KR101491854B1 - Apparatus and method for noninvasively measuring blood sugar level - Google Patents

Apparatus and method for noninvasively measuring blood sugar level Download PDF

Info

Publication number
KR101491854B1
KR101491854B1 KR20080081198A KR20080081198A KR101491854B1 KR 101491854 B1 KR101491854 B1 KR 101491854B1 KR 20080081198 A KR20080081198 A KR 20080081198A KR 20080081198 A KR20080081198 A KR 20080081198A KR 101491854 B1 KR101491854 B1 KR 101491854B1
Authority
KR
South Korea
Prior art keywords
blood vessel
blood
light
position
confocal
Prior art date
Application number
KR20080081198A
Other languages
Korean (ko)
Other versions
KR20100022614A (en
Inventor
오현호
심봉주
강선길
김무섭
구윤희
조성문
Original Assignee
엘지전자 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 엘지전자 주식회사 filed Critical 엘지전자 주식회사
Priority to KR20080081198A priority Critical patent/KR101491854B1/en
Publication of KR20100022614A publication Critical patent/KR20100022614A/en
Application granted granted Critical
Publication of KR101491854B1 publication Critical patent/KR101491854B1/en

Links

Images

Abstract

The present invention relates to an apparatus and a method for measuring non-invasive blood glucose, and more particularly, to an apparatus and method for measuring non-invasive blood glucose in blood vessels by detecting a blood vessel position and setting a confocal point to the detected blood vessel position, It is possible to accurately measure the amount of blood glucose of the subject to be examined, thereby improving the reliability.
In addition, since the non-invasive blood glucose measuring apparatus and method of the present invention can measure the blood glucose contained in the blood in the blood vessel, the blood glucose level of the subject can be accurately measured and the reliability can be improved.
Blood glucose, blood vessels, Raman, confocal, non-invasive

Description

[0001] Apparatus and method for measuring non-invasive blood glucose [

The present invention relates to a non-invasive blood glucose measurement apparatus and method capable of accurately measuring the blood glucose level of a subject.

Diabetes is one of the most common diseases of modern people. Even in the US alone, more than 5% of the total population is suffering from diabetes.

Diabetes is a hormone secreted by the pancreas is less secreted or not function properly, the sugar in the blood is transferred to the cells can not be used as energy and blood sugar accumulation in the blood, hypertension, kidney failure, vision damage can cause complications have.

Diet, exercise and drug therapy are being performed to manage the sugar in the blood. Knowing the exact amount of blood sugar on the basis of these therapies is basic.

The blood glucose measurement method most commonly used up to now is an electrochemical detection method using an enzyme called glucose oxidase (glucose oxidase). The blood stuck to the finger tip of the finger is put on an electrode having a pattern of glucose oxidase, The reduction potential is applied to measure the amount of current depending on the amount of glucose.

That is, as shown in FIG. 1, in the prior art, the fingertip was pierced by the blood-syringe 10 to draw blood, and blood glucose was measured.

In this way, the most accurate method of measurement after electrochemical measurement or optical measurement after blood sampling, patients suffering from chronic diabetic and diabetic complications are suffering from blood collection several times a day, It has a disadvantage that the strip must be continuously purchased.

Also, in case of a first diabetic patient who can not secrete insulin at all, it is necessary to check the change of blood glucose level for 24 hours for a certain period of time and determine the prescription such as drug or insulin injection.

Currently, the glucose concentration of the interstitial fluid in the tissue is measured continuously for about 3-5 days by using a continuous glucose monitoring system (CGMS), and the drug and insulin injection are prescribed by the change of the concentration .

In the case of a continuous blood glucose meter, since it measures the interstitial fluid in the tissue rather than directly measuring the glucose in the blood, it does not exactly match the pattern of change in blood glucose, has a certain time delay time, There is a disadvantage that the correction value must be input through the blood sampling method.

The present invention solves the problem of measuring pain and incorrect blood glucose value of a testee of the prior art.

According to a first aspect of the present invention,

A blood vessel image capturing section for capturing blood vessel images;

A blood vessel position extracting unit for extracting a blood vessel position from the blood vessel image photographed by the blood vessel image capturing unit;

A confocal Raman microscope for setting a position of a blood vessel extracted by the blood vessel position extracting unit as a confocal point, irradiating light at the blood vessel position, and acquiring a Raman scattered light spectrum in the blood vessel;

And a blood glucose value extracting unit for extracting a blood glucose value from the Raman scattered light spectrum of the blood vessel obtained in the confocal Raman microscope.

