KR101503272B1 - Multi-modal imaging device for arthritis diagnosis - Google Patents

Abstract

The present invention relates to a multi-mode optical imaging apparatus capable of acquiring three images including a color image, a laser speckle image, and a red-blood image. More specifically, the present invention relates to a multi- A light source for a large image and a white light source for an erythema image having a wavelength of 400 to 700 nm are mounted respectively and a diffuser is mounted on the other end of the two optical fibers, a beam splitter is positioned below a lens of a CCD camera as a detector, The present invention relates to a multimode optical imaging apparatus for diagnosing arthritis, which is capable of diagnosing arthritis more accurately, easily, quickly and quantitatively.
A multimode optical imaging apparatus of the present invention includes: a light source for a laser speckle image, which is mounted at one end of a first optical fiber transmission body and emits laser light of an infrared or near infrared ray wavelength band to a first optical fiber transmission body; A light source for erythema images, which is mounted at one end of the second optical fiber transmission body and emits white light having a wavelength range of 400 to 700 nm to the second optical fiber transmission body; An optical diffuser for diffusing and irradiating the laser light incident through the first optical fiber transmission body or the white light incident through the second optical fiber transmission body; A first polarizer located next to the optical diffuser, the first polarizer being positioned horizontally in line with the optical diffuser and linearly polarizing the light emitted from the optical diffuser; A second polarizer disposed next to the first polarizer and positioned horizontally in line with the first polarizer, for emitting light incident from the first polarizer onto a sample on the sample stage, A beam splitter for outputting to a 2 polarizer; A second polarizer positioned above the beam splitter, the second polarizer being positioned to be perpendicular to the beam splitter and linearly polarizing the light incident from the beam splitter; And a camera positioned above the second polarizer, the imaging lens being positioned so as to be perpendicular to the second polarizer, and detecting the image through the imaging lens, the light incident from the second polarizer .

Description

[0001] Multi-modal imaging device for arthritis diagnosis [

The present invention relates to a multi-mode optical imaging apparatus capable of acquiring three images including a color image, a laser speckle image, and a red-blood image. More specifically, the present invention relates to a multi- A light source for a large image and a white light source for an erythema image having a wavelength of 400 to 700 nm are mounted respectively and a diffuser is mounted on the other end of the two optical fibers, a beam splitter is positioned below a lens of a CCD camera as a detector, The present invention relates to a multimode optical imaging apparatus for diagnosing arthritis, which is capable of diagnosing arthritis more accurately, easily, quickly and quantitatively.

Rheumatoid arthritis is a chronic inflammatory disease of unknown origin characterized by multiple arthritis. Initially, the synovial membrane that encircles the joint is inflamed, but the cartilage and bone are gradually inflated to cause destruction and deformation of the joints. As well as the joints, the joint symptoms include anemia, dry syndrome, subcutaneous nodule, pulmonary fibrosis, , Skin ulceration, and the like.

An important feature of rheumatoid arthritis is pain and swelling of the involved joint. Rheumatoid arthritis affects the middle and palms of the fingers, and the joints of the fingertip tend not to invade well. Involuntary joints are painful when touched, limited in movement, accompanied by erythema of the palms, obstacles to bending the wrists backward, difficulty in flexing the fingers, and inability to hold the fist tightly. It helps to understand disease activity and progress.

Tests for rheumatoid arthritis include blood tests, liver function tests, renal function tests, and rheumatoid factor tests.

In the rheumatoid factor test, rheumatoid factor is positive only in 80% of patients with rheumatoid arthritis, and 7% in normal people can be positive. Therefore, it can not be diagnosed as rheumatoid arthritis.

 General blood tests, liver function tests, and kidney function tests are mainly used to monitor the side effects of treatments or other organ invasion.

 Currently, X-ray, CT, ultrasound imaging, MRI, and nuclear medicine imaging are used as diagnostic techniques for rheumatoid arthritis. Recently, optical techniques have been studied for the diagnosis of arthritis.

In recent years, optical techniques such as transillumination images, diffuse optical images, fluorescence images, bioluminescence images, and photoacoustic images have been studied for the diagnosis of arthritis.

