JPWO2023080246A5 - - Google Patents
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- Publication number
- JPWO2023080246A5 JPWO2023080246A5 JP2023558098A JP2023558098A JPWO2023080246A5 JP WO2023080246 A5 JPWO2023080246 A5 JP WO2023080246A5 JP 2023558098 A JP2023558098 A JP 2023558098A JP 2023558098 A JP2023558098 A JP 2023558098A JP WO2023080246 A5 JPWO2023080246 A5 JP WO2023080246A5
- Authority
- JP
- Japan
- Prior art keywords
- mutation
- amino acid
- mutations
- acid sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000035772 mutation Effects 0.000 claims description 75
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 34
- 230000002238 attenuated effect Effects 0.000 claims description 15
- 125000000539 amino acid group Chemical group 0.000 claims description 11
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 238000006467 substitution reaction Methods 0.000 claims description 9
- 230000037430 deletion Effects 0.000 claims description 8
- 238000012217 deletion Methods 0.000 claims description 8
- 241000008904 Betacoronavirus Species 0.000 claims description 7
- 101710172711 Structural protein Proteins 0.000 claims description 6
- 101800001768 Exoribonuclease Proteins 0.000 claims description 5
- 101800001704 Guanine-N7 methyltransferase Proteins 0.000 claims description 5
- 101800001862 Proofreading exoribonuclease Proteins 0.000 claims description 5
- 101800002929 Proofreading exoribonuclease nsp14 Proteins 0.000 claims description 5
- 101800000578 Uridylate-specific endoribonuclease Proteins 0.000 claims description 5
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 5
- 239000004474 valine Substances 0.000 claims description 5
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- 239000004471 Glycine Substances 0.000 claims description 4
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims description 4
- 101800001779 2'-O-methyltransferase Proteins 0.000 claims description 2
- 101800003073 2'-O-methyltransferase nsp16 Proteins 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- 101710144127 Non-structural protein 1 Proteins 0.000 claims description 2
- 101710144111 Non-structural protein 3 Proteins 0.000 claims description 2
- 101800001255 Putative 2'-O-methyl transferase Proteins 0.000 claims description 2
- 102100031776 SH2 domain-containing protein 3A Human genes 0.000 claims description 2
- 102100021798 SH2 domain-containing protein 3C Human genes 0.000 claims description 2
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims 11
- 235000018102 proteins Nutrition 0.000 claims 8
- 229940124590 live attenuated vaccine Drugs 0.000 claims 3
- 229940023012 live-attenuated vaccine Drugs 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 2
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 2
- 229960000310 isoleucine Drugs 0.000 claims 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 2
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 2
- 241001678559 COVID-19 virus Species 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 101710198378 Uncharacterized 10.8 kDa protein in cox-rep intergenic region Proteins 0.000 claims 1
- 230000004777 loss-of-function mutation Effects 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 description 13
- 108090000765 processed proteins & peptides Proteins 0.000 description 13
- 102000004196 processed proteins & peptides Human genes 0.000 description 13
- 230000035945 sensitivity Effects 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024175879A JP2025005450A (ja) | 2021-11-08 | 2024-10-07 | ベータコロナウイルス弱毒株 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021182051 | 2021-11-08 | ||
| JP2021182051 | 2021-11-08 | ||
| JP2022133080 | 2022-08-24 | ||
| JP2022133080 | 2022-08-24 | ||
| PCT/JP2022/041445 WO2023080246A1 (ja) | 2021-11-08 | 2022-11-07 | ベータコロナウイルス弱毒株 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024175879A Division JP2025005450A (ja) | 2021-11-08 | 2024-10-07 | ベータコロナウイルス弱毒株 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2023080246A1 JPWO2023080246A1 (https=) | 2023-05-11 |
| JPWO2023080246A5 true JPWO2023080246A5 (https=) | 2024-07-12 |
| JP7594686B2 JP7594686B2 (ja) | 2024-12-04 |
Family
ID=86241618
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023558098A Active JP7594686B2 (ja) | 2021-11-08 | 2022-11-07 | ベータコロナウイルス弱毒株 |
| JP2024175879A Pending JP2025005450A (ja) | 2021-11-08 | 2024-10-07 | ベータコロナウイルス弱毒株 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024175879A Pending JP2025005450A (ja) | 2021-11-08 | 2024-10-07 | ベータコロナウイルス弱毒株 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20250002871A1 (https=) |
| EP (1) | EP4431599A4 (https=) |
| JP (2) | JP7594686B2 (https=) |
| KR (1) | KR20240099257A (https=) |
| AU (1) | AU2022380191A1 (https=) |
| TW (1) | TW202334404A (https=) |
| WO (1) | WO2023080246A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102748970B1 (ko) * | 2024-05-02 | 2024-12-31 | 전북대학교 산학협력단 | N 유전자의 전사 억제 및 nsp1 단백질의 돌연변이를 포함하는 약독화된 SARS-CoV-2 백신주 및 이의 용도 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230084180A (ko) * | 2020-10-14 | 2023-06-12 | 잇판사이단호진한다이비세이부쯔뵤우겐큐우카이 | 베타 코로나바이러스 저온순화 주 및 백신 |
-
2022
- 2022-11-07 US US18/708,189 patent/US20250002871A1/en active Pending
- 2022-11-07 WO PCT/JP2022/041445 patent/WO2023080246A1/ja not_active Ceased
- 2022-11-07 JP JP2023558098A patent/JP7594686B2/ja active Active
- 2022-11-07 AU AU2022380191A patent/AU2022380191A1/en active Pending
- 2022-11-07 KR KR1020247015314A patent/KR20240099257A/ko active Pending
- 2022-11-07 EP EP22890066.8A patent/EP4431599A4/en active Pending
- 2022-11-08 TW TW111142589A patent/TW202334404A/zh unknown
-
2024
- 2024-10-07 JP JP2024175879A patent/JP2025005450A/ja active Pending
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