기 때문에 식용으로 사용하기 위해서는 독성을 제거한 법제유황(processed sulfur)을 사용하는 것이 바람직하다. 본 발명에서 주성분으로 사용되는 법제유황 분산체는 통상의 법제유황에 안정제인 제올라이트를 일정 비율로 혼합하여 제조되며 다른 주성분인 계피추출물 분말과의 혼합시 열반응 및 가스형성을 방지하여 준다.Sulfur is a kind of minerals that constitute the body of human or animal. It has anti-inflammatory action, anti-bacterial action, sterilization, insecticidal action and subcutaneous action. In the field of human, Sulfur is effective against chronic bronchitis, asthma, hypertension, diarrhea, It is recommended to use it as a ring or by spraying on the skin (Chinese medicine pharmacology, Kim Ho-chul, Jungmun-dang). However, since sulfur is toxic, it is desirable to use processed sulfur which is toxic to be used for edible purposes. The sulfur-containing dispersant used as a main component in the present invention is prepared by mixing zeolite, which is a stabilizer, in a conventional process sulfur at a certain ratio, and prevents thermal reaction and gas formation when mixed with the other main ingredient, cinnamon extract powder.

본 발명에서 부형제로 사용되는 구운 왕겨분말은 통상의 왕겨를 소성하여 멸균하고 100메쉬 내외로 분쇄한 분말로서 반응성이 없고 함습도가 낮아 본 조성물의 부형제로 사용하였다.The baked rice husk powder used as an excipient in the present invention is a powder obtained by firing and sterilizing conventional rice hulls and crushing it to about 100 mesh, and is used as an excipient of the present composition because of its low reactivity and low humidity.

본 발명에 사용되는 주성분인 계피추출물 분말은 전체 조성물의 중량을 기준으로 6 ~ 14중량%를 사용하는 것이 바람직하다.The cinnamon extract powder, which is a main component used in the present invention, is preferably used in an amount of 6 to 14% by weight based on the weight of the whole composition.

상기 계피추출물 분말이 6중량% 이하인 경우에는 와구모 구제효과가 미흡하고, 14중량% 이상일 때에는 조성물의 안정성이 저하되어 바람직하지 못하다.When the content of the cinnamon extract powder is 6% by weight or less, the effect of the woogeoligosan is insufficient, and when it is 14% by weight or more, the stability of the composition deteriorates, which is not preferable.

상기 경구용 닭 와구모 구제제 조성물의 주성분인 법제유황 분산체는 전체 조성물의 중량을 기준으로 30 ~ 70중량% 포함하는 것이 바람직하다. It is preferable that the legal sulfur dispersing agent which is the main component of the oral chicken antimicrobial composition comprises 30 to 70% by weight based on the weight of the whole composition.

상기 법제유황 분산체가 30중량% 이하인 경우에는 와구모 구제효과가 미흡하고, 70중량% 이상인 경우에는 조성물의 안정성이 저하되어 바람직하지 못하다.When the legal sulfur content is less than 30% by weight, the effect of wetting agent is insufficient, and when it is more than 70% by weight, the stability of the composition deteriorates, which is not preferable.

본 발명에 사용되는 부형제인 구운 왕겨분말은 전체 조성물의 중량을 기준으로 16 ~ 64중량%를 사용하는 것이 바람직하다. The baked rice husk powder, which is an excipient used in the present invention, is preferably used in an amount of 16 to 64% by weight based on the weight of the whole composition.

상기 구운 왕겨분말이 16중량% 이하인 경우에는 조성물의 안정성에 문제를 초래할 수 있으며, 64중량% 이상 시는 상대적으로 주성분인 계피추출물 분말과 법제유황 분산체의 조성물 중량비가 낮아져서 바람직하지 못하다.
When the baked rice husk powder is less than 16% by weight, the stability of the composition may be deteriorated. When the baked rice husk powder is not less than 64% by weight, the weight ratio of the cinnamon extract powder and the legal sulfur dispersant is relatively low.

