KR100470763B1 - 아미노산 킬레이트의 제조방법 - Google Patents
아미노산 킬레이트의 제조방법 Download PDFInfo
- Publication number
- KR100470763B1 KR100470763B1 KR10-2003-0088214A KR20030088214A KR100470763B1 KR 100470763 B1 KR100470763 B1 KR 100470763B1 KR 20030088214 A KR20030088214 A KR 20030088214A KR 100470763 B1 KR100470763 B1 KR 100470763B1
- Authority
- KR
- South Korea
- Prior art keywords
- calcium
- amino acid
- carbonate
- metal
- sulfate
- Prior art date
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- 239000013522 chelant Substances 0.000 title claims abstract description 98
- 150000001413 amino acids Chemical class 0.000 title claims abstract description 89
- 238000000034 method Methods 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims description 26
- 229910052751 metal Inorganic materials 0.000 claims abstract description 66
- 239000002184 metal Substances 0.000 claims abstract description 66
- 239000000203 mixture Substances 0.000 claims abstract description 62
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 30
- 235000013305 food Nutrition 0.000 claims abstract description 13
- 230000002378 acidificating effect Effects 0.000 claims abstract description 11
- 239000007864 aqueous solution Substances 0.000 claims abstract description 11
- 235000013361 beverage Nutrition 0.000 claims abstract description 8
- 239000002537 cosmetic Substances 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 239000011575 calcium Substances 0.000 claims description 139
- 229910052791 calcium Inorganic materials 0.000 claims description 105
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 104
- 229940024606 amino acid Drugs 0.000 claims description 89
- 235000001014 amino acid Nutrition 0.000 claims description 89
- 238000006243 chemical reaction Methods 0.000 claims description 84
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 82
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 52
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 41
- 235000010216 calcium carbonate Nutrition 0.000 claims description 39
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 38
- 229910021645 metal ion Inorganic materials 0.000 claims description 32
- 239000004220 glutamic acid Substances 0.000 claims description 31
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 30
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 27
- 235000013922 glutamic acid Nutrition 0.000 claims description 27
- 229940009098 aspartate Drugs 0.000 claims description 24
- 241001474374 Blennius Species 0.000 claims description 23
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 21
- 235000003704 aspartic acid Nutrition 0.000 claims description 15
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 15
