KR101675609B1 - １-피라졸로［４,３-ｃ］이소퀴놀린 유도체, 그의 제조법 및 그의 치료 용도 - Google Patents

１-피라졸로［４,３-ｃ］이소퀴놀린 유도체, 그의 제조법 및 그의 치료 용도 Download PDF

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Publication number
KR101675609B1
KR101675609B1 KR1020117027900A KR20117027900A KR101675609B1 KR 101675609 B1 KR101675609 B1 KR 101675609B1 KR 1020117027900 A KR1020117027900 A KR 1020117027900A KR 20117027900 A KR20117027900 A KR 20117027900A KR 101675609 B1 KR101675609 B1 KR 101675609B1
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KR
South Korea
Prior art keywords
pyrazolo
isoquinoline
group
difluorophenyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020117027900A
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English (en)
Korean (ko)
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KR20120007060A (ko
Inventor
죠르쥐 델레트레
스테파니에 데프레트
프랑끄 알레
로렝 쉬오
파비엔느 톰송
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사노피
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Publication of KR20120007060A publication Critical patent/KR20120007060A/ko
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Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020117027900A 2009-04-24 2010-04-22 １-피라졸로［４,３-ｃ］이소퀴놀린 유도체, 그의 제조법 및 그의 치료 용도 Expired - Fee Related KR101675609B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR09/01995 2009-04-24
FR0901995A FR2944792B1 (fr) 2009-04-24 2009-04-24 Derives de 1h-pyrazolo[4,3-c]isoquinoleines, leur preparation et leur application en therapeutique
PCT/FR2010/050773 WO2010122272A1 (fr) 2009-04-24 2010-04-22 DERIVES DE 1-PYRAZOLO[4,3-c]ISOQUINOLEINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (2)

Publication Number Publication Date
KR20120007060A KR20120007060A (ko) 2012-01-19
KR101675609B1 true KR101675609B1 (ko) 2016-11-11

Family

ID=41259738

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117027900A Expired - Fee Related KR101675609B1 (ko) 2009-04-24 2010-04-22 １-피라졸로［４,３-ｃ］이소퀴놀린 유도체, 그의 제조법 및 그의 치료 용도

Country Status (25)

Country Link
US (1) US8461175B2 (https=)
EP (1) EP2421864B1 (https=)
JP (1) JP5722880B2 (https=)
KR (1) KR101675609B1 (https=)
CN (1) CN102459260B (https=)
AR (1) AR076393A1 (https=)
AU (1) AU2010240742B2 (https=)
BR (1) BRPI1013724A2 (https=)
CA (1) CA2791947A1 (https=)
CY (1) CY1115678T1 (https=)
DK (1) DK2421864T3 (https=)
ES (1) ES2515240T3 (https=)
FR (1) FR2944792B1 (https=)
HR (1) HRP20141058T1 (https=)
IL (1) IL215733A (https=)
MX (1) MX2011011246A (https=)
MY (1) MY156362A (https=)
PL (1) PL2421864T3 (https=)
PT (1) PT2421864E (https=)
RU (1) RU2530775C2 (https=)
SG (1) SG175338A1 (https=)
SI (1) SI2421864T1 (https=)
TW (1) TWI468405B (https=)
UY (1) UY32575A (https=)
WO (1) WO2010122272A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109020972B (zh) * 2018-10-08 2021-03-09 广东石油化工学院 一种三唑并[1，5-a]喹啉衍生物的制备方法
WO2023039510A1 (en) * 2021-09-10 2023-03-16 The Trustees Of Columbia University In The City Of New York Gpx4 inhibitors and uses thereof
CN116535356B (zh) * 2023-03-06 2026-03-17 中国药科大学 3-氨基-5-苯基-吡唑类衍生物微管蛋白抑制剂及其制备和医药用途
EP4506003A1 (en) 2023-08-07 2025-02-12 S.Yu Yunusov Institute of Chemistry of Plant Substances of the Academy of Sciences of the Republic of Uzbekistan Halogen derivatives of (4´,5´- methylenedioxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline for use in the treatment of leukemia

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040097541A1 (en) 2002-07-03 2004-05-20 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinoline derivatives for inhibiting NFkappaB-inducing kinase
US20070032515A1 (en) 2003-07-23 2007-02-08 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
WO2007060198A1 (en) 2005-11-25 2007-05-31 Palau Pharma, S. A. Pyrazoloisoquinoline derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600752D0 (en) * 1986-01-14 1986-02-19 Roussel Lab Ltd Chemical compounds
US7132428B2 (en) * 2003-07-03 2006-11-07 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders
EP1644371B1 (en) * 2003-07-03 2008-02-13 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivatives as kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040097541A1 (en) 2002-07-03 2004-05-20 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinoline derivatives for inhibiting NFkappaB-inducing kinase
US20070032515A1 (en) 2003-07-23 2007-02-08 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
WO2007060198A1 (en) 2005-11-25 2007-05-31 Palau Pharma, S. A. Pyrazoloisoquinoline derivatives

Also Published As

Publication number Publication date
WO2010122272A1 (fr) 2010-10-28
AU2010240742B2 (en) 2015-11-19
FR2944792A1 (fr) 2010-10-29
SG175338A1 (en) 2011-11-28
MX2011011246A (es) 2012-02-13
HRP20141058T1 (hr) 2014-12-19
DK2421864T3 (da) 2014-11-10
KR20120007060A (ko) 2012-01-19
FR2944792B1 (fr) 2011-05-20
TWI468405B (zh) 2015-01-11
HK1167387A1 (en) 2012-11-30
JP5722880B2 (ja) 2015-05-27
US8461175B2 (en) 2013-06-11
BRPI1013724A2 (pt) 2016-04-05
SI2421864T1 (sl) 2014-11-28
US20120115898A1 (en) 2012-05-10
CA2791947A1 (fr) 2010-10-28
HK1170736A1 (en) 2013-03-08
JP2012524766A (ja) 2012-10-18
CN102459260B (zh) 2015-06-10
AU2010240742A1 (en) 2011-11-17
ES2515240T3 (es) 2014-10-29
RU2011147658A (ru) 2013-05-27
AR076393A1 (es) 2011-06-08
PL2421864T3 (pl) 2014-12-31
CY1115678T1 (el) 2017-01-25
CN102459260A (zh) 2012-05-16
EP2421864B1 (fr) 2014-08-06
TW201041887A (en) 2010-12-01
UY32575A (es) 2010-11-30
IL215733A (en) 2014-02-27
PT2421864E (pt) 2014-10-07
MY156362A (en) 2016-02-15
IL215733A0 (en) 2012-01-31
EP2421864A1 (fr) 2012-02-29
RU2530775C2 (ru) 2014-10-10

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