KR100204686B1 - A weed control composition containing a heterocyclic compound - Google Patents

Abstract

The present invention relates to herbicides containing a compound of the general formula (I) as an active substance:

In the above formula, W, X, Y ¹ , Y ² , Z, R ¹ , R ² and R ¹⁴ are as defined above.

Description

Herbicide Compositions Containing Heterocyclic Compounds

The present invention relates to a heterocyclic compound having herbicidal activity and a herbicide composition containing the same.

The present invention relates to heterocyclic compounds, and more particularly to 2-heterocyclyloxy / thio-pyrimidines and -1,3,5-triazines of the general formula (I):

In the above formula,

W is a divalent group of the formulas a) to d):

X, Y ¹ and Y ² are each oxygen or sulfur,

Z is CR ¹³ or nitrogen,

R ¹ is hydrogen, fluoro, chloro, C _1-3 -alkyl, halomethyl, methoxymethyl, C _1-3 -alkoxy, difluoromethoxy or methylthio,

R ² is methyl, C _1-2 -alkoxy, C _1-2 -fluoroalkoxy, C _1-2 -alkylamino, di (C _1-2 -alkyl) -amino or N-methoxymethylamino,

R ³ is hydrogen, fluoro, chloro, bromo, optionally substituted C _1-6 -alkyl, C _2-3 -alkenyl, C _2-3 -alkynyl, optionally substituted phenyl, hydroxy Optionally substituted C _1-6 -alkoxy, C _1-6 -alkylthio, phenoxy, phenylthio, cyano, thiocyanato, formyl, carboxy, C _2-5 -alkoxycarbonyl, carbon Barmoyl, formyloxy, C _2-5 -alkanoyloxy, C _2-5 -alkoxycarbonyloxy, C _2-3 -alkylcarbamoyloxy, di (C _1-2 -alkyl) carbamoyloxy Or di (C _1-2 -alkoxy) phosphonyl,

R ⁴ is hydrogen, C _1-6 -alkyl or trifluoromethyl,

R ⁵ is hydrogen, C _1-6 -alkyl or phenyl optionally substituted;

R ⁶ is hydrogen or methyl,

R ⁷ , R ⁸ and R ⁹ are independently of each other hydrogen or C _1-3 -alkyl,

R ¹⁰ is hydrogen or C _1-3 -alkoxy,

R ¹¹ and R ¹² are independently of each other hydrogen or C _1-3 -alkyl,

R ¹³ is hydrogen, fluoro, chloro or methyl,

R ¹⁴ is hydrogen, halogen, C _1-2 -alkyl or C _1-2 -alkoxy.

Compounds of general formula (I) which are compounds according to the invention have herbicidal activity and are suitable as active substances of herbicides. Furthermore, the compounds of the present invention have plant growth regulating activity and are therefore particularly suitable as agents which have a positive effect on the growth of useful plants.

Thus, the present invention also encompasses herbicides and plant growth regulators containing the compounds of the present invention as active ingredients, methods of preparing such compounds, and the use of these compounds or agents for weed control or plant growth control.

In the above general formula (I), halo on its own or as part of a more complex group (such as halomethyl) includes fluoro, chloro, bromo and iodo, with fluoro and chloro being preferred. . Alkyl-, alkenyl- and alkynyl groups can be straight or branched chains, which also apply to the respective alkyl moieties of alkoxy-, alkylthio-, alkoxycarbonyl- and other alkyl-containing groups. Preferred C _2-3 -alkenyl- and -alkynyl groups are vinyl or ethynyl. Halomethyl or fluoroalkoxy groups can have one or more fluorine atoms, and examples of such groups include chloromethyl, trifluoromethyl and difluoromethoxy as described above. Optionally substituted C _1-6 -alkyl (R ³ ) are especially halogen (particularly chloro), hydroxy, methoxy, ethoxy, nitro, cyano, vinyl, ethynyl, carboxy, C _2-5 -alkoxy Alkyl groups substituted by carbonyl (particularly methoxy- or ethoxycarbonyl) or optionally (particularly with methoxy) substituted phenyl groups. Preferred as optionally substituted alkyl groups are optionally substituted methyl or ethyl, in particular methyl groups. Preferred C _1-6 -alkoxy (R ³ ) optionally substituted are halogen (especially fluoro or chloro), vinyl, ethynyl, cyclopropyl, phenyl, C _1-2 -alkoxy, C _1-2 -alkyl Thio, cyano, carboxy, C _2-5 -alkoxycarbonyl (particularly methoxy- or ethoxycarbonyl), carbamoyl, N- (C _1-2 -alkyl) carbamoyl, N, N-di It may be an alkoxy group substituted with (C _1-2 -alkyl) carbamoyl or C _3-5 -alkylideneiminooxy. The optionally substituted phenyl group (R ³ , R ⁵ ) may in particular have fluoro, chloro, methyl, methoxy or trifluoromethyl as substituents. Preferred C _2-5 -alkanoyloxy-, C _2-5 -alkoxycarbonyloxy-, C _2-3 -alkylcarbamoyloxy-, di (C _1-2 -alkyl) carbamoyloxy- and di (C _1-2 -alkoxy) -phosphonyl group (R ³ ) is acetyloxy or propionyloxy; Methoxycarbonyloxy or ethoxycarbonyloxy; Methylcarbamoyloxy; Dimethylcarbamoyloxy; Or dimethoxy-phosphonyl.

If an asymmetric carbon atom is present in the compound of formula (I), a compound in optical isomer form may result. If aliphatic C═C-double bonds are present, geometric isomers may also occur.

Formula (I) is intended to include mixtures thereof, including these and other possible isomeric forms.

Preferred groups of the compounds of formula (I) are those in which W represents a group and R ³ is hydrogen, fluoro, chloro, bromo, optionally substituted C _1-6 -alkyl (if a substituent is present Such substituents are in particular halogen, methoxy, ethoxy, nitro, cyano, methoxycarbonyl, ethoxycarbonyl, phenyl or methoxyphenyl), C _2-3 -alkenyl, C _2-3 -alky Neyl, optionally substituted phenyl (if substituents are present, such substituents are especially fluoro, chloro, methyl, methoxy or trifluoromethyl), hydroxy, C _1-6 -alkoxy, C _{1- 6} -alkylthio, phenoxy, phenylthio, cyano or C _2-5 -alkoxycarbonyl, R ⁴ is hydrogen or C _1-6 -alkyl, or R ³ is hydrogen, fluoro, chloro, bromo , C _1-6 -alkyl, hydroxy, C _1-6 -alkoxy, C _1-6 -alkylthio, phenoxy, phenylthio or cyano and R ⁴ is trifluoromethyl; Or W represents a b), c) or d) group and R ⁵ to R ¹² are as defined above; X is oxygen, Y ¹ and Y ² are each oxygen or sulfur, Z is CR ¹³ or nitrogen, R ¹ is fluoro, chloro, C _1-3 -alkyl, fluoromethyl, methoxymethyl, C _{1 -3} -alkoxy, difluoromethoxy or methylthio, R ² is methyl, C _1-2 -alkoxy or C _1-2 -fluoroalkoxy, R ¹³ is hydrogen, fluoro, chloro or methyl, R ^And compounds of formula (I) wherein ¹⁴ is hydrogen.

Independently of one another, W is preferably a) or b), in particular a); X and / or Y ¹ are particularly preferably both X and Y ¹ are oxygen; Y ² is preferably oxygen; Z is preferably CH or nitrogen, in particular CH; R ¹ is preferably hydrogen, chloro, methyl, methoxy or difluoromethoxy, R ² is preferably methoxy, ethoxy, methylamino, dimethylamino or N-methoxymethylamino, R ¹ and It is particularly preferable that at least one of R ² has a methoxy group; R ³ in the group a) is preferably hydrogen, vinyl, ethynyl, hydroxy, C _1-4 -alkoxy or halogen, vinyl, ethynyl, C _1-2 -alkoxy, cyano, carboxy or C _{2 -3-alkoxycarbonyl} substituted by a C _1-2 -alkoxy, C _1-2 - alkylthio, cyano, carboxymethyl, C _2-3 - alkoxy-carbonyl-methyl or carbamoyl, R ⁴ is preferably Is hydrogen or C _1-4 -alkyl; R ⁵ in the group b) is preferably hydrogen or C _1-3 -alkyl and R ⁶ is preferably hydrogen; c) R ⁷ , R ⁸ and R ^{9 in the group} are preferably hydrogen or methyl; d) R ¹¹ and R ^{12 in the group} are preferably each hydrogen or methyl; R ¹⁴ is preferably hydrogen or methyl, in particular hydrogen.

Especially preferred among the compounds of formula (I) are the following compounds:

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide,

3-ethyl-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-isopropyl-phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methoxy-phthalide,

7-[(4-methoxy-6-methyl-pyrimidin-2-yl) oxy] -3-methyl-phthalide,

7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -3-methyl-phthalide,

3-ethylidene-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide (especially its (Z) -isomer),

8-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-isochroman-1-one,

7-[(4,6-dimethoxy-pyrimidin-2-yl) thio] -3-methyl-phthalide,

3-ethoxy-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3,6-dimethyl-phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methoxy-3-methyl-phthalide,

3-carbamoyl-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide,

3- (2-chloroethoxy) -7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-propargyloxy-phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3- (n-propoxy) -phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3- (2-methoxy-ethoxy) -phthalide,

7-[(4-chloro-6-methoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide,

7-[(4-methoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide,

7-[(4-ethoxy-6-methoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide,

7-[(4-chloro-6-methoxy-pyrimidin-2-yl) oxy] -3-methoxy-phthalide,

7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) thio] -3-methyl-phthalide,

7-[(4-dimethylamino-6-methoxy-1,3,5-triazin-2-yl) oxy] -3-methyl-phthalide,

7-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl) oxy] -3-methyl-phthalide,

7-[(4-methoxy-6-methylamino-1, 3,5-triazin-2-yl) oxy] -3-methyl-phthalide,

7-[(4-chloro-6-methylamino-1, 3,5-triazin-2-yl) oxy] -3-methyl-phthalide,

3-ethyl-7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -phthalide,

8-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3,4-dimethyl-isochroman-2-one,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxy-phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methylthio-phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-vinyl-phthalide,

3-cyano-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide,

3-cyanomethoxy-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3- (methoxycarbonylmethoxy) -phthalide,

3-ethoxycarbonylmethyl-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-2-benzothiophen-1 (3H) -one,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-isobenzofuran-1 (3H) -thione,

7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -3-methyl-isobenzofuran-1 (3H) -thione,

7-[(4-difluoromethoxy-6-methoxy-pyrimidinyl) oxy] -3-methyl-phthalide,

8-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -4-methylisochroman-1-one and

3-acetoxy-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide.

