KR100886633B1 - Skin pricking micro projection apparatus having reservoir space of materials for transdermal delivery in front side - Google Patents

Abstract

The present invention relates to a fine projection device for penetrating the skin having a receiving space of the body delivery material to be delivered to the body through the skin in the front portion. The present invention is a substrate; Fine protrusions for skin penetration protruding from the front surface of the substrate; And a wall surrounding the fine protrusions for penetrating the skin on the front of the substrate and formed higher than the fine protrusions for penetrating the skin. According to the present invention, an accommodation space for the delivery material in the body is provided through the skin on the front surface where the minute protrusions are formed, thereby enabling quantitative and effective delivery of the delivery material in the body. And because the structure is simple and does not need a hole for mass transfer to the fine projections, it is easy to manufacture and simple to use.

Microprotrusion devices, microneedles, skin, drug delivery, drug storage

Description

Skin pricking micro projection apparatus having reservoir space of materials for transdermal delivery in front side}

1 is a perspective view of a fine protrusion device for penetrating skin according to a first embodiment of the present invention,

2 is a cross-sectional view showing an installation state of the fine projection device for penetration according to the first embodiment;

3A to 3C are diagrams illustrating a state of use of the fine protrusion device for penetrating the skin according to the first embodiment of the present invention;

Figure 4 is a cross-sectional view showing the installation state of the fine projection device for penetration in accordance with a second embodiment of the present invention,

Figure 5 is a cross-sectional view showing the configuration of the fine projection device for penetration in accordance with a third embodiment of the present invention,

Figure 6 is a cross-sectional view showing the installation state of the fine projection device for penetration in accordance with a fourth embodiment of the present invention,

7 is a cross-sectional view showing the installation state of the fine projection device for penetration in accordance with a fifth embodiment of the present invention;

8 is a cross-sectional view showing the installation state of the fine projection device for penetration in accordance with a sixth embodiment of the present invention;

9 is a cross-sectional view showing the configuration of a fine projection device for penetration in accordance with a seventh embodiment of the present invention;

10 is a cross-sectional view of a fine protrusion device for penetrating skin according to an eighth embodiment of the present invention.

Explanation of symbols on the main parts of the drawings

10; Fine protrusions for skin penetration

11; Substrate 12; Fine projection

13; Wall 20; skin

30,45; Receiving space for body delivery material

35; Body delivery substance 40; syringe

41; Injection needle 44; pellicle

50,62; Adhesive layer 60; Fixed band

61; Secondary wall

The present invention relates to a micro-projection device for penetrating skin to deliver a drug or skin cosmetic material through the skin, and more particularly, it can be easily manufactured to improve the delivery of the drug or skin cosmetic material to the body through the skin. It relates to a fine projection device for skin penetration.

As a method of delivering a drug or skin cosmetic material into the body through the skin, a method of permeating skin tissue and delivering it to the body is known. This delivery method has the advantage of local and continuous delivery, painless and easy to use. However, this method of delivery has the disadvantage that the absorption of drugs or skin cosmetics is very low. In particular, when the hydrophilicity or the molecular weight is large, the water absorption is further lowered. This is because the stratum corneum of 10 to 50 μm prevents the outflow of substances in the body and the penetration of the substances into the body.

In order to improve such a problem, a technique of delivering a drug or a skin cosmetic material by forming a channel in the skin with fine protrusions has been introduced. This technique solves the above-mentioned disadvantages of delivery by forming a channel through which a drug or a skin cosmetic material can be delivered to the stratum corneum using a microprojection, such as a micro needle.

For example, US Pat. No. 3,964,482 discloses a microprotrusion device through which the drug is delivered to the skin to penetrate the skin so that the drug in the drug receiving space at the rear is delivered to the skin through the hole. The micro-projection device for constructing and delivering the micro-projection portion to include the material, and the micro-projection device for delivering the drug through a hole formed in the substrate between the micro-projections. However, the microprotrusion device having a microneedle having a hole or a microneedle of a material containing a substance to be delivered into the body is not easy to manufacture, and the microprotrusion device that delivers through a hole between the microprotrusions is a drug delivery. There is a problem that the amount is not accurate and the drug delivery efficiency is low.

