KR101381183B1 - Blending material For Anastomosis Apparatus For Blood vessel And Anastomosis Apparatus manufacturing the same - Google Patents

Abstract

The present invention relates to a blood vessel anastomosis device, and a polycaprolactone and 2-octylcyanoacrylate, polyoctylcyanoacrylate and polyoctylcyanoacrylate blended with the polycaprolactone in a predetermined ratio as a central agent. 3,5-diiodine-4-pyridone-1-acetic acid (3,5-diiodo-4-pyridone-1-actetic acid) containing at least one composition of the cyanoacrylate-based composition containing an anion stabilizer A blending composition for the manufacture of a vascular anastomosis device and a vascular anastomosis device made from the composition is disclosed.

Description

Blending composition for the manufacture of vascular anastomosis device and vascular anastomosis device manufactured on the basis of the same {Blending material For Anastomosis Apparatus For Blood vessel And Anastomosis Apparatus manufacturing the same}

The present invention relates to a blood vessel anastomosis device, and more particularly, has a simple structure and excellent adhesion, providing sufficient support for blood vessel anastomosis, and a blending composition for preparing a blood vessel anastomosis device composed of a biodegradable material and the base thereof It relates to a blood vessel anastomosis device manufactured.

Recently, due to lack of exercise and westernization of diet, the incidence of vascular disease is increasing year by year. In particular, the majority of heart diseases are myocardial infarction and angina, caused by ischemia, which is blocked by blood vessels supplying nutrients and oxygen to the heart.

As a method of treating such closed vessels or almost closed vessels, drug therapy and surgical therapy using muscle relaxants or anti calcium agents that expand vascular muscles are used. Drug therapy is useful for early-stage therapies, but it does not work well for blood vessels that have already undergone a significant degree of occlusion and cannot be a fundamental countermeasure. Therefore, many surgical therapies, which are direct treatments of occluded blood vessels, are being performed.

The surgical method is largely an internal medical method and a surgical method. The medical method is a method of inserting a metal mesh (stent) through a blood vessel such as a femoral vein into a closed part and expanding a metal mesh there, to be. However, this method has a problem that when a long time after the operation, the lesion tissue is splattered out between the metal mesh and new granulation tissue grows inside the metal mesh and the closure process is progressed again.

Therefore, as a more fundamental solution, a surgical procedure is mainly performed in which a chest is cut open and blood vessels (mainly leg veins) drawn from elsewhere are bypassed to connect the blocked area. At this time, one end of the leg vein is end-to-end, or end-to-end, to an internal mammary artery (IMA) that supplies blood to the chest and abdominal tissue and muscles. Side-to-side, and end-to-end, end-to-side, or side-to-side to the blood vessel beyond the closure site.

Blood vessels are largely composed of the inner layer (Intima), the middle layer (Media) and the outer layer (Adventitia). When the two vessels anastomosis, the inner layers must be connected to the inner layers. In addition to the treatment of heart disease as described above, when reconstruction by flap transfer or anastomosis of the cut blood vessels, the microsurgical surgeon uses a suture to secure the enlarged field of view with a microscope or a high magnification magnifier and suture by hand. The method is mainly used. However, suturing can only be performed by a highly skilled physician and requires a lot of time and effort. In particular, it is very difficult to suture the blood vessels in a region where the periodic beating is continuously performed like the heart. Accordingly, there is an urgent need for providing methods and devices capable of performing vascular anastomosis in an easier manner.

In order to solve the conventional problems as described above, an object of the present invention is a blending composition for producing a blood vessel anastomosis device that can simply connect the end of one blood vessel and the end of the other blood vessel without using a suture and produced based on the In providing a vascular anastomosis device.

It is another object of the present invention to provide a blending composition for the preparation of a vascular anastomosis device that can be biodegradable over time and minimize the time required for vascular anastomosis while maintaining a suitable intensity, and a vascular anastomosis device manufactured based on the same. Is in.

In order to achieve the above object, the present invention is a polycaprolactone, 2-octylcyanoacrylate, polyoctylcyanoacrylate and polyoctylcyanoacrylate blended in a certain ratio with the polycaprolactone as a main agent and 3 Vascular anastomosis comprising at least one composition of cyanoacrylate-based composition using, 5-diiodine-4-pyridone-1-acetic acid (3,5-diiodo-4-pyridone-1-actetic acid) as an anion stabilizer Disclosed is a composition of a blending composition for device manufacture.

Wherein the blending ratio between the polycaprolactone and the at least one composition is

10:90 to 90:10.

In addition, the present invention is a 3,5-diiodine-4-pyridine with a 2-octylcyanoacrylate, a polyoctylcyanoacrylate, or a polyoctylcyanoacrylate blended with a polycaprolactone in a predetermined ratio as a central agent. It is made of a blending composition comprising any one of the cyanoacrylate-based composition using a don-1-acetic acid (3,5-diiodo-4-pyridone-1-actetic acid) as an anion stabilizer to fix the first blood vessel 3,5-diiodine-4-pyridone, with 2-octylcyanoacrylate, polyoctylcyanoacrylate, or polyoctylcyanoacrylate blended in a proportion with the outer coupler and polycaprolactone as a main agent It is made of a blending composition comprising any one of the cyanoacrylate-based composition with -1-acetic acid (3,5-diiodo-4-pyridone-1-actetic acid) as an anion stabilizer, and fixes the second vessel Disclosed is a configuration of a vascular anastomosis device including an inner engaging tool that engages with the outer engaging device.