- -1 zinc bisglutamate Zinc bisaspartate Chemical compound 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 8
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 8
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 8
- 239000011667 zinc carbonate Substances 0.000 claims description 8
- 235000004416 zinc carbonate Nutrition 0.000 claims description 8
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 8
- UIOULKWHZFUGJO-DFWYDOINSA-N (2s)-2-aminopentanedioic acid;iron Chemical compound [Fe].OC(=O)[C@@H](N)CCC(O)=O UIOULKWHZFUGJO-DFWYDOINSA-N 0.000 claims description 7
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims description 7
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 7
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 7
- 229960001763 zinc sulfate Drugs 0.000 claims description 7
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 6
- 229910000358 iron sulfate Inorganic materials 0.000 claims description 6
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 6
- 235000016709 nutrition Nutrition 0.000 claims description 6
- RYVCHORNKKBBJW-QHTZZOMLSA-J [Fe+4].[O-]C(=O)[C@@H](N)CCC([O-])=O.[O-]C(=O)[C@@H](N)CCC([O-])=O Chemical compound [Fe+4].[O-]C(=O)[C@@H](N)CCC([O-])=O.[O-]C(=O)[C@@H](N)CCC([O-])=O RYVCHORNKKBBJW-QHTZZOMLSA-J 0.000 claims description 5
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 5
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 5
- 229940099596 manganese sulfate Drugs 0.000 claims description 5
- 239000011702 manganese sulphate Substances 0.000 claims description 5
- 235000007079 manganese sulphate Nutrition 0.000 claims description 5
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 5
- YVHGUOMYKODENE-QHTZZOMLSA-J (2S)-2-aminopentanedioate chromium(4+) Chemical compound [Cr+4].[O-]C(=O)[C@@H](N)CCC([O-])=O.[O-]C(=O)[C@@H](N)CCC([O-])=O YVHGUOMYKODENE-QHTZZOMLSA-J 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 4
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 102000002322 Egg Proteins Human genes 0.000 claims description 3
- 108010000912 Egg Proteins Proteins 0.000 claims description 3
- NKKATTXYBIGWMW-PREAGGAWSA-H N[C@@H](CCC(=O)[O-])C(=O)[O-].[Cr+3].N[C@@H](CCC(=O)[O-])C(=O)[O-].N[C@@H](CCC(=O)[O-])C(=O)[O-].[Cr+3] Chemical compound N[C@@H](CCC(=O)[O-])C(=O)[O-].[Cr+3].N[C@@H](CCC(=O)[O-])C(=O)[O-].N[C@@H](CCC(=O)[O-])C(=O)[O-].[Cr+3] NKKATTXYBIGWMW-PREAGGAWSA-H 0.000 claims description 3
- SQLZCNCPUNKHPX-CEOVSRFSSA-J [Cr+4].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O Chemical compound [Cr+4].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O SQLZCNCPUNKHPX-CEOVSRFSSA-J 0.000 claims description 3