한편, 본 발명에 따른 경구용 닭 와구모 구제제 조성물은 제1 내지 제3단계(S100 ~ S300)의 공정을 거쳐 완성되는바 그 제조방법은 다음과 같다.Meanwhile, the composition for oral chicken wart depot preparation according to the present invention is completed through the steps of the first to third steps (S100 to S300), and the preparation method thereof is as follows.

상기 제1단계(S100)는 계피 추출물을 제조하는 공정으로서, 70% 에탄올 100중량%에 대하여 20중량%의 건조된 계피를 세절하여 넣고 4중량%의 완두콩 크기 맥반석과 1중량%의 아스코르브산을 투입하여 3 ~ 7일간 실온에서 추출, 숙성한 후 20매쉬 체로 여과, 농축한 다음 이산화규소에 흡착하여 70% 에탄올 100중량%에 대하여 20중량%의 계피추출물 분말을 제조한다.The first step (S100) is a process for producing a cinnamon extract, wherein 20% by weight of dried cinnamon is crushed into 100% by weight of 70% ethanol, 4% by weight of pea size quartz and 1% by weight of ascorbic acid And the mixture is extracted and aged at room temperature for 3 to 7 days. The mixture is then filtered and concentrated in a 20-mesh sieve, and then adsorbed on silicon dioxide to prepare 20% by weight of cinnamon extract powder based on 100% by weight of ethanol.

이때, 상기 제1단계(S100) 계피추출물 분말 제조단계에서 추출 및 숙성시간은 3 내지 7일이 바람직하며, 3일 이하인 경우에는 추출 상태가 미흡하고 7일 이상인 경우에는 더 이상 추출이 일어나지 않기 때문에 바람직하지 못하다.At this time, the extraction and aging time is preferably 3 to 7 days in the step of producing the cinnamon extract powder in the first step (S100). If the extracting time is 3 days or less, the extraction state is insufficient. If the extraction time is more than 7 days, It is not desirable.

상기 제2단계(S200)는 법제유황의 혼합도와 안정성을 향상시키기 위하여 법제유황 분산체를 제조하는 공정으로서, 통상의 법제유황을 혼합기에 넣고 40rpm속도를 유지하면서 법제유황 100중량%에 대하여 5 ~ 20중량%의 200메쉬 내외 고운 제올라이트를 서서히 가하면서 10 내지 30분간 혼합하여 법제유황 분산체를 제조한다.The second step (S200) is a step of preparing a sulfur-containing formaldehyde dispersion in order to improve the mixing and stability of the sulfur-containing sulfur. The sulfur-containing sulfur is fed into a mixer at a rate of 40 rpm, 20% by weight of 200 mesh of fine zeolite was added slowly to the mixture for 10 to 30 minutes to prepare a formal sulfur dispersion.

이때, 상기 제2단계(S200) 법제유황 분산체 제조공정에서 제올라이트는 법제유황 100중량%을 기준으로 5 내지 20중량%를 사용하는 것이 바람직하며, 5중량% 이하인 경우에는 계피추출물 분말과 혼합시 가스가 형성되는 등 안정성에 문제를 초래할 수 있으며 20중량% 이상인 경우에는 과량 사용으로 바람직하지 못하다.In the second step (S200), the zeolite is preferably used in an amount of 5 to 20% by weight based on 100% by weight of sulfur, and when it is 5% by weight or less, It may cause problems in stability such as formation of gas, and when it is 20 wt% or more, excessive use is not preferable.

상기 제3단계(S300)는 최종 조성물을 제조하는 단계로, 상기 제1단계(S100)에서 제조된 계피추출물 분말 6 ~ 14중량%와 제2단계(S200)에서 제조된 법제유황 분산체 30 ~ 70중량% 및 구운 왕겨분말 16 ~ 64중량%를 각각 혼합기에 투입한 후 120rpm 속도로 10 ~ 30분간 혼합하여 최종 조성물을 제조한다.The third step (S300) is a step of preparing the final composition. In the third step (S300), 6 to 14% by weight of the cinnamon extract powder prepared in the first step (S100) and the legal sulfur dispersant 30 to 30% 70% by weight and baked rice husk powder 16 to 64% by weight are put into a mixer and mixed at a speed of 120 rpm for 10 to 30 minutes to prepare a final composition.