Here, the outer coupler includes a first blood vessel coupling portion for fixing the first blood vessel, a funnel portion formed in series with the first blood vessel coupling portion and extended in a direction joining the inner blood vessel, and the inner coupling portion includes: A second blood vessel engaging portion for fixing the second blood vessel, a funnel contact portion in contact with an inner surface of the funnel portion, and having a second empty space, disposed between the second vessel engaging portion and the funnel contact portion, The second blood vessel may be disposed and include a contact support for supporting the funnel contact.

The outer coupler may further include a connection space provided as a predetermined space between the first blood vessel coupling portion and the funnel portion, and the second blood vessel may include a blood vessel protrusion protruding a predetermined length from an end of the funnel contact portion. can do.

The outer coupler may further include an alignment mark groove or an alignment mark line disposed between the connection space and the first blood vessel coupling portion and used as a reference point when the first vessel is disposed, and the inner coupling portion may include the funnel contact portion. It may further include an alignment mark portion protruding in the longitudinal direction from the end to a length corresponding to the width of the connection space and used as a reference point when the second blood vessel is disposed.

And at least one of the outer coupling and the inner coupling may be formed in the longitudinal direction may include an incision line is provided so that the cavity inside is exposed to the outside by pressing.

According to the blending composition for producing a vascular anastomosis device according to the present invention and a vascular anastomosis device manufactured based on the same, the present invention has a relatively high elasticity compared to other materials and has a high binding force due to the coupling of a coupler. As a result, the procedure is quick and cost-effective.

In addition, the present invention is excellent in biodegradability and can be biodegraded after the procedure to be removed slowly to assist the subject to prevent the foreign body.

1A and 1B are schematic views showing an external appearance of a blood vessel anastomosis device according to a first embodiment of the present invention.
2 is a view showing one end surface of the blood vessel anastomosis device according to the first embodiment of the present invention.
3 is a front view of the blood vessel anastomosis device according to the first embodiment of the present invention.
4 is a view showing a combined state of the blood vessel anastomosis device according to the first embodiment of the present invention.
5 is a cross-sectional view of a blood vessel anastomosis device according to a second embodiment of the present invention.
6 is a view showing a combined state of the blood vessel anastomosis device according to a second embodiment of the present invention.
7 is a flowchart illustrating a method for manufacturing a blood vessel anastomosis device of the present invention.

In the following description, only parts necessary for understanding the embodiments of the present invention will be described, and the description of other parts will be omitted so as not to obscure the gist of the present invention.

The terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary meanings and the inventor is not limited to the meaning of the terms in order to describe his invention in the best way. It should be interpreted as meaning and concept consistent with the technical idea of the present invention. Therefore, the embodiments described in the present specification and the configurations shown in the drawings are merely preferred embodiments of the present invention, and are not intended to represent all of the technical ideas of the present invention, so that various equivalents And variations are possible.

1A and 1B are schematic views illustrating an external appearance of a vascular anastomosis device 10 according to a first embodiment of the present invention, and FIG. 2 is a view of a vascular anastomosis device 10 according to a first embodiment of the present invention. It is a figure which shows one end surface. 3 is a front view of the vascular anastomosis device 10 according to the first embodiment of the present invention, and FIG. 4 is a view for explaining a coupling state of the vascular anastomosis device 10 according to the first embodiment of the present invention.

1A to 4, the blood vessel anastomosis device 10 according to the embodiment of the present invention fixes the outer coupler 100 and the end of the second blood vessel 12 to fix the end of the first blood vessel 11. And it may include an inner coupler 200 that binds to the outer coupler (100). Here, the main feature of the present invention is not in the form of the outer coupler 100 and the inner coupler 200 described below, but the material capable of manufacturing the outer coupler 100 and the inner coupler 200. Accordingly, it should be understood that the vascular anastomosis device 10 of the present invention also includes a change to more various forms using the materials described below.

The blood vessel anastomosis device 10 of the present invention fixes the end of the first blood vessel 11 to the outer coupler 100 and the end of the second vessel 12 to the inner coupler 200. ) Is inserted into the funnel 130 of the outer coupler 100 to support the blood vessel anastomosis function. Here, the outer coupler 100 and the inner coupler 200 may be a composition in which 2-octylcyanoacrylate and polycaprolactone are blended at a predetermined ratio or octylcyanoacrylate used as a thickener described below. Polyoctylcyanoacrylate, a byproduct of polycaprolactone, may be prepared in a blended composition. In addition, the material used for the outer coupler 100 and the inner coupler 200 contains polyoctylcyanoacrylate as a thickener, and 3,5-diiodine-4-pyridone-1- as an anion stabilizer. A cyanoacrylate-based composition containing acetic acid (3,5-diiodo-4-pyridone-1-actetic acid) and a blending composition may be used in which the polycaprolactone is blended at a predetermined ratio.