As another technique, US Pat. No. 6,230,051 introduces a microprotrusion device without channels as well as drug reservoirs. The microprotrusion device delivers the drug by precoating the drug on the microneedle or by forming a hole in the skin using the microneedle and then applying the drug to the site. This technology has the advantage of easy manufacturing, but the exact amount of drug delivery is difficult, and when used by coating has the disadvantage that the drug to be applied must be transformed into a form that can be coated.

As another technique, U.S. Patent No. 6,607,513 introduces a microprotrusion device that forms a part that can be connected to a cylinder of a syringe and does not have a drug reservoir by itself, but connects another device to supply a drug. . This micro-protrusion device also has a disadvantage that it is not easy to manufacture because a fine needle with a channel is required.

SUMMARY OF THE INVENTION An object of the present invention is to provide a fine projection device for penetrating the skin that is accurate in the amount of the substance to be delivered to the body through the skin to solve the above-mentioned problems and is easy to manufacture.

In order to achieve the above object, the present invention is a base plate (base plate); A plurality of fine protrusions for penetrating the skin protruding from the front surface of the substrate; And a wall which is formed higher than the fine protrusions for penetrating the skin at the front of the substrate to surround the fine protrusions for penetrating the skin, thereby forming a receiving space of the intracorporeal delivery material. .

In addition, in order to achieve the above object, the present invention is a substrate; A fine protrusion array attached to the front surface of the substrate and arranged with fine protrusions for penetrating the skin so as to protrude from the opposite side of the attached surface; And a wall surrounding the fine protrusion array for skin penetration in a front surface of the substrate and formed higher than the fine protrusion for skin penetration to form a receiving space of the intracorporeal delivery material. do.

Hereinafter, the micro-projection device for penetrating the skin according to the present invention will be described in detail with reference to the accompanying drawings. However, in the drawings and the description of the embodiments, illustration and description of parts not related to the central technical idea of the present invention will be omitted so as not to obscure the gist of the present invention. In addition, detailed description of components having substantially the same configuration and function will be omitted. For the same reason, some components in the accompanying drawings are exaggerated, omitted, or schematically illustrated, and the size of each component does not entirely reflect the actual size.

On the other hand, the term "in vivo delivery material" used throughout this specification means a drug or skin cosmetic material to be delivered to the body through the skin. And it should be noted that the term "fine protrusions" is a term of concept that includes a fine needle.

First embodiment

1 is a perspective view of a fine protrusion device for penetrating the skin according to a first embodiment of the present invention, Figure 2 is a cross-sectional view showing the installation state of the fine protrusion device for penetration according to the first embodiment.

1 and 2, the micro-projection device 10 for penetrating the skin of the present embodiment includes a substrate 11 having a disc shape and a wall 13 formed at a predetermined height along the front edge of the substrate 11, and the same. And a plurality of fine protrusions 12 for penetrating the skin disposed inside the wall 13. An accommodating space 30 of the intracorporeal delivery material to be delivered into the body by the substrate 11 and the wall 13 is formed in the front side of the substrate 11 and in the front of the substrate 11 an accommodating space ( 30, the fine protrusions 12 protrude.

The substrate 11 is made of a flexible material such that when the upper surface of the wall 13 is in contact with the skin 20 and pressed by an external force, the fine protrusions 12 for skin penetration are advanced toward the skin 20 to allow skin penetration. It is preferable to comprise. Here, the substrate 11 is preferably made of a material that can be penetrated by the syringe needle so as to inject the delivery material in the body with the syringe into the receiving space 30 of the delivery material. Even if the substrate 11 is made of a hard material, since the skin is elastic, the minute protrusion 12 for penetrating the skin may penetrate the skin 20, and thus the substrate 11 may be made of a hard material. On the other hand, the shape of the substrate 11 is not limited to the original plate may have a variety of forms.

The wall 13 is formed at a predetermined height along the front edge of the substrate 11. The wall 13 together with the substrate 11 determines the size of the receiving space 30 in which the intracorporeal delivery material is accommodated. Here, the wall 13 is formed higher than the height of the skin protrusion fine protrusions 12 on the substrate 11 and surrounds the skin protrusion fine protrusions 12. Accordingly, the fine protrusions 12 for skin penetration may be protected from external physical contact.