이때, 상기 계피추출물 분말과 법제유황 분산체의 혼합비는 1:4 ~ 1:6 임이 바람직하다.
At this time, the mixing ratio of the cinnamon extract powder and the legal sulfur dispersant is preferably 1: 4 to 1: 6.

본 발명은 다음 실시 예 및 실험 예에 의해서 보다 구체적으로 이해될 수 있으며, 다음의 실시 예는 본 발명을 예시하기 위한 것에 지나지 않으며 본 발명의 범위를 제한하고자 하는 것은 아님을 밝히는 바이다.The present invention can be understood more specifically by the following examples and experimental examples, and it is to be understood that the following examples are intended to illustrate the present invention and are not intended to limit the scope of the present invention.

다음의 표 1과 같은 성분으로부터 경구용 닭 와구모 구제제 조성물을 제조한다.An oral chicken wax emollient composition is prepared from the ingredients shown in Table 1 below.

성 분ingredient 1kg 중In 1kg 계피추출물 분말 Cinnamon extract powder 100g100g 구운 왕겨분말Roasted rice husk powder 900g900g

이에 경구용 닭 와구모 구제제 조성물을 제조하는 과정은 다음과 같다. 계피추출물 분말과 구운 왕겨분말을 각각 혼합기에 투입한 후 120rpm 속도로 20분간 혼합하여 경구용 닭 와구모 구제제 조성물을 제조하는 것이다. The process for preparing the oral and parenteral compositions of the present invention is as follows. Cinnamon extract powder and baked rice hull powder were each put into a mixer and mixed at a speed of 120 rpm for 20 minutes to prepare a composition for oral chicken wax extract.

다음의 표 2의 성분으로부터 경구용 닭 와구모 구제제 조성물을 제조한다.An oral chicken wax emollient composition is prepared from the ingredients in Table 2 below.

성 분ingredient 1kg 중In 1kg 계피추출물 분말Cinnamon extract powder 700g700g 구운 왕겨분말Roasted rice husk powder 300g300g

이에 경구용 닭 와구모 구제제 조성물을 제조하는 과정은 다음과 같다. 계피추출물 분말과 구운 왕겨분말을 각각 혼합기에 투입한 후 120rpm 속도로 20분간 혼합하여 경구용 닭 와구모 구제제 조성물을 제조하는 것이다. The process for preparing the oral and parenteral compositions of the present invention is as follows. Cinnamon extract powder and baked rice hull powder were each put into a mixer and mixed at a speed of 120 rpm for 20 minutes to prepare a composition for oral chicken wax extract.

다음의 표 3의 성분으로부터 경구용 닭 와구모 구제제 조성물을 제조한다.An oral chicken wax emollient composition is prepared from the ingredients in Table 3 below.

성 분ingredient 1kg 중In 1kg 법제유황 분산체A legal sulfur dispersant 100g100g 구운 왕겨분말Roasted rice husk powder 900g900g

이에 경구용 닭 와구모 구제제 조성물을 제조하는 과정은 다음과 같다. 법제유황 분산체와 구운 왕겨분말을 각각 혼합기에 투입한 후 120rpm 속도로 20분간 혼합하여 경구용 닭 와구모 구제제 조성물을 제조하는 것이다. The process for preparing the oral and parenteral compositions of the present invention is as follows. And the baked rice husk powder was put into a mixer and mixed at a speed of 120 rpm for 20 minutes to prepare a composition for oral chicken wax emulsion composition.

다음의 표 4의 성분으로부터 경구용 닭 와구모 구제제 조성물을 제조한다.An oral chicken wax emollient composition is prepared from the ingredients in Table 4 below.

