KR101681542B1 - Interchangeable cartridge device for artificial pancreas - Google Patents

Abstract

The present invention relates to an exchangeable cartridge device for implementing an artificial pancreas in which blood is supplied to insulin by exposing the pancreatic islet cells to a pancreatic islet cell, and a cartridge connection part for switching a blood circulation path between the cartridge and the blood vessel connection part, It is possible to replace the cartridge containing the pancreatic islet while maintaining the pancreatic islet cell, and it is possible to use it in some of the in vitro system as well as the transplantation of the apparatus, and it is possible to avoid the vascular operation of the vena cava and to facilitate the blood glucose level, The present invention also provides an exchangeable cartridge device which enables the user to know the cartridge type.

Description

≪ Desc / Clms Page number 1 > INTERCHANGEABLE CARTRIDGE DEVICE FOR ARTIFICIAL PANCREAS <

The present invention relates to a medical device for implementing an artificial pancreas, and more particularly, to an exchangeable cartridge device for an artificial pancreas implementation in which blood is supplied to insulin by exposing the pancreatic islet cells.

The amount of insulin produced in the pancreatic islet cell, that is, the pancreatic cell beta cell, changes according to the amount of glucose in the blood. Essentially, insulin converts glucose into glucose, which is converted into polysaccharide glycogen, It also plays a role of lowering.

Type 1 diabetes mellitus is a type of diabetes mellitus in which islet cells of the pancreas lose their function or part or all of the pancreas is removed by pancreatectomy for the treatment of pancreatic cancer or pancreatic disease, It is a disease that causes various complications.

The number of patients with type 1 diabetes is increasing worldwide, and various methods of treatment are being studied. Drug-type drugs are mostly accompanied with side effects. Recently, a commercially available automatic insulin injection device There is a potential risk of causing hypoglycemic shock in a short time due to excessive insulin input due to mechanical malfunction.

On the other hand, the method of homologous transplantation has not been commercialized because of lack of donors. Therefore, there have been many studies on transplantation of heterologous islet cells (transplantation of islet cells) using pig tissue of pig pancreas for a long time, There is no successful commercialization of an effective treatment method using heterogeneous tissue because of the inability to effectively solve various problems encountered in the application.

In order for the treatment method using the heterologous taxa to be commercially successful, the following problems must be solved: 1) long-term storage of heterogeneous taxa; 2) measures to prevent viral and bacterial infection of heterologous taxa; 3) Preventive measures against human immune rejection after transplantation, 4) preventive measures against migration of the heterologous graft to a place other than the transplanted blood vessel region, 5) determination of whether the grafted heterologous grafts are functioning normally, 6) 7) The measures for the exchange of new normal heterotopic tissues according to the collected amount, 8) The vascular damage due to the transplantation of the heterotopic tissue several times over a long period of time. 9) measures against the risk of vascular surgery near important organs such as the pancreas or liver, 10) lack of medical institutions having intravenous transplantation techniques of heterogeneous hepatocytes, The spread measures such as the skill level that can be done in half-surgical hospitals should be addressed to pre-defined enemy.

Among them, 1) above is a method disclosed in Korean Patent No. 10-0686383 (Isolation method of pancreatic islet cells for xenotransplantation) and 10-0855104 (Handling method for long-term preservation of pancreatic islet cells) (SPF: specific pathogen free) pigs are used in Korean Patent No. 10-0628700 (a method of producing small-sized pigs for experimental use) in connection with the above 2) . The above-mentioned 3) has usually been researched by encapsulation of heterotopic capsules. In connection with the above 4), a device for injecting heterotransported blood into the portal vein, (Korean Patent Nos. 10-1132746, 10-1242656, and 10-2013-0115408).

However, as for the above-mentioned 5) to 10), although the treatment method using heterotransport is also an important issue for commercial success, researches and experiments on these have not yet been known.

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide an exchangeable cartridge device for an artificial pancreas, which is a solution for effective commercial deployment as well as solving all of the above problems.

In order to achieve the above object, according to the present invention, there is provided an exchangeable cartridge device for implementing an artificial pancreas comprising: an exchangeable cartridge containing a plurality of pancreatic islet cells; A blood vessel connection portion connected to the blood vessel so that blood is circulated in the cartridge; And a cartridge connecting portion which is fastened between the cartridge and the blood vessel connecting portion so as to form a blood circulation path, wherein the cartridge connecting portion is configured so that the blood circulation path can be bypassed without passing through the cartridge when the cartridge is exchanged .