- DYNAPBNBYCFIJB-QHTZZOMLSA-J [Cu+4].[O-]C(=O)[C@@H](N)CCC([O-])=O.[O-]C(=O)[C@@H](N)CCC([O-])=O Chemical compound [Cu+4].[O-]C(=O)[C@@H](N)CCC([O-])=O.[O-]C(=O)[C@@H](N)CCC([O-])=O DYNAPBNBYCFIJB-QHTZZOMLSA-J 0.000 claims description 3
- GRWVQDDAKZFPFI-UHFFFAOYSA-H chromium(III) sulfate Chemical compound [Cr+3].[Cr+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRWVQDDAKZFPFI-UHFFFAOYSA-H 0.000 claims description 3
- 210000003278 egg shell Anatomy 0.000 claims description 3
- 229930195712 glutamate Natural products 0.000 claims description 3
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 3
- 239000001095 magnesium carbonate Substances 0.000 claims description 3
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 3
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 3
- CFSIMSPVBRMSRX-DFWYDOINSA-L (2s)-2-aminopentanedioate;manganese(2+) Chemical compound [Mn+2].[O-]C(=O)[C@@H](N)CCC([O-])=O CFSIMSPVBRMSRX-DFWYDOINSA-L 0.000 claims description 2
- MUARKRXWUCMPOS-CEOVSRFSSA-J [Mn+4].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O Chemical compound [Mn+4].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O MUARKRXWUCMPOS-CEOVSRFSSA-J 0.000 claims description 2
- GLTMXYSRENMKGS-QHTZZOMLSA-J [Mn+4].[O-]C(=O)[C@@H](N)CCC([O-])=O.[O-]C(=O)[C@@H](N)CCC([O-])=O Chemical compound [Mn+4].[O-]C(=O)[C@@H](N)CCC([O-])=O.[O-]C(=O)[C@@H](N)CCC([O-])=O GLTMXYSRENMKGS-QHTZZOMLSA-J 0.000 claims description 2
- 235000013921 calcium diglutamate Nutrition 0.000 claims description 2
- UMVAYAXXQSFULN-QHTZZOMLSA-L calcium;(2s)-2-aminopentanedioate;hydron Chemical group [Ca+2].[O-]C(=O)[C@@H](N)CCC(O)=O.[O-]C(=O)[C@@H](N)CCC(O)=O UMVAYAXXQSFULN-QHTZZOMLSA-L 0.000 claims description 2
- XHFVDZNDZCNTLT-UHFFFAOYSA-H chromium(3+);tricarbonate Chemical compound [Cr+3].[Cr+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O XHFVDZNDZCNTLT-UHFFFAOYSA-H 0.000 claims description 2
- 229910021446 cobalt carbonate Inorganic materials 0.000 claims description 2
- 229910000361 cobalt sulfate Inorganic materials 0.000 claims description 2
- 229940044175 cobalt sulfate Drugs 0.000 claims description 2
- KTVIXTQDYHMGHF-UHFFFAOYSA-L cobalt(2+) sulfate Chemical compound [Co+2].[O-]S([O-])(=O)=O KTVIXTQDYHMGHF-UHFFFAOYSA-L 0.000 claims description 2
- ZOTKGJBKKKVBJZ-UHFFFAOYSA-L cobalt(2+);carbonate Chemical compound [Co+2].[O-]C([O-])=O ZOTKGJBKKKVBJZ-UHFFFAOYSA-L 0.000 claims description 2
- 229940116318 copper carbonate Drugs 0.000 claims description 2
- GEZOTWYUIKXWOA-UHFFFAOYSA-L copper;carbonate Chemical compound [Cu+2].[O-]C([O-])=O GEZOTWYUIKXWOA-UHFFFAOYSA-L 0.000 claims description 2
- SSFMKHSRFMRWFB-NVKWYWNSSA-J dicalcium (2S)-2-aminobutanedioate Chemical compound [Ca+2].[Ca+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O SSFMKHSRFMRWFB-NVKWYWNSSA-J 0.000 claims description 2