성 분ingredient 1kg 중In 1kg 법제유황 분산체A legal sulfur dispersant 700g700g 구운 왕겨분말Roasted rice husk powder 300g300g

이에 경구용 닭 와구모 구제제 조성물을 제조하는 과정은 다음과 같다. 법제유황 분산체와 구운 왕겨분말을 각각 혼합기에 투입한 후 120rpm 속도로 20분간 혼합하여 경구용 닭 와구모 구제제 조성물을 제조하는 것이다. The process for preparing the oral and parenteral compositions of the present invention is as follows. And the baked rice husk powder was put into a mixer and mixed at a speed of 120 rpm for 20 minutes to prepare a composition for oral chicken wax emulsion composition.

다음의 표 5의 성분으로부터 경구용 닭 와구모 구제제 조성물을 제조한다.An oral chicken wart detergent composition is prepared from the ingredients in Table 5 below.

성 분ingredient 1kg 중In 1kg 계피추출물 분말Cinnamon extract powder 100g100g 법제유황 분산체A legal sulfur dispersant 100g100g 구운 왕겨분말Roasted rice husk powder 800g800g

이에 경구용 닭 와구모 구제제 조성물을 제조하는 과정은 다음과 같다. 계피추출물 분말, 법제유황 분산체 및 구운 왕겨분말을 각각 혼합기에 투입한 후 120rpm 속도로 20분간 혼합하여 경구용 닭 와구모 구제제 조성물을 제조하는 것이다.The process for preparing the oral and parenteral compositions of the present invention is as follows. Cinnamon extract powder, formaldehyde dispersion, and baked rice hull powder were each put into a mixer and mixed at a speed of 120 rpm for 20 minutes to prepare a composition for oral chicken wax emulsion composition.

다음의 표 6의 성분으로부터 경구용 닭 와구모 구제제 조성물을 제조한다.An oral chicken wart detergent composition is prepared from the ingredients in Table 6 below.

성 분ingredient 1kg 중In 1kg 계피추출물 분말Cinnamon extract powder 100g100g 법제유황 분산체A legal sulfur dispersant 300g300g 구운 왕겨분말Roasted rice husk powder 600g600g

이에 경구용 닭 와구모 구제제 조성물을 제조하는 과정은 다음과 같다. 계피추출물 분말, 법제유황 분산체 및 구운 왕겨분말을 각각 혼합기에 투입한 후 120rpm 속도로 20분간 혼합하여 경구용 닭 와구모 구제제 조성물을 제조하는 것이다.The process for preparing the oral and parenteral compositions of the present invention is as follows. Cinnamon extract powder, formaldehyde dispersion, and baked rice hull powder were each put into a mixer and mixed at a speed of 120 rpm for 20 minutes to prepare a composition for oral chicken wax emulsion composition.

다음의 표 7의 성분으로부터 경구용 닭 와구모 구제제 조성물을 제조한다.An oral chicken wart detergent composition is prepared from the ingredients in Table 7 below.

성 분ingredient 1kg 중In 1kg 계피추출물 분말Cinnamon extract powder 100g100g 법제유황 분산체A legal sulfur dispersant 500g500g 구운 왕겨분말Roasted rice husk powder 400g400g

이에 경구용 닭 와구모 구제제 조성물을 제조하는 과정은 다음과 같다. 계피추출물 분말, 법제유황 분산체 및 구운 왕겨분말을 각각 혼합기에 투입한 후 120rpm 속도로 20분간 혼합하여 경구용 닭 와구모 구제제 조성물을 제조하는 것이다.The process for preparing the oral and parenteral compositions of the present invention is as follows. Cinnamon extract powder, formaldehyde dispersion, and baked rice hull powder were each put into a mixer and mixed at a speed of 120 rpm for 20 minutes to prepare a composition for oral chicken wax emulsion composition.

다음의 표 8의 성분으로부터 경구용 닭 와구모 구제제 조성물을 제조한다.An oral chicken wax emollient composition is prepared from the ingredients in Table 8 below.