Accordingly, the vascular anastomosis device 10 composed of the outer coupler 100 and the inner coupler 200 according to the present invention has a simple structure, but the outer coupler 100 and the inner coupler may be formed by the characteristics of the material itself. The binding between the 200 is excellent and there is no toxicity to the blood vessels, and after a certain period of time after the biodegradation to support to prevent foreign matter. Hereinafter, the detailed forms of the outer coupler 100 and the inner coupler 200 as one example that may be configured using the blending composition described above will be described in detail.

The outer coupler 100 is formed in series with the first vessel coupler 110 and the first vessel coupler 110 on which the first vessel 11 is seated and fixed, and is jointed until the coupling of the inner coupler 200. It may include a connection space 120 to be maintained in a state, the funnel 130 formed in series with the connection space 120.

The first blood vessel coupling unit 110 may be formed in various diameters according to the shape and thickness of the first blood vessel 11. Although the center has been described as being manufactured in the shape of an empty cylinder, it may be provided in a structure in which one side is cut for the introduction of the first blood vessel (11). The first blood vessel coupling portion 110 having one side cut off may be provided with a predetermined space so that the first blood vessel 11 may be easily introduced by expanding the incision region by pressing the incision region when the first vessel 11 is coupled. Can be. After insertion of the first blood vessel 11, the incision region may be restored to work so that the first blood vessel coupling part 110 completely surrounds the outer wall of the first blood vessel 11. To this end, the circumference of the first blood vessel coupling unit 110 may be formed to be larger than the circumference of the first blood vessel 11, and the incision region surrounding one side of the first blood vessel 11 may have one incision region above the other incision region. Can be arranged to cover. As described above, the first blood vessel coupling part 110 uses a material blended with octylcyanoacrylate having its own hardening property by moisture. When water is provided, the incision areas can be glued together resulting in a strong fixation of the end of the first blood vessel 11. Due to the nature of the treatment environment, since the blood having a certain moisture or water is provided, the first blood vessel coupling unit 110 may fix the end of the first blood vessel 11 in an easy environment.

The connection space 120 is formed in series with the first blood vessel coupling unit 110, and the second blood vessel is not disposed while the first blood vessel 11 is disposed and the inner coupling hole 200 is coupled to the outer coupling hole 100 later. It may be an area in which the protrusion of 12 is disposed. That is, the connection space 120 may be an area where the end portions of the first blood vessel 11 and the end portion of the second blood vessel 12 face each other. At this time, it is preferable to perform the procedure such that the end of the first vessel 11 and the end of the second vessel 12, in particular, the inner layer of the vessel, are completely in contact with each other.

The funnel 130 is formed in series with the connection space 120, and is formed to have a predetermined slope in an outward direction from one end. In particular, the funnel 130 may be formed in a shape that extends outwardly from the connection space 120. The funnel 130 serves to wrap the funnel contact portion 230 formed in the inner coupler 200, and the second vessel 12 fixed to the inner coupler 200 is correctly directed toward the connection space 120. It can serve to guide the import. The end of the funnel 130 may be rounded. Substantially, the blending composition forming the outer coupler 100 of the present invention has a material property that is excellent in flexibility and elasticity, so that the end portion is less risk of injury to other organs of the subject, but rounding for a safer procedure Could be processed.

On the other hand, the outer coupler 100 may be provided with an outer coupler incision 150 to fix the first blood vessel (11). As described above, the outer coupler incision line 150 may cross the length direction of the first blood vessel coupling unit 110 and may be formed to cross the connection space 120 and the funnel 130. Alternatively, the outer coupler incision 150 of the present invention may be formed only up to the first blood vessel coupling portion 110 and the connection space 120. The operator exposes the inner side of the first blood vessel coupling unit 110 and the connection space 120 by using the outer coupler incision line 150, and connects the first vessel 11 to the first vessel through the exposed region. Work to be seated inside the portion (110).

In addition, an alignment mark groove 140 may be provided in a boundary area between the connection space 120 and the first blood vessel coupling unit 110. The alignment mark groove 140 is provided to appropriately secure the connection space 120 when the first blood vessel 11 is seated on the first blood vessel engaging portion 110. In the above description, the alignment mark groove 140 is formed, but the present invention is not limited thereto. That is, the alignment mark groove 140 is provided to distinguish the first blood vessel coupling unit 110 from the connection space 120 and may be provided as a specific line indicating an alignment mark without forming a separate groove. There will be.

