KR101602949B1 - Plasma separation apparatus - Google Patents

Abstract

The present invention relates to a plasma separation apparatus, and more particularly, to a plasma separation apparatus comprising: a middle plate having a chamber portion filled with blood and to which a predetermined filter is seated; An upper plate disposed on the middle plate and covering the chamber section; A lower plate disposed below the middle plate and covering the lower portion of the middle plate; Wherein the middle plate has a blood inlet for injecting blood into the chamber and a plasma outlet for discharging plasma separated from the blood to the outside of the chamber is provided on one side of the middle plate, A separation pattern portion on which the filter is seated is formed on a surface of the filter, and the separation pattern portion includes a plurality of protrusions contacting the at least one portion of the filter to support the filter, and a plurality of protrusions formed between the protrusions, And a plurality of depressed portions formed with the depressions.

Description

[0001] PLASMA SEPARATION APPARATUS [0002]

The present invention relates to a plasma separation apparatus, and more particularly, to a plasma separation apparatus comprising: a middle plate having a chamber portion filled with blood and to which a predetermined filter is seated; An upper plate disposed on the middle plate and covering the chamber section; A lower plate disposed below the middle plate and covering the lower portion of the middle plate; And a blood outlet for injecting blood into the chamber is provided at one side of the middle plate and a plasma outlet for discharging plasma separated from the blood to the outside of the chamber is provided at one side of the middle plate, And a separation pattern portion on which the filter is seated is formed on the bottom surface, the separation pattern portion includes a plurality of protrusions contacting the at least one portion of the filter to support the filter, and a plurality of protrusions formed between the protrusions, And a plurality of depressions formed with spaces are formed.

Blood is a fluid that flows through the blood vessels. It contains various substances such as red blood cells, white blood cells, and platelets, and supplies nutrients and various necessary elements to all parts of the body. The state of the blood is an important factor for representing the health state of the body, and the blood test has a very important position in the physical examination.

In order to inspect such blood, a device for separating plasma from blood and performing an inspection is widely used. However, in the conventional plasma separation apparatus, plasma is separated using a predetermined filter, space for plasma separation is large, space utilization is low, and the flow of blood and plasma is very slow in the plasma separation process, There were low disadvantages.

Patent Document 10-2013-0016562

SUMMARY OF THE INVENTION Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, and an object of the present invention is to provide a middle plate having a chamber portion filled with blood and to which a predetermined filter is seated. An upper plate disposed on the middle plate and covering the chamber section; A lower plate disposed below the middle plate and covering the lower portion of the middle plate; And a blood outlet for injecting blood into the chamber is provided at one side of the middle plate and a plasma outlet for discharging plasma separated from the blood to the outside of the chamber is provided at one side of the middle plate, And a separation pattern portion on which the filter is seated is formed on the bottom surface, the separation pattern portion includes a plurality of protrusions contacting the at least one portion of the filter to support the filter, and a plurality of protrusions formed between the protrusions, And a plurality of depressions formed with a space are formed.

A plasma separation apparatus according to an embodiment of the present invention includes: a middle plate having a chamber part filled with blood and in which a predetermined filter is seated; An upper plate disposed on the middle plate and covering the chamber section; A lower plate disposed below the middle plate and covering the lower portion of the middle plate; / RTI >

A blood outlet is provided at one side of the middle plate for injecting blood into the chamber and a plasma outlet for discharging plasma separated from the blood to the outside of the chamber is provided at one side of the middle plate, A separation pattern portion on which the filter is seated is formed,

The separation pattern portion has a plurality of protrusions contacting the at least one portion of the filter to support the filter and a plurality of depressions formed between the protrusions and having a space through which the separated plasma is guided.

Preferably, the separation pattern portion has a central depression line extending in the longitudinal direction at a central portion of the chamber, and the protrusion portion and the depression portion are formed on both sides of the central depression line.

Preferably, the separation pattern portion has a first pattern portion and a second pattern portion in which the plurality of protrusions and recesses are alternately formed and arranged with a predetermined array, and the first pattern portion and the second pattern portion The first protruding pattern and the second protruding pattern are formed such that protrusions and depressions are alternately formed in a direction in which the central depression line extends .

Preferably, each of the protrusions of the first pattern portion and each of the depressions of the second pattern portion are arranged to face each other with the central depression line therebetween.

Preferably, each of the projections is formed such that a width of a portion adjacent to the central submerged line is larger than a width of a portion spaced apart from the central submerged line, and each of the depressions has a width Is smaller than the width of the portion spaced apart from the central depression line.

Preferably, each of the projections has a triangular or trapezoidal shape having a base portion as a base portion in contact with the central depression line.

Preferably, each of the projections is formed so that a height of a portion adjacent to the central depression line is greater than a height of a portion apart from the central depression line, and each of the depressions has a depth Is greater than the depth of the portion spaced apart from the central depression line.

Preferably, the central depression line is formed such that the depth of the central portion is deeper than the depth of the outer portion.

Preferably, the upper surface formed by the upper portion of each of the protrusions forms a flat surface.

Preferably, microchannels extending in the direction of the central depression are formed in the depressions.

Preferably, a seating surface for seating a predetermined filter is formed on the inner periphery of the chamber portion.

Preferably, a coupling frame disposed on the seating surface is provided, and a predetermined filter is disposed between the coupling frame and the seating surface to fix the filter.

Preferably, the blood injection port has a blood injection hole formed outside the chamber portion, and a chamber injection hole connected to the blood injection hole and formed in the chamber portion.

Preferably, the middle plate comprises a blood injection channel consisting of a predetermined recess formed in the lower surface, the blood injection hole and the chamber injection hole penetrating at least a part of the middle plate, And to connect the blood injection hole and the chamber injection hole.

Preferably, the lower plate has an auxiliary blood injection channel formed on the upper surface and formed at a position corresponding to the blood injection channel.

Preferably, a predetermined first projection or a first groove is formed on the outer side of the blood injection channel to surround the blood injection channel. The lower plate is formed on an upper surface of the first projection, And a second groove portion or a second groove portion is formed to correspond to the first projection portion or the first groove portion.