Generally, a laser speckle image is a technique for acquiring scattered light generated when a laser is irradiated on a living tissue through a detector such as a CCD camera, and then measuring the blood flow through image processing. Shape and perfusion imaging, and in particular provides various information of a living tissue through image acquisition of a region where blood vessels are distributed. However, it has not yet been applied to arthritic diagnostic devices.

Japanese Unexamined Patent Application Publication No. 2009-95350 discloses an apparatus for detecting an image in a human body using a laser speckle. However, the laser beam is emitted to the fundus and reflected from the retinal vessels of the fundus and the blood vessel layer of the internal fundus The light is image-formed as a laser speckle on an image sensor using an optical system. The amount of change in the amount of light received in each pixel of the laser speckle is calculated, and the two- And a personal authentication method and apparatus for comparing and checking personal data registered in advance by using blood flow distribution data or the like observed in a blood flow map.

Japanese Unexamined Patent Publication No. 2009-95350 is not an apparatus for diagnosing arthritis and therefore does not have a configuration for detecting color images and erythema images and does not have a rotatable polarizer and is more accurate, Quantitative diagnosis is not possible.

SUMMARY OF THE INVENTION It is an object of the present invention to provide a multimode optical imaging apparatus for diagnosing arthritis which is capable of acquiring three images of a color image, a laser speckle image, and a erythema image.

Another object of the present invention is to provide a method of manufacturing an optical fiber having a light source for a laser speckle image in an infrared or near infrared ray wavelength band and a white light source for an erythema image in a wavelength region of 400 to 700 nm respectively mounted on one end of two optical fibers, A multi-mode optical imaging apparatus for diagnosing arthritis is provided in which a beam splitter for positioning the optical axis and the image axis in a straight line and minimizing noise is positioned below a lens of a CCD camera as a detector .

Another problem to be solved by the present invention is to provide a polarizer capable of precisely acquiring information inside the skin by removing reflection of a sample surface, being positioned at a front end of a diffuser and a lens, wherein the polarizer is rotatable, Mode imaging apparatus capable of acquiring polarized images at 90 degrees, and for diagnosing arthritis.

In order to solve the above problems, a multi-mode optical imaging apparatus of the present invention is a multi-mode optical imaging apparatus, which is mounted at one end of a first optical fiber transmission body and emits a laser light of an infrared or near infrared ray wavelength band to a first optical fiber transmission body, ; A light source for erythema images, which is mounted at one end of the second optical fiber transmission body and emits white light having a wavelength range of 400 to 700 nm to the second optical fiber transmission body; An optical diffuser for diffusing and irradiating the laser light incident through the first optical fiber transmission body or the white light incident through the second optical fiber transmission body; A first polarizer located next to the optical diffuser, the first polarizer being positioned horizontally in line with the optical diffuser and linearly polarizing the light emitted from the optical diffuser; A second polarizer disposed next to the first polarizer and positioned horizontally in line with the first polarizer, for emitting light incident from the first polarizer onto a sample on the sample stage, A beam splitter for outputting to a 2 polarizer; A second polarizer positioned above the beam splitter, the second polarizer being positioned to be perpendicular to the beam splitter and linearly polarizing the light incident from the beam splitter; And a camera positioned above the second polarizer, the imaging lens being positioned so as to be perpendicular to the second polarizer, and detecting the image through the imaging lens, the light incident from the second polarizer .

Also, the multimode optical imaging apparatus of the present invention may be configured such that an optical diffuser, a first polarizer, and a beam splitter are arranged in order of a laser beam having a wavelength of 600 to 900 nm and a white light having a wavelength of 400 to 700 nm, A beam splitter, a second polarizer, and an imaging lens are sequentially passed through the sample stage, and the light reflected by the sample of the sample stage and positioned so as to be vertically aligned is passed through the lens array in order to detect the image from the camera .

The first polarizer and the second polarizer are made rotatable.

The camera can acquire polarized images at 0 degrees, 45 degrees, and 90 degrees, and the camera is a CCD camera with a resolution of 1 million pixels or more.