The inner coupler 200 has a second vessel coupler 210 on which the second vessel 12 is seated and fixed, and the second vessel 12 is successively seated, and a funnel portion of the outer coupler 100 ( And a funnel contact portion 230 facing the 130 and a contact support portion 220 disposed between the funnel contact portion 230 and the second blood vessel engaging portion 210. Here, the second blood vessel 12 may be disposed to protrude by a predetermined length from the end of the funnel contact portion 230. Accordingly, the blood vessel protrusion 13 may be provided from the end of the funnel contact portion 230. The inner coupler 200 may also be provided with an inner coupler incision 250 that cuts through the center in the longitudinal direction similarly to the outer coupler 100. In addition, an alignment mark part 240 may be provided at one end of the inner coupler 200.

The second blood vessel coupling unit 210 performs a function similar to the first blood vessel coupling unit 110 of the outer coupling unit 100 described above. That is, the second blood vessel engaging portion 210 serves to support the second blood vessel 12 by being seated on the trunk of the second blood vessel 12.

The contact support portion 220 may be disposed between the funnel contact portion 230 and the second blood vessel coupling portion 210 and may have a predetermined slope at the end of the second blood vessel coupling portion 210 to protrude. . That is, the contact support 220 may be formed to have a slope that gradually increases from the surface of the second blood vessel coupling portion 210. And the other end of the contact support 220 may be arranged in connection with the start area of the funnel contact portion 230. The contact support part 220 may have an inner side in which the second blood vessel 12 is seated.

The funnel contact portion 230 is formed in series with the contact support portion 220 and has a slope opposite to that of the contact support portion 220. The funnel contact portion 230 is provided with an inner hollow shape, and the second blood vessel 12 may be seated. The slope of the funnel contact portion 230 may be formed to have the same slope as the slope of the inner surface of the funnel 130 provided in the outer coupler 100.

The inner coupler 200 may include an inner coupler incision 250 that cuts the second blood vessel coupler 210, the contact support 220, and the funnel contact portion 230 in a longitudinal direction. Accordingly, the operator can open the inner cavity of the inner coupler 200 by using the inner coupler incision 250, and seat the second blood vessel 12 on the inside thereof. In this case, a part of the second blood vessel 12 may be disposed to protrude from the end of the funnel contacting portion 230 by a predetermined length, so that the blood vessel protrusion 13 may be provided. In addition, an alignment mark part 240 may be provided at one side of the inner coupler 200 to adjust the protruding length of the blood vessel protrusion 13. The alignment mark part 240 may be provided to protrude by a predetermined length in the longitudinal direction from the end of the funnel contact portion 230. The length of the alignment mark part 240 may have a length corresponding to the length of the connection space 120 provided in the outer coupling hole (100). Accordingly, the operator may arrange the second blood vessel 12 based on the alignment mark part 240 when the second blood vessel 12 is disposed in the cavity of the inner coupling hole 200.

In the above, the form of the outer coupler 100 and the exemplary embodiment of the inner coupler 200 are proposed, and the main feature of the present invention is to fix the first vessel 11 and the second vessel 12 and then to the mutual coupling. According to the present invention, the polyoctylcyanoacrylate and the polycaprolactone, which provide a constant binding force and can be biodegraded over time, are prepared from a blending composition. Here, the polyoctylcyanoacrylate may be replaced with a cyanoacrylate-based composition having the aforementioned 2-octylcyanoacrylate and polyoctylcyanoacrylate as a thickener and an anion stabilizer formed at a predetermined ratio. . The anion stabilizer may be 3,5-diiodo-4-pyridone-1-acetic acid (3,5-diiodo-4-pyridone-1-actetic acid).

Meanwhile, the blending ratio of the polyoctylcyanoacrylate and polycaprolactone may be adjusted within a ratio of 10:90 to 90:10, and may be diversified according to the purpose of use. In particular, polycaprolactone can change the blending concentration to control the time of biodegradation. That is, when fast biodegradation is required according to the purpose of the procedure, the vascular anastomosis device 10 may be manufactured in which the ratio of polycaprolactone is reduced and the ratio of polyoctylcyanoacrylate is increased. On the contrary, in a procedure requiring a slow biodegradation time point, a blood vessel anastomosis device 10 having a higher ratio of polycaprolactone and a lower ratio of polyoctylcyanoacrylate may be manufactured. Such adjustment of the blending concentration may be obtained through a biodegradation process according to the reaction rate between the blood vessel anastomosis device 10 and the blood of the present invention manufactured in a certain ratio unit.

The ratio of the polyoctylcyanoacrylate may influence the adhesion. Accordingly, in a procedure requiring high adhesion, a blood vessel anastomosis device 10 made of a blending material having a high proportion of polyoctylcyanoacrylate may be used. On the contrary, in a procedure requiring low adhesion, the vessel anastomosis device 10 manufactured by lowering the ratio of polyoctylcyanoacrylate may be used.

The polyoctylcyanoacrylate is prepared by reacting cyanoacetic acid and octane alcohol in a 1: 1 equivalent ratio in the presence of a solvent to produce octylcyanoacetate, and the octylcyanoacetate and paraformaldehyde in a solvent of 1: 1. Reacting in an equivalent ratio, removing the solvent after completion of the reaction, separating and purifying octylcyanoacrylate, and purifying octylcyanoacrylate and obtaining polyoctylcyanoacrylate from the remaining byproduct. Can be.

