KR101970644B1 - Multifunctional skin treatment device for enhancement of transdermal delivery - Google Patents

Abstract

The present invention generates a plasma by a high voltage plasma generating unit for spraying on the skin; And an iontophoretic unit having a plurality of electrodes spaced on the skin to apply at least one of a voltage signal and a current signal to the skin so that a microcurrent flows through the skin, wherein the plasma generating unit includes one or more electrodes, electrodes, and skin. The present invention relates to a complex surgical device for promoting transdermal delivery, comprising a patterned dielectric portion disposed therebetween. According to a plasma device for promoting transdermal delivery of various embodiments of the present invention, plasma and iontophoresis may be simultaneously or sequentially performed. It can be provided as, and can improve the penetration rate, flow rate and absorption rate of the drug through the transdermal can provide high sterilization and skin cosmetic effect.

Description

MULTIFUNCTIONAL SKIN TREATMENT DEVICE FOR ENHANCEMENT OF TRANSDERMAL DELIVERY}

The present invention relates to a complex surgical device for promoting transdermal delivery, and more particularly to a complex surgical device for promoting transdermal delivery that can increase the penetration rate, flow rate and absorption of the drug into the skin using plasma and iontophoresis. will be.

Promoting transdermal delivery of skin care or therapeutic drugs has long been a challenge for researchers in the field. For the treatment or skin care of skin diseases it is necessary to infiltrate the therapeutic or cosmetic composition into the stratum corneum, epidermal layer or dermis layer of the skin. However, the stratum corneum of the skin acts as a barrier not only to external pollutants or harmful substances but also to skin care or therapeutic drugs, making it difficult to penetrate. Drugs for skin care or treatment are slightly absorbed in the stratum corneum but are very slow to absorb, requiring long treatment times and high doses.

Several technologies are being developed to address this problem and to promote transdermal delivery of skin care or therapeutic drugs. Techniques for facilitating transdermal delivery can be divided into two categories of size, one to increase the permeability of the skin and the other to improve the flow rate within the skin. The method of increasing the skin penetration rate uses a technique of applying an electric shock in the skin, and the method of improving the flow rate is to generate an energy gradient in the skin to increase the transdermal flow by moving the active ingredient below the stratum corneum.

Current methods for transdermal and intradermal delivery of active therapies have very low rates of efficacy of the active skin components passing through the stratum corneum and reaching the epidermal and dermal layers, resulting in ineffective and desired effects without the use of specially formulated compositions. There is no limit.

On the other hand, recently, plasma beauty devices that can provide a medical device or skin massage function to sterilize bacteria adhered to the skin using plasma have been developed. Related prior arts include Korean Patent Publication No. 2012-0136524, Domestic Patent No. 10-1422823, and Domestic Patent No. 10-773847.

As described above, various techniques have been developed to increase the penetration rate or flow rate of the skin care or therapeutic drug into the skin, but in order to obtain various cosmetic effects, the use of each device alternately performing individual functions There is an inconvenience, and if you purchase each equipment separately there was a problem that the economic burden is increased.

KR 10-2012-0136524 A1 KR 10-1422823 B1 KR 10-773847 B1

The present invention has been made to solve the above problems, one object of the present invention is to manufacture a complex surgical device that can improve the skin penetration rate as well as the flow rate and absorption rate of the drug, to clean the skin by the sterilization function It is to provide a complex surgical device for promoting transdermal delivery that can be maintained, and at the same time to perform a variety of skin beauty functions in combination to maximize the skin beauty effect.

Another object of the present invention is to provide a complex surgical device for promoting transdermal delivery configured to enable comprehensive skin care by enabling complex skin care according to the user's skin condition or the user's choice.

Another object of the present invention is to provide a function to remove the residual ozone in the plasma space, a complex procedure for promoting transdermal delivery that can be user-friendly and efficient skin treatment, regeneration, wrinkle and hair loss improvement can be achieved To provide a device.

It is still another object of the present invention to provide a complex surgical device for promoting transdermal delivery that can effectively improve bacterial diseases caused on the skin by performing a combination of plasma sterilization and drug sterilization.

Another object of the present invention is to provide a complex surgical device for promoting transdermal delivery that can maximize the effect of the plasma treatment by removing the discharge space and water on the skin.

Still another object of the present invention is to provide a complex surgical device for promoting transdermal delivery that can be safely performed by dividing the dielectric area of the plasma generating unit to prevent skin electric shock due to high voltage.

One aspect of the present invention for achieving the above object,

Plasma generating unit for generating a plasma by a high voltage to spray on the skin; And

And an iontophoretic unit having a plurality of electrodes spaced apart on the skin to apply at least one of a voltage signal and a current signal to the skin so that microcurrent can flow through the skin.

The plasma generating unit relates to a complex surgical device for promoting transdermal delivery, characterized in that it comprises at least one electrode and a patterned dielectric portion disposed between the electrode and the skin.

The patterned dielectric portion is composed of a patterned dielectric portion having a three-dimensional pattern that can provide a space for generating a plasma between the electrode and the surface of the skin and can lower the discharge voltage, the patterned dielectric portion is stripe, mesh, grid , Comb, honeycomb, or slit, or a dielectric portion having a hemispherical, square pillar, pyramidal, polygonal columnar ridges.

The electrode generating the plasma of the plasma generating unit may be composed of a mesh electrode, a grid electrode, a comb type, a honeycomb type, or a slit type electrode.

The plasma generating unit and the iontophoretic unit may be arranged side by side adjacent to the head of the complex surgery apparatus, or the plasma generating unit may be detachable on the iontophoretic unit.

The complex surgical device may further include an ultrasonic generator for delivering ultrasonic energy to skin tissue.

The complex surgical device may further include an electroporation electrode unit for emitting a pulse forming a microchannel on the skin.

The complex surgery apparatus may include a power supply unit including a power supply unit and a high voltage generation unit, and the plasma electrode may be connected to the high voltage generation unit.

The combined surgical device may further include a drug applicator for applying the cosmetics or drugs contained in the container to the skin, the drug applicator is a ball which is rotatably installed by exposing a portion to the end of the container body to the skin It may be a roll-on type drug applicator comprising or a drug applicator configured to apply the drug to the skin by an actuator or a compressed gas.

The complex surgical device may further include an ozone filter for removing residual ozone excessively generated. The ozone filter may be a filter coated with a photocatalyst that is configured to be fixed to the inside of the plasma generation unit or to the outside of the housing and reduces ozone to oxygen.

The complex surgical apparatus may further include an interference blocking unit for preventing an interference phenomenon caused by electromagnetic waves between the plasma generating unit and the iontophoretic unit.

The combined surgical device may include a handpiece connected to the main body, and the handpiece may be a cart-type device configured to supply plasma or microcurrent to the skin.

The complex surgical device further includes a housing for receiving and supporting the components of the complex surgical device, and the housing may be portable with one hand.