More representative of the compounds of formula (I) are the following compounds:

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-isobutyl-phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-secondary butyl-phthalide,

W represents group a), X, Y ¹ and Y ² are all oxygen, Z is CH, R ¹ and R ² are both methoxy, R ⁴ and R ¹⁴ are both hydrogen, R ³ is bromo , Chloromethyl, trichloromethyl, hydroxymethyl, methoxymethyl, cyanomethyl, carboxymethyl, methoxycarbonylmethyl, allyl, ethynyl, propargyl, n-butoxy, cyclopropylmethoxy, difluor To methoxy, 2,2,2-trifluoroethoxy, methoxymethoxy, methylthiomethoxy, 2-methylthio-ethoxy, carboxymethoxy, 1-carboxyoxy, 1-methoxycarbonyl Methoxy, ethoxycarbonylmethoxy, 1-ethoxycarbonylethoxy, N-methylcarbamoylmethoxy, 2- (N, N-dimethylamino) -ethoxy, formyl, carboxy, ethoxycarbonyl A compound of formula (I) which is formyloxy, acetyloxy, methoxycarbonyloxy, ethoxycarbonyloxy or N, N-dimethylcarbamoyloxy;

W represents a group, X, Y ¹ and Y ² are all oxygen, Z is CH, R ¹ and R ² are both methoxy, R ⁴ is methyl, R ¹⁴ is hydrogen, and R ³ is A compound of formula (I) which is fluoro, vinyl, hydroxy, ethoxy, methylthio, carboxy or methoxycarbonyl;

3-ethyl-7-[(4,6-dimethyl-pyrimidin-2-yl) oxy] -3-methoxy-phthalide,

7-[(4,6-dimethyl-pyrimidin-2-yl) oxy] -3-methoxy-3-trifluoromethyl-phthalide,

3-ethoxy-7-[(4,6-dimethyl-pyrimidin-2-yl) oxy] -3-trifluoromethyl-phthalide,

W represents a group, X, Y ¹ and Y ² are all oxygen, Z is CH, R ¹ and R ² are both methoxy, R ³ is methyl, R ⁴ is hydrogen, R ¹⁴ is A compound of formula (I) which is 4-fluoro, 5-fluoro, 6-fluoro, 6-chloro, 4-methyl, 5-methyl, 4-methoxy, 5-methoxy or 6-methoxy;

W represents group a), X, Y ¹ and Y ² are all oxygen, Z is CH, R ² is methoxy, R ³ is methyl, R ⁴ and R ¹⁴ are both hydrogen, and R ¹ is A compound of formula (I) which is fluoro, ethyl or methylthio;

W represents group a), X, Y ¹ and Y ² are all oxygen, Z is CH, R ¹ is methoxy, R ³ is methyl, R ⁴ and R ¹⁴ are both hydrogen, R ² is A compound of formula (I) which is methylamino, dimethylamino or ethylamino;

W represents group a), X, Y ¹ and Y ² are all oxygen, Z is nitrogen, R ¹ and R ² are both methoxy, R ⁴ and R ¹⁴ are both hydrogen, R ³ is hydrogen, A compound of formula (I) which is ethyl, n-propyl or n-butyl;

7-[(4-methoxy-6- {N-methoxymethylamino} -1,3,5-triazin-2-yl) oxy] -3-methyl-phthalide,

7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -3-methoxy-3-methyl-phthalide,

7-[(4,6-dimethyl-1,3,5-triazin-2-yl) oxy] -3-methyl-phthalide,

W represents a group, X, Y ¹ and Y ² are all oxygen, Z is CH, R ¹ and R ² are both difluoromethoxy, R ³ is hydrogen, methoxy or ethoxy, R A compound of formula (I) wherein ^tetravalent hydrogen, methyl or ethyl and R ¹⁴ is hydrogen;

W represents group a), X and Y ¹ are both oxygen, Y ² is sulfur, Z is CH, R ¹ and R ² are both methoxy, R ⁴ and R ¹⁴ are both hydrogen, R ³ A compound of the formula (I) which is hydrogen, ethyl, methoxycarbonylmethyl, hydroxy, methoxy, ethoxy or methoxycarbonyloxy;

7-[(4,6-dimethoxy-pyrimidin-2-yl) thio] -3-methyl-isobenzofuran-1 (3H) -thione,

7-[(4,6-dimethoxy-pyrimidin-2-yl) thio] -3-methyl-2-benzothiophen-1 (3H) -one,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-2-benzothiophen-1 (3H) -thione,

3-ethyl-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -isobenzofuran-1 (3H) -thione,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methoxy-isobenzofuran-1 (3H) -thione,

3-ethyl-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -2-benzothiophen-1 (3H) -one,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methoxy-2-benzothiophen-1 (3H) -one,

7-[(4,6-dimethyl-pyrimidin-2-yl) thio] -3-methyl-phthalide,

7-[(4-methoxy-6-methyl-pyrimidin-2-yl) thio] -3-methyl-phthalide,

7-[(5-chloro-4,6-dimethoxy-pyrimidin-2-yl) thio] -3-methyl-phthalide,

7-[(4,6-dimethoxy-5-fluoro-pyrimidin-2-yl) oxy] -3-methyl-phthalide,

7-[(4,6-dimethoxy-5-methyl-pyrimidin-2-yl) oxy] -3-methyl-phthalide,

7-[(5-chloro-4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methylidene-phthalide,

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-propylidene-phthalide,

3-butylidene-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide,

3-ethylidene-7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -phthalide,

3-methylidene-7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -phthalide,

W represents group c), X, Y ¹ and Y ² are all oxygen, Z is CH, R ¹ and R ² are both methoxy, R ⁷ , R ⁸ and R ⁹ are all hydrogen, R ¹⁴ Is hydrogen and R ¹⁰ is hydrogen, methoxy or ethoxy;

8-[(4-methoxy-6-methyl-pyrimidin-2-yl) oxy] -4-methyl-isochromen-1-one,

8-[(4,6-dimethyl-pyrimidin-2-yl) thio] -3-methyl-isochroman-1-one,

8-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -isochromen-1-one,

8-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -4-methyl-isochroman-1-one,

8-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -4-methyl-isochromen-1-one,

4-ethyl-8-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -isochromen-1-one,

8-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3,4-dimethyl-isochromen-1-one and

8-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -3-methyl-isochromen-1-one.

The process of the present invention for preparing compounds of formula (I) is characterized by reacting a compound of formula (II) with a compound of formula (III):

(Wherein W, X, Y ¹ , Y ² and R ¹⁴ are as defined above),

(Wherein R ¹ , R ² and Z are as defined above and L represents a leaving group).

The term leaving group (L) is in particular a halogen atom, preferably chloro or bromo or optionally substituted alkylthio-, benzylthio-, phenylthio-, alkylsulfinyl-, benzylsulfinyl-, phenylsul Finyl-, alkylsulfonyl-, benzylsulfonyl-, phenylsulfonyl-, alkylsulfonyloxy-, benzylsulfonyloxy-, phenylsulfonyloxy- or 3-alkylsulfonyl-1H-1,2,4- Triazol-1-yl group (such as 3-methylsulfonyl-1H-1,2,4-triazol-1-yl). Particularly preferred among such sulfur-containing leaving groups L are methanesulfonyl, ethanesulfonyl and benzylsulfonyl.

This reaction is conveniently carried out in an inert diluent in the presence of a base or reaction promoter at temperatures ranging from 0 ° C. to 160 ° C., preferably from 20 ° C. to 100 ° C. or to the boiling point of the reaction mixture. Diluents are in particular organic solvents, preferably aprotic aliphatic or cyclic ethers such as dimethoxyethane and tetrahydrofuran; Aliphatic ketones such as acetone and 2-butanone; Aliphatic nitriles such as acetonitrile and propionitrile; Dimethylformamide; Dimethylacetamide; And heteroaromatic compounds such as pyridine and lutidine can be used, and examples of the base include in particular alkali metal hydrides such as sodium hydride and potassium hydride; Alkaline earth metal hydrides such as calcium hydride; Alkali metal hydrogen carbonates such as sodium bicarbonate and potassium bicarbonate; Alkali metal carbonates such as sodium carbonate and potassium carbonate; Alkaline earth metal carbonates such as calcium carbonate and magnesium carbonate; Aliphatic tertiary amines such as triethylamine; Fully substituted amidines such as diazabicycloundecene; And basic heteroaromatic compounds such as pyridine. Suitable as reaction promoters are substances which promote the reaction, in particular by crown ethers and phase transfer catalysts, and also by activating the leaving group L when the leaving group L is temporarily substituted or when L = halogen. Examples of the first described substance are dimethylaminopyridine, and examples of the second described substance are silver and copper salts such as silver nitrate and copper (I) chloride.

Other processes for the preparation of compounds of formula (I) according to the invention, wherein W is a) or b) and X and Y ¹ represent oxygen, respectively, are provided by the corresponding alkylation reactions, Consists of treatment with silylation reaction, carbonylation reaction, carbamoylation reaction, halogenation reaction, substitution reaction, Grignard reaction or Wittich reaction:

(Wherein R ¹ , R ² , R ¹⁴ and Z are as defined above), which similarly applies to the following methods relating to the preparation of starting materials of general formula (II).

Moreover, the compound represented by the general formula (I) the X and / or Y ¹ represents sulfur may be prepared by sulfurization of the corresponding compound which is represented by the general formula (I) represents the X and / or Y ¹ oxygen.

The obtained compound of formula (I) can be separated and purified by a known method.

If the desired synthesis cannot separate pure isomers, the product can be obtained as a mixture of two or more isomers. Isomers can be cleaved by known methods. If desired, pure optically active isomers can be prepared, for example by synthesizing from the corresponding optically active starting material.

Starting materials of formula (II) are partially novel and partially known. For example, 7-hydroxyphthalide and 3,7-dihydroxy-phthalide (wherein W is methylene or hydroxymethylene, X, Y ¹ and Y ² are each oxygen and R ¹⁴ is hydrogen, Compounds) are described in EL Eliel et al., J. Org. Chem. 18, 1679 ff. (1953). Furthermore, the preparation of 7-hydroxy-3-methyl-phthalide and 3-ethyl-7-hydroxy-phthalide is described in S. Kushner group, JACS 75, 1097 ff. (1953) and J. Blair and GT Newbold, J. Org. Chem. 1955, 2871 ff. Also known is an approach towards 3,7-dihydroxy-3-methyl-phthalide [Z. Horii group, J. Pharm. Soc. Japan 74, 466 ff. (1954). New starting materials of general formula (II) can be prepared according to known methods.

Starting materials of the general formula (II) wherein W is a) or b) and X and Y ¹ are both oxygen can be prepared in a known manner, for example according to Schemes 1 and 2 below:

Y ² , R ³ , R ⁴ , R ⁵ and R ¹⁴ in the schemes 1 and 2 are as defined above; R ^{3 '} is optionally substituted C _1-6 -alkyl, C _2-3 -alkenyl, C _2-3 -alkynyl, optionally substituted phenyl or optionally substituted C _1-6 -alkoxy ego; R ³ is optionally substituted C _1-6 -alkyl, C _2-3 -alkenyl, C _2-3 -alkynyl or optionally substituted phenyl; R ^{4 '} is C _1-6 -alkyl; R ^{14 '} is hydrogen or C _1-2 -alkyl; R ¹⁵ is an alkanoyl, in particular a C _2-5 -alkanoyl or —Si (CH ₃ ) ₂ R ¹⁹ group, wherein R ¹⁹ represents C _1-6 -alkyl; R ¹⁶ is hydrogen, methyl, tertiary butyl or a protecting group customary in the chemical field such as benzyl, p-methoxybenzyl or methoxyethoxymethyl; R ¹⁷ is hydrogen or C _1-2 -alkyl, R ¹⁸ is C _1-4 -alkyl, or R ¹⁷ and R ¹⁸ are bonded together to represent tetramethylene which may be substituted with a methoxy- or hydroxymethyl group .