Preferably, the plasma outlet has a chamber discharge hole formed in the chamber portion, and a plasma discharge hole connected to the chamber discharge hole and formed outside the chamber portion.

Preferably, the middle plate includes a plasma discharge channel formed of a predetermined recess formed on a lower surface thereof, the chamber discharge hole and the plasma discharge hole penetrating at least a part of the middle plate, And to connect the chamber discharge hole and the plasma discharge hole.

Preferably, the lower plate has an auxiliary plasma discharge channel formed on the upper surface and formed at a position corresponding to the plasma discharge channel.

Preferably, a predetermined third projection or a third recessed portion surrounding the plasma discharge channel is formed outside the plasma discharge channel, and the lower plate is formed on the upper surface, and the third projection, And a fourth groove portion or a fourth groove portion which is formed in correspondence with the third projected portion or the third groove portion is formed.

Preferably, the middle plate has an air inlet for injecting outside air into the chamber portion.

Preferably, the air inlet has a first air inlet hole formed in the chamber, and a second air inlet hole connected to the first air inlet hole and formed outside the chamber portion.

Preferably, the first air injection hole has a hydrophobic coating formed on its inner surface to prevent the flow of plasma or the like.

Preferably, the middle plate includes an air inlet channel formed of a predetermined recess formed on a lower surface thereof, the first air inlet hole and the second air inlet hole penetrating at least a part of the middle plate, The air injection channel is configured to connect the first air inlet hole and the second air inlet hole.

Preferably, the lower plate has an auxiliary air injection channel formed on an upper surface thereof and formed at a position corresponding to the air injection channel.

Preferably, a fifth convex portion or a fifth groove portion surrounding the air injection channel is formed on the outer side of the air injection channel, and the lower plate is formed on the upper surface of the fifth projection portion or the fifth groove portion, And a sixth groove portion or a sixth groove portion which is formed to correspond to the fifth projection portion or the fifth groove portion and is in close contact with the fifth projection portion.

Preferably, the upper plate has an upper chamber formed on a lower surface thereof and having a predetermined space, and a plurality of supports extending in a downward direction and pressing a predetermined filter are disposed in the upper chamber.

Preferably, the upper plate has an upper discharge port for discharging the air in the upper chamber to the outside.

Preferably, the chamber portion is configured to have a rectangular outer shape, and the middle plate is provided with a plurality of chamber portions having the rectangular outer shape.

In the plasma separation apparatus according to the present invention, the flow of separated blood is promoted and the plasma separation efficiency can be improved. In addition, during the blood injection and plasma separation process, the air inside the chamber can be easily discharged, and plasma and blood flow can be smoothly performed. Further, the space portion in which the plasma separation is performed can have a rectangular appearance, and space utilization can also be improved.

1 is a view illustrating a plasma separation apparatus according to an embodiment of the present invention.
FIG. 2 is a view showing a coupling between a top plate, a middle plate, and a bottom plate of a plasma separation apparatus according to an embodiment of the present invention.
3 is a top view of a plasma separation apparatus according to an embodiment of the present invention.
4 is a bottom view of a top plate of a plasma separation apparatus according to an embodiment of the present invention.
5 is a top view of a plasma separation apparatus according to an embodiment of the present invention.
6 is a bottom view of a top plate of a plasma separation apparatus according to an embodiment of the present invention.
FIG. 7 is a bottom view of a plasma separator according to an embodiment of the present invention. FIG.
8 is an enlarged view of a separation pattern portion of the plasma separation apparatus according to an embodiment of the present invention.
9 is an enlarged view of a separation pattern portion of the plasma separation apparatus according to an embodiment of the present invention.
10 is a view showing a state in which a filter is placed in a chamber part of a plasma separation apparatus according to an embodiment of the present invention.
11 is a view showing a flow pattern of plasma due to plasma separation through the plasma separation apparatus according to an embodiment of the present invention.
12 is a view showing a flow pattern of blood and plasma through the plasma separation apparatus according to an embodiment of the present invention.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention, and the manner of achieving them, will be apparent from and elucidated with reference to the embodiments described hereinafter in conjunction with the accompanying drawings. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. To fully disclose the scope of the invention to those skilled in the art, and the invention is only defined by the scope of the claims. Like reference numerals refer to like elements throughout the specification.

Spatially relative terms such as " lower ", "upper ", " side ", and the like are used to easily describe one member or components and other members or components Spatially relative terms should be understood to include, in addition to the directions shown in the drawings, terms that include different orientations of the elements at the time of use or operation. For example, when reversing a member shown in the figure, Quot; upper "of the other member may be placed" lower " of the other member. Thus, by way of example, the term "upper" may include both downward and upward directions. , So that spatially relative terms can be interpreted according to orientation.

The terminology used herein is for the purpose of illustrating embodiments and is not intended to be limiting of the present invention. In the present specification, the singular form includes plural forms unless otherwise specified in the specification. As used in the specification, "comprises" and / or "comprising " do not exclude the presence or addition of one or more other members other than the recited member.

Unless defined otherwise, all terms (including technical and scientific terms) used herein may be used in a sense commonly understood by one of ordinary skill in the art to which this invention belongs. Also, commonly used predefined terms are not ideally or excessively interpreted unless explicitly defined otherwise.

In the drawings, the thickness and size of each part are exaggerated, omitted, or schematically shown for convenience and clarity of explanation. Also, the size and area of each component do not entirely reflect actual size or area.

Further, in the embodiment, the directions mentioned in the process of describing the structure of the present invention are based on those described in the drawings. In the description of the structure constituting the present invention in the specification, reference points and positional relations with respect to directions are not explicitly referred to, reference is made to the related drawings.

