KR100642110B1 - 시간적 및 공간적 조절을 제공하는 경구투여용 제어 약물 전달 시스템 - Google Patents
시간적 및 공간적 조절을 제공하는 경구투여용 제어 약물 전달 시스템 Download PDFInfo
- Publication number
- KR100642110B1 KR100642110B1 KR1020017003232A KR20017003232A KR100642110B1 KR 100642110 B1 KR100642110 B1 KR 100642110B1 KR 1020017003232 A KR1020017003232 A KR 1020017003232A KR 20017003232 A KR20017003232 A KR 20017003232A KR 100642110 B1 KR100642110 B1 KR 100642110B1
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- weight
- abandoned
- pharmaceutical composition
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2660DE1997 IN186245B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-09-19 | 1997-09-19 | |
| US09/152,932 US6261601B1 (en) | 1997-09-19 | 1998-09-14 | Orally administered controlled drug delivery system providing temporal and spatial control |
| US09/152,932 | 1998-09-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010075079A KR20010075079A (ko) | 2001-08-09 |
| KR100642110B1 true KR100642110B1 (ko) | 2006-11-10 |
Family
ID=11092787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020017003232A Expired - Fee Related KR100642110B1 (ko) | 1997-09-19 | 1999-01-19 | 시간적 및 공간적 조절을 제공하는 경구투여용 제어 약물 전달 시스템 |
Country Status (5)
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462162B2 (en) | 2001-09-04 | 2008-12-09 | Broncus Technologies, Inc. | Antiproliferative devices for maintaining patency of surgically created channels in a body organ |
| US6613357B2 (en) * | 2000-01-13 | 2003-09-02 | Osmotica Corp. | Osmotic device containing pseudoephedrine and an H1 antagonist |
| US7147870B2 (en) * | 2000-01-13 | 2006-12-12 | Osmotica Corp. | Osmotic device containing pseudoephedrine and an H1 antagonist |
| US7674480B2 (en) * | 2000-06-23 | 2010-03-09 | Teva Pharmaceutical Industries Ltd. | Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition |
| US6476006B2 (en) | 2000-06-23 | 2002-11-05 | Teva Pharmaceutical Industries, Ltd. | Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates |
| US6881420B2 (en) * | 2000-06-23 | 2005-04-19 | Teva Pharmaceutical Industries Ltd. | Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation |
| DE10031043A1 (de) * | 2000-06-26 | 2002-02-14 | Bayer Ag | Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung |
| BR0113055A (pt) * | 2000-08-08 | 2003-07-08 | Daiichi Seiyaku Co | Preparação sólida altamente absorvìvel |
| US20110171296A1 (en) * | 2000-10-30 | 2011-07-14 | Biohit Oyj | Method and preparation for binding acetaldehyde in saliva, the stomach and the large intestine |
| FI121528B (fi) * | 2000-10-30 | 2010-12-31 | Biohit Oyj | Farmaseuttinen koostumus syöpään sairastumisen riskin vähentämiseen paikallisesti sitomalla asetaldehydi syljessä, mahalaukussa tai paksusuolessa |
| MXPA03008292A (es) * | 2001-03-13 | 2003-12-11 | Penwest Pharmaceuticals Co | Formas de dosificacion cronoterapeuticas que contienen glucocorticosteroides. |
| EP1411901B1 (en) * | 2001-07-04 | 2010-08-18 | Sun Pharma Advanced Research Company Ltd | Gastric retention controlled drug delivery system |
| AU2002327418A1 (en) * | 2001-08-01 | 2003-02-17 | Bristol-Myers Squibb Company | Taste masking composition |
| US20040219186A1 (en) * | 2001-08-16 | 2004-11-04 | Ayres James W. | Expandable gastric retention device |
| US20050053657A1 (en) * | 2001-08-29 | 2005-03-10 | Ashok Rampal | Controlled release formulation of clarithromycin or tinidazol |
| US6673369B2 (en) | 2001-08-29 | 2004-01-06 | Ranbaxy Laboratories Limited | Controlled release formulation |
| US7708712B2 (en) * | 2001-09-04 | 2010-05-04 | Broncus Technologies, Inc. | Methods and devices for maintaining patency of surgically created channels in a body organ |
| US20030091630A1 (en) * | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
| US20030104052A1 (en) * | 2001-10-25 | 2003-06-05 | Bret Berner | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
| CA2409552A1 (en) * | 2001-10-25 | 2003-04-25 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
| US20030152622A1 (en) * | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
| AU2002302890A1 (en) * | 2002-02-04 | 2003-12-02 | Ranbaxy Laboratories Limited | Hydrodynamically balancing oral drug delivery system with biphasic release |
| US20060013876A1 (en) * | 2002-06-26 | 2006-01-19 | Lohray Braj B | Novel floating dosage form |
| US20040224024A1 (en) * | 2003-04-23 | 2004-11-11 | Massachusetts Institute Of Technology | Controlled drug release formulations containing polyion complexes |
| US8308682B2 (en) | 2003-07-18 | 2012-11-13 | Broncus Medical Inc. | Devices for maintaining patency of surgically created channels in tissue |
| US7554452B2 (en) * | 2003-07-18 | 2009-06-30 | Cary Cole | Ingestible tracking and locating device |
| ATE390122T1 (de) * | 2003-09-01 | 2008-04-15 | Jpm The Jordanian Pharmaceutic | Universelle zusammensetzung zur kontrollierten wirkstofffreigabe enthaltend xanthangummi und natriumalginat |
| CA2539051C (en) * | 2003-09-19 | 2014-08-12 | Penwest Pharmaceuticals Co. | Delayed release dosage forms |
| AU2004273958A1 (en) * | 2003-09-19 | 2005-03-31 | Penwest Pharmaceuticals Co. | Chronotherapeutic dosage forms |
| US20050074489A1 (en) * | 2003-10-01 | 2005-04-07 | Pediamed Pharmaceuticals, Inc. | Effervescent and effervescent-dispersion compositions for medicaments and methods of use thereof |
| US20050181050A1 (en) * | 2004-01-28 | 2005-08-18 | Collegium Pharmaceutical, Inc. | Dosage forms using drug-loaded ion exchange resins |
| TW200533391A (en) | 2004-03-25 | 2005-10-16 | Sun Pharmaceutical Ind Ltd | Gastric retention drug delivery system |
| BRPI0510226A (pt) * | 2004-05-06 | 2007-10-23 | Emisphere Tech Inc | composição farmacêutica sólida, forma de dosagem sólida, método para administrar heparina a um animal, método para tratar ou evitar trombose em um animal, método para preparar uma forma de dosagem sólida de heparina umidecida |