Each reaction, such as various Grignard-reactions using R ^{4 '} Mg halide, R ^4' LiR ³ Mg halide, R ³ Mg halide or R ³ Li, concentrated sulfuric acid (H ₂ SO ₄ ) Hydrolysis, reduction of cyclic carbonyl groups (such as reaction stage VII → IIa) or reduction of hydroxy groups (such as reaction stage IIb → IId), oxidation using manganese dioxide (MnO ₂ ), and Wittich reactions are those skilled in the art. For example, compounds of formula (VII) may be prepared from compounds of formula (VI) according to the provisions of J. -AH Nasman, Synthesis 1985, 788 (in which case R ¹⁵ is 2,2- Dimethylpropanoyl group). Furthermore, for example, compounds of formula (VII) can be prepared from the corresponding o-nitrophthalic anhydrides according to generally known specifications (see, eg, EL Eliel, JACS 77, 5092 ff. (1955)). At this time, the nitro group is first reduced and then converted to the corresponding hydroxy compound by diazotization. More important literature on what reaction conditions are appropriate for any reaction step is:

J. Blair and G.T. Newbold, J. Org. Chem. 1955, 2871 ff. And B.L. Chenard group, J. Org. Chem. 49, 318 ff. (1984).

In reaction step 2, TMEDA is tetramethylethylenediamine, THF is tetrahydrofuran, DMF is dimethylformamide, and L 'is chloro, acetyl, imidazolyl, N, O-dimethylhydroxyamino or dimethylamino Leaving group such as Preferred groups N ¹⁷ R ¹⁸ for the direct metallization (reaction step IX → X) in the ortho position to the carboxamide functional group CONR ¹⁷ R ¹⁸ are diethylamino [V. Snieckus, Heterocycles 14, 1649 ff. (1980)], methylamino [SN Yeola and RS Mali, Ind. J. Chem. 25B, 804 ff. (1986) and NS Narasimhan and RS Mali, Synthesis 1983, 957 ff. And tertiary butylmethylamino [DB Reitz and SM Massey, J. Org. Chem. 55, 1375 ff. (1990).

Especially in the case of a few cases where the reaction conditions (RB) are not indicated, such as reaction stages IIe → IIf and XI → XIV, the reaction conditions depend on the nature of the groups R ³ or R ⁴ introduced. R ³ represents optionally substituted C _1-6 -alkyl, C _2-3 -alkenyl, C _2-3 -alkynyl or optionally substituted phenyl (R ³ ) or R ⁴ represents C _{1- In case of 6} -alkyl (R ^{4 '} ), R ³ Mg halide or R ^4' Mg halide or R ³ Li or R ^{4 '} Li is effectively used as R ³ -or R ^4' -containing reagent. When R ³ represents optionally substituted C _1-6 -alkoxy, the starting material IIb or IIe is treated with the corresponding hydroxy compound R ³ H under an acid catalyst such as sulfuric acid, p-toluenesulfonic acid or trifluoroacetic acid. do. Examples of initial reaction types are described in particular in J. Grandguillot and F. Roussac, Synthesis 1979, 607 ff and P. Canonne group, Tetrahedron Lett. 26, 4719 (1985).

The reaction stages XII → IIh, XII → IIi and XIV → IIj are more generally known, wherein the phenolic methylether group or the corresponding thioether group (R ¹⁶ = methyl) is hydrobromic acid in water or glacial acetic acid, tri Easily separated into hydroxy- or thiol groups (R ¹⁶ = hydrogen) by using boron bromide or boron tribromide-dimethylsulfide complex in methylene- or ethylenedichloride. Other suitable separation reagents are aluminum trichloride, boron trichloride, dimethylborobromide (in methylene chloride) alkyl mercaptide, such as sodium methyl mercaptide (in toluene or xylene).

Starting materials of the general formula (IIb) and the corresponding protected compounds wherein R ^{4 ′} is methyl or ethyl may react with the corresponding phthalic anhydride as a base such as triethylamine (TEA) or pyridine (Py) (these may also act as diluents). Is reacted with malonic acid or methylmalonic acid while heating until generation of carbon dioxide ceases, and can be represented by the following scheme:

Wherein R ²⁰ is hydrogen or methyl.

Other methods for preparing starting materials of general formula (II) are known from the technical literature. For example, 3-hydroxyphthalide of the one shown in Scheme 2 is described in B.M. Trost group, J. Org. Chem. 45, 1835 ff. (1980), F. Hauser R. Lee, J. Org. Chem. 45, 3061 ff. (1980) and J. N. Freskos group, J. Org. Chem. 50, 805 ff. (1985), which can then be converted into the corresponding starting materials of formula (IIg) or (IIj) as indicated above.

In order to obtain an optically active compound of general formula (IIi), a chiral lithium hydride reagent in which a compound of general formula (IIb), (IIb ′) or (XIII) is converted into an optically active reducing agent such as vinaphthol (R)-or (S) -BINAL-H [R. Noyori group, J.A.C.S. 106, 6717 ff. (1984)] or optically active chiral hydrogenation catalysts such as ruthenium [(R)-or (S) -BINAP] [R. Noyori et al., J. A. C. S. 109, 5856 ff., (1987)].

Other modifications for the preparation of optically active compounds of general formula (IIi) are described in Trost et al., J. Org. Chem. 45, 1835 ff. (1980) according to the method described in this section consists of sequentially treating chiral carbinol with n-butyllithium / tetramethylethylenediamine, carbon dioxide or ethylchloroformate, and hydrobromic acid, which corresponds to the following scheme:

Starting materials of the general formula (IX) are sometimes known or may be prepared according to known methods.

Starting materials of the general formula (II) wherein W is a) and R ³ is chloro or bromo are those starting materials of the general formula (II) wherein R ³ is hydroxy (such as the general formulas (IIb) and (IIe) Can be prepared by halogenating). Suitable as halogenating agents (chlorinating or brominating agents) are, in particular, the corresponding thionyl halides SOHal ^' ₂ , phosphoroxyoxyhalides POHal ^' ₃ , phosphorotrihalides PHal ^' ₃ or phosphoropentahalides PHal ^' ₅ Wherein Hal 'each represents chloro or bromo. Other methods for preparing such chlorine- or bromine-containing starting materials of formula (II) include the corresponding starting materials (II) wherein R ³ is hydrogen (e.g. starting materials of general formula (IIi) above). It consists of treating with N-chloro- or N-bromosuccinimide. To obtain a starting material of formula (II) wherein W is a) and R ³ is fluoro, C _1-6 -alkylthio, cyano or thiocyanato, a general formula (II) wherein R ³ is chloro or bromo. Corresponding starting materials of) may be subjected to halogen exchange reactions using, for example, alkali metal fluorides such as potassium fluoride, sodium mercaptide, sodium cyanide or potassium rhodamide. All such modifications can be carried out under reaction conditions known per se.

The starting material of formula (II) wherein W is group a) and R ³ is cyano is the starting material of the corresponding starting material of formula (II) wherein R ³ is hydroxy (e.g., starting from formula (IIb) Material) can be prepared by treating with potassium cyanide or cyanic acid under reaction conditions known per se (see, eg, JN Frescos et al., J. Org. Chem. 50, 805 ff (1985).

W is a) a group R ³ represents a C _2-7 - alkyl, carboxy (substituted C _1-6 according to any-a is R ³ The compounds of Examples of alkyl), carboxy or carbamoyl of the formula (II) ( The corresponding compounds of formula (II) which are C _2-5 -alkoxycarbonyl) -C _1-6 -alkyl, C _2-7 -alkoxycarbonyl or cyano can be prepared by conventional hydrolysis.

W is a) a group R ³ represents a formyloxy, C _2-5 - alkanoyloxy, C _2-5 - alkoxycarbonyloxy, C _2-3 - alkyl-carbamoyl-oxy or di (C _1-2 - Compounds of formula (II) wherein alkyl) carbamoyloxy are typically prepared by formylating, acylating, carbonylating or carbamoylating the corresponding compounds of formula (II) wherein R ³ is hydroxy. Can be.

Finally, a compound of formula (II) wherein W is a) and R ³ is di (C _1-2 -alkoxy) -phosphonyl, gives C _{1-2 a} corresponding compound (II) wherein R ³ is hydroxy. It is prepared by reacting with alkyl phosphite.

Starting materials of the general formula (II) wherein W represents group b) and Y ¹ and Y ² are both oxygen and R ⁶ is hydrogen are prepared according to Scheme 3, for example, wherein R ⁵ , R ¹⁴ and R ¹⁶ are As defined, R ²¹ and R ²² each represent methoxy or ethoxy.

See R.S. Mali and S.L. Patil, Synthetic Comm. 20, 167 ff (1990) and in E. Napolitano et al., Syntheses 1985, 38-40, describe similar schemes for describing individual reaction steps.

The starting materials of the general formula (II), wherein W represents group c) and X and Y ¹ represent oxygen, are known per se in a manner known per se, such as in NS Narasimhan and BH Bhide, Tetr. 27, 6171 (1971), by J. Sinha, J. Ind. Chem. Soc. 63, 907 (1986) and by HN Singh and RP Singh, J. Ind. Chem. Soc. 65, 685 (1988), and also according to Scheme 4 below:

In the scheme, Y ² , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹⁴ , R ¹⁶ , R ¹⁷ , R ¹⁸ , TMEDA, THF and L 'have the meanings as defined above. LDA represents lithium diisopropylamide, NBS represents N-bromosuccinimide, and L represents a leaving group such as halogen, in particular chloro, or 2-imidazolyl.

In addition, the individual reactions included in the scheme are known per se.

Starting materials of formula (II) wherein W is group d) and X and Y ¹ are oxygen are described, for example, in NL Lewis group, Synthesis 1986, 944 and FM Hauser group, J. Org. Chem. 53, 4676 (1988).

In general, starting materials of formula (II) in which X and / or Y ¹ are oxygen are X and / according to the known sulfiding methods (see for example N. Lozach, Sulfur Reports 9, 153 ff (1980)). Or a corresponding starting material of formula (II) wherein Y ¹ is sulfur. For sulfiding, it is conveniently optionally optionally phosphoropentasulfide in the presence of pyridine (e.g., as phosphoropentasulfide-pyridine (1: 2) -complex), Lawesson reagent 2,4-bis- (4-methoxyphenyl) -1,2-dithioxo-1,3,2,4-dithiaphosphetane [eg S. -O. Lawesson group, Bull, Soc. Chim. Belg. 87, 229-238 (1978)] or Davy reagent 2,4-bis- (methylthio) -1,3,2,4-dithiadiphosphate (see, eg, Sulfur Lett. 1983, 1, 167). ) Is preferably used in stoichiometric amounts or slightly excess (eg up to 20%). Conveniently high temperatures in inert organic diluents, such as optionally halogenated aromatic compounds (eg toluene or dichlorobenzene) or aliphatic or cyclic ethers (eg dimethoxyethane), in particular from 80 ° C. to the reflux temperature of the reaction mixture Work at temperatures up to Also advantageously add about 0.1 to 10% by weight of hexamethylphosphorotriamide relative to the catalytic amount, ie the amount of compound (II). This method is particularly suitable for preparing compounds of formula (II), wherein X is oxygen and Y ¹ is sulfur.