The fine protrusions 12 for penetrating the skin have a conical shape, and are formed to have a size that allows a small hole in the skin 20 by advancing toward the skin 20 when the substrate 11 is pressed. When the substrate 11 is pressed while the upper surface of the wall 13 is in contact with the skin 20, the substrate 11 is bent or the wall 13 is immersed into the skin due to elasticity of the skin, thereby causing fine protrusions for skin penetration. 12 is advanced toward the skin 20 to form a hole of a fine size in the skin (20).

The height of the fine protrusions 12 for skin penetration may be lowered or increased depending on the degree of skin penetration or the height of the wall 13. The size, arrangement, and spacing of the fine protrusions 12 for penetrating the skin may be appropriately determined in consideration of the use purpose or the application range. For example, the fine protrusions 12 for penetrating the skin are preferably disposed at a distance from the wall 13. This is because when the fine protrusions 12 for penetrating the skin are disposed near the wall 13, the degree of warpage of the substrate 11 may be lower than that of the center part due to the wall 13.

Hereinafter, a process of delivering a skin permeation liquid such as a drug or a skin cosmetic liquid to the skin using the skin penetration protrusion of the first embodiment will be described. Through this, the fine protrusions for penetrating the skin of the first embodiment of the present invention will be more clearly understood.

3A to 3C are diagrams illustrating a state of use of the fine protrusions for penetrating the skin according to the first embodiment of the present invention.

First, as shown in FIG. 3a, the micro-projection device 10 for skin penetration according to the present invention is in close contact with the skin 20. In this state, the intracorporeal delivery material 35 to be delivered to the body is injected into the receiving space 30 in which the intracorporeal delivery material between the microprotrusion device 10 and the skin 20 is accommodated using the syringe 40. A syringe needle 41 may be penetrated through the substrate 11 to inject a predetermined amount of intracorporeal delivery material 35. When the injection of the intracorporeal delivery material 35 is completed, the syringe 40 is separated from the microprotrusion device 10.

Subsequently, as illustrated in FIG. 3B, the substrate 11 is pressed to form a hole 25 through the skin 20 with the fine protrusions 12 for penetrating the skin, thereby forming a channel through which the body delivery material 35 may be transferred. When the pressing force of the substrate 11 is removed, the fine protrusions 12 for penetrating the skin are separated from the skin 50 by the restoring force of the substrate 11.

Accordingly, as shown in FIG. 3C, the intracorporeal delivery material 35 is absorbed into the body through the portion of the hole 25 formed in the skin 20. In this process, if the substrate 11 is pressed to an appropriate level, the transmission material 35 in the body may be pressurized to increase the speed of penetration.

On the other hand, the hole formed in the substrate 11 by the needle 41 of the syringe 40 can be filled again by the elasticity of the material of the substrate 11. In order to completely block the tape, the substrate 11 may be attached to a hole where a hole is formed.

Second embodiment

Figure 4 is a cross-sectional view showing the installation state of the fine projection device for penetration in accordance with a second embodiment of the present invention.

The fine protrusions 10a for skin penetration of the present invention shown in FIG. 4 are assembled in a state in which the substrate 11a and the wall 13a are individually manufactured. In the present embodiment, the fine protrusions 12a for skin penetration are formed together or separately manufactured in the manufacturing process of the substrate 11a and then bonded to the substrate 11a.

Here, the substrate 11a and the wall 13a and the fine protrusions 12a for penetrating the skin may be made using the same material or different materials. On the other hand, the wall 13a is preferably composed of an elastic material, for example, rubber. This is because the substrate 11a can be pressed more easily, so that the penetration of the fine protrusions 12a into the skin becomes easier.

Third embodiment

5 is a cross-sectional view showing the configuration of a fine projection device for penetration according to a third embodiment of the present invention.

The fine protrusions 310 for skin penetration of the present invention shown in FIG. 5 are stretchable as a substrate 311a and a sheet-like fine protrusion array 311b (hereinafter referred to as a "fine protrusion array sheet") and a wall. It includes a spacer (313) having a structure, which is manufactured after being assembled individually. Unlike the above-described embodiments, the micro-projection device 310 has a micro-projection array sheet 311b manufactured separately from the substrate 311a. A plurality of fine protrusions 312 are formed on one surface of the fine protrusion array sheet 311b.