| PT2305245T (pt) | 2004-05-14 | 2019-03-19 | Merck Sharp & Dohme | Tratamento de doenças associadas com a utilização de antibióticos |
| NZ597499A (en) | 2004-05-14 | 2013-04-26 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| US20050260263A1 (en) * | 2004-05-18 | 2005-11-24 | Panion & Bf Biotech Inc. | Sustained release formulation for sparingly soluble main drugs |
| EP1761265A2 (en) * | 2004-06-28 | 2007-03-14 | ALZA Corporation | A drug/polymer complex, preferably ciprofloxacin/hpmc, its method of manufacturing using lyophilization and its use in an osmotic device |
| US8409167B2 (en) | 2004-07-19 | 2013-04-02 | Broncus Medical Inc | Devices for delivering substances through an extra-anatomic opening created in an airway |
| CA2589551A1 (en) * | 2004-12-03 | 2006-06-08 | Dr. Reddy's Laboratories Ltd. | Modified release ciprofloxacin compositions |
| CA2596035A1 (en) * | 2005-01-28 | 2006-08-03 | Collegium Pharmaceutical, Inc. | Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents |
| ATE396710T1 (de) * | 2005-07-19 | 2008-06-15 | Ethypharm Sa | Gastroretentive zusammensetzungen und verfahren zur herstellung |
| GB0515492D0 (en) * | 2005-07-28 | 2005-08-31 | Reckitt Benckiser Healthcare | Improvements in or relating to compositions,articles and methods |
| WO2007031887A2 (en) * | 2005-08-30 | 2007-03-22 | Nicholas Piramal India Limited | Extended release pharmaceutical composition of metformin and a process for producing it |
| NL2000281C2 (nl) * | 2005-11-02 | 2007-08-07 | Pfizer Prod Inc | Vaste farmaceutische samenstellingen die pregabaline bevatten. |
| EP1962586B1 (en) * | 2005-12-22 | 2017-07-12 | Oakwood Laboratories L.L.C. | Sublimable sustained release delivery system and method of making same |
| NZ573174A (en) * | 2006-06-01 | 2012-01-12 | Msd Consumer Care Inc | Sustained release pharmaceutical dosage form containing phenylephrine |
| ATE460934T1 (de) * | 2006-07-19 | 2010-04-15 | Tabuk Pharmaceutical Mfg Co | Pharmazeutische zubereitungen von ciprofloxacin |
| US8789536B2 (en) | 2007-10-17 | 2014-07-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US8303573B2 (en) | 2007-10-17 | 2012-11-06 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US8707964B2 (en) | 2007-10-31 | 2014-04-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US8808276B2 (en) | 2007-10-23 | 2014-08-19 | The Invention Science Fund I, Llc | Adaptive dispensation in a digestive tract |
| US8109920B2 (en) * | 2007-10-31 | 2012-02-07 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US8333754B2 (en) * | 2007-10-31 | 2012-12-18 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US8808271B2 (en) | 2007-10-31 | 2014-08-19 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
| US20100159001A1 (en) * | 2008-12-19 | 2010-06-24 | Cardinal John R | Extended-Release Pharmaceutical Formulations |
| US20100160363A1 (en) * | 2008-12-19 | 2010-06-24 | Aaipharma Services Corp. | Extended-release pharmaceutical formulations |
| FR2945947B1 (fr) | 2009-05-29 | 2011-07-29 | Flamel Tech Sa | Compositions pharmaceutiques flottantes a liberation controlee |
| JP5605365B2 (ja) * | 2009-08-31 | 2014-10-15 | ゼリア新薬工業株式会社 | 経口腸管洗浄用錠剤 |
| CA2790164A1 (en) | 2010-02-17 | 2011-08-25 | Sun Pharma Advanced Research Company Ltd. | Method of treating a disease condition susceptible to baclofen therapy |
| JP5426018B2 (ja) * | 2010-03-31 | 2014-02-26 | 持田製薬株式会社 | 易服用性固形製剤 |
| US9345532B2 (en) | 2011-05-13 | 2016-05-24 | Broncus Medical Inc. | Methods and devices for ablation of tissue |
| US8709034B2 (en) | 2011-05-13 | 2014-04-29 | Broncus Medical Inc. | Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall |
| CN107049979B (zh) | 2011-09-30 | 2020-08-14 | 持田制药株式会社 | 易服用性固体制剂 |
| WO2013078235A1 (en) | 2011-11-23 | 2013-05-30 | Broncus Medical Inc | Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall |
| ES2981892T3 (es) * | 2012-06-07 | 2024-10-11 | Epitomee Medical Ltd | Dispositivo expandido |
| GB201303781D0 (en) | 2013-03-04 | 2013-04-17 | Gauthier Pierre Pascal | Oral timer device and method of using same |
| CN105899198A (zh) | 2013-12-05 | 2016-08-24 | 图利普医疗有限公司 | 用于药物活性试剂的原位释放的滞留装置和系统 |
| EP3079663A1 (en) | 2013-12-13 | 2016-10-19 | Biogen MA Inc. | Controlled release dosage form for once daily administration of dimethyl fumarate |
| US10335374B2 (en) | 2014-12-04 | 2019-07-02 | University System of Georgia, Valdosta State University | Tablet composition for anti-tuberculosis antibiotics |
| CN109890371A (zh) | 2016-08-26 | 2019-06-14 | 斯瑞尼瓦萨饶·韦帕切杜 | 组合物及其方法 |
| CA3103661A1 (en) | 2018-05-09 | 2019-11-14 | Yale University | Particles for spatiotemporal release of agents |
| CN114191307A (zh) | 2020-09-17 | 2022-03-18 | 上海汉都医药科技有限公司 | 一种口腔滞留装置及其制备方法 |
| US11911513B2 (en) | 2018-05-23 | 2024-02-27 | Shanghai Wd Pharmaceutical Co., Ltd | Controlled-release system of active pharmaceutical ingredient and preparation method therefor |
| WO2019223753A1 (zh) | 2018-05-23 | 2019-11-28 | 上海汉都医药科技有限公司 | 活性药物成分的控释系统及其制备方法 |
| MX2020013654A (es) | 2018-06-19 | 2021-03-25 | Nat Univ Singapore | Formulaciones de 5-hidroxitriptofano (5-htp) para mejor biodisponibilidad para diversas indicaciones. |
| CN108567754A (zh) * | 2018-06-25 | 2018-09-25 | 江苏鹏鹞药业有限公司 | 盐酸环丙沙星片及其制备方法 |
| US12409163B2 (en) | 2021-07-30 | 2025-09-09 | Evecxia Therapeutics, Inc. | Method of enhancing 5-hydroxytryptophan (5-HTP) exposure |
| IL310523A (en) | 2021-07-30 | 2024-03-01 | Evecxia Therapeutics Inc | 5-hydroxytryptophan gastroretentive dosage forms |
| US11779567B2 (en) | 2021-10-14 | 2023-10-10 | Evecxia Therapeutics, Inc. | Method for optimizing 5-hydroxytryptamine function in the brain for therapeutic purposes |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5292518A (en) * | 1988-06-28 | 1994-03-08 | Hauser-Kuhrts | Prolonged-release drug tablet formulations |