The multimode optical imaging apparatus of the present invention includes an A / D converter for converting an image output to a camera into a digital signal; An arithmetic processing unit for receiving the image received from the A / D conversion unit and outputting the received image to the display unit; And a memory unit for storing the image received from the operation processing unit.

The sample on the sample stage is the area of the human body with arthritis.

The camera can shoot either color image, laser speckle image, or erythema image.

A light emitting diode is used as a light source for erythema imaging.

The present invention relates to a polarizer fixture having a cylindrical shape, a second polarizer mounted on the inner side, and a plurality of grooves on the outer lower side; A polariser support having a through hole on its inner side, a plurality of bearings on its inner wall, a plurality of bearings and a plurality of grooves of the polarizer fixture coupled to each other, the polarizer support being rotatably mounted; .

When the first polarizer and the second polarizer are in the same direction, the camera obtains an image polarized at zero, and when the directions of the first and second polarizers are orthogonal to each other, the camera obtains an image polarized at 90 degrees , And if the angular difference between the directions of the first and second polarizers is greater than when they are in the same direction and less than when they are orthogonal to each other, the camera is assumed to acquire an image polarized at 45 degrees.

In the present invention, only one of the light source for erythema image or the laser speckle image is driven. When the light source for the erythema image is driven, the camera detects the color image. When the light source for the laser speckle image is driven, The camera detects the laser speckle raw (unprocessed) image.

The color image detected by the camera is received by the arithmetic processing unit through the A / D conversion unit, and the arithmetic processing unit calculates the erythema index (EI) for each pixel of the received color image

(Where, R _g extracts the image of a green (Green) channel in a color image, and the normalized (normalized) value, R _r extracts the image of the red (Red) channel in a color image normalized (normalized) the value)

And outputs the erythema image as a erythema image, and the display unit displays the erythema image received from the operation processing unit.

The arithmetic processing unit receives the laser speckle raw (unprocessed) image detected by the camera through the A / D conversion unit, and the arithmetic processing unit performs arithmetic processing for each pixel of the received laser speckle raw (unprocessed) The Speckle Contrast

(Where _s is the standard deviation for the nine pixels surrounding each pixel, and < I > is the average intensity for the nine pixels surrounding each pixel)

And outputs the laser speckle image, and the display unit displays the laser speckle image output from the calculation processing unit.

According to the multimode optical imaging apparatus of the present invention, a light source for a laser speckle image of an infrared or near infrared ray wavelength band and a white light source for an erythema image of 400 to 700 nm are mounted on one end of two optical fibers, A beam splitter for positioning the optical axis and the image axis in a straight line and minimizing noise is positioned below the lens of the CCD camera as a detector, and a color image, a laser speckle image, It is possible to acquire three images of the image, so that arthritis can be diagnosed more accurately, easier, faster and quantitatively.

In the multimode optical imaging apparatus of the present invention, a polarizer for eliminating the reflection of the sample surface and allowing information to be accurately obtained inside the skin is disposed at the front end of the diffuser and the lens, and the polarizer is rotatable, It is possible to obtain polarized images of 0, 45, and 90 degrees, which enables more accurate diagnosis of arthritis.

In other words, the present invention is advantageous in that the image can be acquired for the arthritic lesion, and based on the obtained image, the visual inspection and morphological inspection, which are widely used in the existing diagnosis, can be diagnosed through the image.

The present invention can diagnose the severity of early diagnosis and lesion which was difficult to discriminate with the naked eye through laser speckle image and erythema image.

The present invention shortens the diagnosis time which has been taking a long time to a short time, and makes it possible to diagnose the prognosis more precisely according to the time according to the lesion treatment through quantitative diagnosis.

The present invention can acquire lesion images in various image modes, enabling more accurate diagnosis and quantitative analysis through image analysis.

The present invention is applicable not only to arthritis but also to diseases with similar prognosis.