FIG. 1 is a view showing a plasma separation apparatus 1 according to an embodiment of the present invention. FIG. 2 is a sectional view of a plasma separation apparatus 1 according to an embodiment of the present invention, FIG. 3 is a view illustrating a top plate 100 of the plasma separation apparatus 1 according to an embodiment of the present invention, and FIG. 4 is a cross-sectional view of a top plate 100 according to an embodiment of the present invention. 5 is a view illustrating a middle plate 200 of the plasma separation apparatus 1 according to an embodiment of the present invention. FIG. 6 is a cross- 7 is a view illustrating a lower plate 300 of the plasma separation apparatus 1 according to an embodiment of the present invention, and FIG. 7 is a view illustrating a lower plate 300 of the plasma separation apparatus 1 according to an embodiment of the present invention FIG. 8 is an enlarged view of the separation pattern unit 400 of the plasma separation apparatus 1 according to the embodiment of the present invention, and FIG. 9 is a cross- 10 is an exploded perspective view of a plasma processing apparatus according to an embodiment of the present invention. Referring to FIG. 10, FIG. 11 is a view showing a flow pattern of plasma due to plasma separation through the plasma separation apparatus 1 according to an embodiment of the present invention. FIG. FIG. 1 is a view showing a flow pattern of blood and plasma through the plasma separation apparatus 1 according to an embodiment of the present invention. FIG.

The plasma separation apparatus 1 according to an embodiment of the present invention includes a middle plate 200 having a chamber part 220 filled with blood and on which a predetermined filter 500 is mounted; An upper plate (100) disposed on the middle plate (200) and covering the chamber part (220); A lower plate 300 disposed under the middle plate 200 and covering a lower portion of the middle plate 200; And a blood inlet for injecting blood into the chamber 220 is provided on one side of the middle plate 200. Plasma separated from the blood is supplied to one side of the middle plate 200, And a separation pattern part 400 on which the filter 500 is mounted is formed on the bottom surface of the chamber part 220. The separation pattern part 400 includes at least a part of the filter 500, A plurality of protrusions for supporting the filter 500 and a plurality of depressions formed between the protrusions and having a space for guiding the separated plasma are formed.

The upper plate 100, the middle plate 200 and the lower plate 300 are names denoted by the height at which the three largest members constituting the plasma separating apparatus 1 according to the present invention are arranged, Can be seen differently depending on the manner in which the device 1 is oriented. A member covering the chamber part 220 is referred to as an upper plate 100 and a member covering the lower part of the middle plate 200 is referred to as a lower plate 300. [ And the upper plate 100, the middle plate 200, and the upper plate 100 are not necessarily limited to a plate member.

The middle plate 200 is a member having a body 210 having a predetermined thickness and area, and a predetermined chamber 220 is formed in the body 210. The chamber part 220 is a part having a space in which blood or the like is contained and on which the filter 500 or the like is seated. The chamber part 220 surrounds the depression area having the predetermined depression surface 212 and the depression area, The second wall portion 214 may be formed of a predetermined second wall portion 214. Preferably, the chamber part 220 may have a generally rectangular outer shape. Accordingly, the plasma separation apparatus 1 according to the present invention has a plurality of chamber parts 220, and can have a spatially dense arrangement, thus improving the space utilization. For example, as shown in the figure, the chamber part 220 may have a rectangular configuration and a plurality of chamber parts 220 arranged side by side. At this time, each of the chamber parts 220 may have a configuration in which a predetermined partition wall W is interposed therebetween.

An upper plate 100 is disposed on the middle plate 200 and covers the chamber 220. The upper plate 100 has a body 310 having a predetermined area. The upper plate 100 may be disposed on the middle plate 200 and coupled to the middle plate 200 through a predetermined method or means. 4, a predetermined contact protruding portion 116 is formed on the lower plate 300 and a predetermined contact groove portion 214 is formed on the middle plate 200 to connect the middle plate 200 and the upper plate 100, Can be achieved. Preferably, the upper plate 100 and the middle plate 200 are tightly coupled with each other to prevent the inside of the external environment from being exposed, thereby preventing blood and the like injected into the chamber 220 from being contaminated.

The upper plate 100 has a predetermined body 110 and an upper chamber 120 formed on the lower surface of the body 110 and having a predetermined space. The upper chamber 120 A plurality of support bars 130 extending downward and pressing a predetermined filter 500 may be disposed. That is, as shown in FIG. 4, an upper chamber 120 having a predetermined space may be formed in the upper plate 100 corresponding to the chamber 220 formed in the middle plate 200. Accordingly, the upper plate 100 may have a predetermined plate 112 and a predetermined first wall 114 provided at an outer periphery of the plate 112. The first wall portion 114 may engage with the second wall portion 214 of the middle plate 200.

Accordingly, the upper chamber 120 and the chamber part 220 form a predetermined space, so that the filling space for the blood can be secured more widely. In addition, a plurality of predetermined supports 130 projecting downward may be disposed in the upper chamber 120 so that the filter 500 placed on the chamber 220 can be pressed and fixed.

A predetermined coupling protrusion 116 is formed along the first wall portion 114 of the upper plate 100 and each chamber portion 220 formed in the middle plate 200 corresponding to the coupling protrusion 116, A predetermined engaging groove 216 engaging with the engaging protrusion 116 may be formed along the second wall 214 of the engaging protrusion 216. [ Accordingly, the close and close contact between the upper plate 100 and the lower plate 300 can be achieved and the space in the chamber part 220 can be sealed. Meanwhile, the coupling recesses 216 and the coupling protrusions 116 may be formed in mutually opposite positions.

Preferably, the upper plate 100 has an upper outlet 140 for discharging the air in the upper chamber 120 to the outside. That is, as the blood is injected into the chamber part 220, the space inside the chamber part 220 is filled with blood. At this time, the air in the chamber part 220 is easily discharged, A predetermined upper discharge port 140 may be formed in the upper plate 100 to be easily filled. The upper discharge port 140 may have a relatively small size as a predetermined hole passing through the upper chamber 120 of the upper plate 100. The upper discharge port 140 may penetrate the upper chamber 120, There is no need.