Starting materials of the general formula (II) wherein X is sulfur and Y ¹ is oxygen may be, for example, a hydroxy compound or a general formula (XII) (see Scheme 2) or (XXV) (see Scheme 4). XXII) compounds (see Scheme 4) can be prepared by converting the compounds of the formula (II) into the corresponding thiol compounds according to modification reactions well known to those skilled in the art such as halogenation and sulfidation reactions:

R ^{3 ′} and R ⁴ of compound (XXVIII) in the above schemes are R ³ and R ⁴ or R ⁷ depending on whether it is derived from a compound of formula (XII) or a compound of formula (XXII). And R ⁸ .

Starting materials of the general formula (II) wherein Y ² is sulfur can not be obtained by preparation according to the methods described so far (e.g., see Schemes 2, 4 and 5). It may be prepared according to Table 6. In the table below, W, X, Y ¹ and Y ¹⁴ are as defined above.

In the schemes 1 to 6 and the reaction formulas (XV → IIb; XVI → IIi ′), the products of formulas (IIa to IIq) represent subgroups belonging to the starting materials of formula (II). Starting materials of the general formulas (IV), (V), (IX), (XV), (XVI) and (XVII) are known or can be prepared according to known methods per se.

Starting materials of the general formula (III) are mostly known, and new starting materials (III) can be prepared similarly to the known starting materials (III).

Compounds of general formula (I) (hereinafter referred to as compounds or active ingredients of the invention) have herbicidal properties and have a variety of useful crops, especially rice (especially hydroponic rice), wheat, corn, soybeans, rape and cotton Weeds, including grass weeds for cultivation, especially Agropyron repens, Alopecurus myosuroides, Avena fatua, Bromus inermis, Eki Echinochloa crus-galli, Poa annua, Sorghum halepense, Abutilon theophrasti, Amaranthus retroflexus, Cassia obtusifolia Kenopodium album, Gallium aparine, Matricaria chamomilla, Synapsis Arvensis and Stellaria media suitable for removing tellaria media). The compounds are also herbicides before germination and herbicides after germination. Some representative compounds (I) have been found to have good selectivity in removing, for example, weeds (grass and weeds for cotton weeding).

Furthermore, the compounds of the present invention have plant growth control properties and are suitable as active substances for positively affecting the growth of useful crops. This effect not only can cause desired growth inhibition in the cultivated plants, but also allows control of the weeds after germination to remove weeds as competitors of the cultivated plants. Considering the ecological point of view, this is an advantageous advantage and therefore very desirable. Particularly in this case is the protection of the surface from drying and / or corrosion and the reduction of weed-seed storage in the ground (while simultaneously suppressing flowering and new seed formation). Thus, this action is advantageous over weed germination, which in some cases is complete but may be limited in time.

In practice, a concentration of 1 g to 3 kg / ha of the compound of the present invention, preferably 10 g to 1 kg / ha of the compound of the present invention is sufficient to achieve the desired herbicidal effect. The range of 10 to 100 g / ha in pre-germination and 100 to 1000 g / ha in post-germination treatment is particularly good in order to achieve the optimum useful crop tolerance with the desired herbicidal effect.

The herbicides and plant growth regulators according to the invention are characterized in that they comprise an effective amount of at least one compound of formula (I) as defined above and a formulation aid. The composition is conveniently a solid carrier; Solvents or dispersants; Surfactants (wetting agents and emulsifiers); Dispersants (without surfactant activity); And at least one compounding aid selected from the group consisting of stabilizers. These and other auxiliaries can be used to convert these compounds, i.e., herbicidal active ingredients, into conventional combinations of dusting agents, powders, granules, solutions, emulsions, suspensions, emulsifiable concentrates, pastes and the like.

Compounds of general formula (I) are usually water-insoluble and can be formulated to the water-insoluble compounds using the relevant formulation aids by conventional methods. The compositions can be used, for example, by mixing each active ingredient with a solid carrier, by dissolving or suspending it in a suitable solvent or dispersant using a surfactant and / or dispersant as a wetting agent or emulsifier, or by using a pre-prepared emulsifying concentrate as a solvent or dispersant. It can be prepared by a known method such as dilution.

Suitable solid carriers are mainly natural minerals such as chalk, dolomite, limestone, alumina and silica and salts thereof such as diatomaceous earth, kaolin, bentonite, talc, attapulgite and montmorillonite; Synthetic minerals such as highly dispersed silica, alumina and silicates; Organic materials such as cellulose, starch, urea and synthetic resins; And fertilizers such as phosphates and nitrates, such carriers may be present, for example, in powder or granules.

Suitable solvents or dispersants are mainly aromatic compounds such as benzene, toluene, xylene and alkylnaphthalene; Chlorinated aromatic compounds and chlorinated aliphatic hydrocarbons such as chlorobenzene, chloroethylene and methylene chloride; Aliphatic hydrocarbons such as cyclohexane and paraffins such as mineral oil fractions; Alcohols such as butanol and glycols and ethers and esters thereof; Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone; And strong polar solvents or dispersants such as dimethylformamide, N-methylpyrrolidone and dimethyl sulfoxide (preferably such solvents have a flash point of at least 30 ° C. and a boiling point of at least 50 ° C.), and water. Also suitable among these solvents and dispersants are so-called liquefied gaseous extenders or carriers which are gaseous products at room temperature and atmospheric pressure. Examples of such products are in particular aerosol gunpowder gases (eg halohydrocarbons such as dichlorodifluoromethane). If the herbicides according to the invention are present in the form of pressurized gas packaging, it is convenient to use a solvent in addition to the sand spray gas.

Surfactants (wetting agents and emulsifiers) include condensation products of fatty acids, fatty alcohols or fatty-substituted phenols with ethylene oxide; Fatty acid esters and ethers of sugars or polyhydric alcohols; Products obtained from sugars or polyhydric alcohols by condensation with ethylene oxide; Block polymers of ethylene oxide and propylene oxide; Or nonionic compounds such as alkyldimethylamine oxides.

Surfactants also include soaps; Fatty sulfate esters such as sodium dodecyl sulfate, sodium octadecyl sulfate and sodium cetyl sulfate; Alkylsulfonates, arylsulfonates and fatty aromatic sulfonates such as alkylbenzenesulfonates (eg calcium dodecylbenzenesulfonate) and butylnaphthalenesulfonate; And more complex fatty sulfonates such as amide condensation products of oleic acid and N-methyltaurine and anionic compounds such as sodium sulfonate of dioctylsuccinate.

Finally, the surfactant may be a cationic compound such as alkyldimethylbenzylalmonium chloride, dialkyldimethylammonium chloride, alkyltrimethylammonium chloride and ethoxylated quaternary ammonium chloride.

Suitable dispersants (without surfactant action) are mainly lignin, sodium and ammonium salts of ligninsulfonic acid, sodium salts of maleic anhydride / diisobutylene copolymers, sodium and ammonium salts and sulfites of sulfonated polycondensation products of naphthalene and formamide Waste solution.

Dispersants that can be used, which are particularly suitable as thickeners and antisettling agents, are for example methylcellulose, carboxymethylcellulose, hydroxyethylcellulose, polyvinylalcohol, alginate, caseinate and serum albumin.

Examples of suitable stabilizers include acid-binding agents such as epichlorohydrin, phenylglycidyl ether and epoxidized soybean oil; Antioxidants such as gallic acid ester and butylhydroxy toluene; UV absorbers such as substituted benzophenones, diphenylacrylic acid esters and cinnamic acid esters; And salts of deactivators such as ethylenediaminotetraacetic acid and polyglycol.

The herbicides according to the invention may contain, in addition to the active ingredients according to the invention, synergists and other active ingredients such as insecticides, mites, fungicides, plant growth regulators and fertilizers. Such combinations are suitable for enhancing activity or broadening the activity spectrum.

The herbicides according to the invention generally contain from 0.001 to 95% by weight, preferably from 0.5 to 75% by weight of one or more compounds according to the invention as active substance (s). They may be present in a form suitable for storage and transportation. In such combinations, for example emulsifiable concentrates, the concentration of the active ingredient is generally in a higher range, preferably 1 to 50% by weight, in particular 5 to 30% by weight. Such formulations may, for example, be diluted to a concentration of the active ingredient suitable for practical use, i. However, the concentration of the active ingredient may also be smaller or larger.

As already mentioned above, the herbicides according to the invention can be prepared by known methods.

Formulations in powder form may be prepared by grinding the active ingredient, ie one or more compounds according to the invention, together with a solid carrier for mixing; Or by dipping the solid carrier into a solution or suspension of the active ingredient and then removing the solvent or dispersant by evaporation, heating or aspiration under reduced pressure. By adding surfactants or dispersants, these powdery compositions can be easily wetted with water, so that these compositions can be converted into aqueous suspensions suitable as spray compositions, for example.

The active ingredient may be mixed with the surfactant and the solid carrier to produce a water dispersible wettable powder, or the active ingredient may be mixed with a previously granulated solid carrier to produce a granulated product.

If desired, the active ingredient may be dissolved in a solvent which is not mixed with water, ie a hydrocarbon having a high boiling point. Such a solvent contains a dissolved emulsifier, so that this solution exhibits the effect of emulsifying itself when added to water. In other cases, the active ingredient may be mixed with an emulsifier and then diluted with water to the desired concentration. The active ingredient may also be dissolved in a solvent and then mixed with the emulsifier. This mixture can also be diluted to the desired concentration with water. In this way an emulsifiable concentrate or ready-to-use emulsion is obtained.

The herbicides according to the invention are used by the usual methods of administration, i.e. by spraying, spraying, spraying, pouring or spraying, which is one subject of the invention. The herbicidal method according to the invention is characterized by treating the object and / or weed to be protected from weeds with a compound of the general formula (I) according to the invention, or a herbicide according to the invention.

The following examples are intended to illustrate the invention in more detail.

I. Preparation of Compounds of Formula (I):

Example 1

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide

A mixture of 0.4 g of 7-hydroxy-3-methyl-phthalide, 0.52 g of 4,6-dimethoxy-pyrimidine-2-methylsulfone and 1.05 g of potassium carbonate in 5 ml of dimethylformamide was heated to reflux for 2 hours. do. The mixture is diluted appropriately with ethyl acetate and washed once with water and sodium chloride solution. After standing to evaporate the solvent, the crude product is purified by chromatography on silica gel using ethyl acetate / n-hexane (1: 2) as eluent. In this way, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide having the following physical properties is obtained.

Examples 2 to 81

The desired compounds of the general formulas (II) and (III) prepared in a similar manner to those described in Example 1 except for using acetonitrile or tetrahydrofuran as the solvent and sodium hydride as the base are used. It is listed in the following 1-5 with the compound of Formula (I).

Example 82

8-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-isochromen-1-one

Similar to the method described in Example 1, 8-hydroxy-3-methyl-isochromen-1-one was reacted with 4,6-dimethoxy-pyrimidin-2-methylsulphone to achieve a melting point of 188 to 190 ° C. Prepare [[4,6-Dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-isochromen-1-one.

Example 83

3-[(Z) -Ethylidene] -7-[(4,6-dimethoxy-pyrimidin-2-yl) -oxy] -phthalide

350 mg (2 mmol) of 7-hydroxy-3-vinyl-phthalide in 10 ml of dimethylformamide, 460 mg (2.2 mmol) of 4,6-dimethoxy-2-methylsulfonyl-pyrimidine and 414 mg (3 mmol) of potassium carbonate Is heated at 100 ° C. for 1 h. The reaction mixture is then poured into 100 ml of ½ concentrated saline solution and the aqueous mixture is extracted twice using 50 ml of ethyl acetate. The organic phase is dried over anhydrous magnesium sulfate under reduced pressure and the crude product is purified by chromatography on silica gel using ethyl acetate / n-hexane (2: 3) as eluent.