FIG. 1 is a block diagram illustrating a schematic configuration of an apparatus for diagnosing arthritis using a multimode optical imaging apparatus according to an embodiment of the present invention. Referring to FIG.
2 is a photograph showing a rotating structure of the second polarizer.
Fig. 3 is an explanatory view for explaining the rotation structure of the second polarizer of Fig. 2;
FIG. 4 is an example of an image according to the angle of polarization using the rotating structure of the second polarizer.
5 is an example of a color image obtained by imaging the sole of a mouse using the multimode optical imaging apparatus of the present invention.
6 is a erythema image obtained by image processing of the color image of FIG.
7 is an example of a laser speckle raw image obtained by imaging the sole of a mouse using the multimode optical imaging apparatus of the present invention.
8 is a laser speckle image obtained by image processing of the laser speckle raw image of FIG.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a diagnostic apparatus for arthritis using a multimode optical imaging apparatus according to the present invention will be described in detail with reference to the accompanying drawings.

1 is a block diagram illustrating a schematic configuration of an arthritic diagnostic apparatus using a multimode optical imaging apparatus according to an exemplary embodiment of the present invention. Referring to FIG. 1, a light source 110 for a laser speckle image, a light source 130 for a red- A first polarizer 170, a beam splitter 190, a sample stage 200, a second polarizer 210, a camera 250, an arithmetic processing unit 310, and a display unit 320. The diffuser 150, the first polarizer 170, .

The light source 110 for the laser speckle image is a laser light source for acquiring a laser speckle image, and a laser of 600 to 900 nm is used as a light source in an infrared or near-IR wavelength range. The output of the light source 110 for the laser speckle image is transmitted through the first optical fiber transmitter 281.

A light source 130 for erythema images is a white light source for acquiring erythema images, and a light source is a light emitting diode (LED) of 400 to 700 nm. The output of the light source 130 for the erythema image is transmitted through the second optical fiber transmitter 282.

The first optical fiber transmission body 281 and the second optical fiber transmission body 282 are bundled into one bundle and connected to the optical diffusers 150. The optical fiber transmission body 290 includes a first optical fiber transmission body 281 and a second optical fiber transmission body 282. In other words, a light source 110 for a laser speckle image is provided at the end of a 2x1 optical fiber bundled with two optical fibers so that two light sources including a laser speckle image light source 110 and a red light image light source 130 can be irradiated. And a light source 130 for erythema image are connected.

The light diffuser 150 diffuses the light incident from the light source 110 for laser speckle image and the light source for eraser 130 as a means for uniformly irradiating the light source to a wide area. That is, the optical diffuser 150 is located at the end of the optical fiber transmission body 290, as means for making the light source incident on the sample on the sample stage 200 uniform.

The first polarizer 170 is a linear polarizer, positioned next to the optical diffuser 150, and linearly polarizes the light that has passed through the optical diffuser 150. The shape of light passing through the first polarizer 170 is diverged in the form of linearly polarized light and receives the light from the optical diffuser 150 to generate a beam polarized in the horizontal direction. The first polarizer 170 allows only one direction of polarized light to coincide with the polarization direction.

Polarizers 170 and 210 used in the present invention are not in a fixed form but in a rotatable form, which means that the angle of polarization can be changed without being fixed. The polarization direction of the two polarizers 170 and 210 is assumed to be 0 degree when the polarization directions of the two polarizers 170 and 210 are the same direction. And the middle between them is 45 degrees.

A beam splitter 190 emits the horizontal beam incident on the first polarizer 170 to the sample stage 200. The beam splitter 190 reflects the incident light (vertical beam) from the sample stage 200 and outputs it to the second polarizer 210. The beam splitter 190 is positioned below the imaging lens 230 to minimize noise with the optical axis and the image axis aligned.

Light incident on the sample stage 200 through the beam splitter 190 in the first polarizer 170 is reflected from the sample and is transmitted through the beam splitter 190 to the second polarizer 170. [ Lt; / RTI &gt;

The second polarizer 210 transmits the light reflected from the sample stage 200 through the beam splitter 190 to the imaging lens 230 of the camera 250 to detect an image. The second polarizer 210 is made rotatable, which means that the angle of polarization can be changed without being fixed, and the polarization direction is different depending on the polarization angle.