- QIWQPDUTCBLMSG-OYIAIMIOSA-J dicalcium (2S)-2-aminopentanedioate Chemical compound [Ca+2].[Ca+2].[O-]C(=O)[C@@H](N)CCC([O-])=O.[O-]C(=O)[C@@H](N)CCC([O-])=O QIWQPDUTCBLMSG-OYIAIMIOSA-J 0.000 claims description 2
- JVKRVCJEGVAHAO-OYIAIMIOSA-J dimagnesium (2S)-2-aminopentanedioate Chemical compound [Mg+2].[Mg+2].[O-]C(=O)[C@@H](N)CCC([O-])=O.[O-]C(=O)[C@@H](N)CCC([O-])=O JVKRVCJEGVAHAO-OYIAIMIOSA-J 0.000 claims description 2
- UPXURESQFGNHFF-OYIAIMIOSA-J dizinc (2S)-2-aminopentanedioate Chemical compound [Zn+2].[Zn+2].[O-]C(=O)[C@@H](N)CCC([O-])=O.[O-]C(=O)[C@@H](N)CCC([O-])=O UPXURESQFGNHFF-OYIAIMIOSA-J 0.000 claims description 2
- RAQDACVRFCEPDA-UHFFFAOYSA-L ferrous carbonate Chemical compound [Fe+2].[O-]C([O-])=O RAQDACVRFCEPDA-UHFFFAOYSA-L 0.000 claims description 2
- 239000011656 manganese carbonate Substances 0.000 claims description 2
- 235000006748 manganese carbonate Nutrition 0.000 claims description 2
- 229940093474 manganese carbonate Drugs 0.000 claims description 2
- 229910000016 manganese(II) carbonate Inorganic materials 0.000 claims description 2
- XMWCXZJXESXBBY-UHFFFAOYSA-L manganese(ii) carbonate Chemical compound [Mn+2].[O-]C([O-])=O XMWCXZJXESXBBY-UHFFFAOYSA-L 0.000 claims description 2
- GAMIYQSIKAOVTG-UHFFFAOYSA-L zinc;2-aminopentanedioate Chemical compound [Zn+2].[O-]C(=O)C(N)CCC([O-])=O GAMIYQSIKAOVTG-UHFFFAOYSA-L 0.000 claims description 2
- QYPQOBGSGQXODC-DFWYDOINSA-N (2s)-2-aminopentanedioic acid;cobalt Chemical compound [Co].OC(=O)[C@@H](N)CCC(O)=O QYPQOBGSGQXODC-DFWYDOINSA-N 0.000 claims 1
- 241000238366 Cephalopoda Species 0.000 claims 1
- DSNHOAHGBPRRMT-CEOVSRFSSA-J [Fe+4].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O Chemical compound [Fe+4].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O DSNHOAHGBPRRMT-CEOVSRFSSA-J 0.000 claims 1
- HIAAPJWEVOPQRI-DFWYDOINSA-L copper;(2s)-2-aminopentanedioate Chemical compound [Cu+2].[O-]C(=O)[C@@H](N)CCC([O-])=O HIAAPJWEVOPQRI-DFWYDOINSA-L 0.000 claims 1
- IACWRJKFRODGGM-NVKWYWNSSA-J dimagnesium (2S)-2-aminobutanedioate Chemical compound [Mg+2].[Mg+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O IACWRJKFRODGGM-NVKWYWNSSA-J 0.000 claims 1
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- 229940106635 calcium amino acid chelate Drugs 0.000 description 9
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- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000009966 trimming Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
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- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
해조 칼슘 | 유청 칼슘 | |
칼슘 | 34% | 26.4%(26.4%) |
마그네슘 | 3.2% | 1.26%(0.447%) |