Here, the cartridge connecting portion is constituted of a drum holder to which the blood vessel connecting portion is fastened and a rotating drum inserted into the drum holder so as to be rotatable in the left and right direction, wherein the rotating drum has two straight holes for circulating blood to the cartridge, Two U-turns forming a U-turn inner tube between the two linear holes, and a clamp holder connected to the two linear holes at the back and detachably attached to the cartridge .

Wherein the cartridge includes a clamp detachably attached to the clamp holder and a cartridge container attached to the rear of the clamp, the clamp includes a header clamp having both side surface irregularities that can be inserted into the clamp holder, Wherein at least one pancreatic islet is connected between the blood inlet hole and the blood outlet hole, and the pancreatic islet drum comprises an islet drum header, An islet tube for inserting the islet cell in a predetermined place, and an islet hole for the islet of the pancreatic islet.

The cartridge container may have two or more pancreatic islands connected in series through the inter-drum connection, the blood inlet hole connection, and the blood outlet hole connection.

Wherein the two straight holes and the two U-turns are formed to be rotationally symmetrical at a predetermined angle from the front center line of the rotary drum, and the drum holder is arranged to be in front of the two linear holes or the two U- A clamp insertion groove formed at the position of the rotary drum and coupled to the blood vessel connection portion so that the header clamp of the cartridge can be introduced rearward, and two latches for preventing the separation and rotation of the rotary drum are formed .

Wherein the drum holder is further provided with two cleaning holes so as to be rotationally symmetric with respect to the two connection holes at a predetermined angle in front of the drum holder, and screw grooves of a fixing screw for fixing the rotary drum to the side, The hole is formed to be rotationally symmetric at an angle equal to a rotational symmetry angle between the two straight holes and the two U-turns at the front center line of the drum holder, and the rotary drum rotates to correspond to the screw groove Two screw fixing grooves may be further formed on the side surface.

Wherein the clamp insertion grooves are formed in a rear portion of the drum holder corresponding to one of the two cleaning holes, and one of the two clamps is provided at one side of the clamp insertion groove in the state where the rotary drum is inserted, One can be attached to the rear opening of the drum holder opposite each other 180 degrees from the center.

Wherein the screw groove is formed on a side surface adjacent to any one of the two cleaning holes, and the two screw fixing grooves are formed on one side of one of the two linear holes and one side May be formed at positions away from each other by an angle.

The two connection holes may protrude forward and be formed into a nip shape.

Wherein the cartridge container comprises a blood glucose and insulin measurement device provided between the blood discharge hole and an islet drum back hole of the last islet drum, a remote communication device connected to the blood glucose and insulin measurement device and transmitting the measured biometric signal to an external receiver, And a wireless rechargeable battery connected to the remote communication device through a wire to supply necessary electricity.

The blood glucose and insulin measurement device can further measure the blood flow rate as well as the amount of blood glucose and insulin in the blood.

The remote communication apparatus can be programmed to inform the external receiver that the replacement time of the cartridge is the time when the blood flow rate measured by the blood glucose and insulin measurement apparatus is stable and the fasting blood glucose level is always 140 g / dL or more.

The plurality of islet cells may be obtained by extracting specific pathogen free mini-piglet islet cells and encapsulating the same into a single pancreatic islet cell through a certain process.

Wherein the blood vessel connection portion is composed of a supply artificial blood vessel and an artificial artificial blood vessel which are connected to the cartridge connection portion and each of the supply artificial blood vessel and the discharge artificial blood vessel is inserted into a blood vessel cut through a catheter fixing member, And an outlet blood vessel catheter are connected to each other, or a blood inlet portion and a blood outlet portion provided with a muscle fixture, a connecting joint, and a blood injection needle are connected to the distal end of each of the supplying artificial blood vessel and the discharging artificial blood vessel, .

The present invention provides a cartridge connecting portion that can change the circulation path of blood so that even when a cartridge containing an islet cell is replaced, blood circulation is not blocked, necrosis of a related tissue can be prevented, In the case of the degradation of the transplanted islet cells, there is an effect that it is not necessary to repeat the major operation such as collecting the islet cells injected into the blood vessels and re-injecting them into new islet cells.

In addition, it is possible to utilize the veins of non-dangerous parts (e.g., peritoneum, arm, leg, etc.) through the blood vessel connection part of the present invention, and to carry out a dangerous large vein blood vessel operation handling the portal vein, etc., There is an effect that can be avoided.