In this way 250 mg of 3-[(Z) -ethylidene] -7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide having the following physical properties is obtained in the form of colorless crystals.

Melting point 163-165 ° C .; IR-spectrum (CHCl ₃ ): C = O 1765 cm ^-1

These products are identical to the compounds of Example 68.

Example 84

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxy-phthalide

a) 15.2 g of 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methoxy-phthalide (see Example 8) in a 1: 1 mixture of tetrahydrofuran and hydrochloric acid Is heated to reflux for 3 hours. It is placed under reduced pressure and the precipitated crystals are filtered and washed with water. Pure 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxy-phthalide is obtained having the following physical properties:

b) One product of this product can be prepared by dissolving 6 g of 3,7-dihydroxy-phthalide in a methanolic solution of 2.6 g of potassium hydroxide and evaporating the resulting solution with toluene to an azeotrope. Monopotassium salt is added to 100 ml of anhydrous dimethyl sulfoxide and treated in small portions with 1.9 g of sodium digested. Stir at 40 ° C. for 10 minutes and mix with 9.9 g of, 6-dimethoxy-pyrimidinyl-2-methylsulfone at room temperature to maintain the reaction mixture at 30 to 35 ° C. for 1 hour. The mixture is mixed with water and extracted using ethyl acetate to remove impurities. The aqueous phase is acidified with hydrochloric acid and extracted with fresh ethyl acetate. Treated with activated carbon and / or filtered over silica gel to give 7-[(4,6-methoxy-pyrimidin-2-yl) -oxy] -3-hydroxy-phthalide as pale yellow crystals with a melting point of 144-146 ° C. To obtain.

Example 85

3-Chloro-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide

2.3 g of 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxyphthalide (see Example 84) is suspended in about 40 ml of phosphoroxychloride and the suspension is Heat to 90 ° C. for hours. The reaction mixture is added to 250 ml of water at 35 to 45 ° C. Dilution with 500 ml of water is followed by filtration of the precipitated crystals and washing with water to neutrality. Pure 3-chloro-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide with a melting point of 143-144 ° C. is obtained as pale yellow crystals.

Example 86

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-fluoro-phthalide

1.0 g of 3-chloro-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide (see Example 85) and 0.19 g of freshly dried potassium fluoride and 1 spatula amount The mixture of 18-crown-6 is heated to reflux for 100 minutes. Filtrate through Celite ^R and evaporate and crystallize the crude product with ethyl acetate / n-hexane. This affords 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-fluoro-phthalide with a melting point of 172 to 174 ° C.

Example 87

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methylthio-phthalide

1.0 g of 3-chloro-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide (see Example 85) and 0.24 g of sodium methyl mercaptide in about 20 ml of tetrahydrofuran Stir for 16 hours. Filter appropriately through Celite ^R and evaporate to dryness under reduced pressure. Crystallization from diethyl ether / n-hexane affords 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methylthio-phthalide with a melting point of 138 to 140 ° C.

Example 88

3-ethylthio-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide

Similar to the method described above (Example 87), 3-chloro-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] phthalide (see Example 85) and sodium methyl mer From the captide, 3-ethylthio-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide is obtained with a melting point of 103 to 106 ° C.

Example 89

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-thiocyanato-phthalide

A mixture of 1.4 g of 3-chloro-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide (see Example 85) and 0.46 g of potassium thiocyanate was added in an amount of 1 spatula. Heat in 15 ml of acetonitrile in the presence of 18-crown-6 for 4 hours. Filter through Celite ^R , evaporate to dryness and chromatograph with 30% ethyl acetate / n-hexane. 7-[(4,6-dimethoxy-pyrimidin-2-yl) -oxy] -3-thiocyanato-phthalide at melting points 161 to 163 ° C. is obtained as pale yellow crystals.

Example 90

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-phenoxy-phthalide

A mixture of 1.4 g of 3-chloro-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide (see Example 85) and 0.63 g of potassium phenolate was added in 1 spatula amount of 18 Heat to reflux in 15 ml of acetonitrile in the presence of crown-6. After 19 h, filtered through Celite ^R , evaporated to dryness and the crude product was purified by column chromatography (eluent: 25% ethyl acetate / n-hexane). 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-phenoxy-phthalide at a melting point of 155-157 ° C. is obtained as white crystals.

Example 91

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-vinyl-phthalide

3.6 g of 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxy-phthalide (Example 84) was added to 60 ml of anhydrous tetrahydrofuran at -45 deg. The solution is treated with 18 ml of vinyl magnesium chloride 2M solution dissolved in tetrahydrofuran over 10 minutes. After stirring at room temperature for about 16 hours, 6 ml of vinylmagnesium chloride solution is added and heated to reflux for another hour. The cooled reaction solution is acidified with 1N hydrochloric acid and then tetrahydrofuran is removed with a rotary evaporator. The aqueous phase is extracted with tertiary butyl methyl ether and the organic phase is washed and evaporated to dryness under reduced pressure. Pure 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-54 at 97-97 ° C. by silica gel chromatography with ethyl acetate / n-hexane (2: 3) as eluent. Obtain vinyl-phthalide.

Example 92

3-cyano-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide

1.0 g of 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxy-phthalide (see Example 84) was added to a solution of 2.1 g of potassium cyanide dissolved in 15 ml of water. And small amount of this with 10 ml of concentrated hydrochloric acid over 10 minutes under cooling of -7 to -3 占 폚. After stirring for about 16 hours at room temperature the precipitated crystals are filtered off. Wash with water and crystallize from acetone / n-hexane. 0.2 g of 3-carbamoyl-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide (see Example 17) is obtained. The mother liquor is chromatographed with ethyl acetate / n-hexane (1: 1) as eluent. Pure 3-cyano-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide with a melting point of 157-159 ° C. is obtained.

Example 93

3-cyanomethoxy-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide

A mixture of 1.5 g of 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxy-phthalide (see Example 84) and 0.8 ml of chloroacetonitrile was dried with dried potassium carbonate 2.1. g and 1 spatula amount of sodium hydride and 18-crown-6 in 60 ° C. ethylmethyl ketone for 1 hour. The cold reaction product is placed in tertiary butyl methyl ether and the solution is diluted with hydrochloric acid and washed with water, evaporated to dryness and purified by silica gel chromatography (eluent: ethyl acetate / n-hexane 1: 1). 3-cyanomethoxy-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide is obtained at a melting point of 99 to 102 ° C.

Example 94

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3- (methoxycarbonylmethoxy) -phthalide

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxy-phthalide (see Example 84) and chloroacetic acid- in a similar manner as described above (Example 93). From methyl ester, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3- (methoxycarbonylmethoxy) -phthalide having a melting point of 102 to 104 占 폚 is obtained.

Example 95

3-acetoxy-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide

1.3 g of 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxy-phthalide (see Example 84) is dissolved in 30 ml of tetrahydrofuran and the solution is Mix with 0.6 ml of ethylamine and treat in small portions with 0.5 ml of acetyl chloride at 25 ° C. (within temperature range). After stirring for 2 hours at room temperature, the mixture is extracted with iced water and dilute hydrochloric acid using ethyl acetate, the organic phase is washed with sodium chloride solution, dried over anhydrous magnesium sulfate and evaporated to dryness under reduced pressure. Column chromatography on silica gel [eluent: ethyl acetate / n-hexane (2: 3)] to give 3-acetoxy-7-[(4,6-dimethoxy-pyrimidin-2-yl) at a melting point of 119 to 120 < 0 > C. ) Oxy] -phthalide is obtained as white crystals.

Example 96

3- (ethoxycarbonylmethyl) -7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide

1.5 g of 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxy-phthalide (see Example 84) and (ethoxycarbonylmethylene) -triphenyl-phosphorane 2.5 g of the mixture is maintained at reflux for 10 hours in about 40 ml of tetrahydrofuran. This solution is evaporated and the remaining reaction product is purified on a silica gel column (eluent: ethyl acetate / n-hexane 1: 1). This affords 3- (ethoxycarbonylmethyl) -7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide at a melting point of 150-152 ° C.

Example 97

3- (dimethoxyphosphonyl) -7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide

1.0 g of 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxy-phthalide (see Example 84) was dissolved in 30 ml of methanol, and a 5.4 M sodium methylate solution 0.88 ml is added and this is treated in small portions with 0.43 ml of dimethyl phosphite. After standing at room temperature for 1 hour, 0.33 ml of methanesulfonic acid are added and the reaction mixture is evaporated to dryness under reduced pressure. The residue is dissolved in ethyl acetate and the solution is washed once with 2N hydrochloric acid and sodium chloride solution. The organic phase solution is treated with activated carbon and the product is crystallized from ethyl acetate / n-hexane. 3- (dimethoxyphosphonyl) -7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide is obtained having the following physical properties:

Example 98

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-2-benzothiophen-1 (3H) -one

1.21 g of 7-hydroxy-3-methyl-isobenzofuran-1 (3H) -thione is added to 4,6-dimethoxy-pyrimidinyl-2 in 10 ml of acetonitrile in the presence of 1 spatula amount of 18-crown-6. Heat to reflux for 2 hours with 0.83 g methylsulfone and 1.05 g potassium carbonate. The reaction product is dissolved in ethyl acetate and the organic phase solution is washed with water and sodium chloride solution, evaporated to dryness under reduced pressure and purified by chromatography (eluent: 30% diethyl ether in n-hexane). 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-2-benzothiophen-1 (3H) -one having the following physical properties is obtained as a yellowish crystal.

Example 99

7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-isobenzofuran-1 (3H) -thione

6.35 g of 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide (see Example 1) and 2,4-bis- (4-methoxyphenyl)- A mixture of 8.92 g of 2,4-dithioxo-1,3,2,4-dithiadiphosphetane (Rawson's reagent) is maintained at reflux for about 16 hours in 40 ml of xylene. The reaction product is filtered over silica gel (eluent: 30% diethyl ether / n-hexane) and crystallized from ethyl acetate / n-hexane. This gives 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-isobenzofuran-1 (3H) -thione having the following physical properties as yellow crystals:

Example 100

7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -3-methyl-isobenzofuran-1 (3H) -thione

1.0 g of 7-hydroxy-3-methyl-isobenzofuran-1 (3H) -thione was added to a suspension of 0.15 g of sodium hydride in anhydrous dimethylformamide, and 2-chloro-4,6-dimethy after hydrogen gas evolution was completed. Mix with 1.0 g of oxy-1,3,5-triazine. After stirring for 5 hours at room temperature, cold water is added, extracted with ethyl acetate and washed with sodium chloride solution. The evaporated dried product is purified by chromatography (eluent: 45% ethyl acetate in n-hexane) and crystallized from acetone / n-hexane. Thus, yellow crystals of 7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -3-methyl-isobenzofuran-1 (3H) -thione having the following physical properties Obtained as

II. Preparation of Starting Material of Formula (II)

Example 101

7-hydroxy-3-methyl-phthalide

(i) 1- (2,2-dimethylpropaneyloxy) -3,5-dioxo-exo-10-oxatricyclo [5.2.1.0 (2, 6)] Methyl lithium (di) in a solution of 5.32 g of deck-8-ene (R ^{14 '} is hydrogen and R ¹⁵ is 2,2-dimethylpropaneyloxy in the compound of general formula (VI).) 12.5 ml) of 1.6 M in ethyl ether is added dropwise over 30 minutes. After the addition is complete, the mixture is left to come to room temperature and poured into 100 ml of saturated ice cold monopotassium phosphate solution. The aqueous solution is extracted three times with diethyl ether and the combined organic phases are washed with monopotassium phosphate solution, dried over anhydrous magnesium sulfate and decolorized with activated charcoal and filtered. The crude product of the yellow pigment is crystallized from diethyl ether / n-hexane. In this way (3aα, 4β, 7β, 7aα) -hexahydro-1-hydroxy-1-methyl-3-oxo-4,7-epoxyisobenzofuran-4-yl-pivalate having a melting point of 153 to 154 ° C 1.8 g (32% of theory) of the compound of formula (VIII) wherein R ^{4 ′} is methyl, R ¹⁴ is hydrogen and R ¹⁵ is 2,2-dimethylpropaneyloxy are obtained as pale yellow crystals.