황 | 0.3% | - |
나트륨 | 0.2% | 2.6%(0.234%) |
인 | 0.06% | 14.6% |
철 | 0.08% | 0.00815% |
칼륨 | 0.04% | 0.165%(0.14%) |
망간 | 70 ppm | - |
붕소 | 25 ppm | - |
요오드 | 20 ppm | - |
아연 | 22 ppm | - |
셀레늄 | 1 ppm | - |
성분 | 함량 |
칼슘 | 7% |
마그네슘 | 1% |
칼륨 | 2.1% |
나트륨 | 1% |
알루미늄 | 25 ppm |
망간 | 25 ppm |
철 | 20 ppm |
아연 | 10 ppm |
바륨 | 4 ppm |
카드늄, 크롬, 몰리브덴, 코발트 | 5 ppm 미만 |
평가항목평가대상 | 맛 | 외관 | 종합적 평가 | |||
쓴 맛 | 텁텁한 맛 | 떫은 맛 | 색깔 | 청정도 | ||
대조군 (미에로화이바) | 12(+) | 10(+) | 11(+) | 46(++++) | 48(++++) | 48(++++) |
실시예 1의킬레이트 화합물 | 14(+) | 12(+) | 11(+) | 48(++++) | 47(++++) | 47(++++) |
성분 | 함량 |
식물성 단백 가수분해물 (질소함량 3%) | 10% |
참치자숙 농축액 | 4% |
액상당류 | 6% |
정제수 | 50% |
정제염 | 8% |
실시예 1의 화합물 | 10% |
설탕 | 5% |
잔탄검 | 0.3% |
5-뉴클레오타이드 | 0.5% |
양파즙 농축액 | 2% |
마늘즙 농축액 | 1% |
쇠고기 농축액 | 1% |
정제우지 | 1% |
주정 | 0.7% |
수용성 후추 추출액 | 0.5% |
성분 | 함량 |
액상 과당 | 5% |
폴리덱스트로스 | 1% |
구연산 | 5% |
비타민C | 0.02% |
실시예 9의 화합물 | 2% |
오렌지 과즙 농축액 | 25% |
물 | 67% |
성분 | 함량 |
1,3-butylene glycol | 5% |
glycerine | 5% |
EDTA-2Na | 0.02% |
trimethylglycine | 2.0% |
cetanol | 1.0% |
glyceryl monostearate emulsifier | 1.0% |
polysorbate 60 | 1.2% |
sorbitan sesquioleate | 0.3% |
cetyl 2-ethyl-hexaoate | 4.0% |
squalane | 5.0% |
dimethicone | 0.3% |
glyceryl stearate | 0.5% |
carbomer | 0.15% |
triethanoamine | 0.5% |
imidazolidinyl urea | 0.2% |
실시예8 | 2.0% |
정제수 | 71.8% |
성분 | 함량 |
1,3-butylene glycol | 4.0% |
dipropylene glycol | 5.0% |
EDTA-2Na | 0.02% |
octyldodeceth-16 | 0.3% |
PEG60 hydrogenate castor oil | 0.2% |
실시예 8의 화합물 | 0.5% |
정제수 | 90% |
정상군(Normal) | 실험군 | ||||
Ca-free | CaCO3 | Asp-Ca | SW-Ca | ||
Casein | 200 | 200 | 200 | 200 | 200 |
Sucrose | 100 | 100 | 100 | 100 | 100 |
Cellulose | 50 | 50 | 50 | 50 | 50 |
Mineral mix1) | 35 | 35 | 35 | 35 | 35 |
Vitamin mix | 10 | 10 | 10 | 10 | 10 |
DL-methione | 3 | 3 | 3 | 3 | 3 |
Choline bitartrate | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 |
Corn starch | 549.5 | 549.5 | 549.5 | 549.5 | 549.5 |
Corn oil | 50 | 50 | 50 | 50 | 50 |
구강투여(㎎/day) | |||||
CaCO340% | - | - | 80 | - | - |
Asp-Ca 10.8% | - | - | - | 320 | - |
Seaweed Ca 33% | - | - | - | - | 97 |
Liver(mg/BW) | Kidney(mg/BW) | Spleen(mg/BW) | |
Normal | 44.75±1.89a | 8.50±0.29ns | 3.50±0.50ns |
Ca-free | 40.67±1.41ab | 8.83±0.31 | 3.00±0.00 |
CaCO3 | 37.40±1.63b | 8.60±0.40 | 3.00±0.00 |
Asp-Ca | 44.17±1.68a | 8.40±0.26 | 3.00±0.00 |
SW-Ca | 36.00±0.63b | 8.20±0.20 | 3.00±0.32 |
비골 무게(g) | 비골 길이(mm) | |
Normal | 0.403±0.015a | 32.28±0.44ns |
Ca-free | 0.272±0.032b | 29.01±1.06 |
CaCO3 | 0.332±0.033ab | 30.03±1.10 |
Asp-Ca | 0.327±0.031ab | 30.88±1.87 |
SW-Ca | 0.292±0.043b | 28.83±1.49 |
Serum | Urine | |
(mg/dl) | ||
Normal | 10.68±0.18a | 0.20±0.03b |
Ca-free | 8.12±0.52b | 0.11±0.03c |