The 3,5-diiodine-4-pyridone-1-acetic acid used as an anion stabilizer in the present invention is characterized by having an antibacterial effect as well as an anion stabilizing function. The anion stabilizer may be added in an amount of 0.8 to 2.9% by weight based on the total weight of the blending composition including polyoctylcyanoacrylate and polycaprolactone.

In addition, the blending composition containing polyoctylcyanoacrylate and anion stabilizer according to the present invention and comprising polycaprolactone contains at least one polymerizable cyanoacrylate monomer as a main component, and in addition to the thickener and anion stabilizer, It may further comprise any components commonly used in the preparation of the blending composition. For example, the blending compositions according to the invention can be formulated with one or more polymerizable cyanoacrylate monomers, thickeners and anion stabilizers, including free radical stabilizers, anionic gas phase stabilizers, polymerization initiators, plasticizers, colorants, preservatives, heat dispersants. And, at least one of thixotropes and biocompatible agents, more specifically, 90 to 95 wt% of at least one polymerizable cyanoacrylate monomer, 0.01 to free radical stabilizer, based on the total weight of the composition. 0.2 wt%, 0.01 ~ 2 wt% of polymerization initiator and 0.001 ~ 2 wt% of other additives (plasticizer, colorant, preservative or heat dispersant, or biocompatible agent).

In one embodiment of the invention the at least one polymerizable cyanoacrylate monomer is octylcyanoacrylate, dodecylcyanoacrylate, 2-ethylhexylcyanoacrylate, methoxyethylcyanoacrylate, 2-ethoxy Ethylcyanoacrylate, butylcyanoacrylate, ethylcyanoacrylate, methylcyanoacrylate, 3-methoxybutylcyanoacrylate, 2-butoxyethylcyanoacrylate, 2-isopropoxyethyl Cyanoacrylate, 1-methoxy-2-propylcyanoacrylate, butyllactoylcyanoacrylate, butylglycoylcyanoacrylate, isopropylglyloylcyanoacrylate, ethyl lactoylcyanoacrylate, ethyl Glyloylcyanoacrylate, isopropoxyoxycyanoacrylate, methoxybutylcyanoacrylate, and mixtures thereof It can be used at least one selected from the group eojin, and preferably uses dicyano-octyl acrylate.

As the free radical stabilizer, hydroquinone, hydroquinone monomethyl ether, methoxyhydroquinone, catechol, pyrogallol, benzoquinone, 2-hydroxybenzoquinone, p-methoxyphenol, t-butylcatechol, butylated Hydroxyanisole, butylated hydroxytoluene, t-butylhydroquinone and mixtures or combinations thereof can be used.

The anionic gaseous stabilizer may be sulfur dioxide, boron trifluoride or hydrogen fluoride.

The polymerization initiator may be used a quaternary ammonium salt, for example, domiphen bromide, butyrylcholine chloride, benzalkonium bromide, benzalkonium chloride or acetylcholine chloride.

Examples of the plasticizer include acetyl tributyl citrate, dimethyl sebacate, dibutyl sebacate, triethyl phosphate, tri (2-ethylhexyl) phosphate, tri (p-crezyl) phosphate, glyceryl triacetate, and glyceryl tributyrate. , Diethyl sebacate, dioctyl adipate, isopropyl myristate, butyl stearate, lactic acid, trioctyl trimellitate, dioctyl glutarate, polydimethylsiloxane and mixtures thereof.

Examples of the preservative include methyl paraben, methyl paraben sodium, ethyl paraben, propyl paraben, propyl paraben sodium, butyl paraben, cresol or chlorocresol.