According to a second preferred aspect of the present invention,

A blood vessel position extracting unit for extracting a blood vessel position from a blood vessel image;

A blood vessel image in the skin is photographed to output the blood vessel image to the blood vessel position extracting unit, the blood vessel position extracted by the blood vessel position extracting unit is set as the confluent, the light is irradiated to the blood vessel position, A confocal Raman microscope for obtaining a catered light spectrum;

And a blood glucose value extracting unit for extracting a blood glucose value from the Raman scattered light spectrum of the blood vessel obtained in the confocal Raman microscope.

According to a third aspect of the present invention,

Capturing an image of the blood vessel inside the skin in the blood vessel image capturing unit;

Extracting a blood vessel position for measuring blood glucose in a blood vessel image photographed by the blood vessel image capturing unit by a blood vessel position extracting unit;

Setting a position of the blood vessel extracted by the blood vessel position extracting unit as confocal in a confocal Raman microscope;

Irradiating light at the blood vessel location in the confocal Raman microscope and obtaining a Raman scattered light spectrum in the blood vessel;

And extracting a blood glucose value from the blood glucose value extracting unit with the Raman scattered light spectrum of the blood vessel obtained in the confocal Raman microscope.

According to a fourth aspect of the present invention,

Photographing a blood vessel image inside the skin in a confocal Raman microscope;

Extracting a blood vessel position from the blood vessel image photographed by the blood vessel position extracting unit;

Setting a position of a blood vessel extracted by the blood vessel position extracting unit as confocal in the confocal Raman microscope;

Irradiating light at the blood vessel location in the confocal Raman microscope and obtaining a Raman scattered light spectrum in the blood vessel;

And extracting a blood glucose value from the blood glucose value extracting unit with the Raman scattered light spectrum of the blood vessel obtained in the confocal Raman microscope.

The present invention can extract blood glucose contained in the blood within the blood vessel by detecting the blood vessel position and setting the confocal point to the detected blood vessel position to acquire the Raman scattered light spectrum only in the blood vessel, And the reliability can be improved.

Further, since blood glucose can be measured without blood collection, the present invention has the effect of eliminating the suffering of the subject due to blood collection.

In addition, since the present invention can measure the blood glucose contained in the blood in the blood vessel, the blood glucose level of the subject can be accurately measured and the reliability can be improved.

In addition, the present invention can measure an accurate blood glucose value by measuring the blood glucose value using the blood vessel information, and has an effect of making a prescription suitable for the examinee according to the accurate blood sugar value.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings.

FIG. 2 is a schematic diagram for explaining a non-invasive blood glucose measurement apparatus according to the first embodiment of the present invention. The non-invasive blood glucose measurement apparatus of the first embodiment includes a blood vessel image capturing unit (100); A blood vessel position extracting unit 110 for extracting a blood vessel position from a blood vessel image photographed by the blood vessel image capturing unit 100; A confocal Raman microscope (120) for setting the position of the blood vessel extracted from the blood vessel position extraction unit (110) to confocal, irradiating light at the blood vessel position, and acquiring a Raman scattered light spectrum in the blood vessel; And a blood glucose value extractor 130 for extracting a blood glucose value from the Raman scattered light spectrum of the blood vessel obtained in the confocal Raman microscope 120.

Therefore, the non-invasive blood glucose measuring apparatus of the present invention detects blood vessel position and sets the confocal point to the detected blood vessel position to acquire a Raman scattered light spectrum only in the blood vessel, thereby extracting blood glucose contained in the blood in the blood vessel The blood glucose level of the examinee can be accurately measured, and the reliability can be improved.

The operation of the non-invasive blood glucose measurement apparatus of the present invention will now be described. First, the blood vessel image capturing unit 100 captures an image of a blood vessel within a specific skin area.

Here, the blood vessel image capturing unit 100 may be a blood vessel image capturing unit that captures an image of a blood vessel using one of confocal microscopy, ultrasound, and magnetic resonance imaging (MRI).

Then, the blood vessel position extraction unit 110 extracts the blood vessel position from the blood vessel image photographed by the blood vessel image capturing unit 100.

At this time, the blood vessel preferably has a thickness of 50 mu m or more.

If the depth from the skin surface to the blood vessel and the diameter of the blood vessel are obtained from the blood vessel image photographed by the blood vessel image capturing unit 100, the blood vessel position can be extracted.