CaCO3 | 9.13±0.21b | 0.22±0.01b |
Asp-Ca | 10.63±0.21a | 0.22±0.04b |
SW-Ca | 10.44±0.07a | 0.32±0.02a |
Serum(mg/dl) | |
Normal | 12.19±0.38a |
Ca-free | 8.60±0.51b |
CaCO3 | 8.52±0.27b |
Asp-Ca | 11.24±0.85a |
Ca intake(mg/3days) | Fecal Ca excretion(mg/3days) | Apparent absorption(%) | |
Ca-free | 0 | 2.69 | - |
CaCO3 | 96 | 98.68 | -2.79 |
Asp-Ca | 96 | 35.39 | 58.96 |
SW-Ca | 96 | 71.05 | 25.98 |
정상군(Normal) | 실험군 | |||
Fe-free | Heme | Fe-aa | ||
Casein | 200 | 200 | 200 | 200 |
Sucrose | 100 | 100 | 100 | 100 |
Cellulose | 50 | 50 | 50 | 50 |
Mineral mix1) | 35 | 35 | 35 | 35 |
Vitamin mix | 10 | 10 | 10 | 10 |
DL-methione | 3 | 3 | 3 | 3 |
Choline bitartrate | 2.5 | 2.5 | 2.5 | 2.5 |
Corn starch | 549.5 | 549.5 | 549.5 | 549.5 |
Corn oil | 50 | 50 | 50 | 50 |
구강투여(mg/㎖/day) | ||||
1% heme | - | - | 50 | - |
10% Fe-aa | - | - | - | 5 |
Liver(mg/BW) | Kidney(mg/BW) | Spleen(mg/BW) | |
Normal | 39.25±0.85ab | 7.50±0.29ns | 3.00±0.41ns |
Fe-free | 39.90±0.90ab | 7.30±0.21 | 2.70±0.15 |
Heme | 36.90±1.06b | 7.20±0.13 | 2.78±0.15 |
Fe-aa | 40.60±1.00a | 7.50±0.22 | 3.00±0.15 |
IRON | TIBC | |
(㎍/dl) | ||
Normal | 224.50±33.65a | 662.75±17.02c |
Control | 96.13±10.27c | 841.90±13.90a |
Heme | 190.25±28.96ab | 824.63±11.60a |
Fe-aa | 137.63±23.57bc | 735.44±9.30b |
RBC(x 106/mm3) | WBC(x 103/mm3) | Hb(g/dL) | HCT(%) | |
Normal | 7.47±0.16ns | 6.13±0.50b | 13.96±0.42a | 44.20±1.43a |
Fe-free | 6.90±0.20 | 7.55±0.36a | 11.18±0.38c | 35.40±1.28b |
Heme | 7.01±0.16 | 6.12±0.37b | 11.17±0.28c | 36.11±0.89b |
Fe-aa | 7.32±0.35 | 6.02±0.46b | 12.71±0.49b | 39.33±1.86b |
Fe intake(ug/3days) | Fecal Fe excretion(ug/3days) | Apparent absorption(%) | |
Ca-free | 0 | 247.4 | - |
Heme | 1,500 | 1427.4 | 4.86 |
Fe-aa | 1,500 | 1000.6 | 33.33 |
Claims (18)
- 탄산칼슘, 탄산구리, 탄산아연, 탄산철, 탄산코발트, 탄산크롬, 탄산마그네슘 및 탄산망간에서 선택된 2가 또는 그 이상의 원자가를 가진 하나 또는 둘 이상의 천연 또는 비천연의 금속 탄산염(metallic carbonate)과, 글루타민산 또는 아스파르트산 또는 이들의 혼합물인 산성 아미노산을 수용액 중에서 반응시키는 과정을 포함하는 것으로 구성되어 있는 아미노산 킬레이트의 제조방법.
- 삭제
- 제 1 항에 있어서, 상기 금속 탄산염은 천연의 금속 탄산염인 것을 특징으로 하는 제조방법.
- 제 1 항에 있어서, 상기 금속 탄산염은 탄산칼슘인 것을 특징으로 하는 방법.
- 제 4 항에 있어서, 상기 탄산칼슘은 해조칼슘, 난각칼슘, 패각칼슘, 갑오징 어칼슘 등의 천연 소재에서 얻어지는 것을 특징으로 하는 방법.
- 삭제
- 제 1 항에 있어서,상기 금속 탄산염과 산성 아미노산의 반응 부가량은, 몰비(금속 탄산염: 산성 아미노산)로 1 : 1 내지 1 : 4이고;반응온도는 0 내지 100℃이며;반응 pH는 반응종료시에 4 내지 7로 조절하는 것을 특징으로 하는 제조방법.
- 제 7 항에 있어서, 상기 pH 는 4.5 내지 6.5 인 것을 특징으로 하는 제조방법.
- 제 1 항에 있어서, 상기 반응의 개시와 동시에, 또는 반응 중에, 또는 반응 종료 후에 금속 황산염을 더 부가하여 반응시키는 것을 특징으로 하는 제조방법.
- 제 9 항에 있어서, 상기 금속 황산염은 아미노산과 금속 탄산염의 반응 중 또는 그것의 반응 후에 부가하여 반응시키는 것을 특징으로 하는 제조방법.
- 제 9 항에 있어서, 상기 금속 황산염은 황산칼슘, 황산마그네슘, 황산아연, 황산구리, 황산철, 황산망간, 황산크롬, 황산코발트 등에서 선택된 하나 또는 둘 이상의 황산염이며, 금속 탄산염의 금속이온과 다른 금속이온을 포함하고 있는 것을 특징으로 하는 제조방법.