The heat dispersant is potassium nitrate, sodium acetate trihydrate, sodium sulfate decahydrate, barium hydroxide octahydrate, calcium oxalate dihydrate, magnesium oxalate Dihydrate (magnesium oxalate dihydrate), aluminum hydroxide, zinc sulfate, aluminum oxide, barium oxide, titanium oxide, manganese oxide, calcium oxide; Copper, lead, nickel, aluminum, zinc; Carbon black, carbides; Urea, paraffin wax, polyvinyl fluoride; 2-hydroxy-2-trimethylsilanyl-propionitrile, 1-fluorophenacyclo [6.3.0.02,6.03,10.05,9] undecane, 6,7-diazabicyclo [3.2 .1] -6-octene, 5,5,6,6-tetramethylbicyclo [2.2.1] heptan-2-ol, a complex of dimethylmagnesium and trimethylaluminum, N-benzyl-2,2,3,3 , 4,4,4-heptafluoro-butyramide, 3-isopropyl-5,8a-dimethyl-decahydronaphthalen-2-ol, 2-hydroxymethyl-1,7,7-trimethyl-bicyclo [2.2.1] heptan-2-ol, 3,5-dichloro-3-methyl-cyclopentane-1,2-dione, (5-methyl-2-oxo-bicyclo [3.3.1.] Non-3 -En-1-yl) -acetic acid, 4b, 6a, 11,12-tetrahydro-indeno [2,1-a] fluorene-5,5,6,6-tetracarbonitrile, tetracosa Fluoro-tetradecahydro-anthracene, 4,5-dichlorobenzene-1,2-dicarbaldehyde, bicyclo [4,3.1] dec-3-en-8-one, 3-tert -Butyl-1,2-ratio S- (3,5-dimethylphenyl) -3-hydroxyguanidine, 1- [2,6-dihydroxy-4-methoxy-3-methylphenyl] butan-1-one, 2,3,6,7 Tetrachloronaphthalene, 2,3,6-trimethylnaphthalene, dodecafluoro-cyclohexane, 2,2,6,6-tetramethyl-4-hepten-3-one, 1,1,1-trichloro- 2,2,2-trifluoro-ethane, [5- (9H-β-carbolin-1-yl) -furan-2-yl] methanol, 5-nitro-benzo [1,2,3 ] Thiadiazole, 4,5-dichloro-thiophene-2-carboxylic acid, 2,6-dimethyl-isonicotinonitrile, nonafluoro-2,6-bis-trifluoromethyl-piperidine , (Dimethylamino) difluoroborane, dinitrogen pentoxide, chromyl fluoride, and chromium hexacarbonyl; 1-methylcyclohexanol, phenylether, nonadecane, 1-tetradecanol, 4-ethylphenol, benzophenone, maleic anhydride, octacosane, dimethylisophthalate, butylhydride Butylated hydroxytoluene, glycolic acid, vanillin, magnesium nitrate hexahydrate, cyclohexanone oxime, glutaric acid, D-sorbitol, phenanthrene, metaanthene Single or two or more of krillamide, fluorene, 4-hydroxybenzaldehyde, trans-stilbene, neoopentyl glycol, pyrogallol, or diglycolic acid Can be used in combination.

Biocompatible agents are ingredients that reduce the active formaldehyde concentration levels produced during the biodegradation of the polymer, such as, for example, sulfite, bisulfite, or mixtures of sulfite and bisulfite.

As described above, the blood vessel anastomosis device 10 according to the embodiment of the present invention has excellent adhesion and biodegradability, and is non-toxic to the human body of polyoctylcyanoacrylate or its composition and polycaprolactone in a predetermined ratio. It is composed of the material blended with the provided. Accordingly, the blood vessel anastomosis device 10 of the present invention can increase the treatment speed by allowing the anastomosis of blood vessels to be firmly supported while simplifying the shape of the inner coupler 200 and the outer coupler 100. Stability can then be provided. The vascular anastomosis device 10 of the present invention can also be removed extracorporeally over time due to biodegradation to remove foreign body feelings of the subject, and can suppress a separate additional procedure for removing the vascular anastomosis device 10. .

5 and 6 are cross-sectional views for explaining an example of the blood vessel anastomosis device 10 according to the second embodiment of the present invention. In particular, FIG. 5 shows one end surface of a state before the vascular anastomosis device 10 is coupled according to the second embodiment, and FIG. 6 shows one end surface of the vascular anastomosis device 10 according to the second embodiment.

5 and 6, the blood vessel anastomosis device 10 according to the second embodiment of the present invention has an outer coupling hole 100 provided with a fixing groove 160 and a hook inserted into the fixing groove 160. It may include an inner coupler 200 including a jaw (260).

In the blood vessel anastomosis device 10 of the present invention having such a configuration, the engaging jaw 260 is seated in the fixing groove 160 while the inner coupler 200 is inserted into the outer coupler 100 so that the outer coupler 100 is seated. ) And the binding force of the inner coupler 200 can be increased.

The outer coupler 100 is the first blood vessel coupling portion 110, the connection space 120, the funnel 130, the outer coupler incision 150, the alignment mark groove 140 and the fixing groove 160 ) May be included. Here, except for the configuration of the fixing groove 160 of the configuration of the outer coupler 100, the remaining configuration is the same as the configuration of the outer coupler 100 according to the first embodiment of the present invention, detailed description thereof will be omitted. Let's do it.

The fixing groove 160 may be provided in a shape corresponding to the locking step 260 in a predetermined region inside the funnel 130. The fixing groove 160 may serve to fix the inner coupler 200 so that the inner coupler 200 does not move in a direction to be separated from the outer coupler 100 after the coupling of the inner coupler 200. To this end, the fixing groove 160 may be provided such that the end of the groove is inclined in the outward direction of the funnel 130.

The inner coupler 200 includes a second blood vessel coupler 210, a contact supporter 220, a funnel contacting unit 230, an inner coupler incision 250, an alignment mark unit 240, and a locking jaw 260. ) May be included. Here, except for the configuration of the locking step 260 of the configuration of the inner coupler 200, the rest of the configuration is the same as the configuration of the inner coupler 200 according to the first embodiment of the present invention, detailed description thereof will be omitted. Let's do it.

The locking jaw 260 may be provided to protrude with a predetermined slope from the surface of the funnel contact portion 230. The locking jaw 260 is fastened with the fixing groove 160 when the inner coupler 200 is coupled to the inside of the funnel 130 of the outer coupler 100 so that the inner coupler 200 is not relaxed. It plays a role of fixing. The locking step 260 is provided in a shape corresponding to the shape of the fixing groove 160 may be coupled to the fixing groove 160 when fastening.