Further, the replaceable cartridge further includes a means for measuring blood characteristics such as blood glucose and a remote communication device, thereby eliminating the inconvenience of blood glucose measurement by the diabetic patient from time to time to measure the blood glucose, thereby easily knowing the replacement timing of the cartridge.

1 is a perspective view showing a configuration of an exchangeable cartridge device for implementing an artificial pancreas according to an embodiment of the present invention.
FIG. 2 is a partially cutaway exploded perspective view showing the internal structure of the cartridge container 50 in FIG.
3 (a) is an exploded perspective view showing the fastening relationship between the supplying artificial blood vessel 16, the discharging artificial blood vessel 18, the drum holder 20 and the rotary drum 30 in Fig. 1, and Figs. 3 3 (c) is a perspective view showing a front structure of the drum holder 20 and the rotary drum 30, respectively.
4A is a cross-sectional view taken along the line AA in Fig. 4A. Fig. 4C is a sectional view taken along the line AA in Fig. The blood circulation path is bypassed to the inner tube 30a which is U-turned and FIG. 4 (b) shows that the rotary drum 30 is rotated clockwise by 90 degrees in FIG. 4 (a) And FIG. 4 (d) is a sectional view taken along line BB of FIG. 4 (b), showing that a blood circulation path is formed in the cartridge through the two linear holes 33 and 34 of the rotary drum 30 when the cartridge is mounted.
FIG. 5 is a perspective view showing a state in which the cartridge 300 is rotated 90 degrees counterclockwise in the forward direction and is detached from the cartridge connecting part 200 in FIG. 1. The blood circulating path at the time of replacing the cartridge, (30a).
6 (a) to 6 (d) are perspective views of the main parts according to operation steps showing a state in which a new cartridge is mounted in FIG.
FIG. 7 is a perspective view showing a blood vessel connecting part connected to a cut blood vessel according to an embodiment of the present invention. FIG.
FIG. 8 is a perspective view illustrating a state in which a blood vessel connection portion according to an embodiment of the present invention is fastened to a protruding connection hole of a drum holder. FIG.
9 is a perspective view showing the configuration of an exchangeable cartridge device for implementing an artificial pancreas according to another embodiment of the present invention.
FIG. 10 is a use state diagram showing an example in which the replaceable cartridge device of FIG. 1 is implanted into the peritoneum.
Fig. 11 is a use state diagram showing an example in which the replaceable cartridge device of Fig. 9 is used by embedding only a part of the blood vessel connection portion in the arm and fixing it to the human body with the cartridge protective holder and the fixing belt.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings. The structure of the replaceable cartridge device illustrated in the accompanying drawings is only provided to explain the technical idea of the present invention to a person skilled in the art so that the technical idea of the present invention should not be interpreted.

As shown in FIG. 1, the replaceable cartridge device for implementing an artificial pancreas according to an embodiment of the present invention includes: an exchangeable cartridge 300 basically containing a plurality of islet cells 52; A blood vessel connection part (100) connected to the blood vessel so that blood is circulated in the cartridge (300); And a cartridge connecting part 200 which is fastened between the cartridge 300 and the blood vessel connection part 100 to form a blood circulation path.

5, the cartridge connecting part 200 is configured such that the blood circulation path can be bypassed without passing through the cartridge 300 when the cartridge 300 is replaced.

By providing the cartridge connecting part 200 capable of changing the blood circulation path as described above, even when the cartridge containing the pancreatic islet cell 52 is exchanged, blood circulation is not blocked so that necrosis of the related tissue can be prevented do.

3 and 4, the cartridge connecting part 200 includes a drum holder 20 to which the supplying artificial blood vessel 16 and the discharging artificial blood vessel 18 of the blood vessel connecting part 100 are fastened, And a rotary drum 30 inserted in the holder so as to be rotatable in the left and right direction to change the blood circulation path.

The rotary drum 30 includes two linear holes 33 and 34 for circulating blood to the cartridge 300 and an inner tube 30a which is U-turned forward between the two linear holes A linear groove 35 connected to the two linear holes 31 and 32 formed at the rear to connect and detach the cartridge, and clamp holders 36 and 37 formed of both side projections of the linear groove . At this time, the two straight holes 33 and 34 and the two U-turns holes 31 and 32 are rotated at a predetermined angle? 2 from the front center line B of the rotary drum 30 as shown in FIG. So as to be rotationally symmetric. Is shown to be rotationally symmetric by 90 degrees in Fig. 3 (c), but is not limited thereto.