- 제 9 항에 있어서, 상기 금속 황산염의 반응 부가량은 금속 탄산염에 기반한 아미노산 킬레이트에 대하여 1:1 내지 1:4의 몰비(금속 황산염: 금속 탄산염 기반 아미노산 킬레이트)의 범위내에 있는 것을 특징으로 하는 제조방법.
- 제 1 항에 따른 제조방법으로 제조되는 하기 화학식 1 또는 화학식 2의 아미노산 킬레이트.M(AA) 2 (1)M'(AA) 3 (2)상기 식에서, M 은 2가 금속이온이고, M' 는 3가 금속이온이며, AA 는 아미노산이다.
- 제 13 항에 있어서, 상기 아미노산 킬레이트는, 칼슘 글루타메이트/아스파테이트(calcium glutamate/aspartate), 칼슘 비스글루타메이트(calcium bisglutamate), 칼슘 비스아스파테이트(calcium bisaspartate), 구리 글루타메이트/아스파테이트(cooper glutamate/aspartate), 구리 비스글루타메이트(cooper bisglutamate), 구리 비스아스파테이트(cooper bisaspartate), 아연 글루타메이트/아스파테이트(zinc glutamate/aspartate), 아연 비스글루타메이트(zinc bisglutamate), 아연 비스아스파테이트(zinc bisaspartate), 철 글루타메이트/아스파테이트(iron glutamate/aspartate), 철 비스글루타메이트(iron bisglutamate), 철 비스아스파테이트(iron bisaspartate), 철 비스글루타메이트/아스파테이트(iron bisglutamate/aspartate), 철 글루타메이트/비스아스파테이트(iron glutamate/ bisaspartate), 크롬 글루타메이트/아스파테이트(chromium glutamate/aspartate), 크롬 비스글루타메이트(chromium bisglutamate), 크롬 비스아스파테이트(chromium bisaspartate), 크롬 비스글루타메이트/아스파테이트(chromium bisglutamate/aspartate), 크롬 글루타메이트/비스아스파테이트(chromium glutamate/ bisaspartate), 코발트 글루타메이트/아스파테이트(covalt glutamate/aspartate), 코발트 비스글루타메이트(covalt bisglutamate), 코발트 비스아스파테이트(covalt bisaspartate), 마그네슘 글루타메이트/아스파테이트(magnesium glutamate/aspartate), 마그네슘 비스글루타메이트(magnesium bisglutamate), 마그네슘 비스아스파테이트(magnesium bisaspartate), 망간 글루타메이트/아스파테이트(manganese glutamate/aspartate), 망간 비스글루타메이트(manganese bisglutamate), 망간 비스아스파테이트(manganese bisaspartate) 등으로 이루어진 군에서 선택되는 하나 또는 둘 이상인 것을 특징으로 하는 아미노산 킬레이트.
- 유효성분으로서, 제 13 항에 따른 화학식 1 또는 2 의 아미노산 킬레이트를 약제학적 또는 식품영양학적 또는 화장학적 유효량으로 함유하는 조성물.
- 제 15 항에 있어서, 상기 조성물은 약학적으로 허용되는 담체를 포함하는 약제 조성물인 것을 특징으로 하는 조성물.
- 제 15 항에 있어서, 상기 조성물은 식품영양학적으로 허용되는 담체를 포함하는 식품 또는 음료 조성물인 것을 특징으로 하는 조성물.
- 제 15 항에 있어서, 상기 조성물은 화장학적으로 허용되는 담체를 포함하는 화장품 조성물인 것을 특징으로 하는 조성물.