Family Cites Families (272)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2909462A (en) | 1955-12-08 | 1959-10-20 | Bristol Myers Co | Acrylic acid polymer laxative compositions |
| US2993836A (en) | 1958-02-20 | 1961-07-25 | Dow Chemical Co | Sustained release tablets |
| US3079303A (en) | 1958-12-11 | 1963-02-26 | Smith Kline French Lab | Basic tablet granulation and process of using same |
| US3056143A (en) | 1959-09-04 | 1962-10-02 | Foster Benton | Apparatus for automatically flushing a toilet bowl or the like |
| BE604564A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1960-06-06 | |||
| US3133863A (en) | 1961-03-10 | 1964-05-19 | Strong Cobb Arner Inc | Sustained release therapeutic tablet compositions comprising organic solvent-gelled gums |
| US3147187A (en) | 1962-09-10 | 1964-09-01 | Don Hall Lab | Sustained release pharmaceutical |
| US3388041A (en) | 1964-01-27 | 1968-06-11 | Richardson Merrell Inc | High dosage sustained release tablet |
| GB1097207A (en) | 1964-08-24 | 1967-12-29 | Collett & Co As | Process for the preparation of sustained action tablets |
| US3456049A (en) | 1965-05-25 | 1969-07-15 | Ciba Geigy Corp | Gradual-release tablet |
| US3726690A (en) | 1965-10-22 | 1973-04-10 | Kelco Co | Acidified food products containing xanthomonas colloid |
| US3864469A (en) | 1967-12-16 | 1975-02-04 | Hoechst Ag | Xanthines in pharmaceutical preparations and for stabilization of vitamins |
| US3574820A (en) | 1968-01-08 | 1971-04-13 | Upjohn Co | Medicinal dosage forms of unpolymerized thiolated gelatin with a cross-linking accelerating agent providing slowly released medication from a swollen matrix |
| US3627583A (en) | 1969-04-29 | 1971-12-14 | Sucrest Corp | Direct compression vehicles |
| US3639169A (en) | 1969-04-29 | 1972-02-01 | Sucrest Corp | Direct compression vehicles and method therefor |
| US3629393A (en) | 1969-09-11 | 1971-12-21 | Nikken Chemicals Co Ltd | Release-sustaining-tablet |
| US3963822A (en) | 1969-09-12 | 1976-06-15 | Noma Lites Canada Limited | Method of molding electrical lamp sockets |
| GB1359643A (en) | 1970-09-28 | 1974-07-10 | Controlled Medications | Controlled release medicament |
| US4072535A (en) | 1970-12-28 | 1978-02-07 | A. E. Staley Manufacturing Company | Precompacted-starch binder-disintegrant-filler material for direct compression tablets and dry dosage capsules |
| FR2138492A1 (en) | 1971-05-27 | 1973-01-05 | Cerm Cent Europ Rech Mauvernay | Basic aluminium salts of gum xanthane - pharmaceutical gelling agents |
| DE2130545A1 (de) | 1971-06-19 | 1972-12-21 | Merck Patent Gmbh | Pharmazeutischer Formkoerper |
| US3773920A (en) | 1971-07-14 | 1973-11-20 | Nikken Chemicals Co Ltd | Sustained release medicinal composition |
| US3836618A (en) | 1971-12-23 | 1974-09-17 | American Home Prod | Process for the uniform distribution of a drug on a granulated base |
| FR2183546B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-05-10 | 1975-06-20 | Servier Lab | |
| US3963832A (en) | 1973-01-24 | 1976-06-15 | Teijin Limited | Liquid or pasty dentifrice and process for its preparation |
| JPS5512411B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-03-12 | 1980-04-02 | ||
| US4013820A (en) | 1974-11-07 | 1977-03-22 | Abbott Laboratories | Universally useable tableting ingredients |
| US4036228A (en) | 1975-09-11 | 1977-07-19 | Alza Corporation | Osmotic dispenser with gas generating means |
| US4077407A (en) | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
| US4332789A (en) | 1975-12-15 | 1982-06-01 | Hoffmann-La Roche Inc. | Pharmaceutical unit dosage forms |
| US4344857A (en) | 1975-12-22 | 1982-08-17 | The United States Of America As Represented By The Secretary Of Agriculture | Encapsulation by entrapment |
| US4126672A (en) | 1976-02-04 | 1978-11-21 | Hoffmann-La Roche Inc. | Sustained release pharmaceutical capsules |
| US4167558A (en) | 1976-02-13 | 1979-09-11 | Hoffmann-La Roche Inc. | Novel sustained release tablet formulations |
| US4140755A (en) | 1976-02-13 | 1979-02-20 | Hoffmann-La Roche Inc. | Sustained release tablet formulations |
| US4101650A (en) | 1977-04-06 | 1978-07-18 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Pepstatin floating minicapsules |
| US4163777A (en) | 1977-04-29 | 1979-08-07 | Lewis/Howe Company | Controlled antacid delivery form and method of treatment therewith |
| GB1579818A (en) | 1977-06-07 | 1980-11-26 | Yamanouchi Pharma Co Ltd | Nifedipine-containing solid preparation composition |
| US4361545A (en) | 1979-05-21 | 1982-11-30 | Rowell Laboratories, Inc. | Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion |
| CA1146866A (en) | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| US4248858A (en) | 1979-08-09 | 1981-02-03 | American Home Products Corporation | Sustained release pharmaceutical compositions |
| US4309405A (en) | 1979-08-09 | 1982-01-05 | American Home Products Corporation | Sustained release pharmaceutical compositions |
| FR2470599A1 (fr) | 1979-12-07 | 1981-06-12 | Panoz Donald | Perfectionnements apportes aux procedes de preparation de formes galeniques a action retard et a liberation programmee et formes galeniques de medicaments ainsi obtenus |
| US4259314A (en) | 1979-12-10 | 1981-03-31 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals |
| US4308251A (en) | 1980-01-11 | 1981-12-29 | Boots Pharmaceuticals, Inc. | Controlled release formulations of orally-active medicaments |
| US4344929A (en) | 1980-04-25 | 1982-08-17 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4620007A (en) | 1980-09-03 | 1986-10-28 | Bayer Aktiengesellschaft | 6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid |
| US4670444B1 (en) | 1980-09-03 | 1999-02-09 | Bayer Ag | and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds |
| US4439453A (en) | 1980-12-22 | 1984-03-27 | Monsanto Company | Directly compressible acetaminophen granulation |
| DE3127237A1 (de) | 1981-07-10 | 1983-01-20 | Hoechst Ag, 6000 Frankfurt | Magenvertraegliche arzneiformen von xanthinderivaten und verfahren zu ihrer herstellung |
| US4375468A (en) | 1981-07-13 | 1983-03-01 | Verex Laboratories, Inc. | Constant order release aspirin composition and method of treating arthritis |
| US4424235A (en) | 1981-09-14 | 1984-01-03 | Hoffmann-La Roche Inc. | Hydrodynamically balanced controlled release compositions containing L-dopa and a decarboxylase inhibitor |
| JPS5846019A (ja) | 1981-09-14 | 1983-03-17 | Kanebo Ltd | 持続性ニフエジピン製剤 |
| US4369172A (en) | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| US4525345A (en) | 1981-12-24 | 1985-06-25 | Verex Laboratories, Inc. | Constant order release, solid dosage indomethacin formulation and method of treating arthritis and other inflammatory conditions |
| US4434153A (en) | 1982-03-22 | 1984-02-28 | Alza Corporation | Drug delivery system comprising a reservoir containing a plurality of tiny pills |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4414198A (en) | 1982-04-23 | 1983-11-08 | Joseph Michaelson | Rapidly disintegrable tablet composition and method |
| US4556678A (en) | 1982-06-24 | 1985-12-03 | Key Pharmaceuticals, Inc. | Sustained release propranolol tablet |
| US4444769A (en) | 1982-07-27 | 1984-04-24 | Mylan Pharmaceuticals, Inc. | Antihypertensive diuretic combination composition and associated method |
| ATE51147T1 (de) | 1982-07-27 | 1990-04-15 | Mylan Pharmaceuticals Inc | Verfahren zur herstellung einer kombinierten pharmazeutischen zusammensetzung in einer granulaeren heterogenen dosisform mit erhoehter bioverfuegbarkeit. |
| US5366738A (en) | 1982-07-29 | 1994-11-22 | Merck & Co., Inc. | Controlled release drug dispersion delivery device |
| CA1207231A (en) | 1982-08-24 | 1986-07-08 | Hans W. Zulliger | Medicated suppository |
| US4698101A (en) | 1982-08-30 | 1987-10-06 | Suomen Sokeri Oy (Finnish Sugar Company Ltd.) | Binder-diluent composition and method |
| US4547498A (en) | 1983-01-06 | 1985-10-15 | Mylan Pharmaceuticals Inc. | Pharmaceutical combination composition and associated method |
| US4526777A (en) | 1983-01-06 | 1985-07-02 | Mylan Pharmaceuticals Inc. | Pharmaceutical combination composition and associated method |
| DE3435325A1 (de) | 1983-04-09 | 1986-04-17 | Nikken Chemicals Co., Ltd., Tokio/Tokyo | Langzeitwirkende theophyllin-tablette und verfahren zu deren herstellung |
| DE3318649A1 (de) | 1983-05-21 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | Zweiphasenformulierung |
| GB8323624D0 (en) | 1983-09-02 | 1983-10-05 | Reckitt & Colmann Prod Ltd | Medicinal compositions |
| DE3333719A1 (de) | 1983-09-17 | 1985-04-04 | Bayer Ag | Loesungen milchsaurer salze von piperazinylchinolon- und piperazinyl-azachinoloncarbonsaeuren |
| US4717713A (en) | 1983-10-31 | 1988-01-05 | Research Corporation | Controlled release liquid pharmaceutical |
| DE3346571A1 (de) | 1983-12-23 | 1985-07-04 | Bayer Ag, 5090 Leverkusen | Oral retardierte acetylsalicylsaeureformulierungen |
| US4613497A (en) * | 1984-02-29 | 1986-09-23 | Health Products Development, Inc. | Dry, water-foamable pharmaceutical compositions |
| US4849229A (en) | 1984-03-26 | 1989-07-18 | Forest Laboratories, Inc. | Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants |
| US4540566A (en) | 1984-04-02 | 1985-09-10 | Forest Laboratories, Inc. | Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose |
| JPS60219238A (ja) | 1984-04-14 | 1985-11-01 | Hayashibara Biochem Lab Inc | 徐崩性プルラン含有成形物とその製法 |
| US4590062A (en) | 1984-04-16 | 1986-05-20 | Tech Trade Corp. | Dry direct compression compositions for controlled release dosage forms |
| JPS60174728U (ja) | 1984-04-26 | 1985-11-19 | 山田 喜一 | 消雪屋根の構造 |
| DE3420116A1 (de) | 1984-05-30 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | Immunstimulierende mittel |
| DE3420770A1 (de) | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| JPS6124516A (ja) | 1984-07-12 | 1986-02-03 | Fujisawa Pharmaceut Co Ltd | 持続性錠剤 |
| JPS6143108A (ja) | 1984-08-03 | 1986-03-01 | Nippon Shinyaku Co Ltd | 医薬品製剤及びその製造法 |
| US4610870A (en) | 1984-10-05 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| GB8426152D0 (en) | 1984-10-16 | 1984-11-21 | Reckitt & Colmann Prod Ltd | Medicinal compositions |
| DE3440288C2 (de) | 1984-11-05 | 1987-03-12 | Gergely, Gerhard, Dr.-Ing., Wien | Pharmazeutische Zubereitung mit einem Gehalt an Ibuprofen sowie Verfahren zu ihrer Herstellung |
| BE901111A (fr) | 1984-11-22 | 1985-03-15 | Benfar Representee Par Vanderl | Composition pharmaceutiques a liberation prolongee, leur procede de preparation et leur utilisation. |
| EP0182772A3 (fr) | 1984-11-22 | 1987-04-01 | Benfar | Compositions pharmaceutiques à libération prolongée, leur procédé de préparation et leur utilisation |
| US4839171A (en) | 1984-11-30 | 1989-06-13 | Techmix, Inc. | Composition for treating impaired lactation |
| DE3517709A1 (de) | 1985-01-05 | 1986-07-10 | Bayer Ag | Basische zubereitungen von chinoloncarbonsaeuren |
| EP0188040B1 (en) | 1985-01-11 | 1991-08-14 | Abbott Laboratories Limited | Slow release solid preparation |
| US4639458A (en) | 1985-01-22 | 1987-01-27 | Merck & Co., Inc. | Tablet and formulation |
| US4747881A (en) | 1985-02-05 | 1988-05-31 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| DE3504643A1 (de) | 1985-02-12 | 1986-08-14 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl)-3-chinolin carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3509546A1 (de) | 1985-03-16 | 1986-09-25 | Bayer Ag, 5090 Leverkusen | 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| GB8507779D0 (en) | 1985-03-26 | 1985-05-01 | Fujisawa Pharmaceutical Co | Drug carrier |