Another aspect of the invention the plasma generating unit for generating a plasma by a high voltage sprayed to the skin; And a drug applicator disposed on one side of the plasma generating unit and configured to apply cosmetics or drugs contained in the container to the skin.

Another aspect of the present invention is a plasma generating unit for generating a plasma by a high voltage in the plasma space between the skin and the dielectric portion to spray on the skin; And a water removal unit provided on one side of the plasma generation unit to remove water in the plasma space.

Another aspect of the present invention is a complex surgical device comprising a patterned dielectric portion having a three-dimensional pattern disposed between the one or more electrodes and the electrode and the skin, and having a plasma generating portion for generating a plasma by high voltage and spraying it on the skin, The apparatus includes an iontophoretic unit having a plurality of electrodes spaced apart on the skin to apply at least one of a voltage signal and a current signal to the skin so that microcurrent can flow through the skin; An ultrasonic generator for transferring ultrasonic energy to skin tissue; And an electroporation electrode part for emitting a pulse forming a microchannel in the skin.

The patterned dielectric part may be a stripe, a mesh, a grid, a comb, a honeycomb, or a slit, a dielectric having a hemispherical shape, a square pillar shape, a pyramid shape, and a polygonal pillar shape.

The plasma generating unit, the iontophoretic unit, the ultrasonic wave generating unit, and the electroporation electrode unit may be disposed adjacent to each other in a direction parallel to the surface of the skin in the complex surgical device of this embodiment. Alternatively, the iontophoretic unit, the ultrasonic generator, and the electroporation electrode unit are disposed adjacent to each other in a direction parallel to the skin surface, and the plasma generation unit is detachable on the iontophoretic unit, the ultrasonic generator and the electroporation electrode unit. It can be mounted as.

According to the plasma apparatus for promoting transdermal delivery of various embodiments of the present invention, plasma treatment and iontophoresis may be simultaneously or sequentially provided by switching probes or switching modes to provide high sterilization and skin cosmetic effects.

According to the complex surgical device of the present invention, when there is a problem such as trouble, atopy, bacteria or immune disease on the skin, sterilization is performed by high sterilizing power of plasma, and the electrochemical action penetrates the drug deeply into the dermal layer of the skin for faster and more sterilization. Can provide an effect.

According to the complex surgical device of the present invention, the fibroblasts of the dermal layer may be stimulated by plasma to promote collagen synthesis, thereby providing a skin wrinkle and elasticity improving effect and maximizing penetration of active skin components such as skin moisturizing. Thus, the synergistic action of the two therapies can provide a better anti-aging effect and skin care effect.

According to the complex surgical device of the present invention, the plasma generating unit, iontophoretic unit, ultrasonic wave generating unit, and electroporation electrode unit are all-in-one compactly configured to promote transdermal delivery of drugs, thereby saving space, manufacturing, purchasing and It can provide a significant reduction in maintenance costs.

The complex surgical device according to another embodiment of the present invention can perform complex skin care according to the skin condition of the user or the user's selection by using plasma, ultrasound, iontophoresis, and electroporation. In the process of flowing to the skin in parallel with the electroporation to promote the absorption of the active ingredient applied to the skin, it is possible to enhance the therapeutic effect by the drug.

According to the present invention, ozone generated from the plasma by the ozone filter is removed while only the plasma is released, so that efficient skin treatment, regeneration, wrinkle and hair loss improvement can be achieved.

According to a plasma device for promoting transdermal delivery of another embodiment of the present invention, a drug applicator is built in the device, and the drug can be applied to the skin simultaneously with or before the plasma procedure, and in particular, to improve the penetration of the skin, After injecting the drug, it is possible to maximize the drug application effect by increasing the flow rate and absorption while performing other ultrasound, iontophoresis, and the like.

In addition, according to the present invention, by absorbing moisture in the atmosphere in the plasma space, it is possible to prevent erroneous discharge from occurring in the plasma electrode, thereby improving the discharge efficiency in the plasma generating unit.

1 is a schematic perspective view of a complex surgical device for promoting cart-type transdermal delivery according to an embodiment of the present invention.
Figure 2 is a schematic perspective view of a complex surgical device for promoting transdermal delivery according to another embodiment of the present invention.
Figure 3 is a schematic cross-sectional view of a complex surgical device for promoting transdermal delivery according to an embodiment of the present invention.
Figure 4 is a schematic perspective view of the back surface of the patterned dielectric portion of the plasma generating portion of the complex surgical device for promoting cart-type transdermal delivery according to an embodiment of the present invention.
Figure 5 is a schematic perspective view of the back surface of the patterned dielectric portion of the plasma generating unit of the complex surgical apparatus for promoting cart-type transdermal delivery according to another embodiment of the present invention.
Figure 6 is a schematic cross-sectional view of a complex surgical device for promoting transdermal delivery according to another embodiment of the present invention.
Figure 7 is a schematic cross-sectional view of a complex surgical device for promoting transdermal delivery according to another embodiment of the present invention.
8 is a schematic cross-sectional view of a complex surgical device for promoting transdermal delivery according to another embodiment of the present invention.
Figure 9 is a schematic perspective view of a combined surgical device for promoting transdermal delivery according to another embodiment of the present invention.
10 is a schematic cross-sectional view of a complex surgical device for promoting transdermal delivery according to another embodiment of the present invention.
Figure 11 is a schematic block diagram of a combined surgical device for promoting transdermal delivery according to another embodiment of the present invention.

Hereinafter, the present invention will be described in more detail with reference to the accompanying drawings.

The terms used in the present invention have been selected as widely used general terms as possible in consideration of the functions in the present invention, but this may vary according to the intention or precedent of the person skilled in the art, the emergence of new technologies and the like. When a component is described as being "connected" or "coupled" to another component, that component may be directly connected to or coupled to that other component, but other components may be "interposed" between each component. It is to be understood that each component may be "connected" or "coupled" through another component.

When a part of the present specification "includes" any component, this means that it may further include other components, except to exclude other components unless specifically stated otherwise. In addition, terms, such as ~ part, ~ module described in the specification means a unit for processing at least one function or operation, which may be implemented in hardware or software, or a combination of hardware and software.

In the drawings, in order to effectively explain the gist of the present invention, the detailed sizes, shapes, thicknesses, etc. of the respective components may be exaggerated or illustrated.

As used herein, the term "skin" refers to a tissue covering the body surface of humans and animals, and includes the scalp and hair as well as all tissues covering the body surface of the body such as the face or fingers and toes.

As used herein, the term "skin active ingredient" means an active ingredient provided to the skin or scalp for therapeutic or cosmetic purposes. In the present invention, the skin active ingredient includes a pure charge of either positive or negative charge. In the present invention, the word "skin active ingredient" is used interchangeably with the word "drug".