성 분ingredient 1kg 중In 1kg 계피추출물 분말Cinnamon extract powder 100g100g 법제유황 분산체A legal sulfur dispersant 700g700g 구운 왕겨분말Roasted rice husk powder 200g200g

이에 경구용 닭 와구모 구제제 조성물을 제조하는 과정은 다음과 같다. 계피추출물 분말, 법제유황 분산체 및 구운 왕겨분말을 각각 혼합기에 투입한 후 120rpm 속도로 20분간 혼합하여 경구용 닭 와구모 구제제 조성물을 제조하는 것이다.The process for preparing the oral and parenteral compositions of the present invention is as follows. Cinnamon extract powder, formaldehyde dispersion, and baked rice hull powder were each put into a mixer and mixed at a speed of 120 rpm for 20 minutes to prepare a composition for oral chicken wax emulsion composition.

다음의 표 9의 성분으로부터 경구용 닭 와구모 구제제 조성물을 제조한다.An oral chicken wax emollient composition is prepared from the ingredients in Table 9 below.

성 분ingredient 1kg 중In 1kg 계피추출물 분말Cinnamon extract powder 300g300g 법제유황 분산체A legal sulfur dispersant 100g100g 구운 왕겨분말Roasted rice husk powder 600g600g

이에 경구용 닭 와구모 구제제 조성물을 제조하는 과정은 다음과 같다. 계피추출물 분말, 법제유황 분산체 및 구운 왕겨분말을 각각 혼합기에 투입한 후 120rpm 속도로 20분간 혼합하여 경구용 닭 와구모 구제제 조성물을 제조하는 것이다.The process for preparing the oral and parenteral compositions of the present invention is as follows. Cinnamon extract powder, formaldehyde dispersion, and baked rice hull powder were each put into a mixer and mixed at a speed of 120 rpm for 20 minutes to prepare a composition for oral chicken wax emulsion composition.

다음의 표 10의 성분으로부터 경구용 닭 와구모 구제제 조성물을 제조한다.An oral chicken and egg extract composition is prepared from the ingredients in Table 10 below.

성 분ingredient 1kg 중In 1kg 계피추출물 분말Cinnamon extract powder 500g500g 법제유황 분산체A legal sulfur dispersant 100g100g 구운 왕겨분말Roasted rice husk powder 400g400g

이에 경구용 닭 와구모 구제제 조성물을 제조하는 과정은 다음과 같다. 계피추출물 분말, 법제유황 분산체 및 구운 왕겨분말을 각각 혼합기에 투입한 후 120rpm 속도로 20분간 혼합하여 경구용 닭 와구모 구제제 조성물을 제조하는 것이다.The process for preparing the oral and parenteral compositions of the present invention is as follows. Cinnamon extract powder, formaldehyde dispersion, and baked rice hull powder were respectively added to a mixer and mixed at a speed of 120 rpm for 20 minutes to prepare a composition for oral chicken wax extract.

다음의 표 11의 성분으로부터 경구용 닭 와구모 구제제 조성물을 제조한다.An oral chicken wax emollient composition is prepared from the ingredients in Table 11 below.

성 분ingredient 1kg 중In 1kg 계피추출물 분말Cinnamon extract powder 700g700g 법제유황 분산체A legal sulfur dispersant 100g100g 구운 왕겨분말Roasted rice husk powder 200g200g

이에 경구용 닭 와구모 구제제 조성물을 제조하는 과정은 다음과 같다. 계피추출물 분말, 법제유황 분산체 및 구운 왕겨분말을 각각 혼합기에 투입한 후 120rpm 속도로 20분간 혼합하여 경구용 닭 와구모 구제제 조성물을 제조하는 것이다.The process for preparing the oral and parenteral compositions of the present invention is as follows. Cinnamon extract powder, formaldehyde dispersion, and baked rice hull powder were each put into a mixer and mixed at a speed of 120 rpm for 20 minutes to prepare a composition for oral chicken wax emulsion composition.