| DK162986A (da) | 1985-04-12 | 1986-10-13 | Forest Laboratories | Terapeutisk middel i enhedsdosisform |
| DE3517535A1 (de) | 1985-05-15 | 1986-11-20 | Bayer Ag, 5090 Leverkusen | 1-aryl-4-chinolon-3-carbonsaeuren |
| US4695463A (en) | 1985-05-24 | 1987-09-22 | Warner-Lambert Company | Delivery system for active ingredients and preparation thereof |
| US4666705A (en) | 1985-06-03 | 1987-05-19 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| DE3681348D1 (de) | 1985-06-11 | 1991-10-17 | Teijin Ltd | Oral-arzneizubereitung mit retardwirkung. |
| EP0227814A1 (en) | 1985-07-02 | 1987-07-08 | The Upjohn Company | Therapeutic formulations with bimodal release characteristics |
| DE3608745A1 (de) | 1985-07-24 | 1987-01-29 | Bayer Ag | Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin |
| GB8518927D0 (en) | 1985-07-26 | 1985-09-04 | Vincent Processes Ltd | Tablets |
| GB8522453D0 (en) | 1985-09-11 | 1985-10-16 | Lilly Industries Ltd | Chewable capsules |
| JPS62103012A (ja) | 1985-10-23 | 1987-05-13 | Eisai Co Ltd | 多重顆粒 |
| DE3537761A1 (de) | 1985-10-24 | 1987-04-30 | Bayer Ag | Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure |
| US4734285A (en) | 1985-10-28 | 1988-03-29 | The Dow Chemical Company | Sustained release compositions |
| US4704285A (en) | 1985-11-18 | 1987-11-03 | The Dow Chemical Company | Sustained release compositions comprising hydroxypropyl cellulose ethers |
| US4977154A (en) | 1985-12-12 | 1990-12-11 | Warner-Lambert Company | 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents |
| IT1188212B (it) | 1985-12-20 | 1988-01-07 | Paolo Colombo | Sistema per il rilascio a velocita' controllata di sostanze attive |
| GB8601204D0 (en) | 1986-01-18 | 1986-02-19 | Boots Co Plc | Therapeutic agents |
| US5286754A (en) | 1986-01-21 | 1994-02-15 | Bayer Aktiengesellschaft | Pharmaceutical formulations of ciprofloxacin |
| IE63321B1 (en) | 1986-02-03 | 1995-04-05 | Elan Corp Plc | Drug delivery system |
| GB2186485B (en) | 1986-02-13 | 1988-09-07 | Ethical Pharma Ltd | Slow release formulation |
| DE3705621C2 (de) | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
| IT1191674B (it) | 1986-03-07 | 1988-03-23 | Eurand Spa | Formulazioni per la preparazione di farmaci a rilascio prolungato adatte alla somministrazione per via orale |
| GB8608818D0 (en) | 1986-04-11 | 1986-05-14 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions |
| US4798725A (en) | 1986-06-16 | 1989-01-17 | Norwich Eaton Pharmaceuticals, Inc. | Sustained release capsule |
| US4847093A (en) | 1986-06-19 | 1989-07-11 | Alza Corporation | Dosage form with means for governing rate of gas formation |
| JPH0798742B2 (ja) | 1986-07-03 | 1995-10-25 | ゼリア新薬工業株式会社 | 徐放性製剤組成物 |
| JPH0826346B2 (ja) | 1986-07-10 | 1996-03-13 | 株式会社林原生物化学研究所 | 固状油溶性物質の製法 |
| GB8618847D0 (en) | 1986-08-01 | 1986-09-10 | Smith Kline French Lab | Pharmaceutical formulations |
| US4800083A (en) | 1986-10-20 | 1989-01-24 | R. P. Scherer Corporation | Sustained release method and product |
| DE3636123A1 (de) | 1986-10-23 | 1988-05-05 | Rentschler Arzneimittel | Arzneizubereitungen zur oralen verabreichung, die als einzeldosis 10 bis 240 mg dihydropyridin enthalten |
| GB8628359D0 (en) | 1986-11-27 | 1986-12-31 | Zyma Sa | Galenical formulation |
| ES2040697T3 (es) | 1986-12-18 | 1993-11-01 | Kurt H. Prof. Dr. Bauer | Concentrado de nifedipina estabilizado frente a la influencia de la luz, y procedimiento para su preparacion. |
| IE59540B1 (en) | 1987-01-09 | 1994-03-09 | Elan Corp | Sustained release capsule or tablet formulation |
| US5015479A (en) | 1987-02-02 | 1991-05-14 | Seamus Mulligan | Sustained release capsule or tablet formulation comprising a pharmaceutically acceptable dihydropyridine |
| GB8705083D0 (en) | 1987-03-04 | 1987-04-08 | Euro Celtique Sa | Spheroids |
| US4786503A (en) | 1987-04-06 | 1988-11-22 | Alza Corporation | Dosage form comprising parallel lamine |
| US4808413A (en) | 1987-04-28 | 1989-02-28 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions in the form of beadlets and method |
| KR960011236B1 (ko) | 1987-05-08 | 1996-08-21 | 스미스 클라인 앤드 프렌취 라보라토리스 리미티드 | 제약학적 조성물 및 고체 제형 |
| DE3719764A1 (de) | 1987-06-13 | 1988-12-22 | Bayer Ag | Ionenaustauscherharze beladen mit chinoloncarbonsaeurederivaten, ihre herstellung und verwendung |
| DE3720757A1 (de) | 1987-06-24 | 1989-01-05 | Bayer Ag | Dhp-manteltablette |
| US5219575A (en) | 1987-06-26 | 1993-06-15 | Duphar International Research B.V. | Compositions with controlled zero-order delivery rate and method of preparing these compositions |
| US4814178A (en) | 1987-07-01 | 1989-03-21 | Sanford Bolton | Floating sustained release therapeutic compositions |
| US4792452A (en) | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| US4803205A (en) | 1987-08-07 | 1989-02-07 | Warner-Lambert Company | Quinolones as antibacterial agents |
| US4994276A (en) | 1988-09-19 | 1991-02-19 | Edward Mendell Co., Inc. | Directly compressible sustained release excipient |
| GB8722306D0 (en) | 1987-09-22 | 1987-10-28 | Aps Research Ltd | Sustained-release formulation |
| SE8703881D0 (sv) | 1987-10-08 | 1987-10-08 | Haessle Ab | New pharmaceutical preparation |
| GB8723896D0 (en) | 1987-10-12 | 1987-11-18 | Aps Research Ltd | Controlled-release formulation |
| US5023245A (en) | 1987-11-10 | 1991-06-11 | Hauser-Kuhrts, Inc. | Improved niacin formulation |
| US5466469A (en) | 1988-06-28 | 1995-11-14 | Cibus Pharmaceutical, Inc. | Granular drug delivery system |
| US4965252A (en) | 1988-06-28 | 1990-10-23 | Hauser-Kuhrts, Inc. | Cholesterol-lowering combination compositions of guar gum and niacin |
| DE3803482A1 (de) | 1988-02-05 | 1989-08-17 | Lohmann Therapie Syst Lts | Schwimmfaehiges orales therapeutisches system |