1 is a schematic perspective view of a complex surgical device for promoting transdermal delivery according to an embodiment of the present invention, Figure 2 is a schematic perspective view of a complex surgical device for promoting transdermal delivery according to another embodiment of the present invention, Figure 3 is a schematic cross-sectional view of a complex surgical device for promoting transdermal delivery according to an embodiment of the present invention of Figure 2, Figure 4 is a composite surgical device for promoting transdermal delivery according to an embodiment of the present invention It is a schematic perspective view of the back surface of the patterned dielectric part of a plasma generation part.

The complex surgical device of the present invention is implemented as a cart type as shown in Figure 1, or can be carried by the user as shown in Figure 2, a portable complex surgical device capable of carrying a hand-held complex management function is integrated It can be implemented as.

The handpiece, which is separately connected to the main body in FIG. 1, generates a plasma by high voltage, and generates plasma by spraying onto the skin, and iontophoresis in which a microcurrent is flowed to facilitate drug penetration. The structure including the iontophoretic unit 32 for) is shown. Meanwhile, FIG. 2 illustrates a structure in which the portable complex surgery apparatus in which the main body and the handpiece are integrated includes the plasma generation unit 100 and the iontophoretic unit 200 in one embodiment.

The cart-type combined surgery apparatus shown in FIG. 1 may be used in a beauty care room by adjusting a specification or used for treating a disease such as atopy by a specialist (doctor) in a hospital by being approved as a medical device. Or a portion of the iontophoretic unit 32 may be used to replace or form other complex surgical functions in addition to its function. The handpieces 30 and 15 that can be detachably connected to the main body may be used as a single handpiece by mounting a plurality of functions as shown in the drawing, or may be installed to be used in multiple targets or target parts at the same time. . In the case of configuring a plurality of handpieces 30 and 15 configured differently according to the use, it may be connected to the main body in advance and selected and used according to the skin condition of the target site or the judgment of the operator. In addition, the handpieces 30 and 15 may be configured to be detachably or permanently connected, or may be used in a Bluetooth manner by removing the connection unit 17. In addition, the main body 18 may further include a display unit 12 which visually shows the procedure guide data or data or skin condition to the user. The user input unit may be integrally coupled to the display unit 12, for example, in the form of a touch pad, or may be provided as a separate user interface unit 13. In addition, the operator (user) may directly select the desired function, or may be recommended to proceed with the data analysis according to the skin type or input condition, or to perform the procedure according to the preset matching value.

Meanwhile, in the case of the portable type of FIG. 2, the plasma generation unit 100 and the iontophoretic unit 200 are formed in a portable housing (or case) 21 that can be directly managed by a consumer at home. Can be. The portable complex surgery apparatus 20 includes a head in which the plasma generating unit 100 and the iontophoretic unit 200 are formed in the housing or the case 21, a rechargeable battery (not shown) supplied with an available voltage from the outside, and is supplied from the battery. A high voltage supply module (not shown) for outputting DC power as AC power, buttons 24 for selecting an on / off switch or mode, and optionally a display unit 23 may be included. In addition, on the opposite side of the head may be formed a sedation portion 22 capable of low temperature treatment to soothe the skin.

3 is a cross-sectional view of a complex surgical device for promoting transdermal delivery of an embodiment of the present invention, the power supply unit 610, the control unit inside the device housing 21 including the plasma generating unit 100 and the iontophoretic unit 200 500 and a high voltage generation unit 620 is provided. In addition, the iontophor 200 applies at least one of a voltage signal and a current signal to the skin to allow microcurrent to flow to the skin to promote transdermal delivery of the drug. It may include a structure in which the electrodes 210 and 220 are spaced apart from each other.

1 to 3 includes an electrode part 110 for voltage formation for plasma generation and a dielectric part 140 for direct formation of plasma, and the dielectric part 140. 4 can be implemented in various forms of structure as shown in FIG. In this case, although not shown, the dielectric member 140 may be additionally formed at an appropriate position such as a periphery or a center of the dielectric member 140 by using a plastic cover formed with a separate through part, for maintaining the gap with the skin.

The plasma generating unit 100 of the complex surgical apparatus of the present invention is an atmospheric pressure plasma generating apparatus, which generates plasma without additional gas inflow, and has a dielectric barrier discharge (DBD) form to prevent transition to arc plasma. To generate plasma using pulse power, AC power or RF power.

In more detail, dielectric barrier discharge is a method in which a dielectric barrier is formed on two or more pairs of electrodes or one or more electrodes, and a dielectric polarization phenomenon is used. This is to prevent the transition from pulse discharge to arc discharge. Dielectric barrier discharge can achieve a relatively uniform plasma, which can generate a large area plasma and does not use other gases such as helium or argon. Therefore, the plasma generation unit 100 includes two or more electrodes 110 to which a high voltage is applied and dielectric parts 130 and 140 between the electrodes, and the plasma generation unit discharges the plasma by a dielectric barrier discharge between the electrode and the skin surface. Is configured to occur. Atmospheric-pressure plasma generated by the plasma generator 100 is generated by a strong electric field between the electrode and the insulator, the air in the oxygen, hydrogen, moisture, is as ionized ozone, O, O ₂ nitrogen, etc. ^- different activities, such as Species are produced in large quantities. These various active species have a strong bactericidal effect by destroying the cell walls of bacteria with little effect on living tissues, and the periodic treatment of plasma to the skin stimulates the skin cells to increase collagen in the dermal layer and vascular endothelial cells. Increased secretion of growth factor (VEGF) may help the new blood vessels nourish skin cells and provide anti-aging effects.

One of the two or more electrodes 110 is a power electrode (not shown) connected to the power supply, and the other is a plasma electrode 110 that generates plasma on the skin side. In the present invention, the plasma electrode 110 may be a mesh electrode, a grid electrode, a comb type, a honeycomb type, or a slit type electrode which can lower the discharge voltage. In the present invention, the plasma electrode 110 may be configured in various shapes to narrow the gap between the electrodes and increase the number of electrode arrays per unit area to form a compact electrode, thereby obtaining a low power high density plasma. The narrower the interval between the electrodes, the higher density plasma discharge can be obtained even if the applied voltage is low.

The electrodes 110 may be formed of a conductive material or may be formed by coating a conductive material on an insulating material. The electrodes may be formed in any shape, such as a circle or a square in cross section. The method of coating the dielectric part 130 around the electrode is not particularly limited, but may be coated by, for example, screen printing, spin coating, dip coating, or the like.

The dielectric part 140 may be disposed between the power electrode (not shown) and the plasma electrode 110, or may be formed on one surface of the plasma electrode 110 with a contact or skin space on the surface of the skin. It is formed to have a predetermined interval with the skin of the subject to form a plasma in the space. The dielectric part 140 may be formed by coating the dielectric parts 130 and 140 on the plasma electrode 110 by coating not only one surface of the electrode but also the electrode electrode.