(ii) 1.7 g of the product of the reaction step are added to a suspension of 0.31 g of sodium borohydride in 40 ml of absolute ethanol at 2-4 ° C. under argon. After the addition is complete, the mixture is left to come to room temperature and added to 60 ml of 1N hydrochloric acid. Ethanol is evaporated to dryness under reduced pressure, and the resulting white crystals are filtered off, washed with water and dried. In this way 0.87 g of (3aα, 4β, 7β, 7aα) -hexahydro-1-methyl-3-oxo-4,7-epoxyisobenzofuran-4-yl-pivalate at a melting point of 114 to 115 ° C. 86%) is obtained as colorless crystals.

(iii) 11.4 g of the product of the above reaction step is added dropwise to 30 ml of ethanol / ice cooled concentrated sulfuric acid. After the addition is complete the mixture is poured on ice and the precipitated crystals are filtered off and washed with water to neutrality. In this way, 6.4 g (91% of theory) of 7-hydroxy-3-methyl-phthalide having a melting point of 107 to 108 ° C. are obtained as beige crystals.

Example 102

3,3-dimethyl-7-hydroxy-phthalide

(i) Grignard solution prepared from 1.43 g of magnesium in 65 ml of diethyl ether and 8.37 g of methyl iodide in 1- (2,2-dimethylpropaneyloxy) in 35 ml of tetrahydrofuran at a temperature not exceeding -25 ° C. Add dropwise to a solution of 7.85 g of -3,5-dioxo-exo-10-oxatricyclo [5.2.1.0 (2,6)] dec-8-ene. After the addition is complete, the reaction mixture is stirred for another 1 hour at room temperature, acidified to pH 2 with 2N hydrochloric acid and extracted with diethyl ether. Drying the ether solution and evaporating the solvent left 7.5 g of crude product which was purified by chromatography using diethyl ether / n-hexane (3: 1) as eluent on a suitable silica gel. In this way (3aα, 4β, 7β, 7aα) -hexahydro-1,1-dimethyl-3-oxo-4,7-epoxyisobenzofuran-4-yl-pivalate is obtained as an oil.

(ii) The oily product of the reaction step described above is added to 2.8 ml of concentrated sulfuric acid and the solution is stirred at 5 ° C. for 20 minutes. The solution is poured on ice and extracted with diethyl ether. The organic phase is washed with water and evaporated to dryness over anhydrous magnesium sulfate. In this way 3,3-dimethyl-7-hydroxy-phthalide having a melting point of 128 to 134 ° C. is obtained as colorless crystals.

Example 103

3-ethyl-7-hydroxy-phthalide

(i) Secondary butyl lithium in a solution of 5.2 g of 2-methoxy-N, N-diethyl-benzamide and 2.91 g of tetramethyleneethylenediamine dissolved in 50 ml of anhydrous tetrahydrofuran at a temperature not exceeding -68 ° C. 13.7 ml (1.4 M in cyclohexane / isopentane) are added dropwise. After the addition, the reaction mixture is stirred for another hour at −78 ° C. and 2.5 ml of propionaldehyde is added. The reaction mixture is slowly brought to room temperature, stirred for 1 hour and diluted with 300 ml of diethyl ether. The organic phase is washed with 2N hydrochloric acid followed by saturated sodium chloride solution and evaporated to dryness over anhydrous magnesium sulfate. This affords 6- (1-hydroxyethyl) -2-methoxy-N, N-diethyl-benzamide as a crude product.

(ii) The crude product of the reaction step described above is added to 48% aqueous hydrobromic acid and the solution is heated to reflux for about 16 hours. The mixture is then cooled to room temperature and extracted twice with diethyl ether. Dry over anhydrous magnesium sulfate and the remaining crude product is evaporated to dryness and then purified by chromatography using diethyl ether / n-hexane (1: 4) on suitable silica gel. In this way, 3-ethyl-7-hydroxy-phthalide of IR-spectrum (CHCl ₃ ): C═O 1738 cm ⁻¹ is obtained.

Example 104

7-hydroxy-3-isopropyl-phthalide

(i) 1- (2,2-dimethylpropaneyloxy) -3,5-dioxo-exo-10-oxatricyclo [5.2.1.0 () in 25 ml of tetrahydrofuran at a temperature not exceeding -20 ° C. 2,6)] 8.0 g of Deck-8-ene are added dropwise to a Grignard solution of 6.8 g of isopropylmagnesium chloride in 33 ml of tetrahydrofuran. After addition, the reaction mixture is allowed to come to room temperature and stirred for about 16 hours. Under ice cooling, the mixture was adjusted to 2 with 45 ml of 2N hydrochloric acid, and extracted twice with 300 ml of diethyl ether. The organic phase is dried over anhydrous magnesium sulfate, evaporated under reduced pressure and the resulting crude product is purified by chromatography on silica gel with diethyl ether / n-hexane (3: 7). In this way (3aα, 4β, 7β, 7aα) -hexahydro-1-isopropyl-3-oxo-4,7-epoxyisobenzofuran-4-yl-pivalate is obtained.

(ii) The product of the reaction step is added to concentrated sulfuric acid and the solution is stirred at 5 ° C. for 20 minutes. The mixture is poured on ice and extracted with diethyl ether. The ether solution is evaporated to dryness to afford 7-hydroxy-3-isopropyl-phthalide as colorless crystals.

Example 105

3,7-dihydroxyphthalide

3-hydroxy-7-methoxy-phthalide dissolved in 100 ml of 48% hydrobromic acid [BLChenard et al., J. Org. Chem. 49 , 318 (1984) recipe] Heat 4.4 g at reflux for 75 min. The reaction mixture is suitably added to ice water and the aqueous mixture is extracted four times with ethyl acetate. The combined organic phases are washed with brine solution, dried over anhydrous magnesium sulfate and left under reduced pressure. The crude product is decolorized by filtration in silica gel column for a short time using ethyl acetate as eluent and heating the brown oil thus obtained in the presence of activated carbon. In this way, a yellowish amorphous solid, ie 2.5 g of crude 3,7-dihydroxyphthalide, is obtained, which in some cases is another starting material of general formula (II), namely 7-hydroxy-3-methoxy- It can be used in the crude state to prepare phthalide (see Example 118).

Example 106

3,7-dihydroxyphthalide

The title compound can be prepared as follows:

3-hydroxy-7-methoxy-phthalide [BLChenard group, J. Org. Chem. 49 , 318 (1984)] is added dropwise to a suspension of 8.2 g of aluminum chloride suspended in 50 ml of methylene chloride and left at a temperature around 27 ° C. It is also stirred at room temperature for 5 hours, and this mixture is added to 200 ml of ice-cold 1N hydrochloric acid and extracted three times with 200 ml each of ethyl acetate. The organic solution is washed with sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent is evaporated and then crystallized from ethyl acetate and n-hexane to give pure 3,7-dihydroxyphthalide with a melting point of 124-126 ° C.

Example 107

3,3-diisopropyl-7-hydroxy-phthalide

Similar to the method described in Example 102, 1- (2,2-dimethoxypropanoyloxy) -3,5-dioxo-exo-10-oxatricyclo [5.2.1.0 (2,6)] deck (3aα, 4β, 7β, 7aα) -hexahydro-1,1-diisopropyl-3-oxo-4,7-epoxyisobenzofuran-4-yl- from 8-ene and isopropyl magnesium iodide 3,3-Diisopropyl-7-hydroxy-phthalide is obtained instead of pivalate.

Examples 108-117

Similar to the method described in Example 103, from 2-methoxy-N, N-diethyl-benzamide, butyllithium and the corresponding aldehyde or ketone R ³ R ⁴ CO (see Scheme 2) Obtain starting materials of the general formula (IIh ') or (IIi'') as given in:

Example 118

7-hydroxy-3-methoxy-phthalide

A 2.5 g solution of 3,7-dihydroxyphthalide (crude product—see Examples 105 and 106) dissolved in 70 ml of methanol was mixed with four drops of concentrated sulfuric acid, and after addition, the 3A-molecular sieve was passed for about 16 hours. Let's do it. The mixture is then filtered and the filtrate is evaporated to dryness. 3 g of the crude yellow oil is purified by chromatography (flash chromatography) using ethyl acetate / n-hexane (3: 7) on silica gel. In this way, 1.9 g (70% of theory) of 7-hydroxy-3-methoxy-phthalide having the following physical properties are obtained as reddish crystals.

Melting point 77-79 ° C. (after crystallization from diethyl ether / n-hexane); IR-spectrum (CHCl ₃ ): C = O 1745 cm ^-1

Examples 119-129

Similar to the method described in Example 118, from 3,7-dihydroxyphthalide to 3,7-dihydroxy-3-methyl-phthalide and the corresponding hydroxy compound in the presence of a catalytic amount of sulfuric acid To obtain a starting material of formula (IIc ') or (IIf') shown in 7.

Example 130

7-hydroxy-3-methoxy-3-methyl-phthalide

The title compound (see Example 123) can be prepared as follows:

At room temperature, 1.5 g of 3-hydroxy-7-methoxy-3-methyl-phthalide (see Example 131 below) was left in 50 ml of methanol saturated with hydrochloric acid for 1 hour, and the mixture was added to ethyl acetate and iced. Wash with cooled sodium chloride solution. After removal of the solvent, 3,7-dimethoxy-3-methyl-phthalide having a melting point of 101 to 104 캜 is obtained.

1.45 g of the above-mentioned product in 20 ml of methylene chloride is stirred with 3.4 g of aluminum trichloride for 45 minutes, and the mixture is mixed with cold water and extracted twice with methylene chloride. The organic phase is dried over anhydrous magnesium sulfate and left under reduced pressure. 7-hydroxy-3-methoxy-3-methyl-phthalide having the following physical properties is obtained.

Melting point 106 to 109 ° C; IR-spectrum (CHCl ₃ ), C═O 1740 cm ⁻¹ .