The first polarizer 170 and the second polarizer 210 are used to precisely obtain information inside the skin by eliminating the reflection of the sample surface. And the second polarizer 210 is positioned at the front end of the image-forming lens 230. The first polarizer 170 and the second polarizer 210 are rotatable, and polarized images of 0, 45, and 90 degrees can be obtained.

In other words, when the first polarizer 170 is fixed and the second polarizer 210 is rotatable, and when the polarization directions of the first polarizer 170 and the second polarizer 210 are set to the same direction, And 90 degrees when the directions of the two polarizers are orthogonal to each other, and 45 degrees between the two polarizers.

The camera 250, which is a detector, is composed of a CCD camera and detects light incident through the second polarizer 210. The camera 250 includes an image-forming lens 230. The camera 250 captures an image from the light incident through the second polarizer 210. The camera 250 uses a CCD camera of high resolution (more than 1 million pixels) capable of acquiring a laser speckle image and a color image.

In the present invention, it is possible to acquire three images of color image, laser speckle image, and erythema image.

The A / D conversion unit (not shown) converts the image output from the camera 250 into a digital signal through an A / D conversion unit (not shown) and transmits the digital signal to the operation processing unit 310.

The key input unit (not shown) reads the values of the erythema detection mode or the laser speckle image detection mode set by the user, and transmits the values to the operation processing unit 310.

The arithmetic processing unit 310 stores the image received from the A / D converter (not shown), that is, the color raw image and the laser speckle raw image, in a memory unit (not shown) and outputs the image to the display unit 320 . The arithmetic processing unit 310 is also connected to an A / D converter (not shown) according to the value of the detection mode (erythema detection mode or laser speckle image detection mode) received from the key input unit (Color raw image, laser speckle raw image), stores the result in a memory unit (not shown), and outputs the result to the display unit 320.

When receiving the value of the erythema detection mode from the key input unit (not shown), the arithmetic processing unit 310 calculates the pixel value of the image (color image) received from the A / D converter (not shown) The image processing of the erythema image is performed by Equation (1).

EI (Erythema Index) indicates the erythema index, which indicates the degree of erythema. R _g is a normalized value obtained by extracting a green channel image from a color image, and R _r is a normalized value obtained by extracting a red channel image from a color image. R _g and R _r can be detected and stored at the beginning of use and stored at the factory.

In this way, the erythema index of each pixel is detected using Equation (1), and image processing represented by the image is performed to obtain the erythema image. The erythema image is an index indicating the degree of redness in the image. In the present invention, the erythema is used as a measure for measuring the degree of redness of the skin caused by inflammation reaction of the skin caused by arthritis.

When receiving the value of the laser speckle image detection mode from the key input unit (not shown), the operation processing unit 310 outputs the image of the image (laser speckle raw image) received from the A / D converter The image processing of the laser speckle image is performed on the pixel value using Equation (2).

C is the Speckle Contrast, σ _s is the standard deviation for the nine pixels surrounding each pixel, and <I> is the average intensity for the nine pixels surrounding each pixel. That is, in order to calculate the speckle contrast of each pixel, the standard deviation and the average intensity are calculated for nine pixels surrounding each pixel, and the speckle contrast is calculated using this value.

The speckle contrast of each pixel is detected using Equation (2), and image processing represented by an image is performed to obtain a laser speckle image. In the laser speckle image, the contrast value of the part where the blood vessel exists is displayed differently. Since the contrast value is displayed differently according to the flow of the blood flow, it is possible to check whether the blood vessel exists in the area , It will be used as a measure of how blood flow is flowing.

FIG. 2 is a photograph showing the rotation structure of the second polarizer, FIG. 3 is an explanatory diagram illustrating the rotation structure of the second polarizer of FIG. 2, and FIG. FIG.