| US5133090A (en) | 1988-02-11 | 1992-07-28 | The Trustees Of Columbia University In The City Of New York | Antiviral glove |
| US5019096A (en) | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
| JP2668730B2 (ja) | 1988-03-09 | 1997-10-27 | 雪印乳業株式会社 | 天然ポリマーを用いた徐放性製剤 |
| DE3902079A1 (de) | 1988-04-15 | 1989-10-26 | Bayer Ag | I.m. injektionsformen von gyrase-inhibitoren |
| US5271946A (en) | 1988-04-20 | 1993-12-21 | Asta Pharma Aktiengesellschaft | Controlled release azelastine-containing pharmaceutical compositions |
| US4931285A (en) | 1988-04-28 | 1990-06-05 | Alza Corporation | Aqueous based pharmaceutical coating composition for dosage forms |
| US5002772A (en) | 1988-05-31 | 1991-03-26 | Pfizer Inc. | Gastric retention system for controlled drug release |
| US5445826A (en) | 1988-06-28 | 1995-08-29 | Cibus Pharmaceutical, Inc. | Delivery system containing a gel-forming dietary fiber and a drug |
| FR2634376B1 (fr) | 1988-07-21 | 1992-04-17 | Farmalyoc | Nouvelle forme unitaire, solide et poreuse comprenant des microparticules et/ou des nanoparticules, ainsi que sa preparation |
| US5225413A (en) | 1988-09-16 | 1993-07-06 | Bayer-Aktiengesellschaft | pH-neutral aqueous solutions of quinolone-carboxylic acids |
| US5135757A (en) | 1988-09-19 | 1992-08-04 | Edward Mendell Co., Inc. | Compressible sustained release solid dosage forms |
| US5128143A (en) | 1988-09-19 | 1992-07-07 | Edward Mendell Co., Inc. | Sustained release excipient and tablet formulation |
| US5169639A (en) | 1988-09-19 | 1992-12-08 | Edward Mendell Co., Inc. | Controlled release verapamil tablets |
| US4978661A (en) | 1988-09-29 | 1990-12-18 | Innocenzo Caruso | Use of 6-halo-4-quinolone compounds and pharmaceutical compositions thereof for the preparation of a medicament for the therapeutical application in rheumatoid arthritis |
| US5256699A (en) | 1988-10-18 | 1993-10-26 | Ciba-Geify Corporation | Dispersible tablet formulation of diclofenac acid free base |
| GB8903328D0 (en) | 1989-02-14 | 1989-04-05 | Ethical Pharma Ltd | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
| US5007790A (en) | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
| US5126145A (en) | 1989-04-13 | 1992-06-30 | Upsher Smith Laboratories Inc | Controlled release tablet containing water soluble medicament |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US4973470A (en) | 1989-06-26 | 1990-11-27 | Warner-Lambert Company | Sustained release pharmaceutical compositions |
| US5082669A (en) | 1989-07-20 | 1992-01-21 | Dainippon Pharmaceutical Co., Ltd. | Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked |
| US5219574A (en) | 1989-09-15 | 1993-06-15 | Cima Labs. Inc. | Magnesium carbonate and oil tableting aid and flavoring additive |
| EP0418596A3 (en) | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
| US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
| US5223264A (en) | 1989-10-02 | 1993-06-29 | Cima Labs, Inc. | Pediatric effervescent dosage form |
| FR2655545B1 (fr) | 1989-12-11 | 1994-06-10 | Rhone Poulenc Sante | Nouvelle application therapeutique des derives des fluoroquinolones. |
| US4992449A (en) | 1990-02-01 | 1991-02-12 | American Cyanamid Company | 7-(substituted)cycloalkylamino-1-(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
| US5084276A (en) | 1990-01-05 | 1992-01-28 | Abbott Laboratories | Quinolone carboxylic acid compositions with polymeric additive to reduce vein irritation |
| US5198227A (en) | 1990-01-22 | 1993-03-30 | Mcneil-Ppc, Inc. | Dual subcoated simulated capsule medicament |
| US5009895A (en) | 1990-02-02 | 1991-04-23 | Merck & Co., Inc. | Sustained release with high and low viscosity HPMC |
| US5256662A (en) | 1990-04-12 | 1993-10-26 | Warner-Lambert Company | Quinolinecarboxylic acid antibacterial agents |
| DK0537139T3 (da) | 1990-07-02 | 1994-08-22 | Boehringer Mannheim Gmbh | Fremgangsmåde til fremstilling af formede, pressede dosisenheder med forsinket frigørelse og dertil svarende dosisenhed |
| IT1246350B (it) | 1990-07-11 | 1994-11-17 | Eurand Int | Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili |
| GB9022788D0 (en) | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
| SE9003904D0 (sv) | 1990-12-07 | 1990-12-07 | Astra Ab | Method for the manufacture of a pharmaceutical dosage form |
| US5232704A (en) | 1990-12-19 | 1993-08-03 | G. D. Searle & Co. | Sustained release, bilayer buoyant dosage form |
| US5198229A (en) | 1991-06-05 | 1993-03-30 | Alza Corporation | Self-retaining gastrointestinal delivery device |
| YU48263B (sh) | 1991-06-17 | 1997-09-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola |
| US5464632C1 (en) | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
| US5225201A (en) | 1991-08-23 | 1993-07-06 | Minnesota Mining And Manufacturing Company | Salsalate tablet |
| FI93924C (fi) | 1991-09-17 | 1995-06-26 | Martti Lauri Antero Marvola | Menetelmä säädellysti lääkeainetta vapauttavan valmisteen valmistamiseksi |
| JPH0624959A (ja) * | 1991-10-04 | 1994-02-01 | Bayer Yakuhin Kk | 胃内浮遊型薬物徐放性固形製剤 |
| US5169638A (en) | 1991-10-23 | 1992-12-08 | E. R. Squibb & Sons, Inc. | Buoyant controlled release powder formulation |
| EP0546593B1 (en) | 1991-10-30 | 1997-09-03 | Glaxo Group Limited | Multi-layered compositions containing histamine or serotonin antagonists |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| DE4200821A1 (de) | 1992-01-15 | 1993-07-22 | Bayer Ag | Geschmacksmaskierte pharmazeutische mittel |
| KR0159540B1 (ko) | 1992-01-21 | 1998-12-01 | 김정순 | 퀴놀론-카복실산의 염 및 그 함유조성물 |
| US5429822A (en) | 1992-03-13 | 1995-07-04 | Cambridge Scientific, Inc. | Biodegradable bursting release system |
| US5582837A (en) | 1992-03-25 | 1996-12-10 | Depomed, Inc. | Alkyl-substituted cellulose-based sustained-release oral drug dosage forms |
