KR0179990B1 - Tetrahydrofuran antifungals - Google Patents

Tetrahydrofuran antifungals Download PDF

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Publication number
KR0179990B1
KR0179990B1 KR1019960703319A KR19960703319A KR0179990B1 KR 0179990 B1 KR0179990 B1 KR 0179990B1 KR 1019960703319 A KR1019960703319 A KR 1019960703319A KR 19960703319 A KR19960703319 A KR 19960703319A KR 0179990 B1 KR0179990 B1 KR 0179990B1
Authority
KR
South Korea
Prior art keywords
independently
ester
tetrahydrofuran antifungals
polyestherester
antifungals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1019960703319A
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English (en)
Korean (ko)
Inventor
Anil K Saksena
Viyyor M Girijavallabhan
Raymond G Lovey
Russell E Pike
Haiyan Wang
Yi-Tsung Liu
Ashit K Ganguly
Frank Bennett
Original Assignee
Schering Corp
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Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of KR0179990B1 publication Critical patent/KR0179990B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Dental Preparations (AREA)
  • Lubricants (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1019960703319A 1993-12-21 1996-06-21 Tetrahydrofuran antifungals Expired - Lifetime KR0179990B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17108393A 1993-12-21 1993-12-21
PCT/US1994/014236 WO1995017407A1 (en) 1993-12-21 1994-12-20 Tetrahydrofuran antifungals

Publications (1)

Publication Number Publication Date
KR0179990B1 true KR0179990B1 (en) 1999-03-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960703319A Expired - Lifetime KR0179990B1 (en) 1993-12-21 1996-06-21 Tetrahydrofuran antifungals

Country Status (28)

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EP (1) EP0736030B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2834889B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR0179990B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1064685C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE204875T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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CO (1) CO4520281A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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DK (1) DK0736030T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2159623T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI118470B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR06C0009I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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IL (1) IL112081A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU91216I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY130217A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL300219I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (2) NO316173B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ278713A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL181193B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT736030E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (1) SK283035B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW377349B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1995017407A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA9410142B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
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DE69730241T2 (de) * 1996-06-28 2005-08-11 Schering Corp. Feste lösung eines fungizids mit erhöhter bioverfügbarkeit
US5972381A (en) * 1996-06-28 1999-10-26 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
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WO1998021203A1 (en) * 1996-11-12 1998-05-22 Sepracor, Inc. 2r,4s,s,r- and 2s,4r,s,r-hydroxyitraconazole
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CN105579448B (zh) * 2013-07-25 2018-12-21 桑多斯股份公司 制备泊沙康唑的晶型iv的改进方法
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CN105287403A (zh) * 2014-08-02 2016-02-03 陕西合成药业股份有限公司 一种泊沙康唑前体药物的冻干组合物及其制备方法和用途
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
CN107001343B (zh) 2014-12-05 2020-12-11 普尔莫赛德有限公司 抗真菌的化合物
JP6811727B2 (ja) * 2015-05-21 2021-01-20 プルモシデ リミテド 抗真菌性の４−（４−（４−（（（３ｒ，５ｒ）−５−（（１ｈ−１，２，４−トリアゾール−１−イル）メチル）−５−（２，４−ジフルオロフェニル）テトラヒドロフラン−３−イル）メトキシ）−３−メチルフェニル）ピペラジン−１−イル）−ｎ−（２−ヒドロキシシクロヘキシル）ベンズアミド、又はその医薬として許容し得る塩
CN106317032A (zh) * 2015-06-15 2017-01-11 重庆圣华曦药业股份有限公司 一种制备高纯度的泊沙康唑的方法
CN106432338A (zh) * 2015-08-08 2017-02-22 陕西合成药业股份有限公司 泊沙康唑衍生物、合成和在长效制剂中的用途
WO2017051342A1 (en) * 2015-09-23 2017-03-30 Biocon Limited Crystalline forms of posaconazole intermediate and process for the preparation of amorphous posaconazole
CN105606736A (zh) * 2016-01-27 2016-05-25 重庆华邦制药有限公司 分离测定泊沙康唑中间体z1及其有关物质的方法
ES2893793T3 (es) * 2016-03-04 2022-02-10 Zhejiang Ausun Pharmaceutical Co Ltd Posaconazol, composición, producto intermedio, método de preparación para el mismo y usos del mismo
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
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WO2018115319A2 (en) 2016-12-23 2018-06-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
CN106967054A (zh) * 2017-03-30 2017-07-21 成都绿林科技有限公司 一种泊沙康唑的制备方法
CN106883221A (zh) * 2017-04-17 2017-06-23 兰州大学 一种无定形泊沙康唑及其制备方法
CN108341754A (zh) * 2018-03-12 2018-07-31 扬子江药业集团有限公司 泊沙康唑杂质及其制备方法和用途
CN110938093B (zh) * 2018-09-21 2022-08-19 华创合成制药股份有限公司 一种泊沙康唑磷酸酯单胆碱盐及其制备方法和用途
CN112778369B (zh) * 2019-11-05 2024-01-26 华创合成制药股份有限公司 一种三唑类衍生物及其制备方法和用途
CN113666915B (zh) * 2021-08-27 2022-08-16 江苏海洋大学 一种泊沙康唑中间体的制备方法
CN114315811B (zh) * 2021-11-19 2024-04-30 江苏恒盛药业有限公司 一种三氮唑类似物化合物及其制备方法和应用

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LU91216I2 (en) 2006-03-27
CA2179396C (en) 2001-04-17
NO2006002I2 (no) 2011-03-07
FI118470B (fi) 2007-11-30
CN1064685C (zh) 2001-04-18
CN1142828A (zh) 1997-02-12
NZ278713A (en) 1997-12-19
IL112081A (en) 2001-08-26
BR1100154B1 (pt) 2013-11-26
NO316173B1 (no) 2003-12-22
FI962577A0 (fi) 1996-06-20
NO962616D0 (no) 1996-06-20
DE122006000004I1 (de) 2006-04-27
NL300219I1 (nl) 2006-04-03
DK0736030T3 (da) 2001-10-29
HK1008820A1 (en) 1999-05-21
FR06C0009I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2006-05-19
PL181193B1 (pl) 2001-06-29
JPH09500658A (ja) 1997-01-21
CZ294823B6 (cs) 2005-03-16
PL315169A1 (en) 1996-10-14
EP0736030B1 (en) 2001-08-29
HU9601709D0 (en) 1996-08-28
CO4520281A1 (es) 1997-10-15
NO962616L (no) 1996-08-07
AU1512795A (en) 1995-07-10
IL112081A0 (en) 1995-03-15
FI962577L (fi) 1996-06-20
ES2159623T3 (es) 2001-10-16
DE69428125D1 (de) 2001-10-04
SK283035B6 (sk) 2003-02-04
ATE204875T1 (de) 2001-09-15
HUT75879A (en) 1997-05-28
DE122006000004I2 (de) 2007-03-29
MY130217A (en) 2007-06-29
CZ180596A3 (en) 1997-01-15
AU681753B2 (en) 1997-09-04
CA2179396A1 (en) 1995-06-29
EP0736030A1 (en) 1996-10-09
WO1995017407A1 (en) 1995-06-29
TW377349B (en) 1999-12-21
JP2834889B2 (ja) 1998-12-14
PT736030E (pt) 2002-01-30
ZA9410142B (en) 1996-05-02
FR06C0009I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2006-12-29
SK82696A3 (en) 1997-03-05
NO2006002I1 (no) 2006-02-20
HU225062B1 (en) 2006-05-29
DE69428125T2 (de) 2002-05-02
NL300219I2 (nl) 2006-05-01

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