종 류Kinds 경구용 닭 와구모 구제제 조성Composition of oral chicken wax extract 실시 예 1Example 1 계피추출물 분말 10중량%10% by weight of cinnamon extract powder 실시 예 2Example 2 계피추출물 분말 70중량%70% by weight of cinnamon extract powder 실시 예 3Example 3 법제유황 분산체 10중량%10% by weight of the sulfur- 실시 예 4Example 4 법제유황 분산체 70중량%70% by weight < RTI ID = 0.0 > 실시 예 5Example 5 계피추출물 분말 10중량% + 법제유황 분산체 10중량%10% by weight of cinnamon extract powder + 10% by weight of legal sulfur dispersing agent 실시 예 6Example 6 계피추출물 분말 10중량% + 법제유황 분산체 30중량%10% by weight of cinnamon extract powder + 30% 실시 예 7Example 7 계피추출물 분말 10중량% + 법제유황 분산체 50중량%10% by weight of cinnamon extract powder + 50% by weight of legal sulfur-containing dispersion 실시 예 8Example 8 계피추출물 분말 10중량% + 법제유황 분산체 70중량%10% by weight of cinnamon extract powder + 70% 실시 예 9Example 9 계피추출물 분말 30중량% + 법제유황 분산체 10중량%30% by weight of cinnamon extract powder + 10% 실시 예 10Example 10 계피추출물 분말 50중량% + 법제유황 분산체 10중량%50% by weight of cinnamon extract powder + 10% by weight of legal sulfur-containing dispersion 실시 예 11Example 11 계피추출물 분말 70중량% + 법제유황 분산체 10중량%70% by weight of cinnamon extract powder + 10% by weight of legal sulfur-containing dispersion

<경구용 닭 와구모 구제제 조성물의 구성>&Lt; Composition of Oral Formulation for Chicken &amp;

[실험예 1] 와구모 구제효과 실험[Experimental Example 1]

1. 실험 방법1. Experimental Method

와구모에 감염되지 않은 50 ~ 54주령 갈색산란계를 5마리씩 12개군으로 나누어 완전히 격리된 12개의 케이지에 임의적으로 배치하여 5일간 순치한 후 모든 개체에 닭 와구모 50마리씩을 감염시켰다. 대조군에는 아무것도 첨가되지 않은 사료를 급여한 반면 투여1군에는 실시 예 1 조성물이 0.1%, 투여2군에는 실시 예 2 조성물이 0.1%, 투여3군에는 실시 예 3 조성물이 0.1%, 투여4군에는 실시 예 4 조성물이 0.1%, 투여5군에는 실시 예 5 조성물이 0.1%, 투여6군에는 실시 예 6 조성물이 0.1%, 투여7군에는 실시 예 7 조성물이 0.1%, 투여8군에는 실시 예 8 조성물이 0.1%, 투여9군에는 실시 예 9 조성물이 0.1%, 투여10군에는 실시 예 10 조성물이 0.1%, 투여11군에는 실시 예 11 조성물이 0.1%이 함유된 사료를 각각 급여하였다. 음수 및 사료는 무제한 급여하였으며 4주 후에 암관이 설치된 플라스틱 통을 이용하여 와구모를 채집하여 와구모의 무게를 측정하였다.Five 50 - week - old brown laying hens, which were not infected with Wagumo, were randomly placed in 12 completely isolated cages for 5 days and then infected with 50 chicken worms. In the control group, feeds with no additives were fed. In the administration group 1, the composition of Example 1 was 0.1%. In the administration group 2, the composition of the example 2 was 0.1%. In the administration group 3, the composition of the example 3 was 0.1% , The composition of Example 4 was 0.1%, the composition of Example 5 was 0.1%, the composition of Example 6 was 0.1%, the composition of Example 6 was 0.1%, the composition of Example 7 was 0.1% Feeds containing 0.1% of the composition of Example 8, 0.1% of the composition of Example 9, 0.1% of the composition of Example 10, and 0.1% of the composition of Example 11 in the administration group 9 and the administration group 11, respectively . Negative and feed were fed unlimitedly. After 4 weeks, weights were measured by collecting wagamos using a plastic bottle equipped with a canal.