In order to maintain a constant space where a plasma can be generated between the electrode and the skin surface in the present invention, the dielectric portion 140 between the electrode and the skin has a mesh-like pattern or an embossed three-dimensional pattern as shown in FIG. 4. It may be formed of a patterned dielectric portion. That is, it may be formed in a stripe type as shown in Figure 4 (a) or a mesh or grid type as shown in Figure 4 (b), in addition to the comb, honeycomb type or slit type. As described above, the patterned dielectric part 140 is formed in a set part such as a peripheral part or a center part by forming a ridge part 141 having a micro structure similar to a plurality of protrusions by a three-dimensional pattern, so as to form a separate gap maintaining part or a spacer. There is no need to ensure sufficient discharge space for plasma discharge between the electrode and the skin. Meanwhile, a plastic cover provided with a separate through hole for maintaining a space between the skin and the dielectric part 140 is formed to be detachably attached to the top of the dielectric part to provide a space between the skin and the dielectric part to form a plasma. You may. In addition, the shape of the ridge 141 of the dielectric part 140 may have a structure such as a hemispherical shape, a square pillar shape, a pyramid shape, a polygonal column shape, and a cone shape, as shown in FIGS. 4 (c)-(f). It may have, but is not necessarily limited to this shape. The protruding height of the ridge 141 is correlated with the magnitude of power for plasma formation.

The manufacturing method of the patterned dielectric part 140 having such a three-dimensional pattern is not particularly limited. For example, the patterned dielectric part may form a desired pattern using a printing method, and may form a pattern more precisely using photolithography technology. In addition, as a deposition method, a patterned dielectric portion may be formed by using a deposition method such as electron beam deposition, resistive heating deposition, or high frequency induction heating deposition. In addition, the patterned dielectric portion 140 may be formed by any method known in the art. ) May be formed.

The dielectric parts 130 and 140 may be made of a hard material or a flexible material. The hard material may be made of a material such as quartz, sapphire, glass, ceramic, polytetrafluoro ethylene, polyvinylidene fluoride, polycarbonate, or a polymer film such as polypropylene. Synthetic rubber, polyurethane, or polyethylene can be used. The dielectric parts 130 and 140 may be manufactured by coating an insulating material on a conductor or plating with an insulating material.

In the present invention, the plasma generating unit 100, when filling the dielectric between the parallel plate electrodes with a large dielectric constant (ε), to form a dielectric thin film in order to reduce the dielectric thickness (d) and calculate the capacitance (C) It is possible to increase the capacitance C value while reducing the size of the dielectric without increasing the electrode area A (see Equations 1 to 4). Therefore, when the output power value (power consumption W) for plasma generation is made large as shown in Equation 1, the output power value W can be designed as desired without setting the output voltage V value high. As a result, it is possible to form a large output power value (W) without the electric shock as a result of the skin, it can be designed to obtain the desired plasma amount without causing an electric shock to the skin. In more detail, if the dielectric thickness d is applied using a material having a high dielectric constant, the d value can be applied small, and the dielectric portion 142 having a small size as a whole can be formed.

W: power consumption [W], f: drive frequency [Hz]

U: stored energy [J], V: voltage [V]

C: capacitance [F],

: 진공 유전율 [F/m]

: Vacuum permittivity [F / m]

],d : 전극간 거리 [m]K: relative dielectric constant, A: electrode area [

], d: distance between electrodes [m]

5 is a cross-sectional view schematically showing the cross-sectional shape of the electrode and the dielectric of the plasma generating unit of another embodiment of the present invention. Referring to FIG. 5, the electrode 111 is formed in a shape in which the protruding portions are alternately present in the xy-axis direction so that there is no electric shock in one portion of the skin when plasma is formed in each dielectric portion, the dielectric portion 142. ) Is formed such that a space for plasma discharge is secured between the dielectric parts 142 in the xy column direction. The dielectric portion 142 is formed only in the protrusion of the electrode 111 (see FIG. 5 (a)), or is formed on the entire surface of the electrode 111 (see FIG. 5 (b)), or FIG. 5 (c) As such, it may be formed only on the surface of the protrusion and the surface between the protrusions. Although not shown between the dielectric parts 142, a separate shielding film may be formed to form a plasma discharge.

The power supply unit 600 includes a power supply unit 610 corresponding to a commercial power source or a battery, and a high voltage generator 62 to generate a high voltage using a DC power source from the power supply unit 610. The power supply unit 610 is embedded in one side of the inside of the main body or the housing, and converts the voltage input from the general commercial power source or battery into a voltage for driving the iontophoretic unit, the power supply unit 600 converts the voltage After receiving the control voltage (pulse) is output, the control voltage is converted to a high voltage and supplied to the power electrode 110 of the plasma generating unit 100. Alternatively, the power supply unit 600 may be configured to convert the input power into a DC high voltage, and then convert the DC high voltage into a pulse high voltage of a predetermined period and output the same.

In order to obtain sufficient dielectric barrier discharge plasma required for sterilization and skin stimulation using a dielectric formed to be almost in contact with the skin in the plasma generation unit 100 as in an embodiment of the present invention, an output power of about 0.1 W to 3 W is preferable. And, the output power can be adjusted in size depending on the purpose of use, such as sterilization, skin stimulation, skin regeneration. In order to meet the optimum operating conditions, it is necessary to select the capacitance of the dielectric material constituting the dielectric barrier discharge plasma generating unit, which is a variable of the output power, and the applied voltage and frequency to achieve the optimum discharge efficiency. In order to induce the dielectric barrier discharge plasma on the face that is electrically shock free and stable, the input is AC 220V, 50 to 60 Hz, the output voltage is 0.8 to 7 kV, and the output voltage frequency range is about 10 kHz to 30 kHz. It is designed to be about 20kHz. The control unit 500 of the skin treatment apparatus using the plasma according to the present invention supplies the DC power output from the power supply unit 610 to the high voltage generator 620 to control the high frequency and high voltage to be converted into AC power. The power supply unit 600 may further include an output control unit (not shown) for adjusting the high voltage output.

The iontophor 200 is applied with at least one of a voltage signal and a current signal across the electrodes 210 and 220 having a conductive path, thereby generating iontophoretic force on the charged skin active components, and iontophoretic Force forces active transport in the electric field of the drug as the skin active components attempt to move towards the electrode with opposite polarity. Whether the skin active ingredient is positively or negatively charged, iontophoretic unit 200 may be configured to apply the appropriate polarity and current to drive a particular skin active ingredient to the skin. In order to use the repulsive force acting between charges of the same polarity, the iontophoretic unit 200 applies an ionic material having a positive characteristic to the '+' electrode, and an ionic material having a negative characteristic to the '-' electrode. Is applied to allow the ionic material to penetrate the skin easily.