Fourth embodiment

6 is a cross-sectional view showing the installation state of the fine projection device for penetration according to the fourth embodiment of the present invention.

The fine protrusions 110 for skin penetration of the present invention shown in FIG. 6 include a thin film 44 attached to the wall 13 to seal the receiving space 30 of the intracorporeal delivery material. In the microprotrusion apparatus 110 of this embodiment, the receiving space 30 of the intracorporeal delivery material to be delivered into the body by the thin film 44 is secured without being in contact with the skin 20. This microprojection device 110 is an embodiment showing that, unlike the first embodiment described above, it can have its own receiving space 30 of the intracorporeal delivery material. The microprotrusion device 10 may inject the intracorporeal delivery material 35 such as a drug or a skin cosmetic material in advance into the receiving space 30 of the intracorporeal delivery material before attaching to the skin 20.

When the substrate 11 is pressed, the fine protrusions 12 for penetrating the skin form holes in the thin film 44 and form holes in the skin 20. Therefore, this fine protrusion device 10 can be used in the same manner as in the first embodiment described above.

Fifth Embodiment

7 is a cross-sectional view showing the installation state of the fine projection device for penetration according to the fifth embodiment of the present invention.

7 is a structure in which the adhesive layer 50 is formed on the entire surface of the thin film 44 in contact with the skin 20. When the micro-protrusion device 111 is in close contact with the skin 20, the adhesive layer 50 is adhered to the skin 20. The micro-protrusion device 111 of this embodiment is an embodiment showing that the adhesion of the skin 50 can be easily and accurately made by having the adhesive layer 50 in contact with the skin 20.

Here, the adhesive layer 50 may be partially formed without being formed over the entire surface of the thin film 44. In addition, the adhesive layer 50 may be formed on the upper surface of the wall 13 in contact with the skin 20 when there is no thin film 44 as in the first to third embodiments. When the adhesive layer 50 is partially formed, the adhesive layer 50 may be formed to surround the edge of the wall 13 or the thin film 44 to prevent leakage of the intra-body delivery material 35.

Sixth embodiment

8 is a cross-sectional view showing the installation state of the fine projection device for penetration according to the sixth embodiment of the present invention.

The micro-projection device 112 for skin penetration of the present invention shown in FIG. 8 is a structure in which the fixing band 60 is further included in the structure of the above-described fifth embodiment to increase the adhesion. The fixing band 60 covers the substrate 11. The fixing band 60 is a part of which is attached to the entire back side of the substrate 11, and a portion outside the substrate 11 is bent toward the skin 20 to be attached. It is an example showing that the adhesive layer 50 can be attached to the skin itself and the adhesion can be improved by the fixing band 60. Because of the role of the fixing band as described above it can be seen that the need of the fixing band 60 in the structure of the first to fourth embodiments is greater.

Here, the fixing band 60 may be attached to the substrate 11 in advance, or may be attached after the microprotrusion device 112 is in close contact with the skin 20. In addition, the fixing band 60 may be formed in both directions covering or facing the fine protrusions 112 as a whole.

Seventh embodiment

9 is a cross-sectional view showing the installation state of the fine projection device for penetration according to the seventh embodiment of the present invention.

The fine protrusions 113 for penetrating the skin of the present invention shown in FIG. 9 further include an auxiliary wall 61 attached to the fixing band 60 to surround the outside of the substrate 11. The auxiliary wall 61 together with the wall 13 secures the receiving space 30 of the intracorporeal delivery material and double seals the receiving space 30 of the intracorporeal delivery material. This fine projection device 113 is an example configured to disperse the force exerted on the wall 13 by the external force by the auxiliary wall 61 or to prevent the transfer of the intracorporeal delivery material from the outside.

Here, the auxiliary wall 61 is preferably made of a flexible material such as rubber or sponge. In addition, the auxiliary wall 61 may also be formed on the contact surface with the skin 20, like the thin film 50, partially or over the entire surface.

Eighth embodiment

10 is a cross-sectional view of a fine protrusion device for penetrating skin according to an eighth embodiment of the present invention.