The drum holder 20 is basically formed with two connection holes 21 and 22 for fastening the supplying artificial blood vessel 16 and the discharging artificial blood vessel 18 of the blood vessel connecting portion 100 forward . When the two linear holes 33 and 34 and the two U-turns holes 31 and 32 are formed to be rotationally symmetric at a predetermined angle? 2 in the rotary drum 30, the two connection holes 21 and 22 Is formed at a position corresponding to the two linear holes 33, 34 or the two U-turns holes 31, 32.

The supplying artificial blood vessel 16 and the discharging artificial blood vessel 18 are respectively fastened to the two connection holes 21 and 22 by a predetermined adhesive or may be integrally formed. In the latter case, the supplying artificial blood vessel 16 and the discharging artificial blood vessel 18 are preferably made of the same material as the drum holder 20.

8, the two connection holes 21a and 22a are formed in the shape of a nose protruding forward of the drum holder 20a, and the supply artificial blood vessel 16 and the discharge artificial blood vessel 16, (18) may be fastened by force fitting. In this case, it is preferable that the two protruding connection holes 21a and 22a are integrally formed with the drum holder 20a.

In another embodiment of the drum holder 20, two cleaning holes 23 and 24 may be formed in addition to the two connection holes 21 and 22, as shown in FIG. 3 (b). At this time, the two cleaning holes 23 and 24 are formed in the front center line A of the drum holder 20 and the two connection holes 21 and 22, and the two linear holes 33 and 34 and the two U- (I.e.,? 1 =? 2) between the rotational symmetry angle? 2 and the rotational symmetry angle? 2.

4 (a) and 4 (c), when the drum holder 20 is rotated so that the two U-turns holes 31 and 32 meet with the two connection holes 21 and 22 The artificial blood vessel 16 of the blood vessel connection part 100 → the U-turn inner tube 30a of the cartridge connection part 200 → the discharge artificial blood vessel 18 of the blood vessel connection part 100 ) -> blood vessels. Therefore, when the cartridge is exchanged, a blood circulation path bypassing without passing through the cartridge 300 is formed to prevent the blood circulation from being blocked. Further, the two linear holes 33 and 34 are brought into contact with the two cleaning holes 23 and 24 So that the two linear holes 33 and 34 can be cleaned through the two cleaning holes 23 and 24 after the cartridge 300 is removed.

4 (b) and 4 (d), the drum holder 20 is rotated in the opposite direction to that of the previous case so that the two linear holes 33 and 34 are connected to the two connection holes 21 and 22, The blood circulation path is connected to the supply port artificial blood vessel 16 of the blood vessel connection unit 100 through the first straight hole 33 of the cartridge connection unit 200 to the cartridge 300, The second linear hole 34 of the blood vessel connection part 200 and the artificial blood vessel 18 of the blood vessel connection part 100. Therefore, when the cartridge is loaded, the blood circulation path through the cartridge 300 is formed, and the blood circulation path can be changed by the left and right rotation of the drum holder 20 without blocking the blood circulation. The cartridge connecting portion 200 which is connected to the two cleaning holes 23 and 24 and connected to the two cleaning holes 23 and 24 through the two cleaning holes 23 and 24 in a state in which the cartridge 300 is mounted, The U-turn inner tube 30a of the U-turn can be cleaned.

3 (a), the drum holder 20 includes a clamp insertion groove 25 for allowing the header clamp 42 of the cartridge 300, which will be described later, to enter, and a rotary drum 30 inserted therein, And two latches 26 and 27 for imparting a departure prevention and rotation limit of the latches 26 and 27 can be formed. At this time, the clamp insertion groove 25 is formed in the rear piece corresponding to any one of the two cleaning holes 23 and 24, and the two latches 26 and 27 are inserted into the clamp insertion groove 25 after the rotary drum 30 is inserted. One on one side of the groove 25 and the other on the opposite side away from the center by 180 degrees toward the rear opening of the drum holder 20. 6, the header clamp 42 of the cartridge 300 fitted in the clamp holders 36, 37 of the rotary drum 30 is rotated until the head clamp 42 of the rotary drum 30 abuts on one side of the opposite sides of the two latches 26, 27 90 degrees to the left or 90 degrees to rotate the drum holder 20 at the same angle so that the blood circulation path can be changed.