Then, the confocal Raman microscope 120 sets the position of the blood vessel extracted from the blood vessel position extracting unit 110 as confluent, irradiates light at the blood vessel position, and outputs the Raman scattered light spectrum .

Here, since the blood vessel position is set as the confocal, the confocal Raman microscope 120 can obtain the Raman scattered light spectrum only in the blood vessel.

Then, the blood glucose value extracting unit 130 extracts the blood glucose value from the Raman scattered light spectrum of the blood vessel obtained in the confocal Raman microscope 120.

Therefore, the non-invasive blood glucose measuring device of the present invention has an advantage that blood glucose can be measured without blood collection, thereby eliminating the pain of the examinee due to blood collection.

FIG. 3 is a schematic flowchart of a non-invasive blood glucose measurement method according to the present invention, in which an image of a blood vessel inside the skin is taken at a blood vessel image capturing unit (step S110)

Then, a blood vessel position for measuring blood glucose in the blood vessel image photographed by the blood vessel image capturing unit is extracted by the blood vessel position extraction unit (step S120)

Subsequently, the position of the blood vessel extracted from the blood vessel position extracting unit is set as the confluence in the confocal Raman microscope (step S130)

Then, the confocal Raman microscope irradiates light to the blood vessel position, and acquires a Raman scattered light spectrum from the blood vessel (step S140)

Finally, the blood glucose value extraction unit extracts the blood glucose value from the Raman scattered light spectrum of the blood vessel obtained in the confocal Raman microscope (step S150)

FIG. 4 is a schematic diagram for explaining a non-invasive blood glucose measurement apparatus according to a second embodiment of the present invention. The non-invasive blood glucose measurement apparatus of the second embodiment includes a blood vessel position extracting unit 210; A blood vessel image within the skin is photographed to output the blood vessel image to the blood vessel position extracting unit 210, the blood vessel position extracted by the blood vessel position extracting unit 110 is set as the confluent position, A confocal Raman microscope (200) for acquiring a Raman scattered light spectrum in the blood vessel; And a blood glucose value extractor 220 for extracting a blood glucose value from the Raman scattered light spectrum of the blood vessel obtained in the confocal Raman microscope 200.

The blood vessel extracting unit 210, the confocal Raman microscope 200, and the blood glucose value extracting unit 220 are controlled by the controller 230.

The non-invasive blood glucose measurement apparatus according to the second embodiment of the present invention is configured to capture blood vessels with one confocal Raman microscope and acquire Raman scattered light spectra from the blood vessels.

A non-invasive blood glucose measurement method using the non-invasive blood glucose measurement apparatus according to the second embodiment of the present invention will be described. A blood vessel image in the skin is photographed in the confocal Raman microscope (200).

Then, the position of the blood vessel is extracted from the blood vessel image photographed by the blood vessel position extraction unit 210.

Subsequently, the position of the blood vessel extracted by the blood vessel position extracting unit 210 is set as the confluence in the confocal Raman microscope 200.

Thereafter, the confocal Raman microscope 200 irradiates light at the blood vessel position, and obtains a Raman scattered light spectrum in the blood vessel.

Finally, the blood glucose value extracting unit 220 extracts a blood glucose value from the Raman scattered light spectrum of the blood vessel obtained in the confocal Raman microscope 200.

5 is a schematic cross-sectional view for explaining the configuration of a confocal Raman microscope according to the present invention, in which the confocal Raman microscope comprises a light source 610; A focusing lens 620 focusing the light of the light source 610 onto the first pinhole 631; An optical component 640 that transmits or reflects the light focused by the focusing lens 620 according to a component of light incident through the first pinhole 631; An objective lens 690 focusing the light transmitted by the optical component 640 on the blood vessel; A notch filter 650 for transmitting Raman scattered light among the scattered light from the blood vessel reflected from the optical component 640 through the objective lens 690; An optical element 670 transmitting the notch filter 650 and spatially dispersing the Raman scattered light of the blood vessel passing through the second pinhole 661; And a CCD camera 680 for capturing light scattered by the optical element 670.

The optical component 640 is preferably a beam splitter or a dichroic mirror.

The light source 610 is preferably a laser.

In this confocal Raman microscope, the light emitted from the light source 610 is focused on the focusing lens 620.

