JPWO2023109940A5 - - Google Patents
Info
- Publication number
- JPWO2023109940A5 JPWO2023109940A5 JP2024535521A JP2024535521A JPWO2023109940A5 JP WO2023109940 A5 JPWO2023109940 A5 JP WO2023109940A5 JP 2024535521 A JP2024535521 A JP 2024535521A JP 2024535521 A JP2024535521 A JP 2024535521A JP WO2023109940 A5 JPWO2023109940 A5 JP WO2023109940A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sirna
- antisense strand
- group
- sense strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111545699 | 2021-12-16 | ||
| CN202111545699.6 | 2021-12-16 | ||
| PCT/CN2022/139500 WO2023109940A1 (zh) | 2021-12-16 | 2022-12-16 | 靶向lpa的sirna及缀合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024545222A JP2024545222A (ja) | 2024-12-05 |
| JP2024545222A5 JP2024545222A5 (https=) | 2025-12-26 |
| JPWO2023109940A5 true JPWO2023109940A5 (https=) | 2025-12-26 |
Family
ID=86774879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024535521A Pending JP2024545222A (ja) | 2021-12-16 | 2022-12-16 | ＬＰＡを標的とするｓｉＲＮＡ及び複合体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250332190A1 (https=) |
| EP (1) | EP4450624A4 (https=) |
| JP (1) | JP2024545222A (https=) |
| KR (1) | KR20240116539A (https=) |
| CN (1) | CN118076738A (https=) |
| CA (1) | CA3240604A1 (https=) |
| TW (1) | TW202340465A (https=) |
| WO (1) | WO2023109940A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119506275A (zh) * | 2023-08-22 | 2025-02-25 | 苏州炫景生物科技有限公司 | 抑制lpa基因表达的双链寡核苷酸及其应用 |
| CN121079106A (zh) | 2023-05-31 | 2025-12-05 | 上海拓界生物医药科技有限公司 | 一种靶向LPA的dsRNA及其应用 |
| WO2025064821A2 (en) | 2023-09-21 | 2025-03-27 | Ionis Pharmaceuticals, Inc. | Compounds and methods for inhibiting lpa |
| WO2025082059A1 (zh) * | 2023-10-16 | 2025-04-24 | 润佳(上海)医药技术有限公司 | 经修饰的dsRNA、双链RNAi剂及其用途 |
| WO2025120571A1 (en) * | 2023-12-05 | 2025-06-12 | Janssen Biotech, Inc. | Compositions and methods to discover targeted oligonucleotide conjugates |
| WO2025252159A1 (zh) * | 2024-06-06 | 2025-12-11 | 大睿生物医药科技(上海)有限公司 | 调控LPA表达的dsRNA分子 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013299717B2 (en) | 2012-08-06 | 2018-06-28 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugated RNA agents and process for their preparation |
| DK2991656T3 (da) * | 2013-05-01 | 2020-03-23 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression |
| JOP20160211B1 (ar) * | 2015-10-01 | 2021-08-17 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| WO2018013525A1 (en) * | 2016-07-11 | 2018-01-18 | Translate Bio Ma, Inc. | Nucleic acid conjugates and uses thereof |
| WO2019204668A1 (en) * | 2018-04-18 | 2019-10-24 | Casebia Therapeutics Limited Liability Partnership | Compositions and methods for knockdown of apo(a) by gene editing for treatment of cardiovascular disease |
| CN111378655B (zh) * | 2018-12-28 | 2024-03-19 | 苏州瑞博生物技术股份有限公司 | 抑制CTGF基因表达的siRNA、含有该siRNA的药物组合物及其用途 |
| CN112876534B (zh) * | 2019-11-29 | 2024-02-09 | 苏州瑞博生物技术股份有限公司 | 肝靶向化合物及缀合物 |
| US20230201361A1 (en) * | 2020-01-11 | 2023-06-29 | Oncolmmunin, Inc. | Targeted and localized in vivo delivery of oligonucleotides |
| WO2021254360A1 (zh) | 2020-06-16 | 2021-12-23 | 上海拓界生物医药科技有限公司 | 一种碳水化合物分子簇及其制备方法和医药用途 |
| KR102812602B1 (ko) * | 2020-08-05 | 2025-05-28 | 다이서나 파마수이티컬, 인크. | Lpa 발현을 저해하기 위한 조성물 및 방법 |
| WO2022121959A1 (zh) * | 2020-12-09 | 2022-06-16 | 纳肽得有限公司 | siRNA分子及其在治疗冠状动脉疾病中的应用 |
| JP2024534508A (ja) * | 2021-09-18 | 2024-09-20 | 成都心正合医▲葯▼科技有限公司 | Ｌｐａ阻害剤及びその使用 |
| CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
| CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
-
2022
- 2022-12-16 WO PCT/CN2022/139500 patent/WO2023109940A1/zh not_active Ceased
- 2022-12-16 JP JP2024535521A patent/JP2024545222A/ja active Pending
- 2022-12-16 US US18/719,828 patent/US20250332190A1/en active Pending
- 2022-12-16 CN CN202280067981.4A patent/CN118076738A/zh active Pending
- 2022-12-16 EP EP22906685.7A patent/EP4450624A4/en active Pending
- 2022-12-16 TW TW111148548A patent/TW202340465A/zh unknown
- 2022-12-16 KR KR1020247022570A patent/KR20240116539A/ko active Pending
- 2022-12-16 CA CA3240604A patent/CA3240604A1/en active Pending
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