The lower plate 300 is disposed below the middle plate 200 and covers the lower surface of the lower plate 300. The lower plate 300 has a predetermined body 310 and a predetermined recess is formed in the body 310 so that blood, plasma, air, and the like flow through the lower surface of the middle plate 200 Thus covering the recess, thereby forming channels through which blood, plasma, and air flow.

Hereinafter, the chamber part 220 formed in the middle plate 200 and the separation pattern part 400 formed in the chamber part 220 will be described in detail.

The separation pattern part 400 is formed on the bottom surface of the chamber part 220 to receive the filter 500. The separation pattern part 400 contacts the at least one part of the filter 500, A plurality of protrusions for supporting the filter 500 and a plurality of depressions formed between the protrusions and having a space for guiding the separated plasma are formed.

The recessed surface 212 forming the bottom surface of the chamber part 220 is formed with a predetermined protrusion and depressions formed between the protrusions. The protrusions and depressions form a separation pattern part 400 having a predetermined pattern do.

As the protrusions and depressions are formed on the bottom surface of the chamber portion 220 and the filter 500 is placed in the chamber portion 220, the protrusions substantially contact the filter 500, And can act as a supporting surface to be supported. In addition, since a depression is formed between the protrusions to form a predetermined space below the filter 500, the depression can act as a predetermined guide channel through which the separated plasma passes through the filter 500.

At this time, preferably, the upper surface formed by the upper portion of each of the protrusions may form a flat surface. That is, the upper portion of each of the protrusions forms a predetermined flat surface, and the predetermined filter 500 is easily seated on the protrusions and can perform separation. The seating of the filter 500 may be such that the filter 500 corresponding to the contour of the chamber part 220 is seated in the chamber part 220 as shown in FIG.

Preferably, a seating surface for seating a predetermined filter 500 may be formed on the inner periphery of the chamber 220. That is, the protrusions and depressions are not formed in the chamber 220 as a whole but are formed on the inner side with some space with respect to the inner surface of the chamber 220, and a flat surface is formed on a part of the inner surface of the chamber 220 . Accordingly, the flat surface functions as a seating surface on which the predetermined filter 500 is seated, and thus the seating of the filter 500 can be achieved.

At this time, as the filter 500 is placed on the protrusion, the chamber part 220 may have a space separated through the filter 500. That is, the lower chamber portion 222 under the filter 500 and the upper chamber portion 224 above the filter 500 can be distinguished from each other with the filter 500 as a boundary, and the lower chamber portion 222 ) May be a space in which the depression is formed substantially.

Preferably, a predetermined coupling frame (not shown) disposed on the seating surface may be provided. The coupling frame may be composed of, for example, a member such as a predetermined rectangular chassis disposed on the seating surface, and may be coupled by a predetermined means and a method. A predetermined filter 500 may be disposed between the coupling frame and the seating surface, so that the filter 500 can achieve easy fixing.

The separation pattern part 400 preferably has a central depression line 410 extending in a longitudinal direction at a central portion of the chamber part 220 and has protrusions and depressions on both sides of the central depression line 410. [ .

Preferably, the separation pattern unit 400 includes a first pattern unit 420 and a second pattern unit 430, the plurality of protrusions and depressions being alternately arranged and arranged in a predetermined array, The first pattern unit 420 and the second pattern unit 430 are disposed on both sides of the central depression line 410 with the central depression 410 interposed therebetween, And the second pattern part 430 are formed such that protrusions and depressions are alternately formed in a direction in which the central depression line 410 extends.

That is, as shown in FIG. 8, the separation pattern part 400 has a central depression line 410 extending in the longitudinal direction at the center of the chamber part 220. The central depression line 410 is formed as a long depression and extends in the longitudinal direction at a central portion of the chamber portion 220.

The first pattern part 420 and the second pattern part 430 are formed with the central depression line 410 interposed therebetween. As described above, the pattern unit has a plurality of protrusions and depressions, and the first pattern unit 420 and the second pattern unit 430 are also the same. At this time, the first pattern part 420 and the second pattern part 430 have an arrangement in which protrusions and depressions are alternately formed in a direction in which the central depression line 410 extends. That is, as shown in FIG. 8, the plurality of protrusions are arranged side by side along a direction in which the central depression line 410 extends, and recesses are formed between the plurality of protrusions. The protrusions and depressions formed on the first pattern unit 420 are referred to as first protrusions 422 and first depressions 424 and the protrusions and depressions formed on the second pattern units 430 are referred to as second protrusions 422. [ (432) and the second depression (434). Accordingly, the separation pattern portion 400 may have a configuration in which a plurality of protrusions and depressions are formed extending in the both lateral directions from the central depression line 410 with the central depression line 410 at the center.

According to an embodiment of the present invention, micro-channels 436 extending in the direction of the central depression line 410 may be formed in the respective depressions. 9, a microchannel 436 is formed in each depression at a predetermined length. The microchannel 436 is formed in the depression at a central depression And extend in the direction of the line 410. Accordingly, the capillary force is strengthened and guidance of the separated plasma or the like can be easily achieved.

At this time, preferably, each of the protrusions of the first pattern portion 420 and the depressions of the second pattern portion 430 are arranged to face each other with the central depression line 410 therebetween . 8, protrusions and depressions formed in the first pattern units 420 and protrusions and depressions formed in the second pattern units 430 intersect with each other to form the first pattern units 420, And the depressions of the second pattern units 430 may be arranged to face each other with the central depression line 410 interposed therebetween. The first protrusion formed on the first pattern unit 420 faces the second depression 434 formed on the second pattern unit 430 and the first depression formed on the first pattern unit 420, And the second pattern portion 430 may face the second protrusions 432 and 422 formed on the second pattern portion 430. Accordingly, the separated plasma can be easily discharged through the chamber discharging hole 242, which will be described later, by promoting the flow of the fluid.

Hereinafter, the shapes of the projections and depressions forming the separation pattern unit 400 according to the preferred embodiment will be described.