| US5292534A (en) | 1992-03-25 | 1994-03-08 | Valentine Enterprises, Inc. | Sustained release composition and method utilizing xanthan gum and an active ingredient |
| US5518730A (en) | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
| US5288507A (en) | 1992-07-29 | 1994-02-22 | Merck & Co., Inc. | Ibuprofen antacid combinations |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| IT1255522B (it) | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
| IT1256393B (it) | 1992-11-17 | 1995-12-04 | Inverni Della Beffa Spa | Forme matriciali multistrato per il rilascio controllato di principi attivi |
| TW235239B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-11-20 | 1994-12-01 | Pfizer | |
| GB9224855D0 (en) | 1992-11-27 | 1993-01-13 | Smithkline Beecham Plc | Pharmaceutical compositions |
| FR2699076A1 (fr) | 1992-12-11 | 1994-06-17 | Colgate Palmolive Co | Forme pharmaceutique et procédé pour délivrer un ingrédient actif à une poche parodontale. |
| GB2273874A (en) | 1992-12-31 | 1994-07-06 | Pertti Olavi Toermaelae | Preparation of pharmaceuticals in a polymer matrix |
| US5340572A (en) | 1993-02-08 | 1994-08-23 | Insite Vision Incorporated | Alkaline ophthalmic suspensions |
| US6034100A (en) | 1993-03-10 | 2000-03-07 | Otsuka Pharmaceutical Co., Ltd. | Method for inhibiting cytokine secretion |
| US5503846A (en) | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
| IT1264517B1 (it) | 1993-05-31 | 1996-09-24 | Ekita Investments Nv | Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati |
| IT1264696B1 (it) | 1993-07-09 | 1996-10-04 | Applied Pharma Res | Forme farmaceutiche destinate alla somministrazione orale in grado di rilasciare sostanze attive a velocita' controllata e differenziata |
| ES2068762B1 (es) | 1993-07-21 | 1995-12-01 | Lipotec Sa | Un nuevo preparado farmaceutico para mejorar la biodisponibilidad de drogas de dificil absorcion y procedimiento para su obtencion. |
| US5773025A (en) | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
| US5662933A (en) | 1993-09-09 | 1997-09-02 | Edward Mendell Co., Inc. | Controlled release formulation (albuterol) |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5631004A (en) | 1993-09-30 | 1997-05-20 | Alcon Laboratories, Inc. | Use of sustained release antibiotic compositions in ophthalmic surgical procedures |
| FR2711524B1 (fr) | 1993-10-21 | 1995-11-24 | Rhone Dpc Europ | Procédé de préparation de compositions orales contenant des quinolones. |
| FR2711525B1 (fr) | 1993-10-29 | 1996-01-12 | Virbac Laboratoires | Forme Galénique à administration orale pour animaux, son procédé de préparation et ses applications. |
| US5888540A (en) | 1993-10-29 | 1999-03-30 | Sugden; Keith | Pharmaceutical products |
| US5399358A (en) | 1993-11-12 | 1995-03-21 | Edward Mendell Co., Inc. | Sustained release formulations for 24 hour release of metroprolol |
| US5419917A (en) | 1994-02-14 | 1995-05-30 | Andrx Pharmaceuticals, Inc. | Controlled release hydrogel formulation |
| DE4406424A1 (de) | 1994-02-28 | 1995-08-31 | Bayer Ag | Expandierbare Arzneiformen |
| US5399359A (en) | 1994-03-04 | 1995-03-21 | Edward Mendell Co., Inc. | Controlled release oxybutynin formulations |
| JPH07251130A (ja) | 1994-03-11 | 1995-10-03 | Kansai Paint Co Ltd | 撥水性塗膜形成方法 |
| JP2917799B2 (ja) | 1994-03-11 | 1999-07-12 | 田辺製薬株式会社 | 消化管内適所放出型製剤 |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| DE19509807A1 (de) | 1995-03-21 | 1996-09-26 | Basf Ag | Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen |
| US5464633A (en) | 1994-05-24 | 1995-11-07 | Jagotec Ag | Pharmaceutical tablets releasing the active substance after a definite period of time |
| US5567439A (en) | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| US5733575A (en) | 1994-10-07 | 1998-03-31 | Bpsi Holdings, Inc. | Enteric film coating compositions, method of coating therewith, and coated forms |
| US5728402A (en) | 1994-11-16 | 1998-03-17 | Andrx Pharmaceuticals Inc. | Controlled release formulation of captopril or a prodrug of captopril |
| US5585115A (en) | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
| IL139728A (en) | 1995-01-09 | 2003-06-24 | Penwest Pharmaceuticals Compan | Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient |
| FR2729857B1 (fr) | 1995-01-27 | 1997-04-04 | Rhone Poulenc Chimie | Compositions pharmaceutiques sous forme de comprimes a liberation prolongee a base de granules en polysaccharides de haut poids moleculaire |
| US5534263A (en) | 1995-02-24 | 1996-07-09 | Alza Corporation | Active agent dosage form comprising a matrix and at least two insoluble bands |
| US5695781A (en) | 1995-03-01 | 1997-12-09 | Hallmark Pharmaceuticals, Inc. | Sustained release formulation containing three different types of polymers |
| US5612053A (en) | 1995-04-07 | 1997-03-18 | Edward Mendell Co., Inc. | Controlled release insufflation carrier for medicaments |
| US5900425A (en) | 1995-05-02 | 1999-05-04 | Bayer Aktiengesellschaft | Pharmaceutical preparations having controlled release of active compound and processes for their preparation |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US5624677A (en) | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| US5560928A (en) | 1995-06-23 | 1996-10-01 | Defelice; Stephen L. | Nutritional and/or dietary composition and method of using the same |
| US6132768A (en) | 1995-07-05 | 2000-10-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for reversible proton pump inhibitors |
| US5945124A (en) | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
| ES2105970B1 (es) | 1995-08-02 | 1998-07-01 | S A L V A T Lab Sa | Composicion farmaceutica oral de ciprofloxacino, no acuosa, estable y con caracteristicas organolepticas mejoradas. |