The iontophoretic unit 200 may function to flow a fine current through the head, and may adjust the intensity of the microcurrent flowing through the head to various levels. In the iontophoretic unit 200, the first electrode and the second electrode should be spaced apart from each other to contact the user's skin. The second electrode can be mounted on or embedded in the housing. The second electrode may be configured to conduct electricity with the skin of the user through the user's hand holding the housing of the portable device. Alternatively, when the complex surgical device of the present invention is implemented in a cart type, and the iontophoretic unit 200 is operated by a technician other than the operator, both electrodes may be used by the subject to hold the iontophoretic unit 200 by hand. It may be configured to contact the skin of the user without work. For example, the second electrode may contact the user's skin in the form of a pad or the like.

The electrode 210 of the iontophoretic unit 200 may include an ion exchange membrane composed of a porous film and an ion exchange resin filled in a plurality of holes in the porous film. The iontophoretic unit 200 may include an ion exchange membrane that selects ions having the same polarity as the ions of the charged drug. By allowing drug ions to be administered through the ion exchange membrane, release of counter ions from the skin can be suppressed, thereby improving the administration efficiency of the drug ions. In addition, the iontophor 200 is a porous film made of a material such as polyolefin, vinyl chloride-based resin, fluorine-based resin in order to facilitate the passage of relatively large molecular weight drug ions, and effectively suppress the release of counter ions from the skin An ion exchange membrane of the type in which the ion exchange resin is filled can be used.

The electrode 210 of the iontophoretic unit 200 may be an electrode made of any conductive material without particular limitation, but may be preferably an inert electrode made of carbon, platinum, etc., elution of metal ions, And a carbon electrode which does not have a fear of transferring to the living body.

The control unit 500 may include a microprocessor in which data regarding iontophoretic properties of a specific drug administered through the iontophoretic unit 200 are embedded. The data may include correlations between these conditions and delivery rates when certain drugs are delivered into the body through the skin by the iontophor 200 under conditions of specific current and / or flow of ions. The controller 500 may be configured to adjust the intensity of the current supplied to the skin of the user by the iontophor 200. The strength of the current does not necessarily need to be automatically adjusted, but may be one that can adjust the strength of the current according to a user's or operator's decision or need. In addition, the control unit 500 may be configured to be automatically turned on / off at a predetermined time interval the current supplied to the user's skin by the iontophoretic unit 200. As described above, the configuration of the control circuit for performing the current control function is obvious to those of ordinary skill in the art, more detailed description thereof will be omitted.

The iontophoretic unit 200 penetrates the drug ions into the skin by applying a voltage having the same polarity as the drug ions while the first electrode and the second electrode are in contact with the skin. The current supplied to the electrode 210 of the iontophoretic unit 200 may be a direct current or an alternating current in the form of a sine wave or a square wave.

The plasma generation unit 100 and the iontophoretic unit 200 may be connected in various ways.

In one example, the plasma generating unit 100 and the iontophoretic unit 200 may be disposed adjacent to each other in a direction parallel to the surface of the skin as shown in FIG. 2. In the case of using the apparatus having such a structure, the drug may be applied after the plasma treatment and iontophoresis may be performed, and the plasma treatment and the iontophoresis may be simultaneously performed. The plasma generator 100 and the iontophor 200 may be activated simultaneously or sequentially with a parallax under the control of the controller.

In another embodiment, as shown in FIG. 9, the plasma generating unit 100 is formed as a cap mounted on the iontophoretic unit 200, and thus, the cap-shaped plasma generating unit 100 may be replaced by the iontophoretic unit during the plasma treatment. Covered on the (200), and after the plasma treatment, the plasma generating unit can be removed by removing the cap formed by activating the iontophor 200.

In another embodiment, the complex surgical device for promoting transdermal delivery of the present invention may further include an ultrasonic generator 300 for delivering ultrasonic energy to the skin tissue.

The ultrasonic generator 300 is operated by a control signal of the controller 500 to output ultrasonic waves exceeding about 18,000 Hz. Ultrasonic stimulation generated by the ultrasonic generator 300 serves to stimulate the skin, increase muscle strength, increase elasticity, and accelerate nutrition supply in tissues. Providing low frequency ultrasound, coupled to the skin via a cream or gel type cosmetic composition or agent, can increase the transdermal flow of the active ingredients. The increase in kinetic energy by ultrasound causes reversible cleavage of intracellular lipid bilayers in the stratum corneum, allowing larger, more complex or hydrophilic molecules to effectively penetrate the skin.

In another embodiment, the complex surgical device of the present invention may further include an electroporation electrode portion 400 for emitting a pulse forming a microchannel on the skin. The electroporation electrode unit 400 is composed of two electroporation electrodes having different polarities from each other, and the electrode is connected to the control unit 500 and the power supply unit 610 for controlling voltages applied to the electroporation electrodes. The electrodes of the electroporation electrode unit 400 are disposed to be in contact with the skin, and when electricity is applied by the power supply unit 610 in contact with the skin, electroporation pulses are delivered to the skin cells to transmit permeability of the lipid bilayers. Increase temporarily. The electroporation electrode portion 400 generates short bursts of relatively high voltage electric fields, thereby reversibly forming micropores in the lipid bilayers and allowing skin active ingredients to enter the skin through these micropores. Make sure For delivery of skin active ingredients by electroporation Both intracellular and intercellular pathways are formed.

The complex surgical device for promoting transdermal delivery of the present invention, in addition to the plasma generating unit 100, the iontophoretic unit 200, the ultrasonic generator 300, the electroporation electrode unit 400, the plasma generating unit 100, The control unit 500 for controlling the operation between the iontophoretic unit 200, the ultrasonic wave generator 300, and the electroporation electrode unit 400, the power supply unit 600 for supplying power to each unit, the user input Receiving user interface units 12 and 13;

The controller 500 operates between the plasma generator 100, the iontophoretic unit 200, the ultrasonic wave generator 300, the electroporation electrode unit 400, the power supply unit 500, and the user interface 12 and 13. Can be controlled. The controller 500 may control the plasma generator, the ultrasonic generator, the iontophoretic unit, and the electroporation electrode unit to operate simultaneously or sequentially. For example, when the electroporation electrode unit or the iontophor is activated, the operation of the plasma generator or the ultrasonic generator may be stopped, and when the plasma generator or the ultrasonic generator is activated, the operation of the electroporation electrode unit or the iontophor may be stopped.

The complex surgery apparatus of the present invention may further include a display unit 12 and a communication unit (not shown) electrically connected to the control unit. The display unit 12 may display the amount, speed, procedure mode, and current intensity of the drug to be administered under specific conditions included in the control unit 500. The display unit 12 includes any display device known in the art.

The controller 500 may include some of an image processor, a communication unit, and a memory unit, but is not limited thereto. In the present invention, some or all of the image processing unit, the communication unit, the memory, the user interface unit, and the control unit may be operated by a software module, but is not limited thereto. Some of the above-described configurations may be operated by hardware.