Preferably, each of the protrusions is formed so that a width of a portion adjacent to the central depression line 410 is larger than a width of a portion spaced apart from the central depression line 410, The width of the portion adjacent to the line 410 is smaller than the width of the portion spaced apart from the central depression line 410.

That is, as shown in FIG. 8, each of the protrusions and depressions are arranged to extend in both directions around the central depression line 410, and each protrusion has a width May be larger than the width of the portion spaced apart from the central depression line (410). This means that the sizes of D2 and C1 shown in Fig. 8 are larger than D1 and C2, respectively. Accordingly, each depression formed between the protrusions may have a configuration in which a width of a portion adjacent to the central depression line 410 is smaller than a width of a portion apart from the central depression line 410. Accordingly, as shown in FIG. 8, each of the protrusions preferably has a triangular or trapezoidal shape with a base portion as a base portion in contact with the central depression line 410. However, the present invention is not limited to this, and may be configured to have a partially diagonal portion or to reduce the width of one portion, but is not limited thereto.

Accordingly, as the depression has a smaller width in the direction of the central depression line 410, the capillary force due to the capillary phenomenon is strengthened, and the guide of the separated plasma can be promoted.

Preferably, each of the projections is formed so that a height of a portion adjacent to the central depression line 410 is greater than a height of a portion apart from the central depression line 410, The depth of the portion adjacent to the line 410 is formed to be larger than the depth of the portion spaced apart from the central depression line 410.

That is, it means that the size of A1 shown in FIG. 8 is larger than A2. In other words, each of the depressions may have a predetermined inclination deeper toward the central depression line 410. Accordingly, each of the protrusions may have a configuration in which the sides are substantially triangular in shape, and the height of a portion adjacent to the central depression line 410 is increased and the height of a portion spaced apart from the central depression line 410 is reduced . Accordingly, each depression becomes deeper toward the central depression, and the capillary force due to the capillary phenomenon is strengthened, so that the guide of the separated plasma can be promoted.

Preferably, the central depression line 410 is formed such that the depth of the central portion is deeper than the depth of the outer portion.

That is, it means that the size of B1 shown in FIG. 8 is larger than B2. In other words, it means that the height of the protruding portion disposed at the central portion and the depth of the depressed portion are larger than the height of the protruding portion disposed at the outer portion and the depth of the depressed portion . Accordingly, the depth of the center portion of the central depression line 410 is formed deeper than the depth of the outer portion, and the capillary force due to the capillary phenomenon is strengthened, so that the guide of the separated plasma can be promoted. In addition, the space in which the separated plasma is filled can be sufficiently secured and the separation of the plasma can be promoted.

Hereinafter, each means for performing the flow of blood, plasma, air, etc. injected into the chamber part 220 or discharged from the chamber part 220 will be described.

The blood injection port may include a blood injection hole 234 formed outside the chamber 220 and a chamber injection hole 234 connected to the blood injection hole 234 and formed in the chamber 220. [ (232).

A blood injection hole 234 formed as a predetermined hole is formed outside the chamber 220. In addition, a chamber injection hole 232 for injecting blood into the chamber 220 is formed in the chamber 220. The blood injection hole 234 and the chamber injection hole 232 are connected to each other so that blood injected through the blood injection hole 234 can be injected into the chamber portion 220 through the chamber injection hole 232 have. That is, the blood injection hole 234 and the chamber injection hole 232 may be connected to each other to form a predetermined injection line.

At this time, a predetermined injection structure 230 may be disposed around the blood injection hole 234 to facilitate blood injection through a predetermined mechanism. In addition, the chamber injection hole 232 is disposed inside the chamber 220, and blood injected through the chamber injection hole 232 is contained in the upper part of the filter 500, And may be located in the upper part of the chamber part 220 so as to be performed. 5, the chamber injection hole 232 is located in the upper part of the chamber part 220 so that the blood injected through the chamber injection hole 232 flows onto the filter 500 to be separated Can be performed.

6, the middle plate 200 includes a blood injection channel 236 formed of a predetermined recess formed on a lower surface thereof, and the blood injection hole 234 and the chamber injection The hole 232 penetrates at least a portion of the middle plate 200 and the blood injection channel 236 is configured to connect the blood injection hole 234 and the chamber injection hole 232.

That is, the blood injection hole 234 and the chamber injection hole 232 are formed as through holes passing through a part of the upper and lower surfaces of the middle plate 200, And a blood injection channel 236 formed by a predetermined recess connecting the chamber injection hole 232 may be formed. The blood injected through the blood injection hole 234 may flow along the blood injection channel 236 and then be injected into the chamber 220 through the chamber injection hole 232.

7, the lower plate 300 has an auxiliary blood injection channel 320 formed on the upper surface thereof and formed at a position corresponding to the blood injection channel 236. [ That is, the lower plate 300 may have an auxiliary blood injection channel 320 coupled to a lower portion of the middle plate 200 and formed with a predetermined recess. The auxiliary blood injection channel 320 may be coupled to the blood injection channel 236 formed in the middle plate 200 to form a channel such as a predetermined pipe. That is, it can be understood that the recesses formed in the middle plate 200 and the lower plate 300 are combined with each other to form a structure like a predetermined pipe.

The flow of blood according to the above configuration is the same as the arrow S shown in Fig. That is, blood injected through the blood injection hole 234 flows through the blood injection channel 236 and is injected into the chamber part 220 through the chamber injection hole 232.

A predetermined first projection or a first groove 238 surrounding the blood injection channel 236 is formed on the outer side of the blood injection channel 236. The lower plate 300 is formed on the upper surface And a second groove portion or a second projection portion 322 formed to correspond to the first projection or the second groove and closely contacting the first projection or the first projection 238 is formed. Although only the first groove portion 238 and the second projection portion 322 are shown in the drawing, it goes without saying that the reverse is also possible.