Example 131

3,7-dihydroxy-7-methoxy-3-methyl-phthalide

3-methoxy-phthalic anhydride [AVR Rao et al., Indian J. Chem. 20B, 248ff. (1981)] 5.4 g, 4.7 g malonic acid and 9 ml of triethylamine are slowly heated. The suspension becomes fluid at 55 ° C and strongly generates CO ₂ − gas at 68 ° C. It is maintained at 73 ° C. (about 1 hour) until the end of gas evolution and then further heated to reflux (within 85 ° C.) for 4 hours. The cooled reaction mixture is extracted with ethyl acetate against water. The aqueous phase is adjusted to pH 1.7 and extracted three times with freshly prepared ethyl acetate, dried over anhydrous sodium sulfate and evaporated to dryness under reduced pressure. Fractional crystals (ethyl acetate / n-hexane) give 3-hydroxy-7-methoxy-3-methyl-phthalide having the following physical properties.

Melting point 156 to 158 ° C; IR-spectrum (CHCl ₃ ); C = O 1772 cm ^-1

1.9 g of the above-mentioned product is dissolved in 20 ml of methylene chloride, and the solution is treated with 3.5 g of boron tribromide at -70 ° C. The mixture is added to ice cooled dilute hydrochloric acid and the organic phase is extracted with ethyl acetate, dried, dried over anhydrous sodium sulfate and evaporated to dryness under reduced pressure. In this way crude 3,7-dihydroxy-3-methyl-phthalide is obtained as an amorphous solid, optionally with other starting materials of the general formula (II) (ie 7-hydroxy-3-methoxy-3 -Methyl-phthalide) can be used without purification.

Example 132

4-hydroxy-1,3-dihydro-3-oxo-1-isobenzofurancarboxamide

2.8 g of 3,7-dihydroxy-phthalide (see Examples 105 and 106) is added to a solution of 7.5 g of potassium cyanide dissolved in 35 ml of water and the mixture is cooled on ice so that the internal temperature does not exceed 10 ° C. Under slow mixing with 25 ml of concentrated hydrochloric acid. The reaction mixture is held for another 5 hours at room temperature and the crystals are filtered off. The product washed with water and dried (melting point 213-215 ° C.) is pure 4-hydroxy-1,3-dihydro-3-oxo-1-isobenzofurancarboxamide.

Example 133

7-hydroxy-3-trifluoromethyl-phthalide

A mixture of 26.4 g of N, N-dimethyl-2-methoxy-benzamide and 19 ml of tetramethylethylenediamine in 120 ml of anhydrous tetrahydrofuran was treated with 100 ml of a 1.4 molar solution of secondary butyllithium in cyclohexane / isooctane at −70 ° C. After 45 minutes, 27.3 ml of trifluoroacetic acid was added dropwise over 20 minutes and mixed. Allow to stand at room temperature for about 16 hours, mix with 200 ml of water and acidify with hydrochloric acid to adjust to pH2. The mixture is extracted with 600 ml of diethyl ether and the organic phase is dried over anhydrous magnesium sulfate and evaporated to dryness under high pressure. The residue is subjected to silica gel chromatography (eluent: ethyl acetate / n-hexane 1: 1). In this way, 3-hydroxy-7-methoxy-3-trifluoromethyl-phthalide of IR-spectrum (CHCl ₃ ): C═O 1785 cm ⁻¹ is obtained.

11.1 g of the above-mentioned product dissolved in 140 ml of ethanol is mixed with 1.5 g of sodium borohydride at room temperature. Pour into cold brine and extract with freshly prepared diethyl ether. The solvent is removed and then chromatographed appropriately to yield pure 7-methoxy-3-trifluoromethyl-phthalide with IR-Spectrum (CHCl ₃ ): C═O 1785 cm ⁻¹ .

4.6 g of the product in 30 ml of tetrahydrofuran are treated in small portions with 7.0 g of boron tribromide at -70 ° C. Leave to room temperature slowly and pour into iced water with ethyl acetate. The solvent is removed and the crude product is filtered over silica gel (eluent: ethyl acetate / n-hexane 1: 1). Crystalline 7-hydroxy-3-trifluoromethyl-phthalide having the following physical properties is obtained.

IR-spectrum (CHCl ₃ ): C═O 1766 cm ⁻¹ ; ¹ H-NMR (CDCL ₃ ): 5.68 ppm (q, 6 Hz, 1H)

Example 134

3,7-dihydroxy-3-trifluoromethyl-phthalide

Similarly to Example (133) described above, the title compound at melting point 128-129 ° C. was purified from 3-hydroxy-7-methoxy-3-trifluoromethyl-phthalide (see Example 133) and boron tribromide. To obtain.

Example 135

7-mercapto-3-methyl-phthalide

24 g of 7-hydroxy-3-methylphthalide is added to an aqueous solution of 8.2 g of potassium hydroxide dissolved in 130 ml of water and the mixture is treated with 23.5 g of dimethylcarbamoylchloride in small portions under stirring and cooling. After 90 minutes, the solution was adjusted to pH 11 with sodium hydroxide solution, ice was added and extracted twice with ethyl acetate. The solvent was evaporated to dryness and then crystallized from ethyl acetate and n-hexane to form O- (1,3-dihydro-3-methyl-1-oxo-7-isobenzofuranyl) -dimethylthio at a melting point of 163 to 164 캜. Obtain carbamate.

26 g of the compound described above is added to 180 ml of resorcinol-dimethyl ether and the mixture is heated to 212 ° C. for 24 h. The cooled reaction mixture is subjected to silica gel chromatography using ethyl acetate / n-nucleic acid (2: 1) as eluent and crystallized after removing the solvent. S- (1,3-dihydro-3-methyl-1-oxo-7-isobenzofuranyl) -dimethylthiocarbamate having a melting point of 144 to 145 ° C is obtained.

18.4 g of this product dissolved in a mixture of 120 ml of methanol and 60 ml of chloroform are treated with a solution of 4.2 g of sodium in 180 ml of methanol. Stir at room temperature for about 3 hours and add 390 ml of ethyl acetate. Almost all of the solvent is removed under reduced pressure and the residue is separated with respect to saturated sodium chloride solution using ethyl acetate. Filtration with silica gel (eluent: ethyl acetate / n-hexane 1: 2) gave pure 7-mercapto-3-methyl-phthalide with a melting point of 40 ° C.

Example 136

7-hydroxy-3-methyl-isobenzofuran-1 (3H) -thione

3.9 g of 7-hydroxy-3-methyl-phthalide (see Examples 101 and 111) and 5.1 g of Lawson's reagent are heated to 140 ° C. for 4 hours in 20 ml of xylene. The mixture was filtered by chromatography on silica gel (eluent: ethyl acetate / n-hexane (1: 9)) to give 7-hydroxy-3-methyl-isobenzofuran-1 (3H) -thione having the following physical properties. To obtain.

Example 137

7-hydroxy-3-vinyl-phthalide

600 mg of 3,7-dihydroxyphthalide (see Examples 105 and 106) is stirred in 20 ml of anhydrous tetrahydrofuran at -78 ° C. 6 ml of 2 molar vinyl magnesium chloride in tetrahydrofuran are spray-added under argon atmosphere. The reaction mixture is allowed to come to room temperature and added to 100 ml of 1N hydrochloric acid. Each extracted twice with 75 ml of ethyl acetate and the combined organic phases were washed with brine, dried over anhydrous magnesium sulfate and the organic solution was placed under reduced pressure. 600 mg of crude product is left, which is flash chromatographed on silica gel with ethyl acetate / n-hexane (1: 1).

In this way 380 mg (60% of theory) of 7-hydroxy-3-vinyl-phthalide are obtained.

Example 138

7-hydroxy-3-isopropylidene-phthalide

(i) Similar to the method described in Example 104, 1- (2,2-dimethylpropaneoyloxy) -3,5-dioxo-exo-10-oxatricyclo [5.2.1.0 (2,6) 10 g of] -deck-8-ene is added to 25 ml of tetrahydrofuran at -35 ° C and the solution is mixed with 3.9 g of isopropyl magnesium chloride in 30 ml of tetrahydrofuran. The mixture is allowed to come to room temperature, 27 ml of 2N hydrochloric acid is added, extracted twice with diethyl ether, and the organic phase is evaporated to dryness over anhydrous magnesium sulfate. This affords (3aα, 4β, 7β, 7aα) -hexahydro-1-hydroxy-1-isopropyl-3-oxo-4,7-epoxyisobenzofuran-4-yl-pivalate as a crude product .

(ii) The obtained crude product is added to concentrated sulfuric acid at 0 ° C., and the solution is stirred for 20 minutes. This solution is added to ice, the aqueous mixture is extracted with diethyl ether and the organic phase is dried over anhydrous magnesium sulfate. The crude oily product is chromatographed with a 20% solution of diethyl ether in n-hexane. This affords 7-hydroxy-3-isopropylidene-phthalide as a characteristic solid.

Example 139

(Z) -3-ethylidene-7-hydroxy-phthalide

To a solution of 3.6 g of sodium in 130 ml of methanol, 14.5 ml of dimethyl phosphite was added dropwise at -10 DEG C under nitrogen, and at the same time, 20 g of 3-hydroxy-7-methoxy-phthalide (see Example 118) was added in small portions. Add. Then it is stirred for 30 minutes at room temperature and 11.3 ml of methanesulfonic acid is added over 10 minutes. After another hour under reduced pressure, most of the methanol is distilled off, and the residue is poured into 400 ml of dilute hydrochloric acid and ice and the aqueous mixture is extracted three times with 900 ml of ethyl acetate. The organic phase is washed with sodium chloride, dried over anhydrous magnesium sulfate, evaporated to dryness under reduced pressure and the residue is crystallized from ethyl acetate / n-hexane. This gives pure 3-dimethoxyphosphonyl-7-methoxy-phthalide having a melting point of 129 to 131 ° C.

12.3 g of this product are dissolved in 750 ml of anhydrous tetrahydrofuran and the solution is treated with 5.2 g of potassium tertiary butyrate at 3 ° C. After stirring for 1 hour at this temperature, 2.8 ml of acetaldehyde is added dropwise and the reaction mixture is stirred for another hour at 12 ° C. It is poured into dilute hydrochloric acid and ice as described above and extracted with ethyl acetate and the organic phase is washed with water and sodium chloride solution, dried over anhydrous magnesium sulfate and evaporated to dryness under reduced pressure. Filtration through silica gel [eluent: ethyl acetate / n-hexane (7: 3)] afforded crude 7-methoxy-3-ethylidene-phthalide having the following physical properties as an (E / Z) -mixture:

One preliminary fractionation gives pure (Z) -7-methoxy-3-ethylidene-phthalide having a melting point of 106 to 109 ° C.

1.1 g of the product are stirred with 2.8 g of aluminum trichloride in 50 ml of ethylene chloride at room temperature for 2 hours, the mixture is ice cooled, dilute hydrochloric acid is added and extracted with methylene chloride. The organic phase is washed with half saturated sodium chloride solution, dried over anhydrous magnesium sulfate and evaporated to dryness under reduced pressure. In this way, pure (Z) -3-ethylidene-7-hydroxy-phthalide having the following physical properties is obtained.