The user interface units 12 and 13 generate input data input by the user to control the operation of the complex surgical device for promoting transdermal delivery. The user interface units 12 and 13 may include a hardware configuration such as a keypad, a mouse, a touch pad, a trackball, and a jog switch, but are not limited thereto. The voice recognition sensor, the gesture recognition sensor, the fingerprint sensor, the iris recognition sensor, etc. Various configurations of the may further include. In this case, the complex surgical device for promoting transdermal delivery according to an embodiment of the present invention may display the control panel of the device on the touch screen of the display unit 12.

In the user interface of the complex surgery apparatus of the present invention, a mode selection unit (not shown) for inputting which of the plasma generating unit, the ultrasonic generator, the iontophoretic unit, and the electroporation electrode may be formed may be formed.

In another embodiment, the combined surgical device for facilitating transdermal delivery of the present invention can also be implemented in a miniaturized handheld, as shown in FIG. The power supply unit 610 may be a battery, so that the present invention may be used as a miniaturized portable device. In this case, a head, a control unit, and a power supply unit including a plasma generation unit, an ultrasonic wave generation unit, an iontophoretic unit, and an electroporation electrode unit may be disposed in the case or the housing. The case may be made of an insulating material and may have a cylindrical or square pillar shape. The case may be fixed by being coupled with the ground electrode of the plasma generator, the ultrasonic generator, the iontophoretic part, and the electroporation electrode part, and the ground electrode 101 may be grounded by the contact of the user's hand. The battery may be charged by receiving power from an external power source. In addition, the battery may supply a DC voltage to the high voltage generator 620.

The complex surgical apparatus of the present invention may further include an interference blocking unit (not shown) for preventing an interference phenomenon caused by electromagnetic waves between the plasma generating unit, the ultrasonic generator, the iontophoretic unit, and the electroporation electrode unit. When two or more of the plasma generating unit, the ultrasonic generating unit, the iontophoretic unit, and the electroporation electrode unit are activated at the same time, an interference shield composed of an ultra-thin metal shield or a transparent conductive film to prevent interference by electromagnetic waves therebetween. We can arrange wealth.

6 is a schematic cross-sectional view of a complex surgical device of another embodiment of the present invention. Referring to FIG. 6, the complex surgical device according to another embodiment of the present invention may further include an ozone filter 150 for removing ozone that is excessively formed above a required concentration generated from the plasma. When plasma is generated, ozone, nitrogen oxides, and organic volatiles are generated by ionization of oxygen and nitrogen in the atmosphere. Ozone has a problem of lowering the feeling of use due to a vivid smell, the composite surgical device of the present invention can be configured so that the ozone filter 150 can be fixed to the inside of the head or to the outside of the housing, it is arranged to be interchangeable Can be. The ozone filter 150 is a filter for adsorbing and removing ozone by passing ozone through porous activated carbon by using an adsorbent such as activated carbon or silicon nanowires, or by applying ozone to a pre-filter or carbon filter that is easy to replace a network. It may be a chlorine atom or a photocatalyst coated filter that decomposes to oxygen.

7 is a schematic cross-sectional view of another complex surgical device of the present invention. As illustrated in FIG. 7, when ozone is excessively generated at a concentration higher than the required concentration, ozone is harmful to the human body and causes discomfort due to odor, and thus a dust collector 800 for treating the ozone is present. It may further include. The dust collector 800 may be installed in the housing 21 to collect residual amount of ozone, and discharge the collected ozone to a safe place through the duct 801 or the like.

Meanwhile, moisture may exist naturally in the discharge space or the skin of the plasma generating unit of the present invention, and moisture may exist due to the application of a drug during the procedure. When the plasma discharge electrode and the ground electrode are exposed to moisture, misdischarge may occur. This can result in significant noise. In order to prevent this, the present invention may be provided with a water removing unit 900 for absorbing moisture in the air in front and rear of the plasma generating unit, respectively. The moisture removing unit 900 absorbs moisture in the plasma space, thereby preventing a false discharge from occurring at the electrode of the plasma generating unit. The water removing unit 800 may be implemented with a sponge or a water absorbing roller, and the water removing unit 900 may be installed around the periphery of the plasma generating unit 100 using a sponge to remove water. However, the present invention is not limited to this configuration, and may be configured to remove moisture by other known techniques capable of removing moisture.

`Another aspect of the present invention is a plasma generation unit for generating a plasma by a high voltage to spray on the skin; And it is provided on one side of the plasma generating unit relates to a complex surgical device for promoting transdermal delivery, characterized in that it comprises a drug applicator for applying to the skin cosmetics or drugs contained in a container.

The drug applicator may be a drug applicator including a ball which is rotatably installed and partially exposed at the end touching the skin of the container body, or may be a drug applicator configured to apply the drug to the skin by an actuator or a compressed gas.

On the other hand, the plasma generating unit may include a patterned dielectric portion disposed between the electrode and the skin. The patterned dielectric part may have a stripe, a mesh, a grid, a comb, a honeycomb, a slit, a hemispherical shape, a square pillar shape, a pyramid shape, and a polygonal columnar ridge.

Another embodiment of the present invention is a plasma generation unit for generating a plasma by a high voltage in the plasma space between the skin and the dielectric portion to spray on the skin; And a water removal unit provided on one side of the plasma generation unit to remove water in the plasma space.

The plasma generation unit may include a patterned dielectric part disposed between the electrode and the skin. The patterned dielectric part may have a stripe, a mesh, a grid, a comb, a honeycomb, a slit, a hemispherical shape, a square pillar shape, a pyramid shape, and a polygonal columnar ridge.

8 is a schematic cross-sectional view of another complex surgical device of the present invention.

The complex surgical device of the present invention may further include a drug applicator 700 for applying the cosmetics or drugs contained in the container to the skin. Such a drug applicator may be implemented in various forms. For example, the drug applicator 700 includes a roll-on including a ball 710 rotatably installed by exposing a portion of the drug applicator to an end of the container body. on) type drug applicators or drug applicators configured to apply the drug to the skin by an actuator or compressed gas. This type of drug applicator 700 may include one or more outlets for dispensing the cosmetic composition or drug evenly to the skin, which outlets may be disposed adjacent the head of the handpiece or portable device. The combined surgical device of the present invention allows the drug to be delivered deeply down the stratum corneum by plasma treatment and electric field while applying the drug, thereby ensuring a therapeutic or skin improvement effect more quickly and reliably.

Referring to the operation of the combined surgical device for promoting transdermal delivery of the present invention configured as described above are as follows.

