JPWO2023194584A5 - - Google Patents
Info
- Publication number
- JPWO2023194584A5 JPWO2023194584A5 JP2024559584A JP2024559584A JPWO2023194584A5 JP WO2023194584 A5 JPWO2023194584 A5 JP WO2023194584A5 JP 2024559584 A JP2024559584 A JP 2024559584A JP 2024559584 A JP2024559584 A JP 2024559584A JP WO2023194584 A5 JPWO2023194584 A5 JP WO2023194584A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- seq
- antibody
- antagonist
- gremlin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2205200.5A GB202205200D0 (en) | 2022-04-08 | 2022-04-08 | Combination with chemotherapy |
| GB2205200.5 | 2022-04-08 | ||
| PCT/EP2023/059271 WO2023194584A1 (en) | 2022-04-08 | 2023-04-06 | Combination of a gremlin-1 antagonist with a cytidine analogue or deoxycytidine analogue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2025511940A JP2025511940A (ja) | 2025-04-16 |
| JP2025511940A5 JP2025511940A5 (https=) | 2026-04-14 |
| JPWO2023194584A5 true JPWO2023194584A5 (https=) | 2026-04-14 |
Family
ID=81653327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024559584A Pending JP2025511940A (ja) | 2022-04-08 | 2023-04-06 | グレムリン－１アンタゴニストとシチジン類似体又はデオキシシチジン類似体の組み合わせ |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20250243267A1 (https=) |
| EP (1) | EP4504778A1 (https=) |
| JP (1) | JP2025511940A (https=) |
| KR (1) | KR20250004732A (https=) |
| CN (1) | CN119343372A (https=) |
| AU (1) | AU2023251209A1 (https=) |
| CA (1) | CA3255381A1 (https=) |
| GB (1) | GB202205200D0 (https=) |
| IL (1) | IL315762A (https=) |
| MX (1) | MX2024012464A (https=) |
| WO (1) | WO2023194584A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117965736A (zh) * | 2024-02-05 | 2024-05-03 | 南京医科大学康达学院 | Grem1作为预测非小细胞肺癌转移或不良预后的生物标志物及其应用 |
| CN117801109B (zh) * | 2024-03-01 | 2024-05-03 | 再少年(北京)生物科技有限公司 | iPS诱导定向分化成内皮祖细胞的方法及应用 |
| WO2026027660A1 (en) | 2024-08-02 | 2026-02-05 | UCB Biopharma SRL | Formulations of anti-gremlin-1 antibodies |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| WO1991010737A1 (en) | 1990-01-11 | 1991-07-25 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| EP1690934A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0542810A1 (en) | 1990-08-02 | 1993-05-26 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| DK0580737T3 (da) | 1991-04-10 | 2004-11-01 | Scripps Research Inst | Heterodimere receptorbiblioteker ved anvendelse af phagemider |
| GB9113120D0 (en) | 1991-06-18 | 1991-08-07 | Kodak Ltd | Photographic processing apparatus |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| EP0733070A1 (en) | 1993-12-08 | 1996-09-25 | Genzyme Corporation | Process for generating specific antibodies |
| PT1231268E (pt) | 1994-01-31 | 2005-11-30 | Univ Boston | Bancos de anticorpos policlonais |
| US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
| JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
| US7993864B2 (en) | 2002-12-03 | 2011-08-09 | Ucb Pharma S.A. | Assay for identifying antibody producing cells |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| ES2551439T5 (es) | 2003-07-01 | 2018-11-08 | Ucb Biopharma Sprl | Fragmentos Fab de anticuerpos modificados |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0411186D0 (en) | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
| US8383349B2 (en) * | 2007-03-16 | 2013-02-26 | The Board Of Trustees Of The Leland Stanford Junior University | Bone morphogenetic protein antagonist and uses thereof |
| WO2009040562A1 (en) | 2007-09-26 | 2009-04-02 | Ucb Pharma S.A. | Dual specificity antibody fusions |
| JP6339063B2 (ja) * | 2012-03-15 | 2018-06-06 | エスエヌユー アールアンドディービー ファウンデーション | グレムリン−１に対する抗体 |
| ES2898620T3 (es) | 2013-03-14 | 2022-03-08 | Regeneron Pharma | Anticuerpos humanos contra GREM 1 |
| WO2017158396A1 (en) * | 2016-03-16 | 2017-09-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cytidine deaminase inhibitors for the treatment of pancreatic cancer |
| GB201621635D0 (en) | 2016-12-19 | 2017-02-01 | Ucb Biopharma Sprl | Crystal structure |
| PL3806898T3 (pl) | 2018-06-18 | 2026-02-23 | UCB Biopharma SRL | Antagonista gremlin-1 do zastosowania w leczeniu nowotworu |
| JP2024504124A (ja) * | 2021-01-18 | 2024-01-30 | スーチョウ・トランスセンタ・セラピューティクス・カンパニー・リミテッド | 新規の抗グレムリン１抗体 |
-
2022
- 2022-04-08 GB GBGB2205200.5A patent/GB202205200D0/en not_active Ceased
-
2023
- 2023-04-06 AU AU2023251209A patent/AU2023251209A1/en active Pending
- 2023-04-06 JP JP2024559584A patent/JP2025511940A/ja active Pending
- 2023-04-06 EP EP23715889.4A patent/EP4504778A1/en active Pending
- 2023-04-06 CN CN202380040514.7A patent/CN119343372A/zh active Pending
- 2023-04-06 CA CA3255381A patent/CA3255381A1/en active Pending
- 2023-04-06 IL IL315762A patent/IL315762A/en unknown
- 2023-04-06 US US18/854,614 patent/US20250243267A1/en active Pending
- 2023-04-06 KR KR1020247037220A patent/KR20250004732A/ko active Pending
- 2023-04-06 WO PCT/EP2023/059271 patent/WO2023194584A1/en not_active Ceased
-
2024
- 2024-10-07 MX MX2024012464A patent/MX2024012464A/es unknown
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