That is, as shown in FIG. 6, a predetermined first protrusion or first groove 238 surrounding the blood injection channel 236 may be provided on the lower surface of the middle plate 200. 7, a predetermined second groove portion or second projection portion 322 which is in close contact with the first projection portion or the first groove portion 238 corresponding to the first projection portion or the first projection portion 238, And may be formed on the lower plate 300. Accordingly, when the upper plate 100 and the lower plate 300 are closely contacted with each other, the coupling between the protrusions and the groove is achieved and thus the blood injection channel 236 and the auxiliary blood injection channel 320 can be sealed . Accordingly, blood can be prevented from leaking through the blood injection channel 236. Preferably, the first protrusion or first groove portion 238 and the second groove portion or the second protrusion 322 may be adhered to each other through a predetermined ultrasonic wave.

Preferably, the plasma outlet has a chamber discharge hole 242 formed in the chamber portion, and a plasma discharge hole 244 connected to the chamber discharge hole 242 and formed outside the chamber portion.

The plasma outlet basically has a structure similar to that of the blood inlet. A plasma discharge hole 244 formed in a predetermined hole is formed outside the chamber 220 and a chamber discharge hole 244 for discharging plasma in the chamber 220 242 are formed. The plasma discharge hole 244 and the chamber discharge hole 242 are connected to each other so that plasma separated through the filter 500 can be discharged to the outside of the chamber 220. That is, the plasma discharge hole 244 and the chamber discharge hole 242 may be connected to each other to form a predetermined discharge line.

At this time, a predetermined discharge structure 240 may be disposed around the plasma discharge hole 244 to facilitate plasma discharge through a predetermined mechanism. The chamber discharge hole 242 is disposed inside the chamber 220 and the chamber discharge hole 242 is formed in the chamber part 220 so that plasma can be easily discharged through the chamber discharge hole 242. [ As shown in FIG. 5, the chamber discharge hole 242 is located in the lower part of the chamber 220, so that plasma discharged through the chamber discharge hole 242 can be easily discharged to the outside have. At this time, the position of the chamber discharge hole 242 may be the center of the central depression channel 410, and the depression may be the deepest area.

The plasma discharge hole 244 and the chamber discharge hole 242 may be formed in the middle plate 200. The plasma discharge hole 244 and the chamber discharge hole 242 may be formed in the middle plate 200, 200), and the plasma discharge channel (246) is configured to connect the plasma discharge hole (244) and the chamber discharge hole (242).

That is, the plasma discharge hole 244 and the chamber discharge hole 242 are formed as through holes passing through a part of the upper and lower surfaces of the middle plate 200, and the plasma discharge holes A plasma discharge channel 246 formed by a predetermined recess connecting the chamber discharge hole 242 and the chamber discharge hole 242 may be formed. Accordingly, the plasma discharged through the chamber discharge hole 242 flows along the plasma discharge channel 246 and may be discharged to the outside through the plasma discharge hole 244.

The flow of the plasma according to the above configuration is the same as the arrow T shown in Fig. That is, plasma discharged through the chamber discharge hole 242 flows through the plasma discharge channel 246 and is injected into the chamber part 220 through the plasma discharge hole 244. [

Preferably, the lower plate 300 has an auxiliary plasma discharge channel 342 formed on the upper surface thereof and formed at a position corresponding to the plasma discharge channel 246. That is, the lower plate 300 may have an auxiliary plasma discharge channel 342 coupled to the lower portion of the middle plate 200 and formed as a recess. The auxiliary plasma discharge channels 342 may be coupled to each other in correspondence with the plasma discharge channels 246 formed in the middle plate 200 to form a line as a predetermined pipeline. That is, it can be understood that the recesses formed in the middle plate 200 and the lower plate 300 are combined with each other to form a structure like a predetermined pipe.

At this time, a predetermined auxiliary channel 344 may be formed in the auxiliary plasma discharge channel 342. The auxiliary channel 344 extends in the direction in which the plasma flows. That is, the auxiliary channel 344 extends from the chamber discharge hole 242 toward the plasma discharge hole 244. As the auxiliary channel 344 is provided, the movement of the plasma is promoted, so that the plasma can easily flow and be discharged.

In addition, the plasma discharge channel 246 and the auxiliary plasma discharge channel 342 may have a shape having a rounded shape that is not a polygonal shape. Therefore, the plasma can easily flow without being gathered at the corner portion and adsorbed or solidified.

A third recessed portion or a third recessed portion 248 surrounding the plasma discharge channel 246 is formed on the outer side of the plasma discharge channel 246. The lower plate 300 is formed on an upper surface Or a fourth groove portion or a fourth projection portion 342 formed in correspondence with the third or fourth groove portion and closely in contact with the third projection or the third projection 248 is formed. Although only the third groove portion 248 and the fourth projection portion 342 are shown in the drawing, it goes without saying that the reverse is also possible.

6 and 7, the middle plate 200 may be provided at its lower surface with a predetermined third projection or a third groove 248 surrounding the plasma discharge channel 246. As shown in FIG. A predetermined fourth groove portion or fourth projection portion 342 which is in close contact with the third or third groove portion 248 corresponding to the third or third groove portion 248 is formed on the lower plate 300 . Accordingly, when the upper plate 100 and the lower plate 300 are closely contacted with each other, the coupling between the projections and the groove is achieved and thus the plasma discharge channel 246 and the auxiliary plasma discharge channel 342 can be sealed . Whereby blood can be prevented from leaking through the plasma discharge channel 246. Preferably, the third or fourth groove portion 248 and the fourth groove portion or the fourth projection portion 342 can be bonded and bonded to each other through a predetermined ultrasonic wave.

The flow of plasma according to the above-described structure can be performed as shown in FIG. That is, the blood Y contained in the chamber part 220 above the filter 500 is separated through the filter 500, and the plasma flows as indicated by the downward arrow E. At this time, the plasma passes through the arrow F As shown in FIG. Accordingly, the plasma is mainly collected in the central part of the chamber part 220, and thus can flow in the downward direction G along the plasma discharge hole 244.

On the other hand, as described above, the flow of blood plasma and blood do not limit the direction. That is, not only the blood injected through the upper part of the middle plate 200 is separated and the plasma flows in the upper direction of the middle plate 200, and the blood injected into the upper part of the middle plate 200 And the plasma may be discharged downward. In this case, the plasma discharge hole 244 may be formed in the lower plate 300, or may be formed in a horizontal direction with respect to the middle plate 200.