The second polarizer 210 is fixed and mounted in a cylindrical polarizer fixing table as shown in FIG. 2 (a). FIG. 2 (b) is a polarizer support, which is rotatably mounted with a polarizer fixture on its inner side, and has a bearing. Fig. 2 (c) is an exemplary view in which the polarizer fixture is mounted on the polarizer support. That is, the polarizer support of FIG. 2 (b) is in the form of a bearing so that it can be rotated, and a groove like a trough is provided at the bottom of the outer surface of the polarizer fixture of FIG. 2 So that the bearing can be moved. As shown in FIG. 2 (c), polarized light can be acquired at 0, 45, and 90 degrees as the polarizer fixed base rotates. The rotation of the polariser fixture in the polariser support may be by manual or in conjunction with a motor (or an actuator).

More specifically, as shown in Fig. 3 (a), a bearing groove is provided in the polariser fixing table, and a bearing is provided in the polariser support, as shown in Fig. 3 (b), so that the two parts are engaged. When the polariser is rotated by a hand (or motor), the polariser is rotated as a result. The angles of 0, 45, and 90 are 0 degrees when the image is brightest (when the polarizations of the two polarizers are the same) and 0 degrees when the image is dark (when the polarizations of the two polarizers are orthogonal) And the median value thereof is 45 degrees.

4 (a) is an example of a 0-degree polarized image, FIG. 4 (b) is an example of a 45-degree polarized image, and FIG. 4 ) Is an example of a 90 degree polarized image.

The raw image obtained through the multimode optical imaging apparatus of the present invention is roughly classified into two types: raw image of color image and laser speckle. Among them, the color image can be obtained by subdividing into 0, 45, and 90 degree images by setting the angle of the polarizer when acquiring the image. It is possible to acquire erythema images through image processing of acquired color images.

The raw image of the laser speckle is also subjected to image processing to acquire the laser speckle image.

The multimode optical imaging apparatus of the present invention can simultaneously irradiate a laser beam (a light source for a laser speckle image) and a white light (a light source for a red blood image) at the same time. However, Light source), and only the laser light (the light source for the laser speckle image) is irradiated when acquiring the laser speckle image. The acquisition of color images, laser speckle images, and erythema images is the difference between whether they are acquired through image processing or directly by camera.

FIG. 5 is an example of a color image obtained by photographing the sole of a mouse using the multimode optical imaging apparatus of the present invention, and FIG. 6 is a erythema image obtained by image processing of the color image of FIG.

FIG. 5 is an image of the sole of a rat as a result of an experiment for applying the multimode optical imaging apparatus of the present invention to diagnosis of arthritis. This is a color image and the angle of polarization is 90 degrees, that is, Fig. 5 is a 90 degree polarized color image. FIG. 6 is a picture of the erythema obtained by image processing.

FIG. 7 is an example of a laser speckle raw image obtained by imaging the sole of a mouse using the multimode optical imaging apparatus of the present invention. FIG. 8 is a view showing a laser speckle raw image of FIG. It is a big image.

   5 and 7 are images obtained directly from the camera and not processed, and FIGS. 6 and 8 are images obtained through image processing.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, Modification is possible. Accordingly, it is intended that the scope of the invention be defined by the claims appended hereto, and that all equivalent or equivalent variations thereof fall within the scope of the present invention.

110: laser light source 130: white light source
150: optical diffuser 170: first polarizer
190: beam splitter 200: sample stage
210: second polarizer 230: imaging lens
250: camera 281: first optical fiber transmission body
282: second optical fiber transmission body 290: optical fiber transmission body
310: operation processing unit 320:

Claims (19)