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KR20020076803 | 2002-12-05 |
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KR10-2003-0088214A KR100470763B1 (ko) | 2002-12-05 | 2003-12-05 | 아미노산 킬레이트의 제조방법 |
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US (2) | US7375243B2 (ko) |
EP (1) | EP1569943A4 (ko) |
JP (1) | JP4639086B2 (ko) |
KR (1) | KR100470763B1 (ko) |
CN (1) | CN100549015C (ko) |
AU (1) | AU2003302660A1 (ko) |
WO (1) | WO2004050664A1 (ko) |
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Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6078950A (ja) * | 1983-10-14 | 1985-05-04 | フエルラーフアルム アルツナイミツテルフアブリーク アポテーケル ハー.ヤー.フオン エーリツヒ ゲゼルシヤフト ミツト ベシユレンクテル ハフツンク ウント コンパニー カーゲー | アミノジカルボン酸−二価金属−ハロゲン錯塩の製造法及びそれら新規錯塩 |
US4599152A (en) | 1985-05-24 | 1986-07-08 | Albion Laboratories | Pure amino acid chelates |
US4863898A (en) * | 1986-02-06 | 1989-09-05 | Albion International, Inc. | Amino acid chelated compositions for delivery to specific biological tissue sites |
US4830716B1 (en) * | 1986-07-03 | 1999-12-07 | Albion Int | Preparation of pharmaceutical grade amino acid chelates |
US5516925A (en) * | 1994-08-23 | 1996-05-14 | Albion International, Inc. | Amino acid chelates having improved palatability |
US6197815B1 (en) * | 1998-03-18 | 2001-03-06 | J.H. Biotech, Inc. | Amino acid chelates to reduce still births and increase birth weight in non-human animals |
JP3107789B2 (ja) * | 1998-09-25 | 2000-11-13 | キユーピー株式会社 | 卵殻カルシウム組成物及びその製造方法並びに該卵殻カルシウム組成物を含有する食品 |
US6169118B1 (en) * | 1998-11-12 | 2001-01-02 | Block Drug Company, Inc. | Flavor blend for masking unpleasant taste of zinc compounds |
WO2001032037A1 (en) * | 1999-11-01 | 2001-05-10 | Albion International, Inc. | Compositions and methods for calcium fortification of dairy products and oleaginous foods |
US6458981B1 (en) | 2000-10-11 | 2002-10-01 | Albion International, Inc. | Composition and method for preparing amino acid chelate hydroxides free of interfering ions |
US7129375B2 (en) * | 2002-10-16 | 2006-10-31 | Zinpro Corporation | Metal complexes of α amino dicarboxylic acids |
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- 2003-12-05 KR KR10-2003-0088214A patent/KR100470763B1/ko active IP Right Grant
- 2003-12-05 CN CNB2003801050987A patent/CN100549015C/zh not_active Expired - Fee Related
- 2003-12-05 WO PCT/KR2003/002674 patent/WO2004050664A1/en active Application Filing
- 2003-12-05 EP EP03812388A patent/EP1569943A4/en not_active Withdrawn
- 2003-12-05 AU AU2003302660A patent/AU2003302660A1/en not_active Abandoned
- 2003-12-05 US US10/537,409 patent/US7375243B2/en not_active Expired - Fee Related
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KR20190041739A (ko) | 2017-10-13 | 2019-04-23 | 주식회사 소프트아쿠아 | 아미노산-미네랄 복합체를 포함하는 액상 보조사료 조성물 |
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KR102204268B1 (ko) | 2017-11-28 | 2021-01-19 | (주)비티엔 | 신규 아미노산 미네랄 복합체, 및 이를 포함하는 면역 증강용 사료 또는 동물용 의약 조성물 |
KR102501973B1 (ko) | 2017-11-28 | 2023-02-22 | (주)비티엔 | 아연 아스파르트산 복합체, 및 이를 포함하는 면역 증강용 약학 조성물 |
Also Published As
Publication number | Publication date |
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EP1569943A4 (en) | 2007-11-28 |
JP4639086B2 (ja) | 2011-02-23 |
AU2003302660A1 (en) | 2004-06-23 |
KR20040049294A (ko) | 2004-06-11 |
US20100093850A1 (en) | 2010-04-15 |
CN1720249A (zh) | 2006-01-11 |
CN100549015C (zh) | 2009-10-14 |
EP1569943A1 (en) | 2005-09-07 |
WO2004050664A1 (en) | 2004-06-17 |
US20060128799A1 (en) | 2006-06-15 |
US7375243B2 (en) | 2008-05-20 |
JP2006509787A (ja) | 2006-03-23 |
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