Preferably, the middle plate 200 has an air inlet for discharging the air in the chamber 220 to the outside.

That is, as the blood is injected into the chamber part 220 and the blood is separated and the plasma is filled in the lower part of the filter 500, the air introduced into the chamber part 220, Can be formed. The upper outlet 140 formed in the upper plate 100 and the air inlet are different from each other in that the upper outlet 140 discharges air in a space above the filter 500, And the air is injected into the space below the filter 500 filled with the plasma separated by the filter 500.

The air inlet may include a first air inlet hole 252 formed in the chamber portion 220 and a second air inlet hole 252 formed in the outside of the chamber portion 220, And has an air injection hole 250.

The basic configuration of the air inlet is similar to the plasma outlet described above. That is, a predetermined first air injection hole 252 is formed in the chamber part 220, a second air injection hole 250 is formed outside the chamber part 220, and the first air injection hole 252, And the second air injection hole 250 are connected to each other.

The difference is that the chamber discharge hole 242 is formed on the lower surface of the center of the chamber 220 where the plasma is intensively collected so that the plasma can be easily discharged, Is located at the upper part of the part (220). At this time, however, the filter 500 should be located in the lower space, and accordingly, it is preferably formed in the depression located on the relatively outer side as shown in FIG.

Preferably, a hydrophobic coating is formed on the inner surface of the first air injection hole 252 to prevent the flow of plasma or the like. Therefore, it is possible to prevent the separated plasma from being unnecessarily discharged through the first air injection hole 252 despite the fact that the first air injection hole 252 is located in the chamber part 220.

Preferably, the middle plate 200 includes an air injection channel 254 formed of a predetermined recess formed on a lower surface thereof, and the first air injection hole 252 and the second air injection hole 250, And the air injection channel 254 is configured to connect the first air injection hole 252 and the second air injection hole 250. In addition,

Preferably, the lower plate 300 has an auxiliary air injection channel 330 formed on the upper surface thereof and formed at a position corresponding to the air injection channel 254.

A predetermined fifth protruding portion or a fifth groove portion 256 surrounding the air injection channel 254 is formed on the outer side of the air injection channel 254, And a sixth groove portion or a sixth projection portion 332 formed in correspondence with the fifth or sixth groove portion and in close contact with the fifth or fifth groove portion 256 are formed.

The configuration is similar to the air injection channel 254 described above. That is, the second air injection hole 250 and the first air injection hole 252 are formed as through holes passing through a part of the upper and lower surfaces of the middle plate 200, An air injection channel 254 formed by a predetermined recess connecting the second air injection hole 250 and the first air injection hole 252 may be formed.

In addition, the lower plate 300 may have an auxiliary air injection channel 330 coupled to a lower portion of the middle plate 200 and formed with a predetermined recess. The auxiliary air injection channel 330 may be coupled to the air injection channel 254 formed in the middle plate 200 to form a line like a predetermined pipe. That is, it can be understood that the recesses formed in the middle plate 200 and the lower plate 300 are combined with each other to form a structure like a predetermined pipe.

The air flow inside the chamber part 220 according to the above configuration is as shown in FIG. That is, the external air injected through the second air injection hole 250 can be injected into the chamber part 220 through the first air injection hole 252. At this time, the first air injection hole 252 and the second air injection hole 250 flow through a predetermined line L and the direction thereof is indicated by an arrow H. Accordingly, when the plasma is discharged through the chamber discharge hole 242, the empty space that can be generated is filled with air, so that the flow of the plasma can be facilitated.

In FIG. 6, the flow direction of the air is indicated by the arrow T. FIG. That is, the air in the chamber discharged through the first air injection hole 252 flows through the air injection channel 254 and is discharged to the outside through the second air injection hole 250.

Further, as shown in the drawing, a predetermined fifth protrusion or a fifth groove 256 surrounding the air injection channel 254 may be provided on the lower surface of the middle plate 200. A predetermined sixth groove portion or sixth projection portion 332 which closely contacts the fifth protrusion or the fifth groove portion 256 corresponding to the fifth protrusion or the fifth groove portion 256 is formed in the lower plate 300 . Accordingly, when the upper plate 100 and the lower plate 300 are closely contacted with each other, the coupling between the protrusions and the groove is achieved, thereby sealing the air injection channel 254 and the auxiliary air injection channel 330 . Accordingly, blood can be prevented from leaking through the air injection channel 254. Preferably, the fifth protrusion or the fifth groove portion 256 and the sixth groove portion or the sixth protrusion 332 may be bonded and bonded to each other through a predetermined ultrasonic wave. Although only the fifth groove portion 256 and the sixth projection portion 332 are shown in the figure, it goes without saying that the fifth groove portion 256 and the sixth projection portion 332 may be reversed.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, It should be understood that various modifications may be made by those skilled in the art without departing from the spirit and scope of the present invention.

1: Plasma separator
100: top plate
110:
112: Plate
114: first wall portion
116:
120: upper chamber
130: Support
140: upper outlet
200: Middle plate
210:
212:
214: second wall portion
216:
218:
220: chamber part
222: Lower chamber part
224: upper chamber part
230: injection structure
232: chamber injection hole
234: blood injection ball
236: blood injection channel
238: first groove
240: Exhaust structure
242: chamber discharge hole
244: Plasma Exhaust Ball
246: plasma release channel
248: third groove
250: second air injection hole
252: first air injection hole
254: air injection channel
256: fifth groove
300: lower plate
310: Body
312:
320: Auxiliary blood injection channel
322:
330: auxiliary air injection channel
332: sixth projection
342: fourth projection
342: Auxiliary plasma release channel
400: separation pattern portion
410: central depression line
420: first pattern portion
422: second protrusion
424: first depression
430: second pattern portion
432: second projection
434: second depression
500: filter

Claims (24)