The light focused by the focusing lens 620 is transmitted or reflected by the optical component 640 through the first pinhole 631 according to the component of the light, And focuses on the blood vessel through the objective lens 690.

In the blood vessel, light is scattered and reflected by the optical part 640 through the objective lens 690.

Thereafter, the scattered light from the blood vessel reflected by the optical component 640 is transmitted only through the Raman scattered light from the notch filter 650.

Here, in the notch filter 650, Rayleigh scattered light is not transmitted.

The Raman scattered light in the blood vessel transmitted through the notch filter 650 passes through the second pinhole 661 and is spatially dispersed in the optical element 670 and the CCD camera 680 transmits the light And the element 670 images the dispersed light.

Here, as shown in FIG. 5, the Raman scattered light in the focused plane a passes through the second pinhole 661, but the scattered light from the unfocused plane b, c The second pinhole 661 does not pass through the second pinhole 661.

Thereby, the confocal Raman microscope becomes able to acquire Raman scattered light from the blood vessel.

FIG. 6 is a schematic cross-sectional view for explaining a measurement probe of a non-invasive blood glucose measurement device according to the present invention. The confocal Raman microscope of the non-invasive blood glucose measurement device is configured to irradiate light to skin to obtain Raman scattered light from a blood vessel A measurement probe must be provided.

Therefore, as shown in FIG. 6, it is possible to apply the measurement probe 300 having the optical flow-through hole 350 in which the light passes through the skin 400 of the examinee.

The blood vessel image capturing unit captures an image of the blood vessel using the transmitter styluses and the reception transducers, and the measurement probe 300 is equipped with transmission styluses and reception transducers capable of capturing images of blood vessels .

The light A irradiated to the blood vessel 450 inside the skin 400 of the subject and the light B scattered from the blood vessel 450 can be circulated through the optical flow through hole 350 .

7A and 7B are schematic views for explaining another structure of the measurement pad according to the present invention. In the case where the blood vessel image capturing unit is an apparatus for capturing an image of a blood vessel using ultrasound, the blood vessel image capturing unit includes an outgoing turntable And receiving transducers.

At this time, the transmitting stylus oscillates the ultrasonic waves to the skin, and the receiving transducers receive ultrasonic waves reflected from the skin surface and the inside of the skin, and can take an image of the blood vessel.

Here, it is preferable that the transmitting transmitter and the receiving transducer are arrayed.

Therefore, according to the present invention, when the blood vessel image capturing unit includes the transmitting turntables and the receiving transducers, the transmitting turntables and the receiving transducers and the optical flow through holes are arranged in an array on one probe .

That is, as shown in FIG. 7A, the transmitting turntables and the receiving transducers 311a, 311b, 311c, 311d, 311e, and 311f are arrayed at the tip of the probe 300, Through holes 312 may be arranged between the transducers 311a, 311b, 311c, 311d, 311e, and 311f.

Alternatively, as shown in FIG. 7B, the transmitting turntables and the receiving transducers 311a, 311b, 311c, 311d, 311e, 311f, and 311g are arranged in a row at the tip of the probe 300, The optical transmission through holes 312 may be arranged adjacent to the transmission tuner discs 311a, 311b, 311c, 311d, 311e, 311f, and 311g arranged in a line.

It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

1 is a diagram for explaining blood collection for measuring blood glucose according to the prior art;

2 is a schematic diagram for explaining a non-invasive blood glucose measurement device according to the first embodiment of the present invention

3 is a schematic flow chart of a non-invasive blood glucose measurement method according to the present invention

4 is a schematic diagram for explaining a non-invasive blood glucose measurement apparatus according to a second embodiment of the present invention

5 is a schematic cross-sectional view for explaining the configuration of a confocal Raman microscope according to the present invention

6 is a schematic cross-sectional view for explaining a measurement probe of the non-invasive blood glucose measurement apparatus according to the present invention

7A and 7B are schematic views for explaining another structure of the measurement pad according to the present invention

Claims (12)