First, when the surface of the dielectric portion of the plasma generating unit is placed in close proximity to the skin and the operation start button is pressed, the control unit 500 supplies the AC power of the high voltage high frequency from the power supply unit 600 of the plasma generating unit 100. Supply to the power electrode provided on the dielectric upper surface. At this time, the plasma is generated by the dielectric barrier discharge, thereby generating a plasma having an even distribution in the space between the dielectric and the skin. The generated plasma contains various active species, which stimulate and sterilize the target area as they move along the electric field. Since the user interface unit of the complex surgery apparatus of the present invention is provided with a mode selection unit for inputting which one of the plasma generating unit 100 and the iontophoretic unit 200 to activate, these are selectively selected for the skin condition of the user or the judgment of the procedure expert. Can be used to penetrate deep into the skin for cosmetic or therapeutic purposes.

The operating method of the complex surgical device for promoting transdermal delivery of the present invention can be embodied as computer readable codes on a computer readable recording medium. The computer-readable recording medium includes all kinds of recording devices in which data that can be read by a computer system is stored. Examples of computer-readable recording media include ROM, RAM. CDROMs, magnetic tapes, floppy disks, optical data storage devices, and the like, and also include those implemented in the form of carrier waves such as transmission over the Internet. The computer readable recording medium can also be distributed over network coupled computer systems so that the computer readable code is stored and executed in a distributed fashion.

8 is a schematic cross-sectional view of a complex surgical device for promoting transdermal delivery according to another embodiment of the present invention, Figure 9 is a schematic perspective view of a complex surgical device for promoting transdermal delivery according to another embodiment of the present invention 10 is a schematic cross-sectional configuration of a complex surgical device for promoting transdermal delivery according to another embodiment of the present invention, Figure 11 is a complex surgical device for promoting transdermal delivery according to another embodiment of the present invention Is a schematic block diagram of.

8, 10, and 11, the complex surgical device for promoting transdermal delivery of another embodiment of the present invention includes one or more electrodes and a patterned dielectric part having a three-dimensional pattern disposed between the electrode and the skin, and the high voltage Plasma generating unit 100 to generate a plasma by spraying on the skin; An iontophor (200) having a plurality of electrodes spaced apart on the skin to apply at least one of a voltage signal and a current signal to the skin to allow a microcurrent to flow through the skin; Ultrasonic generator 300 for transmitting the ultrasonic energy to the skin tissue; And an electroporation electrode unit 400 for emitting pulses forming microchannels on the skin.

The patterned dielectric part 140 may be formed in a stripe type as shown in FIG. 4 (a) or a mesh type or grid type as shown in FIG. 4 (b), and in addition, a comb type, a honeycomb type, or a slit type. As such, the patterned dielectric part 140 is formed with a three-dimensional pattern of ridges 141 having a micro structure similar to a plurality of protrusions, and the ridges 141 are formed between the electrode and the skin. Since a sufficient discharge space for the plasma discharge is secured, it is not necessary to form a separate interval maintaining portion or a spacer. As shown in FIGS. 4 (c)-(f), for example, the ridge 141 may have a hemispherical shape, a square pillar shape, a pyramid shape, and a polygonal column shape, but is limited to such a shape. It doesn't happen.

In the complex surgical apparatus of the present invention, the electrodes of the plasma generating unit 100, the iontophoretic unit 200, the ultrasonic wave generating unit 300, and the electroporation electrode unit 400 are disposed in the head, and the arrangement thereof may be performed in various ways. It can be arranged as. For example, they may be arranged to be evenly distributed in each quadrant of the head having a rectangular cross section, or each electrode may be configured in a rectangular shape to be arranged side by side in the longitudinal direction. The shape of the head is not particularly limited, and may have any shape such as a circle, a rectangle, a rectangle, an oval, and the like.

The combined surgical device may further include an ozone filter 150 for removing residual ozone, and the ozone filter is configured to be fixed to the inside of the plasma generation unit or to the outside of the housing, and to fix ozone in oxygen. It may be a filter coated with a chlorine atom or a photocatalyst to be reduced to.

The combined surgical device of another embodiment of the present invention further comprises a drug applicator 700 for applying the cosmetic or drug contained in the container to the skin, wherein the drug applicator is formed at the side end, as shown in FIG. Alternatively, as shown in FIG. 10, the plasma generating unit may be formed between the plasma generating unit, the electroporation electrode unit, the iontophoretic unit, and the ultrasonic wave generating unit. The drug applicator 700 is a roll-on type drug applicator including a ball which is rotatably installed by exposing a portion of the container body to an end contacting the skin of the container body or by a pump, an actuator or a compressed gas. It may be a drug applicator configured to apply the drug on the skin.

The plasma generator 100, the iontophoretic unit 200, the ultrasonic wave generator 300, and the electroporation electrode unit 400 are disposed adjacent to each other in a parallel direction with respect to the skin surface, or alternatively, the iontophoretic unit The ultrasonic generator and the electroporation electrode unit are arranged adjacent to each other in a parallel direction with respect to the surface of the skin, or as shown in FIG. 7, the plasma generator 100 includes an iontophoretic unit 200 and an ultrasonic wave generator ( 300 and the electroporation electrode 400 may be mounted in a detachable cap manner.

The complex surgical device according to another embodiment of the present invention may further include an interference blocking unit (not shown) for preventing interference caused by electromagnetic waves between the plasma generating unit, the ultrasonic generator, the iontophoretic unit, and the electroporation electrode unit. Can be. When two or more of the plasma generating unit, the ultrasonic generating unit, the iontophoretic unit, and the electroporation electrode unit are activated at the same time, an interference shield composed of an ultra-thin metal shield or a transparent conductive film to prevent interference by electromagnetic waves therebetween. We can arrange wealth.

Although the embodiments of the present invention have been described and illustrated in detail above, the present invention is not limited to the above-described specific embodiments, and the present invention belongs to the present invention without departing from the gist of the present invention as claimed in the claims. It will be apparent to those skilled in the art that various modifications can be made by those skilled in the art, and thus the protection scope of the present invention should be defined by the appended claims and their equivalents.

100: plasma generating unit
110 electrode 130 dielectric part
140: patterned dielectric portion 150: ozone filter
200: iontophoretic part
300: ultrasonic generator
400: electroporation electrode portion
500: control unit
600: power supply
610: power supply unit 620: high voltage generation unit
700: drug applicator 800: dust collector
900: water removal unit

Claims (32)