Examples 140-144

Similar to the method described in Example 139, 3-dimethoxyphosphonyl is treated with the corresponding aldehyde and aluminum trichloride appropriate to the compound of general formula (XIX) (see Scheme 3: XVII → XVIII → XIX → IIk). From 3-hydroxy-7-methoxy-phthalide instead of -7-methoxy-phthalide is obtained the starting material of formula (IIk ') as shown in Table 8 below:

Example 145

3,4-dihydro-8-hydroxy-4-methyl-1H-2-benzopyran-1-one

39.5 g of N, N-dimethyl-2-methoxy-benzamide and 28.5 ml of tetramethyl ethylenediamine are added to 190 ml of anhydrous tetrahydrofuran and the mixture is added at -70 ° C in 1.4 mole secondary butyl in cyclohexane / isopentane. Lithiate with 150 ml of lithium solution. After stirring at −70 ° C. for 45 minutes, 25.6 ml of ethyl bromide is added dropwise over 25 minutes, and the reaction mixture is slowly allowed to come to room temperature. It is mixed with water, adjusted to pH 2 with hydrochloric acid and extracted twice with diethyl ether. The residue is purified on silica gel using ethyl acetate / n-hexane (4: 6). 6-Ethyl-N, N-dimethyl-2-methoxy-benzamide having the following physical properties is obtained as a colorless oil.

5.8 g of this product in 150 ml of anhydrous tetrahydrofuran and 3.5 g of tetramethylethylenediamine were lithiated at -70 ° C. with 24.8 ml of a 1.4 mol secondary butyllithium solution in cyclohexane / isooctane and after 1 hour freshly prepared purified formaldehyde Mix with 3 g. It is allowed to slowly cool to room temperature, 30 ml of concentrated hydrochloric acid (pH 1.5) is added, and extracted twice with ethyl acetate. The solvent is removed under reduced pressure. The remaining oily product is added to 150 ml of 48% hydrobromic acid and the mixture is heated to reflux for 6 hours. Extract with freshly prepared ethyl acetate, wash with dilute sodium bicarbonate solution, dry over anhydrous magnesium sulfate and evaporate to dryness under reduced pressure. The remaining product is chromatographed (eluent: ethyl acetate / n-hexane 1: 3). 3,4-Dihydro-8-hydroxy-4-methyl-1H-2-benzopyran-1-one having the following physical properties is obtained as a yellow oil.

Example 146

Cis- and trans-3,4-dihydro-8-hydroxy-3,4-dimethyl-1H-2-benzopyran-1-one

Similar to the method described in Example 143, from 6-ethyl-N, N-dimethyl-2-methoxy-benzamide and acetaldehyde used to prepare the compounds of Examples 79 and 80, , 4-trans- and cis-3,4-dihydro-8-hydroxy-3,4-dimethyl-1H-2-benzoylpyran-1-one can be prepared.

IR-spectrum (CHCl ₃ ): 1675 cm ^-1

Example 147

7-hydroxy-3-methyl-isobenzofuran-1 (3H) -thione

1.67 g of 7-hydroxy-3-methyl-phthalide (see Example 101) and 2,4-bis- (4-methoxyphenyl) -2,4-dithioxo-1,3,2,4-diti 2.17 g of adiphosphetane (Rawson's reagent) is heated in 138 ml of xylene to 138 ° C. for 3 hours. The cooled reaction product was filtered directly on silica gel [eluent: ethyl acetate / n-hexane (1: 4)] to 7-hydroxy-3-methyl-isobenzofuran-1 (3H) -thione having the following physical properties Isolate.

III. Formulation Example

Example 148

The following ingredients are mixed together to prepare a 25% hydrating agent:

weight%

Compounds (Active Ingredients) According to the Invention 25

Hydrated Silicate (carrier, grinding aid) 20

Sodium Lauryl Sulfate (wetting agent) 2

Sodium lignosulfonate (dispersant) 4

Kaolin (carrier) 49

100

The liquid or molten active ingredient is first sprayed onto the silica introduced into the powder mixer. The other ingredients are then mixed and the whole mixture is finely ground using a pin mill or comparable grinding tool.

When stirred in water, the resulting wetting agent provides a fine suspension of the desired concentration suitable as a ready-to-use spray mixture.

Particularly the compounds according to the invention that are liquid or have a melting point of up to 100 ° C. are suitable as active ingredients in this formulation example.

Example 149

The compounds according to the invention having a high melting point of up to 100 ° C. can be used as active ingredients, especially in concentrated wetting agents using:

weight%

Compounds (Active Ingredients) according to the Invention 75

Hydrated silicic acid (carrier, grinding aid) 1

Alkyl naphthalenesulfonates and alkylcarboxylate sulfates as sodium salts

MorWett ^R EFW (De Soto) [wetting agent] 2

Sulfonated naphthalene-formaldehyde condensates with sodium salt

Morwett ^R D-425 (De Soto) 10

Polyvinylpyrrolidone

PVP-K-30 (GAF Corp.) [Binder] 1

Kaolin [carrier] 11

The components are mixed together and finely ground using a pin mill or comparable grinding equipment, in particular a radiation grinder. The resulting wetting agent, when stirred in water, provides a fine suspension of suitable concentration as a ready-to-use spray mixture.

Example 150

Hydrating agents based on Formulation Example 149 above may also be prepared as dispersible granules. To this end, an aqueous solution of the binder is sprayed to agglomerate the pulverized powder in a granulation apparatus (e.g., granulation dish, mixing drum, intensive mixer or swivel bed granulator). Removal of the water provided during the drying process produces granules of the desired size. The resulting granules have other advantages over the hydrating agent (no dust on application, easy to manufacture due to better flow properties). The formulation is stirred in water to apply granules after complete grinding of granules of particle size that exactly matches the hydrating agent.

Example 151

The compounds according to the invention are soluble only in conventional organic solvents. Therefore emulsifiable concentrates proportional to concentration are possible:

for example

125 g / l of the compound (active ingredient) according to the present invention

Soprophor ^R BSU (Emulsifier, Rhone-Poulenc) 300g / l

Add 1000 ml of N-methyl-2-pyrrolidone (solvent)

Under stirring, the active ingredient and emulsifier are added to the solvent and the mixture is stirred until a homogeneous solution is obtained.

Emulsification of the resulting emulsifiable concentrate in water yields a ready-to-use spray mixture with the desired concentration.

Example 152

The compounds according to the invention with melting points below 60 ° C. can also be prepared, for example, as suspension concentrates (fluids):

250 g / l of the compound (active ingredient) according to the invention

Ethylene glycol (freezing point depressant) 80 g / l

Silicic acid (precipitating agent) 5g / l

Xanthan gum

Kelzan ^R (Kelco) [Coagulant] 2g / l

Silicone antifoam

Rhodorsil ^R 426 (Rhone-Poulenc) 5 g / l

Nonylphenol-polyethoxylate (wetting agent) 20 g / l

Sulfonated naphthalene-formaldehyde-condensates as sodium salt

Morwett ^R D-425 (De Soto) 40 g / l

Add 1000ml of water

The compounding aid is dissolved in water. The prepulverized active ingredient is dispersed in the solution under stirring. The resulting coarse suspension is wet milled, for example in a colloid mill or stirred action ball mill. If desired, further large amounts such as antifoams, precipitation inhibitors and fungicides are added.

Dilution, optionally with water, to use the resulting flow agent results in a ready-to-use spray mixture of the desired concentration.

Claims (5)

A herbicide composition characterized by containing an effective amount of at least one compound of the general formula (I) and a compounding aid: In the above formula, W is a divalent group of the formulas a) to d): X, Y ¹ and Y ² are each oxygen or sulfur, Z is CR ¹³ or nitrogen, R ¹ is hydrogen, fluoro, chloro, C _1-3 -alkyl, halomethyl, methoxymethyl, C _1-3 -alkoxy, difluoromethoxy or methylthio, R ² is methyl, C _1-2 -alkoxy, C _1-2 -fluoroalkoxy, C _1-2 -alkylamino, di (C _1-2 -alkyl) -amino or N-methoxymethylamino, R ³ is hydrogen, fluoro, chloro, bromo, C _1-6 -alkyl, C _2-3 -alkenyl, phenyl, hydroxy, C _1-6 -alkoxy, C _1-6 -alkylthio, phenoxy , Phenylthio, cyano, rodano, carbamoyl, C _2-5 -alkanoyloxy, or di (C _1-2 -alkoxy) phosphonyl, halogen, cyano, C ₁ -C ₄ alkoxy or C ₁ -C ₆ alkoxy substituted by tinyl, or C ₁ -C ₆ alkyl substituted by nitro, R ⁴ is hydrogen, C _1-6 -alkyl or trifluoromethyl, R ⁵ is hydrogen, C _1-6 -alkyl, phenyl or phenyl substituted by methoxy, R ⁶ is hydrogen or methyl, R ⁷ , R ⁸ and R ⁹ are independently of each other hydrogen or C _1-3 -alkyl, R ¹⁰ is hydrogen, R ¹¹ and R ¹² are independently of each other hydrogen or C _1-3 -alkyl, R ¹³ is hydrogen, fluoro, chloro or methyl, and R ¹⁴ is hydrogen, halogen, C _1-2 -alkyl or C _1-2 -alkoxy. The herbicide composition according to claim 1, which contains an effective amount of at least one compound selected from the group consisting of the following compounds and a compounding aid: 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide, 3-ethyl-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-isopropyl-phthalide, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methoxy-phthalide, 7-[(4-methoxy-6-methyl-pyrimidin-2-yl) oxy] -3-methyl-phthalide, 7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -3-methyl-phthalide, (Z) -3-ethylidene-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide, 8-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-isochroman-1-one, 7-[(4,6-dimethoxy-pyrimidin-2-yl) thio] -3-methyl-phthalide, 3-ethoxy-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methoxy-3-methyl-phthalide, 7-[(4-chloro-6-methoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide, 7-[(4-ethoxy-6-methoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide, 7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) thio] -3-methyl-phthalide, 7-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl) oxy] -3-methyl-phthalide, 3-ethyl-7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -phthalide, 8-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3,4-dimethyl-isochroman-2-one, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methylthio-phthalide, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-vinyl-phthalide and 3-cyano-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide. The herbicide composition according to claim 1, which contains an effective amount of at least one compound selected from the group consisting of the following compounds and a compounding aid: 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3,6-dimethyl-phthalide, 3-carbamoyl-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide, 3- (2-chloroethoxy) -7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-propargyloxy-phthalide, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3- (n-propoxy) -phthalide, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3- (2-methoxy-ethoxy) -phthalide, 7-[(4-methoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide, 7-[(4-chloro-6-methoxy-pyrimidin-2-yl) oxy] -3-methoxy-phthalide, 7-[(4-dimethylamino-6-methoxy-1,3,5-triazin-2-yl) oxy] -3-methyl-phthalide, 7-[(4-methoxy-6-methylamino-1, 3,5-triazin-2-yl) oxy] -3-methyl-phthalide, 7-[(4-chloro-6-methylamino-1, 3,5-triazin-2-yl) oxy] -3-methyl-phthalide, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-hydroxy-phthalide, 3-cyanomethoxy-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-2-benzothiophen-1 (3H) -one, 7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -3-methyl-isobenzofuran-1 (3H) -thione, 7-[(4,6-dimethoxy-1,3,5-triazin-2-yl) oxy] -3-methyl-isobenzofuran-1 (3H) -thione, 7-[(4-difluoromethoxy-6-methoxy-pyrimidin-2-yl) oxy] -3-methyl-phthalide, 8-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -4-methyl-isochromen-1-one and 3-acetoxy-7-[(4,6-dimethoxy-pyrimidin-2-yl) oxy] -phthalide. A weed control method comprising treating an object or weed or plant to be protected from weeds with an effective amount of the composition according to claim 1. A weed control method comprising treating an object or weed to be protected from weeds with an effective amount of the composition according to claim 2.