In the vessel anastomosis device 10 according to the second embodiment of the present invention described above, the fixing groove 160 and the locking jaw 260 are further provided, so that the binding force between the inner coupler 200 and the outer coupler 100 is provided. Can be further enhanced.

Meanwhile, in the above description, the incision line is disposed in each of the components in order to arrange the blood vessels in the outer coupler 100 and the inner coupler 200, but the present invention is not limited thereto. That is, the outer coupler 100 and the inner coupler 200 may not be provided with separate cut lines. In this case, after penetrating the cavity using a structure, for example, tweezers, which penetrates the central cavity of the outer coupler 100 and the inner coupler, the end of the vessel end is grasped and the outer coupler 100 and the inner coupler 200 Vascular placement may be performed by inducing and inwardly seating.

In addition, in the above description, the connection space 120 is provided in the outer coupling device 100 of the present invention, and the second blood vessel 12 is partially projected toward the end of the funnel contacting part 230 of the inner coupling device 200. Although providing the blood vessel protrusion 13 has been described as an example, the present invention is not limited thereto. That is, the first blood vessel 11 may be disposed in the outer coupling hole 100 even up to the connection space 120, and in this case, the second blood vessel 12 may be disposed only to the end of the funnel contacting portion 230. . Since the funnel 130 of the outer coupler 100 and the funnel contact portion 230 of the inner coupler 200 are in contact with each other, the end of the first vessel 11 and the end of the second vessel 12 face each other. In this case, when the contact between the funnel 130 and the funnel contacting portion 230, the curing process is performed by the pre-coated moisture, etc. The blood vessel anastomosis device 10 may provide a solid binding force.

7 is a view for explaining a method of manufacturing a blood vessel anastomosis device 10 according to an embodiment of the present invention.

Referring to FIG. 7, first, in order to blend a predetermined amount of polycaprolactone as in step 701, the liquid is converted into a molten state. To this end, a certain solvent may be added to the polycaprolactone, or the environment may be provided at a temperature higher than a predetermined temperature, for example, 60 ° C or higher.

Next, in step 703, a dry state in which water in the air is removed is prepared, and the polyoctylcyanoacrylate and the prepared polycaprolactone are blended at a blending ratio according to a preliminary manufacturing purpose. Moisture can be cured by reacting with polyoctylcyanoacrylate, so it is desirable to work in a dry state with no moisture in the working environment.

After the blending is completed, the blending composition is injected into the casting mold corresponding to the aforementioned various types of blood vessel anastomosis device 10 in step 705 to manufacture the blood vessel anastomosis device 10. In this case, the blood vessel anastomosis device 10 may be manufactured as a product having an incision according to the design intention of the manufacturer. Alternatively, a blood vessel anastomosis device 10 without a separate incision may be manufactured.

After manufacture, vacuum packing may be performed as in step 707 to remove moisture contact and prevent product deterioration. On the other hand, when performing the vascular anastomosis procedure using the vascular anastomosis device 10 of the present invention vacuum-packed, the packaging is removed, the incision is opened to surround the first vessel 11 and the second vessel 12, respectively To work.

As described above, the vascular anastomosis device 10 manufactured by the blending composition in which polyoctylcyanoacrylate and polycaprolactone are blended in a predetermined ratio is not toxic to the human body and provides high binding force to provide vascular anastomosis. It can help to perform the procedure more quickly and reliably. In addition, the blending composition of the present invention may provide biodegradability to prevent extracorporeal formation by discharging the blood vessel anastomosis device 10 outside the body without additional treatment after the procedure. In addition, the present invention can adjust the adhesive force through the change in the blending concentration and can also control the decomposition time can be supported to enable the production of a variety of products for a variety of treatment environment.

It should be noted that the embodiments of the present invention disclosed in the present specification and drawings are only illustrative of specific examples for the purpose of understanding and are not intended to limit the scope of the present invention. It will be apparent to those skilled in the art that other modifications based on the technical idea of the present invention are possible in addition to the embodiments disclosed herein.

10: blood vessel anastomosis device 11: the first blood vessel
12: second vessel 13: vessel bulge
100: outer coupling port 110: first blood vessel coupling portion
120: connection space 130: funnel
140: alignment mark groove 150: outer coupling incision line
160: fixing groove 200: inner coupling
210: second blood vessel coupling portion 220: contact support
230: funnel contact portion 240: alignment mark portion
250: internal coupler incision 260: locking jaw