2. 실험 결과2. Experimental results

실험 결과 계피추출물 분말이나 법제유황 분산체를 단독으로 급여한 군보다 계피추출물 분말과 법제유황 분산체를 복합 조성하여 급여한 군의 와구모 구제효과가 혁신적으로 증가하였다. 또한 계피추출물 분말과 법제유황 분산체의 조성비에 따라서 와구모 구제효과가 커다란 차이를 보였으며 계피추출물 분말과 법제유황 분산체의 조성비가 1:5일 때 가장 우수한 와구모 구제효과를 나타내었다. As a result of the experiment, the effects of the cinnamon extract powder and the conventional sulfur dispersing agent were more improved than those of the cinnamon extract powder and the legal sulfur dispersing agent. In addition, the effect of woogeomugae was different according to the composition ratio of cinnamon extract powder and the conventional sulfur powder. The composition ratio of cinnamon extract powder and volatile sulfur compound was 1: 5.

각 실시 예 조성물의 닭 와구모 구제효과는 다음의 표 13과 같다.The effect of chicken wart deterrent on the composition of each example is shown in Table 13 below.

종류Kinds 마리당 평균 총 와구모 무게Average total weight per pig 대조구 대비 감소율Reduction rate compared to control 대조구Control 628 mg628 mg -- 실시 예 1Example 1 615 mg615 mg 2.1 %2.1% 실시 예 2Example 2 598 mg598 mg 4.8 %4.8% 실시 예 3Example 3 594 mg594 mg 5.4 %5.4% 실시 예 4Example 4 577 mg577 mg 8.1 %8.1% 실시 예 5Example 5 371 mg371 mg 40.9 %40.9% 실시 예 6Example 6 182 mg182 mg 71.0 %71.0% 실시 예 7Example 7 69 mg69 mg 89.0 % 89.0% 실시 예 8Example 8 95 mg95 mg 84.9%84.9% 실시 예 9Example 9 357 mg357 mg 43.2 %43.2% 실시 예 10Example 10 383 mg383 mg 39.0 %39.0% 실시 예 11Example 11 339 mg339 mg 46.0%46.0%

<4주 후 와구모 구제효과><Four weeks after the effect of Waguomo>

[실험예 2] 조성물의 안정성 실험[Experimental Example 2] Stability test of composition

1. 실험 방법1. Experimental Method

실시 예 조성물 5, 6, 7, 8, 9, 10 및 11을 1kg 은박포장지(PET+PE+AL+PE+LLDPE)에 각각 포장하여 항온 항습기에 넣어 온도 40 상대습도 75%로 설정하여 3개월 간 보관 후 성상변화, 가스형성 유무 및 유황과 신남산(cinnamic acid)의 함량을 측정하였다.Example Compositions 5, 6, 7, 8, 9, 10 and 11 were packaged in a 1 kg silver foil wrapping paper (PET + PE + AL + PE + LLDPE) and placed in a thermostatic chamber at a temperature of 40 relative humidity of 75% After storage of the liver, changes in properties, presence of gas formation, and content of sulfur and cinnamic acid were measured.

2. 실험 결과2. Experimental results

실시 예 5, 6, 7 및 8 조성물은 안정성이 양호하였으나 실시 예 9, 10 및 11 조성물은 성상이 변하고 가스가 형성 되는 등 안정성이 불량하였다. The compositions of Examples 5, 6, 7, and 8 had good stability, but the compositions of Examples 9, 10, and 11 had poor stability such as changes in properties and formation of gas.

각 실시 예 조성물의 안정성은 다음의 표 14와 같다.The stability of each example composition is shown in Table 14 below.

종류Kinds 성상Appearance 가스형성 유무Presence or absence of gas formation 유황 함량
(Sulfur/g)Sulfur content
(Sulfur / g) 신남산 함량
(Cinnamic acid/g)Shin Nansan content
(Cinnamic acid / g) 실시 예 5Example 5 양호Good 무radish 98.9mg(98.9%)98.9 mg (98.9%) 178.8mg(105.2%)178.8 mg (105.2%) 실시 예 6Example 6 양호Good 무radish 297.3mg(99.1%)297.3 mg (99.1%) 167.2mg(98.4%)167.2 mg (98.4%) 실시 예 7Example 7 양호Good 무radish 493.5mg(98.7%)493.5 mg (98.7%) 173.9(102.3%)173.9 (102.3%) 실시 예 8Example 8 양호Good 무radish 708.4mg(101.2%)708.4 mg (101.2%) 166.3mg(97.8%)166.3 mg (97.8%) 실시 예 9Example 9 불량Bad 유U 95.4mg(95.4%)95.4 mg (95.4%) 452.4mg(88.7%)452.4 mg (88.7%) 실시 예 10Example 10 불량Bad 유U 97.38mg(97.8%)97.38 mg (97.8%) 640.0mg(75.3%)640.0 mg (75.3%) 실시 예 11Example 11 불량Bad 유U 92.7mg(92.7%)92.7 mg (92.7%) 830.6mg(69.8%)830.6 mg (69.8%)