3 (a), a screw groove 28 of a fixing screw 29 for fixing the rotary drum 30 rotated at a predetermined angle is further formed on the side surface of the drum holder 20, The rotary drum 30 may be further formed with two screw fixing grooves 38 and 39 on the side thereof so as to correspond to the screw groove 28 by rotating. In the case where the screw groove 28 is formed in the side surface adjacent to any one of the two cleaning holes 23 and 24, the two screw fixing grooves 38 and 39 are formed by one of the two straight holes 33 and 34 And is formed at a position spaced apart from the center line by 90 degrees on each side adjacent to one of the U-turn holes 31 and 32. [ 6, after the drum holder 20 is rotated at a predetermined angle by the rotation of the header clamp 42 of the cartridge 300 to change the above-described blood circulation path, it is tightened with the fixing screw 29, Unnecessary rotation of the drum holder 20 can be prevented at the time of replacement or after use of the cartridge.

1 to 5, the cartridge 300 includes a clamp 40 detachably attached to the clamp holders 36 and 37 and a cartridge container 50 attached to the rear of the clamp 40 .

The clamp 40 has a header clamp 42 having both side surface concave-convex portions 41 that can be inserted into the clamp holders 36 and 37, a blood inlet 42 formed at a position corresponding to the two linear holes 33 and 34, A hole 43 and a blood discharge hole 44. [

One or more pancreatic islets 60 and 70 are connected in series between the blood inlet hole 43 and the blood outlet hole 44 of the clamp 40 in the cartridge container 50, 60 and 70 may be composed of pancreatic islet drum headers 62 and 72 and pancreatic islet tubes 64 and 74 for inserting the pancreatic islet cells 52 at predetermined positions.

As described above, since the cartridge 300 includes the clamp 40 attached to and detached from the clamp holders 36 and 37 of the rotary drum 30 and the cartridge container 50 attached to the clamp, 4 to 6 so as to rotate the rotary drum 30 until the header clamp 42 is brought into contact with at least one of the two latches 26 and 27 or one side of each side as described above, The blood circulation path is bypassed through the U-turn inner tube 30a of the rotary drum 30 so that the two U-turn holes 31 and 32 meet the two connection holes 21 and 22, The header clamp 42 of the cartridge 300 is separated from the clamp holders 36 and 37 along the clamp insertion groove 25 and the straight groove 35 and the new cartridge 300 is inserted in the reverse order .

6 (a) to 6 (d) show a state in which the blood circulation path is detached through the U-turn inner tube 30a of the rotary drum 30 and mounted with the new cartridge 300 as shown in FIG. 5 It shows by operation step.

The blood circulation path is formed between the blood inlet hole 43 of the clamp 40 and the blood inlet port 43 of the clamp 40 so that the two straight holes 33 and 34 meet the two connection holes 21 and 22, Through the outlet hole 44, through the pancreatic islet cell inside the cartridge container 50.

The cartridge container 50 fixes a plurality of islet cells 52 in a predetermined place and effectively passes between the islets 52 through the blood inlet hole 43. When the blood glucose level of the blood is high, And the like.

In order to realize the function of the cartridge container 50, the cartridge container 50 has a predetermined space portion and a space between the blood inlet hole 43 of the clamp 40 and the blood outlet hole 44 (Not shown), and a plurality of pancreatic islets 52 are fixed to the pancreatic islet drum. The blood that has entered the blood inlet hole 43 passes through the pancreatic islet cell 52 of the pancreatic islet, Can be configured to exit to the discharge hole (44). At this time, the pancreatic islet can be made into a bow-shaped curve.

In another embodiment of the cartridge container 50, two or more pancreatic islets 42, which have a predetermined space inside and connect the blood inlet hole 43 of the clamp 40 and the blood outlet hole 44, As shown in FIG.

1 and 2, two pancreatic islets 60 and 70 are connected in series between the blood inlet hole 43 and the blood outlet hole 44 of the clamp 40 in the cartridge container 50, However, the present invention is not limited to this, and two or more pancreatic islets may be connected in series, parallel, or a combination of serial and parallel, between the blood inlet hole 43 and the blood outlet hole 44 It is possible.

When two or more islets are connected in series, as shown in FIGS. 1 and 2, the blood inlet hole connecting portion 61 connected to the blood inlet hole 43, The ninth islet drum 70, the blood discharge hole connecting portion 75, and the blood discharge hole 44, as shown in FIG.