As shown in FIG. 10, the micro-projection device 410 for penetrating the skin is attached with a micro-projection array sheet 411b on the substrate 411a as shown in FIG. And an intermediate plate 480 having a hole 485 through which the micro-projections 412 can penetrate at a position corresponding to the micro-projections 412 on the wall 413. ), A protective film 444 is attached, and the intra-body delivery material 435 is accommodated in the space surrounded by the protective film 444 and the protective cover 490. Here, the protective film 444 and the protective cover 490 protects the body delivery material 435 from external contamination and prevents flow, especially when the viscosity of the delivery material 435 is low.

The process of using the fine protrusion 410 of this embodiment is similar to the above-described embodiments. However, when the material to be delivered into the body is a highly viscous material, it is more preferable to remove the protective cover 490 immediately before use.

The fine protrusions for skin penetration according to the present invention as described above is provided with a receiving space of the body delivery material to be delivered to the body in the front portion is formed with a fine protrusion. Delivery of a quantitative drug or skin cosmetic material through the skin is possible by filling an appropriate amount of drug or skin cosmetic material in the accommodation space of the body delivery material or by forming an accommodation space of the body delivery material in an appropriate size.

In addition, the micro-projection device for skin penetration according to the present invention is capable of effective delivery of drugs or skin cosmetics by pressing the substrate.

In addition, the micro-projection device for skin penetration according to the present invention has a simple structure and does not require a hole for delivery of a drug or a skin cosmetic material to the micro-projection, and thus is easy to manufacture.

Moreover, the micro-projection device for skin penetration according to the present invention can be used simply by putting the substrate on the site where the drug or skin cosmetic material is to be penetrated.

Claims (18)

A base plate made of a flexible material that can be bent by an external force; A plurality of fine protrusions for penetrating the skin protruding from the front surface of the substrate; A wall formed on the front surface of the substrate so as to enclose the fine protrusions for penetrating the skin to form an accommodation space of the body delivery material; And A thin film covering the wall to seal the receiving space with the substrate and the wall; Fine protrusions for skin penetration comprising a. delete According to claim 1, The apparatus for penetrating skin, characterized in that the body delivery material is stored in the receiving space of the body delivery material. Board; A fine protrusion array attached to a front surface of the substrate and arranged with fine protrusions for penetrating the skin so as to protrude from an opposite side of the attached surface; A wall enclosing the array of fine protrusions for penetrating the skin on a front surface of the substrate and formed higher than the fine protrusions for penetrating the skin to form an accommodation space of the body delivery material; And A thin film covering the wall to seal the receiving space with the substrate and the wall; Fine protrusions for skin penetration comprising a. The fine protrusions for penetrating skin of claim 1 or 4, further comprising an intermediate plate attached to the wall and having a through hole formed at a position corresponding to the fine protrusions for penetrating the skin. The method of claim 5, And a protective film attached to the intermediate plate to seal the receiving space of the intracorporeal delivery material. The method of claim 6, A protective cover attached to the protective film to form an inner space in which the body delivery material is received; And An intracorporeal delivery material formed in an interior space in which the intracorporeal delivery material is received; Fine protrusions for skin penetration, characterized in that it further comprises. The method according to claim 1 or 4, The wall and the substrate and the fine projection for skin penetration is characterized in that the fine projection device for skin penetration characterized in that formed integrally. The method according to claim 1 or 4, The wall, the substrate and the skin penetration projections are configured independently of each other, characterized in that the fine projections for skin penetration. The method according to claim 1 or 4, The substrate and the skin protruding protrusions are integrally formed, and the walls are configured independently and are bonded to the substrate. The method of claim 4, wherein The skin penetration protrusion array is a fine projection device for skin penetration, characterized in that the sheet (sheet) form. The method of claim 4, wherein The substrate is a fine projection device for skin penetration, characterized in that the flexible material that can be bent by an external force.  The method according to claim 1 or 4, The wall is a fine projection device for penetrating the skin, characterized in that the elastic material. The method of claim 13, The elastic material is a fine projection device for skin penetration, characterized in that the rubber. The method according to claim 1 or 4, The micro-protrusion apparatus for skin penetration, characterized in that it further comprises an adhesive layer formed on the surface in contact with the skin of the wall. The method according to claim 1 or 4, And a fixing band attached to the substrate and partially attached to the skin. The method of claim 16, And the fixing band further comprises an auxiliary wall attached to an outer portion of the wall. The method of claim 17, And the auxiliary wall further comprises an adhesive layer formed on the skin contact surface.

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