| ES2106680B1 (es) | 1995-08-03 | 1998-07-01 | Vita Invest Sa | Composiciones acuosas conteniendo ciprofloxacino y utilizacion y procedimiento correspondientes. |
| US5773019A (en) | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| US5811126A (en) | 1995-10-02 | 1998-09-22 | Euro-Celtique, S.A. | Controlled release matrix for pharmaceuticals |
| DE19539361A1 (de) | 1995-10-23 | 1997-04-24 | Basf Ag | Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung |
| US5686095A (en) | 1995-10-23 | 1997-11-11 | Price, Jr.; Francis W. | Method of treating canker sores |
| US5733578A (en) | 1995-11-15 | 1998-03-31 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
| US5705190A (en) | 1995-12-19 | 1998-01-06 | Abbott Laboratories | Controlled release formulation for poorly soluble basic drugs |
| WO1997026865A1 (en) | 1996-01-29 | 1997-07-31 | Edward Mendell Co., Inc. | Sustained release excipient |
| IT1282650B1 (it) * | 1996-02-19 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici |
| US6096339A (en) | 1997-04-04 | 2000-08-01 | Alza Corporation | Dosage form, process of making and using same |
| US5858409A (en) | 1996-04-17 | 1999-01-12 | Fmc Corporation | Hydrolyzed cellulose granulations for pharmaceuticals |
| US5837292A (en) | 1996-07-03 | 1998-11-17 | Yamanouchi Europe B.V. | Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug |
| CA2262595C (en) | 1996-08-15 | 2005-10-18 | Losan Pharma Gmbh | Easy to swallow oral medicament composition |
| US6503881B2 (en) | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| ES2565163T3 (es) | 1996-10-28 | 2016-03-31 | General Mills, Inc. | Imbibición y encapsulación de partículas de liberación controlada y producto encapsulado |
| US5807580A (en) | 1996-10-30 | 1998-09-15 | Mcneil-Ppc, Inc. | Film coated tablet compositions having enhanced disintegration characteristics |
| US5759579A (en) | 1996-12-05 | 1998-06-02 | American Home Products Corporation | Pharmaceutical suspension systems |
| CA2227314A1 (en) | 1997-01-24 | 1998-07-24 | Hoechst Aktiengesellschaft | Preparation of concealed taste preparations of antibacterially active quinolone derivatives |
| US5891474A (en) | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
| US5788987A (en) | 1997-01-29 | 1998-08-04 | Poli Industria Chimica Spa | Methods for treating early morning pathologies |
| DE19706978A1 (de) | 1997-02-21 | 1998-08-27 | Ulrich Dr Posanski | Kombinationspräparat für oral applizierbare Antibiotika |
| US5948787A (en) | 1997-02-28 | 1999-09-07 | Alza Corporation | Compositions containing opiate analgesics |
| DE19710213A1 (de) | 1997-03-12 | 1998-09-17 | Basf Ag | Verfahren zur Herstellung von festen Kombinationsarzneiformen |
| US5728401A (en) | 1997-04-16 | 1998-03-17 | Ranbaxy Laboratories, Ltd. | Effervescent ranitidine formulations |
| US5840329A (en) | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| WO1999007342A1 (en) | 1997-08-11 | 1999-02-18 | Alza Corporation | Prolonged release active agent dosage form adapted for gastric retention |
| TW477702B (en) | 1997-10-23 | 2002-03-01 | Dev Center Biotechnology | Controlled release tacrine dosage form |
| US6017912A (en) | 1998-02-27 | 2000-01-25 | Bussell; Letantia | Topical fluoroquinolone antibiotics in an alcohol and acetone vehicle |
| US6174524B1 (en) | 1999-03-26 | 2001-01-16 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
-
1997
- 1997-09-19 IN IN2660DE1997 patent/IN186245B/en unknown
-
1998
- 1998-09-14 US US09/152,932 patent/US6261601B1/en not_active Expired - Fee Related
-
1999
- 1999-01-19 YU YU19501A patent/YU19501A/sh unknown
- 1999-01-19 KR KR1020017003232A patent/KR100642110B1/ko not_active Expired - Fee Related
- 1999-07-02 US US09/347,315 patent/US6960356B1/en not_active Expired - Fee Related
- 1999-09-10 GT GT199900151A patent/GT199900151A/es unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5292518A (en) * | 1988-06-28 | 1994-03-08 | Hauser-Kuhrts | Prolonged-release drug tablet formulations |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010075079A (ko) | 2001-08-09 |
| IN186245B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2001-07-14 |
| US6960356B1 (en) | 2005-11-01 |
| US6261601B1 (en) | 2001-07-17 |
| GT199900151A (es) | 2001-03-03 |
| YU19501A (sh) | 2003-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100642110B1 (ko) | 시간적 및 공간적 조절을 제공하는 경구투여용 제어 약물 전달 시스템 | |
| EP1107741B1 (en) | Orally administered controlled drug delivery system providing temporal and spatial control | |
| EP2238975B1 (en) | Gastric retention controlled drug delivery system | |
| US6899896B2 (en) | Hydrogel-driven layered drug dosage form | |
| EP0795324A2 (en) | A pharmaceutical tablet characterized by a showing high volume increase when coming into contact with biological fluids | |
| US20050163839A1 (en) | Oral controlled release pharmaceutical composition containing metaxalone as active agent | |
| KR20030009374A (ko) | 시프로플록사신의 1일 1회 투여를 위한 경구 투여용제어된 전달 시스템 | |
| HK1037967B (en) | Orally administered controlled drug delivery system providing temporal and spatial control | |
| HK1053422A (en) | Orally administered controlled drug delivery system providing temporal and spatial control | |
| AU2006201553A1 (en) | Orally administered controlled delivery system for once daily administration of ciprofloxacin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| R17-X000 | Change to representative recorded |
St.27 status event code: A-3-3-R10-R17-oth-X000 |
|
| A201 | Request for examination | ||
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R13-asn-PN2301 St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| LAPS | Lapse due to unpaid annual fee | ||
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20091028 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20091028 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-5-5-R10-R18-oth-X000 |