The islet drums 60 and 70 of the respective embodiments described above are provided with the islet drum headers 62 and 72 and the islet tubes 63 and 73 and the pancreatic drum back holes 64 and 74, ≪ / RTI >

The islet tubes 63 and 73 may have various structures for fixing the pancreatic islets 52 therein. For example, the pancreatic ducts 63 and 73 may be made of a mesh-shaped sheet made of PMMA or PCL.

One pancreatic islet may vary in size depending on the structure, but the number of pancreatic islets having an average size of 200 to 400 μm can be increased to 2 to 30,000, and the number of pancreatic islets can be selected according to the amount of pancreatic islets required by the patient desirable.

Since the cartridge container 50 and the pancreatic islets 60 and 70 enclose the outside of the cartridge and the pancreatic islet tubes 63 and 73 respectively as a strong material that is not damaged by the force of muscles, biocompatibility and interfacial compatibility, it is preferable to use titanium or a chromium-cobalt alloy or the like.

The pancreatic islet cell 52 used in each of the above embodiments may be homogeneous but may be a specific pathogen free (SPF) micropigment, for example, And may be encapsulated in one islet cell to protect against the attack of the human immune system. Regarding specific pathogen member (SPF) mini pigs, reference can be made to Korean Patent No. 10-0628700 (production method of small pigs for experimental pathogens).

2 and 10, the cartridge container 50 has a structure in which blood glucose and insulin measured between the pancreatic drum backhaul 74 of the last pancreatic islet 70 connected in series with the blood discharge hole 44 in the internal space A remote communication device 90 connected to the blood glucose and insulin measurement device for transmitting the measured biological signal to the external receiver 2 and a wireless communication device 90 connected to the remote communication device by a wire 92 to supply necessary electric power, A rechargeable battery 94 may be further included.

Here, the blood glucose and insulin measurement device 80 is preferably provided to additionally measure the blood flow rate, heart rate, and blood pressure as well as the amount of blood glucose and insulin in the blood.

The remote communication device 90 measures the amount of blood glucose and insulin in the blood by the blood glucose and insulin measuring device 80 from the blood that has passed through the last islet drum 70, 2). Therefore, it is possible to eliminate the inconvenience of blood glucose measurement by the diabetic patient from time to time, and it becomes easy to know the replacement timing of the cartridge.

Particularly, the remote communication device 90 is provided with a predetermined control module so that when the lowest blood glucose level (fasting blood sugar) is always 140 g / dL or more in a state where the blood flow rate measured by the blood glucose and insulin measurement device 80 is stable, It is preferable to be programmed to notify the external receiver 2 of a warning sound or the like indicating that the cartridge 300 is to be replaced when it exceeds the set allowable threshold value. Of course, the conditions such as the replacement timing of the cartridge 300 may be configured to be analyzed by the external receiver 2 and inform the user.

10, the wireless rechargeable battery 94 can be replaced with a rechargeable battery 94 by attaching a dedicated charger to the human skin (near the region where the device is used) even when the replaceable cartridge device 1000 according to the above- And can be periodically recharged by being operated.

As shown in FIGS. 1 and 7, the blood vessel connection part includes an integral blood vessel connection part 100 for cutting and connecting one blood vessel to two blood vessels 110 and 120, and one or more blood vessels 210, 220 connected to each other by a non-cutting method of blood vessels.

1 and 7, the integral blood vessel connection portion 100 is composed of a supply artificial blood vessel 16 and a discharge artificial blood vessel 18 connected to the cartridge connection portion 200, An inlet blood vessel catheter 12 and an outlet blood vessel catheter 14 inserted into the blood vessels cut through the catheter fixing member 11 can be connected to the distal ends of the auxiliary artificial blood vessels 18, respectively.

1 and 7, both ends of the catheter fixing member 11 are shown angularly, but they can be made streamlined like the other configurations such as the cartridge container 50 and the like.

7 shows a state in which an inlet blood vessel catheter 12 and an outlet blood vessel catheter 14 of the integral blood vessel connection portion 100 are connected to the cut blood vessels 110 and 120, respectively.