<6개월 후 각 조성물의 안정성>&Lt; Stability of each composition after 6 months >

상기와 같이 본 발명에 따른 경구용 닭 와구모 구제제 조성물 및 그의 제조방법을 제공함으로써, 닭에 기생하고 있는 와구모를 효과적으로 구제하고 농약성분 잔류문제 걱정이 없는 안전한 계란을 생산할 수 있으며 닭에 살포하는 기존의 방식 대신 사료에 첨가하여 경구적으로 투여하기 때문에 작업자나 닭이 안전하며 사용의 편리성이 향상되어 산업상 이용가능성이 매우 높은 발명인 것이다.As described above, by providing the composition for oral chicken wax depigmenting composition according to the present invention and the method for producing the same, it is possible to effectively prevent the wagmon which are parasitic on the chicken, to produce the safe egg without worrying about the residual problem of pesticide ingredients, The method of the present invention is applied to the feed instead of the method of oral administration so that the operator and the chicken are safe and the convenience of use is improved,

S100 ~ S300 : 제1단계 ~ 제3단계S100 to S300: Steps 1 to 3

Claims (5)

삭제delete 70% 에탄올 100중량%에 대하여 20중량%의 건조된 계피를 세절하여 넣고 4중량%의 완두콩 크기 맥반석과 1중량%의 아스코르브산을 투입하여 3 ~ 7일간 실온에서 추출, 숙성한 후 20매쉬 체로 여과, 농축한 다음 이산화규소에 흡착하여 70% 에탄올 100중량%에 대하여 20중량%의 계피추출물 분말을 형성하는 제1단계와;
통상의 법제유황을 혼합기에 넣고 40rpm속도를 유지하면서 법제유황 100중량%에 대하여 5 ~ 20중량%의 200메쉬 내외 고운 제올라이트를 서서히 가하면서 10 내지 30분간 혼합하여 법제유황 분산체를 형성하는 제2단계; 및
상기 계피추출물 분말 6 ~ 14중량%와 법제유황 분산체 30 ~ 70중량% 및 구운 왕겨분말 16 ~ 64중량%를 각각 혼합기에 투입한 후 120rpm 속도로 10 ~ 30분간 혼합하여 조성물을 형성하는 제3단계;를 포함하되, 상기 계피추출물 분말과 법제유황 분산체의 혼합비는 1:4 ~ 1:6 인 것을 특징으로 하는 경구용 닭 와구모 구제제 조성물의 제조방법.

20% by weight of dried cinnamon was cut into 100% by weight of 70% ethanol, and 4% by weight of pea size quartz and 1% by weight of ascorbic acid were added thereto. The mixture was extracted and aged at room temperature for 3 to 7 days, Filtering, concentrating and then adsorbing on silicon dioxide to form 20% by weight of a cinnamon extract powder based on 100% by weight of 70% ethanol;
A normal process sulfur was charged into a mixer and mixed at a speed of 40 rpm for 10 to 30 minutes while slowly adding 5 to 20% by weight of a 200 mesh inner and outer fine zeolite to 100% step; And
6 to 14% by weight of the cinnamon extract powder, 30 to 70% by weight of the formal sulfur dispersion, and 16 to 64% by weight of the baked rice husk powder were put into a mixer and mixed at a rate of 120 rpm for 10 to 30 minutes to form a composition Wherein the mixing ratio of the cinnamon extract powder to the legal sulfur dispersing agent is 1: 4 to 1: 6.

삭제delete 삭제delete 삭제delete
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