KR100965866B1 - 무수결정형 도세탁셀의 제조방법 - Google Patents
무수결정형 도세탁셀의 제조방법 Download PDFInfo
- Publication number
- KR100965866B1 KR100965866B1 KR1020090055964A KR20090055964A KR100965866B1 KR 100965866 B1 KR100965866 B1 KR 100965866B1 KR 1020090055964 A KR1020090055964 A KR 1020090055964A KR 20090055964 A KR20090055964 A KR 20090055964A KR 100965866 B1 KR100965866 B1 KR 100965866B1
- Authority
- KR
- South Korea
- Prior art keywords
- docetaxel
- solvent
- purity
- purified water
- amorphous
- Prior art date
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
Description
측정기기 | Rigaku, D/MAX 3B, XRPD |
측정방법 | 시료 약 20 mg 을 XRPD sampler에 정착, 상온에서 분으로 5℃에서 25℃까지 스캐닝하여 측정. |
X-선 소스 | CuKα 40kV, 40mA |
기기 | Hewlett Packard 1100 HPLC |
컬럼 | Curosil PFP 4.6X50, 5micron |
컬럼 온도 | 35℃ |
이동상 | 아세토나이트릴:물(35-65% 농도구배) |
유속 | 1ml/min |
주입량 | 10ul |
검출기 | UV(227nm) |
MeOH | EtOH | |||
도세탁셀 순도 변화(%) | 7-epi-docetaxel 생성량 (area%) | 도세탁셀 순도 변화(%) | 7-epi-docetaxel 생성량(area%) | |
0hr | 99.7469 | 0 | 99.7480 | 0 |
1hr | 95.7399 | 4.0163 | 99.2959 | 0.4494 |
5hr | 81.8743 | 17.2282 | 97.8546 | 1.8948 |
10hr | 69.3707 | 28.4728 | 96.8045 | 2.9451 |
24hr | 50.7338 | 41.5352 | 95.1952 | 4.5544 |
Claims (2)
- 도세탁셀 함유물 또는 도세탁셀을 아세톤 용매에 1 내지 30%(w/v)로 혼합하여 현탁된 상태로 콜로이드화시키고상기 얻어진 콜로이드 중의 용매를 35℃ 내지 40℃에서 증발시키고 감압 건조하여, 미세분말의 무수결정형 도세탁셀을 수득하는 단계를 포함하는무수결정형 도세탁셀의 제조 방법.
- 삭제
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020090055964A KR100965866B1 (ko) | 2009-06-23 | 2009-06-23 | 무수결정형 도세탁셀의 제조방법 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020090055964A KR100965866B1 (ko) | 2009-06-23 | 2009-06-23 | 무수결정형 도세탁셀의 제조방법 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020060000276A Division KR100995390B1 (ko) | 2006-01-02 | 2006-01-02 | 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20090074712A KR20090074712A (ko) | 2009-07-07 |
KR100965866B1 true KR100965866B1 (ko) | 2010-06-24 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020090055964A KR100965866B1 (ko) | 2009-06-23 | 2009-06-23 | 무수결정형 도세탁셀의 제조방법 |
Country Status (1)
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KR (1) | KR100965866B1 (ko) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6838569B2 (en) * | 2002-12-16 | 2005-01-04 | Dabur India Limited | Process for preparation of paclitaxel trihydrate and docetaxel trihydrate |
-
2009
- 2009-06-23 KR KR1020090055964A patent/KR100965866B1/ko active IP Right Grant
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6838569B2 (en) * | 2002-12-16 | 2005-01-04 | Dabur India Limited | Process for preparation of paclitaxel trihydrate and docetaxel trihydrate |
Non-Patent Citations (1)
Title |
---|
Bull. Korean Chem. Soc. 22(8), p.925-928(2001)* |
Also Published As
Publication number | Publication date |
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KR20090074712A (ko) | 2009-07-07 |
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