KR101899777B1 - 티아진 아미드 유도체 및 그의 약학 조성물 및 용도 - Google Patents

티아진 아미드 유도체 및 그의 약학 조성물 및 용도 Download PDF

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Publication number
KR101899777B1
KR101899777B1 KR1020157007305A KR20157007305A KR101899777B1 KR 101899777 B1 KR101899777 B1 KR 101899777B1 KR 1020157007305 A KR1020157007305 A KR 1020157007305A KR 20157007305 A KR20157007305 A KR 20157007305A KR 101899777 B1 KR101899777 B1 KR 101899777B1
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South Korea
Prior art keywords
carbon atoms
pharmaceutically acceptable
acceptable salt
solvate
hydrate
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Korean (ko)
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KR20150046257A (ko
Inventor
송 리
준하이 시아오
단 한
우 종
릴리 왕
지빙 젱
윤데 시에
신보 조우
싱조우 리
시아오쿠이 왕
단 지앙
웨이 첸
홍잉 리우
Original Assignee
인스티튜트 오브 파마콜로지 앤드 톡시콜로지 아캐더미 오브 밀리터리 메디칼 사이언시스 피.엘.에이. 차이나
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Application filed by 인스티튜트 오브 파마콜로지 앤드 톡시콜로지 아캐더미 오브 밀리터리 메디칼 사이언시스 피.엘.에이. 차이나 filed Critical 인스티튜트 오브 파마콜로지 앤드 톡시콜로지 아캐더미 오브 밀리터리 메디칼 사이언시스 피.엘.에이. 차이나
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
KR1020157007305A 2012-08-24 2012-08-24 티아진 아미드 유도체 및 그의 약학 조성물 및 용도 Active KR101899777B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2012/080539 WO2014029102A1 (zh) 2012-08-24 2012-08-24 噻嗪酰胺衍生物及其药物组合物和用途

Publications (2)

Publication Number Publication Date
KR20150046257A KR20150046257A (ko) 2015-04-29
KR101899777B1 true KR101899777B1 (ko) 2018-09-20

Family

ID=50149362

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157007305A Active KR101899777B1 (ko) 2012-08-24 2012-08-24 티아진 아미드 유도체 및 그의 약학 조성물 및 용도

Country Status (7)

Country Link
US (1) US9359314B2 (https=)
EP (1) EP2889293B1 (https=)
JP (1) JP6078153B2 (https=)
KR (1) KR101899777B1 (https=)
CA (1) CA2882289C (https=)
ES (1) ES2629019T3 (https=)
WO (1) WO2014029102A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106316982B (zh) * 2015-06-30 2020-08-14 中国人民解放军军事医学科学院毒物药物研究所 噻嗪酰胺衍生物及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130958A1 (en) * 2001-12-06 2005-06-16 Song Li Substituted 6−membered n−heterocyclic compounds and their uses as neurological regulator
WO2010013240A1 (en) * 2008-07-31 2010-02-04 Dekel Pharmaceuticals Ltd. Compositions and methods for treating inflammatory disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102675244B (zh) * 2011-03-16 2016-03-30 中国人民解放军军事医学科学院毒物药物研究所 噻嗪酰胺衍生物及其在制备神经退行性疾病防治药物的用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130958A1 (en) * 2001-12-06 2005-06-16 Song Li Substituted 6−membered n−heterocyclic compounds and their uses as neurological regulator
WO2010013240A1 (en) * 2008-07-31 2010-02-04 Dekel Pharmaceuticals Ltd. Compositions and methods for treating inflammatory disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chinese Chemical letters., 2005., Vol.16, No.2., pp 163-166*
Science in China, 2007.06., Vol.50, No.3, pp405-417*

Also Published As

Publication number Publication date
CA2882289C (en) 2019-09-17
US20150203460A1 (en) 2015-07-23
EP2889293B1 (en) 2017-04-26
KR20150046257A (ko) 2015-04-29
JP2015526447A (ja) 2015-09-10
HK1206019A1 (en) 2015-12-31
ES2629019T3 (es) 2017-08-07
CA2882289A1 (en) 2014-02-27
EP2889293A1 (en) 2015-07-01
WO2014029102A1 (zh) 2014-02-27
JP6078153B2 (ja) 2017-02-08
EP2889293A4 (en) 2015-12-30
US9359314B2 (en) 2016-06-07

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