Claims (7)

delete delete A composition in which 2-octylcyanoacrylate and polycaprolactone are blended in a predetermined ratio, a composition in which polyoctylcyanoacrylate and the polycaprolactone are blended in a predetermined ratio, or the polyoctylcyanoacrylate as a thickener, and Cyanoacrylate blended with polycaprolactone in a ratio using, 5-diiodine-4-pyridone-1-acetic acid (3,5-diiodo-4-pyridone-1-actetic acid) as an anion stabilizer An outer coupler made of a blending composition comprising any one of the system compositions and fixing the first blood vessel;
A composition in which the 2-octylcyanoacrylate and the polycaprolactone are blended in a predetermined ratio, a composition in which the polyoctylcyanoacrylate and the polycaprolactone are blended in a predetermined ratio or the polyoctylcyanoacrylate as a thickener And the 3,5-diiodine-4-pyridone-1-acetic acid (3,5-diiodo-4-pyridone-1-actetic acid) as an anion stabilizer and blended with the polycaprolactone in a proportion An inner coupler made of a blending composition comprising a composition of any one of the noacrylate-based compositions and fixing the second blood vessel and engaging the outer coupler; Lt; / RTI >
The outer coupler
A first blood vessel coupling portion fixing the first blood vessel;
And a funnel formed in series with the first blood vessel engaging portion and disposed in an expanded form in a direction joining with the inner coupling hole.
The inner coupler is
A second blood vessel coupling portion fixing the second blood vessel;
A funnel contact part in contact with an inner surface of the funnel part and having a center thereof;
A contact support disposed between the second blood vessel engaging portion and the funnel contacting portion, the second vessel being disposed at the center thereof, and supporting the funnel contacting portion;
Vascular anastomosis device comprising a. delete A composition in which 2-octylcyanoacrylate and polycaprolactone are blended in a predetermined ratio, a composition in which polyoctylcyanoacrylate and the polycaprolactone are blended in a predetermined ratio, or the polyoctylcyanoacrylate as a thickener, and Cyanoacrylate blended with polycaprolactone in a ratio using, 5-diiodine-4-pyridone-1-acetic acid (3,5-diiodo-4-pyridone-1-actetic acid) as an anion stabilizer An outer coupler made of a blending composition comprising any one of the system compositions and fixing the first blood vessel;
A composition in which the 2-octylcyanoacrylate and the polycaprolactone are blended in a predetermined ratio, a composition in which the polyoctylcyanoacrylate and the polycaprolactone are blended in a predetermined ratio or the polyoctylcyanoacrylate as a thickener And the 3,5-diiodine-4-pyridone-1-acetic acid (3,5-diiodo-4-pyridone-1-actetic acid) as an anion stabilizer and blended with the polycaprolactone in a proportion An inner coupler made of a blending composition comprising a composition of any one of the noacrylate-based compositions and fixing the second blood vessel and engaging the outer coupler; Lt; / RTI >
The outer coupler
A first blood vessel coupling portion fixing the first blood vessel;
And a funnel formed in series with the first blood vessel engaging portion and disposed in an expanded form in a direction joining with the inner coupling hole.
The inner coupler is
A second blood vessel coupling portion fixing the second blood vessel;
A funnel contact part in contact with an inner surface of the funnel part and having a center thereof;
A contact support disposed between the second blood vessel engaging portion and the funnel contacting portion, the second vessel being disposed at the center thereof, and supporting the funnel contacting portion; Lt; / RTI >
The outer coupler
A connection space provided as a predetermined space between the first blood vessel coupling portion and the funnel portion; Further comprising:
The second blood vessel is
A blood vessel protrusion protruding from the end of the funnel contact by a predetermined length; Vascular anastomosis device comprising a. 6. The method of claim 5,
The outer coupler
And an alignment mark groove or an alignment mark line disposed between the connection space and the first blood vessel coupling portion and used as a reference point when the first blood vessel is disposed.
The inner coupler is
An alignment mark part which protrudes in the longitudinal direction from an end of the funnel contact part and has a length corresponding to the width of the connection space and is used as a reference point when the second blood vessel is disposed;
Vascular anastomosis device further comprising. A composition in which 2-octylcyanoacrylate and polycaprolactone are blended in a predetermined ratio, a composition in which polyoctylcyanoacrylate and the polycaprolactone are blended in a predetermined ratio, or the polyoctylcyanoacrylate as a thickener, and Cyanoacrylate blended with polycaprolactone in a ratio using, 5-diiodine-4-pyridone-1-acetic acid (3,5-diiodo-4-pyridone-1-actetic acid) as an anion stabilizer An outer coupler made of a blending composition comprising any one of the system compositions and fixing the first blood vessel;
A composition in which the 2-octylcyanoacrylate and the polycaprolactone are blended in a predetermined ratio, a composition in which the polyoctylcyanoacrylate and the polycaprolactone are blended in a predetermined ratio or the polyoctylcyanoacrylate as a thickener And the 3,5-diiodine-4-pyridone-1-acetic acid (3,5-diiodo-4-pyridone-1-actetic acid) as an anion stabilizer and blended with the polycaprolactone in a proportion An inner coupler made of a blending composition comprising a composition of any one of the noacrylate-based compositions and fixing the second blood vessel and engaging the outer coupler; Lt; / RTI >
At least one of the outer coupler and the inner coupler
An incision formed in the longitudinal direction and provided to expose the cavity inside to the outside by pressure;
Vascular anastomosis device comprising a.

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