  1. A blood vessel image capturing section for capturing blood vessel images;
    A blood vessel position extracting unit for acquiring the diameter of the blood vessel in the blood vessel image taken by the blood vessel image capturing unit and extracting the blood vessel position based on the diameter of the obtained blood vessel;
    A confocal Raman microscope for setting a position of a blood vessel extracted by the blood vessel position extracting unit as a confocal point, irradiating light at the blood vessel position, and acquiring a Raman scattered light spectrum in the blood vessel;
    And a blood glucose value extracting unit for extracting a blood glucose value from the Raman scattered light spectrum of the blood vessel obtained in the confocal Raman microscope.
  2. The method according to claim 1,
    The blood vessel image capturing unit includes:
    Wherein the blood vessel image capturing unit captures an image of a blood vessel using one of confocal microscopy, ultrasound, and magnetic resonance imaging (MRI).
  3. A blood vessel position extracting unit for acquiring the diameter of the blood vessel in the blood vessel image and extracting the blood vessel position based on the diameter of the obtained blood vessel;
    A blood vessel image in the skin is photographed to output the blood vessel image to the blood vessel position extracting unit, the blood vessel position extracted by the blood vessel position extracting unit is set as the confluent, the light is irradiated to the blood vessel position, A confocal Raman microscope for obtaining a catered light spectrum;
    And a blood glucose value extracting unit for extracting a blood glucose value from the Raman scattered light spectrum of the blood vessel obtained in the confocal Raman microscope.
  4. The method according to claim 2 or 3,
    The confocal Raman microscope may further include:
    A light source;
    A focusing lens for focusing the light of the light source onto the first pinhole;
    An optical component that transmits or reflects the light focused by the focusing lens according to a component of light incident through the first pinhole;
    An objective lens for focusing light transmitted through the optical component onto a blood vessel;
    A Notch filter for transmitting Raman scattered light among the scattered light from the blood vessel reflected from the optical component through the objective lens;
    An optical element which transmits the notch filter and spatially disperses Raman scattered light of a blood vessel passing through the second pinhole;
    And a CCD camera for capturing light dispersed in the optical element.
  5. The method of claim 4,
    The optical component includes:
    Wherein the beam splitter is a beam splitter or a dichroic mirror.
  6. The method of claim 4,
    The light source includes:
    Wherein the non-invasive blood glucose measuring device is a laser.
  7. The method according to claim 1,
    The confocal Raman microscope may further include:
    A measurement probe is provided for irradiating the skin of the examinee with light to obtain Raman scattered light from the blood vessel,
    Wherein the measurement probe comprises:
    And a light distribution through hole through which light passes can be formed in close contact with the skin.
  8. The method of claim 7,
    Wherein the blood vessel image capturing unit is provided with transmission turntables and reception transducers for capturing blood vessel images,
    Wherein the measuring probe is equipped with the transmitting turntables and the receiving transducers.
  9. The method of claim 8,
    The originating transmitters and receive transducers,
    The probe being arranged at the tip of the measurement probe,
    The optical communication through-
    Wherein the non-invasive blood glucose measuring device is arranged between the transmitting turntables and the receiving transducers.
  10. The method of claim 8,
    The originating transmitters and receive transducers,
    Wherein the measurement probe is arranged in a line at the tip of the measurement probe,
    The optical communication through-
    And wherein the non-invasive blood glucose measuring device is arranged adjacent to the arrayed transmitting turntables and the receiving transducers.
  11. Capturing an image of the blood vessel inside the skin in the blood vessel image capturing unit;
    Obtaining a diameter of the blood vessel from the photographed blood vessel image and extracting a blood vessel position for measuring blood glucose based on the diameter of the obtained blood vessel;
    Setting the extracted blood vessel location to confocal;
    Irradiating light to the blood vessel position and acquiring a Raman scattered light spectrum in the blood vessel;
    And extracting the blood glucose value from the Raman scattered light spectrum of the acquired blood vessel.
  12. Photographing a blood vessel image inside the skin in a confocal Raman microscope;
    Acquiring the diameter of the blood vessel from the photographed blood vessel image, and extracting the position of the blood vessel based on the diameter of the obtained blood vessel;
    Setting the extracted blood vessel location to confocal;
    Irradiating light to the blood vessel position and acquiring a Raman scattered light spectrum in the blood vessel;
    And extracting the blood glucose value from the Raman scattered light spectrum of the acquired blood vessel.
KR20080081198A 2008-08-20 2008-08-20 Apparatus and method for noninvasively measuring blood sugar level KR101491854B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR20080081198A KR101491854B1 (en) 2008-08-20 2008-08-20 Apparatus and method for noninvasively measuring blood sugar level

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20080081198A KR101491854B1 (en) 2008-08-20 2008-08-20 Apparatus and method for noninvasively measuring blood sugar level

Publications (2)