9, the independent blood vessel connection portion 101 is composed of a supply artificial blood vessel 16 and a discharge artificial blood vessel 18 which are connected to the cartridge connection portion 201 like the above-described integral blood vessel connection portion 100, A blood inflow section 17 and a blood outlet section 19 provided with a muscle fixation 15a, a connection joint 15b and a blood injection needle 15c are provided at the distal ends of the artificial blood vessel 16 and the artificial blood vessel 18 at the discharge section, Respectively.

Here, the connection joint 15b into which the blood vessel injection needle 15c is inserted is replaceably inserted into each tip of the supply artificial blood vessel 16 and the discharge artificial blood vessel 18 in a screw or forced fit manner, The artificial blood vessel 16 and the outlet artificial blood vessel 18 may be bundled into one or more bands 13. [ The muscle fixture 15a is used for anastomosis to nearby muscles in which the blood inflow section 17 and the blood discharge section 19 are embedded with a suture or the like.

10, the replaceable cartridge device 1000 provided with the integral-type blood vessel connection part 100 is used mainly in the body such as the peritoneal membrane 1 as a whole. However, the replaceable blood vessel catheter 12, the discharge vein catheter 14 And the catheter fixing member 11 may be buried in the body part of the supplying artificial blood vessel 16 and the discharging artificial blood vessel 18 while the rest may be used outside the body.

11, the exchange type cartridge device 2000 provided with the independent blood vessel connection part 101 includes a blood inflow part (not shown) provided with a muscle fixture 15a, a connection joint 15b and a blood injection needle 15c Only the portion 3 of the blood vessel connection portion 101 such as the blood discharge portion 17 and the blood discharge portion 19 can be buried in the inside of the body while the rest can be used outside the body.

11, the cartridge holder 4 for protecting the cartridges 300 and 301 and the cartridge holder are attached to the body of the user such as an arm (not shown) 6, a fixing belt 5 is further provided.

As described above, since the cartridges 300 and 301 of the replaceable cartridge apparatuses 1000 and 2000 can be placed outside the body, the cartridge container 50 is provided with the pancreatic islets 60 and 70 It may be made of a transparent or semitransparent material so that it can be seen. As shown in FIG. 9, it may be made of an opaque material such as a metal, and a part of the opening groove 54 may be made so that the inside can be seen.

The specific embodiments of the attached drawings are as described in the brief description of the drawings, and the above-mentioned embodiments are not limited to the specific embodiments of the attached drawings.

11: catheter fixing member 12: incoming blood vessel catheter
13: Band 14: Discharge vessel catheter
15a: Muscle fixture 15b: Connection joint
15c: blood vessel injection needle 16: supply artificial blood vessel
17: blood inflow section 18: discharge section artificial blood vessel
19: blood discharge part 20, 20a: drum holder
21, 22, 21a, 22a: connection holes 23, 24: cleaning hole
25: clamp insert groove 26, 27:
28: screw groove 29: set screw
30: rotary drum 30a: inner tube
31, 32: U-turn hole 33, 34: Straight hole
35: straight groove 36, 37: clamp holder
38, 39: screw fixing groove 40: clamp
41: concave / convex portion 42: header clamp
43: blood inlet hole 44: blood outlet hole
50, 50a: cartridge container 52: islet cell
54: opening groove 60, 70: islet drum
61: blood inlet hole connecting portion 62, 72: islet drum header
63. 73: Islet tube 64, 74: Islet drum backhaul
66: Drum-to-drum connection 75: Blood discharge hole connection
80: blood glucose and insulin measuring device 90: remote communication device
92: wire 94: wireless rechargeable battery
100, 101: blood vessel connection portion 110, 120, 210, 220: blood vessel
200, 201: cartridge connecting portion 300, 301: cartridge
1000, 2000: Replaceable cartridge unit

Claims (15)