Plasma generating unit for generating a plasma by a high voltage to spray on the skin; And an iontophoretic unit having a plurality of electrodes spaced on the skin to apply at least one of a voltage signal and a current signal to the skin so that a microcurrent flows through the skin, wherein the plasma generating unit includes one or more electrodes, electrodes, and skin. Comprising a patterned dielectric portion disposed between, and provided on one side of the plasma generating unit further comprises a water removal unit for removing water in the plasma space complex surgical device for promoting transdermal delivery.
The method of claim 1, wherein the patterned dielectric portion is a stripe, mesh, grid, comb, honeycomb or slit or hemispherical, square pillar, pyramidal, polygonal dielectric portion having a ridge portion characterized in that Complex surgical device for promoting transdermal delivery.
The complex surgical device of claim 1, wherein the plasma generation unit is a mesh electrode, a grid electrode, a comb type, or a slit type electrode.
The method of claim 1, wherein the plasma generating unit and the iontophoretic unit are arranged side by side adjacent to the head of the complex surgical device, or the plasma generating unit is detachable on the iontophoretic unit. Complex surgical device.
The complex surgical device according to claim 1, wherein the complex surgical device further includes an ultrasonic generator configured to deliver ultrasonic energy to skin tissue.
The complex surgical device of claim 1, wherein the complex surgical device further includes an electroporation electrode unit that emits a pulse forming a microchannel on the skin.
According to claim 1, The complex surgical device,
Comprising a power supply comprising a power supply and a high voltage generating unit, the plasma electrode is a complex surgical device for promoting transdermal delivery, characterized in that connected to the high voltage generating unit.
According to claim 1, The complex surgical device,
Complex surgical device for promoting transdermal delivery characterized in that it further comprises a display and a user interface.
According to claim 1, The complex surgical device,
Complex surgical device for promoting transdermal delivery, characterized in that it further comprises a drug applicator for applying a cosmetic or drug contained in the container to the skin.
The method of claim 9, wherein the drug applicator,
Promote transdermal delivery, characterized in that the drug applicator comprising a ball is rotatably installed to the end of the container body is exposed to the skin or a drug applicator configured to apply the drug to the skin by an actuator or compressed gas. Complex surgical device.
According to claim 1, The complex surgical device,
Complex surgical device for promoting transdermal delivery, characterized in that it further comprises an ozone filter or dust collector for removing residual ozone.
The method of claim 11, wherein the ozone filter,
And a photocatalyst coated filter for reducing ozone to oxygen and configured to be fixed inside the plasma generation unit or outside the housing.
According to claim 1, The complex surgical device,
An apparatus for promoting transdermal delivery further comprising an interference blocker for preventing an interference phenomenon caused by electromagnetic waves between the plasma generating unit and the iontophoretic unit.
The complex surgical device according to any one of claims 1 to 13, wherein
And at least one handpiece connected to the instrument body, wherein the handpiece comprises at least one probe configured to supply plasma, or microcurrent, to the skin.
The complex surgical device according to any one of claims 1 to 13, wherein
And a housing for accommodating and supporting the components of the complex surgical device, wherein the housing is handheld and portable.
delete Plasma generating unit for generating a plasma by a high voltage to spray on the skin; A drug applicator provided at one side of the plasma generating unit to apply cosmetic or drug contained in a container to the skin; And a water removal unit provided at one side of the plasma generation unit to remove water in the plasma space.
The method of claim 17, wherein the drug applicator,
Promote transdermal delivery, characterized in that the drug applicator comprising a ball is rotatably installed to the end of the container body is exposed to the skin or a drug applicator configured to apply the drug to the skin by an actuator or compressed gas. Complex surgical device.
18. The complex surgical device of claim 17, wherein the plasma generation unit comprises a patterned dielectric unit disposed between the electrode and the skin.
A plasma generation unit generating plasma by a high voltage in the plasma space between the skin and the dielectric part and spraying the plasma on the skin; And
Combination treatment apparatus for promoting transdermal delivery, characterized in that provided in one side of the plasma generating unit includes a water removal unit for removing water in the plasma space.
21. The complex surgical device of claim 20, wherein the plasma generation unit comprises a patterned dielectric unit disposed between the electrode and the skin.
A plasma generator including at least one electrode and a patterned dielectric part having a three-dimensional pattern disposed between the electrode and the skin, wherein the plasma generating part sprays the skin by generating a plasma by a high voltage; An iontophoresis unit having a plurality of electrodes spaced apart on the skin to apply at least one of a voltage signal and a current signal to the skin to allow a microcurrent to flow through the skin; An ultrasonic generator for transferring ultrasonic energy to skin tissue; And an electroporation electrode part for emitting a pulse to form a microchannel in the skin, the water generation part being provided on one side of the plasma generating part to remove water in the plasma space. Complex surgical device.
The method of claim 22, wherein the patterned dielectric portion,
A complex procedure for promoting transdermal delivery, characterized in that it is a stripe, mesh, grid, comb, honeycomb or slit, or a patterned dielectric having a hemispherical, square pillar, pyramidal, or polygonal columnar ridge. Device.
23. The complex surgical device of claim 22, wherein the electrode is a mesh electrode, a grid electrode, a comb type, or a slit type electrode.
The method of claim 22, wherein the complex surgical device,
Complex surgical device for promoting transdermal delivery, characterized in that it further comprises an ozone filter or dust collector for removing residual ozone.
The method of claim 25, wherein the ozone filter,
And a photocatalyst coated filter for reducing ozone to oxygen and configured to be fixed inside the plasma generation unit or outside the housing.
The method of claim 22, wherein the complex surgical device,
Further comprising a drug applicator for applying a cosmetic or drug contained in the container to the skin, wherein the drug applicator is formed between the plasma generating unit, the electroporation electrode portion, the iontophoretic portion, and the ultrasonic generator, or formed at the side end Complex surgical device for promoting transdermal delivery, characterized in that.
The method of claim 27, wherein the drug applicator,
Percutaneous delivery promotion, characterized in that the drug applicator comprising a ball is rotatably installed and exposed to the end of the container body is a drug applicator configured to apply the drug on the skin by an actuator or compressed gas. Complex surgical device for.
23. The complex surgical device of claim 22, wherein the plasma generating unit, the iontophoretic unit, the ultrasonic wave generating unit, and the electroporation electrode unit are arranged adjacent to each other in a direction parallel to the skin surface.
23. The method of claim 22, wherein the iontophoretic portion, the ultrasonic wave generator, and the electroporation electrode portion is arranged adjacent to the parallel to the skin surface, the plasma generating portion on the iontophoretic portion, the ultrasonic wave generator and the electroporation electrode portion Complex surgical device for promoting transdermal delivery, characterized in that mounted in a removable cap method.
23. The complex surgical device of claim 22, wherein the complex surgical device further includes a water removal unit provided at one side of the plasma generating unit to remove water in the plasma space.
A complex surgical device for facilitating transdermal delivery in which power from an electrode located at the lower end of a housing is directed to a dielectric to generate a plasma in the space between the dielectric and the skin, the electrode having protrusions alternately in the xy axis direction. It is formed in a shape, the dielectric parts are formed on the electrode to ensure a space for the plasma discharge between the dielectric parts, the dielectric parts are formed only in the protruding portion of the electrode, or formed on the entire surface of the electrode, It is formed on the surface between the protrusions and the protrusions, the apparatus is provided on one side of the plasma generating unit further comprises a water removal unit for removing water in the plasma space complex treatment apparatus for promoting transdermal delivery.

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