Publication Number Publication Date
KR20100022614A KR20100022614A (en) 2010-03-03
KR101491854B1 true KR101491854B1 (en) 2015-02-09

Family

ID=42175072

Family Applications (1)

Application Number Title Priority Date Filing Date
KR20080081198A KR101491854B1 (en) 2008-08-20 2008-08-20 Apparatus and method for noninvasively measuring blood sugar level

Country Status (1)

Country Link
KR (1) KR101491854B1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101151790B1 (en) * 2010-03-08 2012-05-31 경북대학교 산학협력단 Cofocal microscopic m-piv using blood cell imaging
KR101144434B1 (en) * 2010-09-29 2012-05-10 정순원 Non-invasive blood glucose measurement apparatus
KR20160028229A (en) 2014-09-03 2016-03-11 삼성전자주식회사 Noninvasive apparatus for testing glycated hemoglobin and noninvasive method for testing glycated hemoglobin
KR20160051471A (en) 2014-11-03 2016-05-11 삼성전자주식회사 Spectrometer including vetical stack structure and non-invasive biometric sensor including the spectrometer
KR101716663B1 (en) * 2015-12-09 2017-03-15 (주)아이에스엠아이엔씨 Method and Apparatus for Correction of Non-Invasive Blood Glucose Measurement

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006520900A (en) 2003-03-11 2006-09-14 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィKoninklijke Philips Electronics N.V. Spectroscopic analysis apparatus and method comprising an excitation system and a focus monitoring system
JP2007097654A (en) 2005-09-30 2007-04-19 Fujifilm Corp Blood information measuring device
JP2008116432A (en) 2006-07-06 2008-05-22 Ricoh Co Ltd Raman spectrometric measuring instrument, and raman spectrometry using same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006520900A (en) 2003-03-11 2006-09-14 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィKoninklijke Philips Electronics N.V. Spectroscopic analysis apparatus and method comprising an excitation system and a focus monitoring system
JP2007097654A (en) 2005-09-30 2007-04-19 Fujifilm Corp Blood information measuring device
JP2008116432A (en) 2006-07-06 2008-05-22 Ricoh Co Ltd Raman spectrometric measuring instrument, and raman spectrometry using same

Also Published As

Publication number Publication date
KR20100022614A (en) 2010-03-03

Similar Documents

Publication Publication Date Title
US10241199B2 (en) Ultrasonic/photoacoustic imaging devices and methods
US20180177399A1 (en) Method and device for multi-spectral photonic imaging
US10390729B2 (en) Method and system for non-invasively monitoring biological or biochemical parameters of individual
Aykut et al. Cytocam-IDF (incident dark field illumination) imaging for bedside monitoring of the microcirculation
US8747335B2 (en) Integrated spot monitoring device with fluid sensor
JP6188225B2 (en) A method for displaying predicted and measured values so that the predicted values and measured values are compared to determine a disease state
US10433733B2 (en) Single-cell label-free photoacoustic flowoxigraphy in vivo
US10433775B2 (en) Apparatus for non-invasive in vivo measurement by raman spectroscopy
US8594757B2 (en) Apparatus for biomedical imaging
US8121663B2 (en) Photoacoustic measurement of analyte concentration in the eye
JP5235586B2 (en) Biological information processing apparatus and biological information processing method
JP5201920B2 (en) measuring device
EP1889039B1 (en) Method and apparatus for optical characterization of tissue
US5119819A (en) Method and apparatus for non-invasive monitoring of blood glucose
JP2015152601A (en) Skin condition diagnosis device and skin condition diagnosis method using the same
JP5646337B2 (en) Optical sensor for determining the concentration of an analyte
JP4455216B2 (en) Detection device
US9167993B2 (en) Noninvasive glucose sensing methods and systems
US20130123604A1 (en) Photoacoustic diagnostic apparatus
DE102006018445B4 (en) Apparatus and method for determining arterio-venous ratio values by quantitative analysis of retinal vessels
JP3579686B2 (en) Measuring position reproducing method, measuring position reproducing device, and optical measuring device using the same
US7050842B2 (en) Method of tissue modulation for noninvasive measurement of an analyte
US7248907B2 (en) Correlation of concurrent non-invasively acquired signals
JP2007510492A (en) Method and system for non-invasive measurement in the human body
JP2012101054A (en) Measurement head for non-invasive blood analysis

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20180124

Year of fee payment: 4

FPAY Annual fee payment

Payment date: 20190123

Year of fee payment: 5