A light source for a laser speckle image mounted on one end of the first optical fiber transmission body and emitting laser light of an infrared or near infrared ray wavelength band to a first optical fiber transmission body;
A light source for erythema images, which is mounted at one end of the second optical fiber transmission body and emits white light having a wavelength range of 400 to 700 nm to the second optical fiber transmission body;
An optical diffuser for diffusing and irradiating the laser light incident through the first optical fiber transmission body or the white light incident through the second optical fiber transmission body;
A first polarizer located next to the optical diffuser, the first polarizer being positioned horizontally in line with the optical diffuser and linearly polarizing the light emitted from the optical diffuser;
A second polarizer disposed next to the first polarizer and positioned horizontally in line with the first polarizer, for emitting light incident from the first polarizer onto a sample on the sample stage, A beam splitter for outputting to a 2 polarizer;
A second polarizer positioned above the beam splitter, the second polarizer being positioned to be perpendicular to the beam splitter and linearly polarizing the light incident from the beam splitter;
A camera positioned above the second polarizer, wherein the imaging lens is positioned so as to be perpendicular to the second polarizer, and wherein the light incident from the second polarizer detects the image through the imaging lens;
The multi-mode optical imaging apparatus of claim 1, A first polarizer, and a beam splitter, in which laser light in a wavelength range of 600 to 900 nm and white light in a wavelength range of 400 to 700 nm are aligned horizontally, and then emitted to a sample stage,
A first polarizer, and an image-forming lens, which are reflected from the sample of the sample stage and are positioned such that the incident light is vertically aligned, and the image is detected by the camera. Device. 3. The method according to any one of claims 1 to 3,
Wherein the first polarizer is fixed and the second polarizer is rotatable. The method of claim 3,
Wherein the camera is capable of acquiring polarized images at 0 degree, 45 degree, and 90 degree. 3. The method according to any one of claims 1 to 3,
Wherein the camera is a CCD camera of at least 1 million pixels. 3. The method according to any one of claims 1 to 3,
An A / D converter for converting an image output from the camera into a digital signal;
An arithmetic processing unit for receiving the image received from the A / D conversion unit and outputting the received image to the display unit;
Further comprising: a plurality of multi-mode optical imaging devices. The method according to claim 6,
And a memory unit for storing an image received from the operation processing unit. 3. The method according to any one of claims 1 to 3,
Wherein the sample of the sample stage is a human body region with arthritis. The method of claim 6, wherein
Wherein the camera captures any one of a color image, a laser speckle image, and a erythema image. The method according to claim 1,
And a light emitting diode is used as a light source for erythema imaging. The method of claim 3,
A polarizer fixture having a cylindrical shape, a second polarizer mounted on the inner side, and a plurality of grooves on the outer lower side;
A polariser support having a through hole on its inner side, a plurality of bearings on its inner wall, a plurality of bearings and a plurality of grooves of the polarizer fixture coupled to each other, the polarizer support being rotatably mounted;
Further comprising: a plurality of multi-mode optical imaging devices. The method of claim 3,
Wherein when the first polarizer and the second polarizer are in the same direction, the camera acquires a zero-polarized image. The method of claim 3,
Wherein when the directions of the first and second polarizers are orthogonal to each other, the camera acquires an image polarized at 90 degrees. The method of claim 3,
Wherein the camera acquires an image polarized at 45 degrees when the angular difference between the directions of the first and second polarizers is larger than when the directions are the same and less than when they are orthogonal to each other. The method according to claim 6,
A light source for erythema images or a light source for laser speckle images,
When the light source for the erythema image is driven, the camera detects the color image,
Wherein when the light source for the laser speckle image is driven, the camera detects the laser speckle raw (unprocessed) image. 16. The method of claim 15,
A color image detected by a camera is received by an arithmetic processing unit through an A / D conversion unit,
The arithmetic processing unit calculates an erythema index (EI) for each pixel of the received color image

(Where, R _g extracts the image of a green (Green) channel in a color image, and the normalized (normalized) value, R _r extracts the image of the red (Red) channel in a color image normalized (normalized) the value)
And outputs the erytheme image as an erythema image. 17. The method of claim 16,
And the display unit displays the erythema image received from the operation processing unit. 16. The method of claim 15,
The arithmetic processing unit receives the laser speckle raw (not processed) image detected by the camera through the A / D converter,
The arithmetic processing unit sets the speckle contrast (Speckle Contrast) for each pixel of the received laser speckle raw (unprocessed) image

(Where _s is the standard deviation for the nine pixels surrounding each pixel, and < I > is the average intensity for the nine pixels surrounding each pixel)
And outputs the detected laser speckle image as a laser speckle image. 19. The method of claim 18,
And the display unit displays the laser speckle image output from the operation processing unit.

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