In the plasma separation apparatus,
A middle plate having a chamber part in which blood is filled and a predetermined filter is seated;
An upper plate disposed on the middle plate and covering the chamber section;
A lower plate disposed below the middle plate and covering the lower portion of the middle plate; / RTI >
A blood injection port for injecting blood into the chamber part is provided on one side of the middle plate,
A plasma discharge port through which plasma separated from the blood is discharged to the outside of the chamber is provided on one side of the middle plate,
An air inlet is provided on one side of the middle plate,
Wherein the chamber portion has a recessed region in which the filter is seated and a second wall portion surrounding the recessed region,
Wherein a separation pattern portion on which the filter is seated is formed on a bottom surface of the recessed region of the chamber portion, the second wall portion has depressed portions depressed outwardly at an upper position than the recessed region,
Wherein the separation pattern portion comprises:
A plurality of protrusions contacting the at least one portion of the filter to support the filter,
A plurality of depressions formed between the protrusions and having a space for guiding the separated plasma are formed,
The blood-
A blood injection hole formed on the outside of the chamber part and formed as a hole penetrating the middle plate in a vertical direction,
A chamber injection hole formed in the chamber portion and formed in a hole penetrating the middle plate in a vertical direction, and
And a blood injection channel which is composed of a recess formed on a lower surface of the middle plate and connects the blood injection hole and the chamber injection hole,
Wherein the chamber injection hole is formed in the depression portion of the second wall portion so that blood injected through the chamber injection hole is contained in the upper portion of the filter,
Wherein the plasma outlet comprises:
A chamber discharge hole formed in the chamber portion and configured to pass through the middle plate in a vertical direction,
A plasma discharge hole formed outside the chamber portion, the plasma discharge hole being composed of a hole penetrating the middle plate in a vertical direction, and
And a plasma discharge channel formed of a recess formed on a lower surface of the middle plate and connecting the chamber discharge hole and the plasma discharge hole,
Wherein the air injection port injects air into a space below the filter to be filled with plasma separated by the filter,
A first air injection hole formed in the chamber portion and vertically penetrating the middle plate,
A second air injection hole formed outside the chamber portion and passing through the middle plate in a vertical direction,
And an air injection channel formed of a recess formed on a lower surface of the middle plate and connecting the first air injection hole and the second air injection hole,
The lower plate,
An auxiliary blood injection channel formed on an upper surface of the blood injection channel and formed at a position corresponding to the blood injection channel, an auxiliary blood plasma discharge channel formed on an upper surface of the auxiliary blood injection channel and corresponding to the plasma discharge channel, An auxiliary air injection channel formed at a corresponding position,
When the middle plate and the lower plate are coupled,
Wherein the blood injection channel and the auxiliary blood injection channel are coupled to each other to flow blood,
Wherein the plasma discharge channel and the auxiliary plasma discharge channel are coupled to each other to flow plasma,
Wherein the air injection channel and the auxiliary air injection channel are coupled to each other to flow air. The method according to claim 1,
Wherein the separation pattern portion comprises:
A central depression line extending longitudinally in the central portion of the chamber,
And the protrusions and depressions are formed on both sides of the central depression line. The method of claim 2,
Wherein the separation pattern portion comprises:
The first pattern portion having a plurality of protrusions and recesses alternately formed and having a predetermined array, and a second pattern portion,
Wherein the first pattern portion and the second pattern portion are disposed on both sides of the central depression line with the central depression line interposed therebetween,
Wherein the first protrusion pattern and the second protrusion pattern are formed such that protrusions and depressions are alternately formed in a direction in which the central depression line extends. The method of claim 3,
Each protrusion of the first pattern portion,
Wherein each of the depressions of the second pattern portion comprises:
Wherein the central depression line is located opposite to the central depression line. The method of claim 2,
Each of the projections
Wherein a width of a portion adjacent to the central depression line is greater than a width of a portion spaced apart from the central depression line,
Wherein each of the depressions comprises:
And a width of a portion adjacent to the central depression line is smaller than a width of a portion spaced apart from the central depression line. The method of claim 2,
Each of the projections
A height of a portion adjacent to the central depression line is greater than a height of a portion spaced apart from the central depression line,
Wherein each of the depressions comprises:
Wherein a depth of a portion adjacent to the central depression line is greater than a depth of a portion spaced apart from the central depression line. The method of claim 2,
The central depression line,
Wherein the depth of the central portion is deeper than the depth of the outer portion. The method of claim 2,
In each of the depressions,
And a microchannel extending in the direction of the central depression is formed. The method according to claim 1,
On the inner periphery of the chamber portion,
Wherein a seating surface for seating a predetermined filter is formed. The method of claim 9,
A coupling frame disposed on the seating surface,
And a filter is disposed between the coupling frame and the seating surface to fix the filter. delete delete delete The method according to claim 1,
On the outside of the blood injection channel,
A predetermined first projection portion or a first groove portion surrounding the blood injection channel is formed,
Wherein the lower plate is formed on the upper surface and is formed so as to correspond to the first projection or the second projection and has a second projection or a second projection which is in close contact with the first projection or the first projection. delete delete delete The method according to claim 1,
On the outside of the plasma discharge channel,
A predetermined third projection portion or a third groove portion surrounding the plasma discharge channel is formed,
Wherein the lower plate is formed on the upper surface and is formed so as to correspond to the third projected portion or the third projected portion and has a fourth groove portion or a fourth projected portion in intimate contact with the third projected portion or the third projected portion. delete delete The method according to claim 1,
The first air injection hole is formed in the first air injection hole,
And a hydrophobic coating is formed on the inner surface to prevent the flow of plasma or the like. delete delete The method according to claim 1,
On the outside of the air injection channel,
A predetermined fifth protruding portion or a fifth groove portion surrounding the air inlet channel is formed,
Wherein the lower plate is formed on the upper surface and is formed so as to correspond to the fifth projected portion or the fifth trough and has a sixth trough or a sixth trough formed in close contact with the fifth projected portion or the fifth trough.

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