An exchangeable cartridge containing a plurality of islet cells;
A blood vessel connection portion connected to the blood vessel so that blood is circulated in the cartridge; And
And a cartridge connecting part which is fastened between the cartridge and the blood vessel connection part to form a blood circulation path,
Wherein the cartridge connecting portion is configured so that the blood circulation path can be bypassed when the cartridge is replaced without going through the cartridge.
The method according to claim 1,
Wherein the cartridge connecting portion comprises a drum holder to which the blood vessel connection portion is fastened and a rotary drum inserted into the drum holder so as to be rotatable in the left and right direction,
The rotary drum includes two linear holes for circulating blood to the cartridge, two U-turns for forming an inner tube U-turned forward between the two linear holes, and two U- And a clamp holder connected to the cartridge holder and detachably attached to the cartridge.
3. The method of claim 2,
Wherein the cartridge comprises a clamp detachably attached to the clamp holder and a cartridge container attached to the rear of the clamp,
Wherein the clamp comprises a header clamp having both side surface irregularities that can be inserted into the clamp holder, a blood inlet hole and a blood outlet hole formed at positions corresponding to the two linear holes,
Wherein one or more pancreatic islets are connected between the blood inlet hole and the blood outlet hole,
Wherein the pancreatic islet comprises a pancreatic islet drum header, an islet tube for fixing the pancreatic islet cell to a predetermined location, and an islet pancreatic islet bag back hole.
The method of claim 3,
Wherein the cartridge receptacle is connected in series with two or more pancreatic islets through a drum-to-drum connection, a blood inlet hole connection, and a blood outlet hole connection.
The method of claim 3,
Wherein the two straight holes and the two U-turns are formed to be rotationally symmetric with respect to the front center line of the rotary drum at a predetermined angle,
The drum holder includes a clamp which is formed at the position corresponding to the two straight holes or the two U-turns and is connected to the blood vessel connection portion and is capable of entering the header clamp of the cartridge backward And a pair of latches for providing an anti-departure and rotation limit of the insertion groove and the rotary drum are formed.
6. The method of claim 5,
Wherein the drum holder is further provided with two cleaning holes so as to be rotationally symmetric with respect to the two connection holes at a predetermined angle in front of the drum holder, and screw holes of a fixing screw for fixing the rotary drum to the side,
Wherein the two cleaning holes are formed so as to be rotationally symmetric at an angle equal to a rotational symmetry angle between the two straight holes and the two uto holes at the front center line of the drum holder,
Wherein the rotary drum is further formed with two screw fixing grooves on its side so as to correspond to the screw grooves.
The method according to claim 6,
Wherein the clamp insertion groove is formed in a rear part of the drum holder corresponding to one of the two cleaning holes,
One of the two clamps is attached to one side of the clamp insertion groove while the other one of the two clamps is attached toward the rear opening of the drum holder on the opposite side away from the center by 180 degrees in a state where the rotary drum is inserted Replaceable cartridge device for artificial pancreas implementation.
The method according to claim 6,
Wherein the screw groove is formed on a side surface adjacent to any one of the two cleaning holes,
Wherein the two screw fixing grooves are formed at positions separated from each other by 90 degrees from a center line on one side of one of the two linear holes and one side of one of the two of the two mutual slots. Device.
6. The method of claim 5,
Wherein the two connection holes protrude forward and are formed in the shape of a nip.
The method of claim 3,
Wherein the cartridge container comprises a blood glucose and insulin measurement device provided between the blood discharge hole and an islet drum back hole of the last islet drum, a remote communication device connected to the blood glucose and insulin measurement device and transmitting the measured biometric signal to an external receiver, Further comprising a wireless rechargeable battery connected to the remote communication device by a wire to supply the necessary electricity.
11. The method of claim 10,
Wherein the blood glucose and insulin measuring device further measures blood flow rate as well as blood glucose and insulin levels in the blood.
12. The method of claim 11,
Wherein the remote communication device is programmed to inform the external receiver that the replacement time of the cartridge is the time when the blood flow rate measured by the blood glucose and insulin measurement device is stable and the fasting blood glucose level is always 140 g / dL or more. Exchangeable cartridge device.
13. The method according to any one of claims 1 to 12,
Wherein the plurality of pancreatic islet cells are isolated from a specific pathogen free mini-pig, and the pancreatic islet cells are encapsulated in one pancreatic cell through a certain process.
14. The method of claim 13,
Wherein the blood vessel connection portion is composed of a supply artificial blood vessel and an artificial artificial blood vessel which are connected to the cartridge connection portion,
And an inlet blood vessel catheter and an outlet blood vessel catheter inserted into the blood vessel cut through the catheter fixing member are connected to the distal end of the supply artificial blood vessel and the artificial blood vessel of the outlet, respectively.
14. The method of claim 13,
Wherein the blood vessel connection portion is composed of a supply artificial blood vessel and an artificial artificial blood vessel which are connected to the cartridge connection portion,
Wherein a blood inflow section and a blood discharge section each having a muscle fixation unit, a connection joint, and a blood injection needle are connected to the distal end of the supply artificial blood vessel and the artificial blood vessel of the discharge section, respectively.

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