JPWO2023030272A5 - - Google Patents
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- JPWO2023030272A5 JPWO2023030272A5 JP2024513196A JP2024513196A JPWO2023030272A5 JP WO2023030272 A5 JPWO2023030272 A5 JP WO2023030272A5 JP 2024513196 A JP2024513196 A JP 2024513196A JP 2024513196 A JP2024513196 A JP 2024513196A JP WO2023030272 A5 JPWO2023030272 A5 JP WO2023030272A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 10
- 102000025171 antigen binding proteins Human genes 0.000 claims 10
- 108091000831 antigen binding proteins Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 7
- 230000003834 intracellular effect Effects 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 6
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 5
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 5
- 230000000139 costimulatory effect Effects 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102100032937 CD40 ligand Human genes 0.000 claims 4
- 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 claims 4
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims 4
- 102100022132 High affinity immunoglobulin epsilon receptor subunit gamma Human genes 0.000 claims 4
- 108091010847 High affinity immunoglobulin epsilon receptor subunit gamma Proteins 0.000 claims 4
- 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 claims 4
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 3
- 102100038077 CD226 antigen Human genes 0.000 claims 3
- 102100027207 CD27 antigen Human genes 0.000 claims 3
- 108010029697 CD40 Ligand Proteins 0.000 claims 3
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims 3
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 3
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims 3
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 3
- 101001068136 Homo sapiens Hepatitis A virus cellular receptor 1 Proteins 0.000 claims 3
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 3
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 3
- 101000831286 Homo sapiens Protein timeless homolog Proteins 0.000 claims 3
- 101000752245 Homo sapiens Rho guanine nucleotide exchange factor 5 Proteins 0.000 claims 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 3
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 3
- -1 LIGHT Proteins 0.000 claims 3
- 101710172064 Low-density lipoprotein receptor-related protein Proteins 0.000 claims 3
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 3
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 3
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 3
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 3
- 239000012642 immune effector Substances 0.000 claims 3
- 229940121354 immunomodulator Drugs 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 101000884270 Homo sapiens Natural killer cell receptor 2B4 Proteins 0.000 claims 2
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 2
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 2
- 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 claims 2
- 102000008115 Signaling Lymphocytic Activation Molecule Family Member 1 Human genes 0.000 claims 2
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims 2
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 2
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 2
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 101500007118 Bovine leukemia virus Transmembrane protein Proteins 0.000 claims 1
- 102100038078 CD276 antigen Human genes 0.000 claims 1
- 101710185679 CD276 antigen Proteins 0.000 claims 1
- 102100035793 CD83 antigen Human genes 0.000 claims 1
- 102100037904 CD9 antigen Human genes 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 108010021468 Fc gamma receptor IIA Proteins 0.000 claims 1
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 101000868215 Homo sapiens CD40 ligand Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 1
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 1
- 101001050318 Homo sapiens Junctional adhesion molecule-like Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000679903 Homo sapiens Tumor necrosis factor receptor superfamily member 25 Proteins 0.000 claims 1
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 241001502974 Human gammaherpesvirus 8 Species 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102100025390 Integrin beta-2 Human genes 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 102100023437 Junctional adhesion molecule-like Human genes 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 101150030213 Lag3 gene Proteins 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 102000001774 Low Density Lipoprotein Receptor-Related Protein-6 Human genes 0.000 claims 1
- 108010015179 Low Density Lipoprotein Receptor-Related Protein-6 Proteins 0.000 claims 1
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 102000010168 Myeloid Differentiation Factor 88 Human genes 0.000 claims 1
- 108010077432 Myeloid Differentiation Factor 88 Proteins 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 241000713311 Simian immunodeficiency virus Species 0.000 claims 1
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 102100022203 Tumor necrosis factor receptor superfamily member 25 Human genes 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000003738 lymphoid progenitor cell Anatomy 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111004998.9 | 2021-08-30 | ||
| CN202111004998 | 2021-08-30 | ||
| PCT/CN2022/115590 WO2023030272A1 (zh) | 2021-08-30 | 2022-08-29 | 抗gprc5d抗原结合蛋白及其用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024534847A JP2024534847A (ja) | 2024-09-26 |
| JP2024534847A5 JP2024534847A5 (https=) | 2025-03-14 |
| JPWO2023030272A5 true JPWO2023030272A5 (https=) | 2025-03-14 |
Family
ID=85410857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024513196A Pending JP2024534847A (ja) | 2021-08-30 | 2022-08-29 | 抗ｇｐｒｃ５ｄ抗原結合タンパク質とその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240384001A1 (https=) |
| EP (1) | EP4397686A4 (https=) |
| JP (1) | JP2024534847A (https=) |
| CN (1) | CN116063500A (https=) |
| WO (1) | WO2023030272A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023134718A1 (zh) * | 2022-01-14 | 2023-07-20 | 原启生物科技(上海)有限责任公司 | 靶向gprc5d的嵌合抗原受体及其用途 |
| JP2026511074A (ja) * | 2023-03-22 | 2026-04-10 | バイオフロント セラピューティクス （ベイジン） カンパニー リミテッド | Ｇｐｒｃ５ｄに結合するナノボディ及びその使用 |
| WO2025011462A1 (en) * | 2023-07-07 | 2025-01-16 | Overland Therapeutics (Us) Inc. | Single domain antibodies for gprc5d |
| AR133427A1 (es) | 2023-07-31 | 2025-09-24 | Sanofi Sa | Anticuerpos anti-gprc5d y composiciones |
| CN117229407B (zh) * | 2023-11-14 | 2024-02-20 | 成都优赛诺生物科技有限公司 | 一种靶向gprc5d的单域抗体、嵌合抗原受体及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3227324A4 (en) * | 2014-12-05 | 2018-08-29 | Memorial Sloan Kettering Cancer Center | Antibodies targeting g-protein coupled receptor and methods of use |
| SI3227339T1 (sl) | 2014-12-05 | 2022-02-28 | Memorial Sloan-Kettering Cancer Center | Himerni antigenski receptorji, ki ciljajo na receptor, povezan z G-proteinom, in njihova uporaba |
| TWI781108B (zh) * | 2016-07-20 | 2022-10-21 | 比利時商健生藥品公司 | 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途 |
| TW201837174A (zh) * | 2017-02-07 | 2018-10-16 | 日商第一三共股份有限公司 | 抗ｇｐｒｃ５ｄ抗體及包含該抗體之分子 |
| TWI829667B (zh) * | 2018-02-09 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | 結合gprc5d之抗體 |
| US12005080B2 (en) * | 2018-03-26 | 2024-06-11 | Oricell Therapeutics Co., Ltd. | Method for promoting proliferation of immune cells |
| MA54079A (fr) * | 2018-11-01 | 2021-09-08 | Juno Therapeutics Inc | Récepteurs antigéniques chimériques spécifiques du gprc5d (élément d du groupe 5 de classe c des récepteurs couplés à la protéine g) |
| JP2022543551A (ja) * | 2019-07-31 | 2022-10-13 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｇｐｒｃ５ｄに結合する抗体 |
| KR20220122656A (ko) * | 2019-12-06 | 2022-09-02 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ｇｐｒｃ5ｄ-표적화 결합 도메인에 대한 항-이디오타입 항체 및 관련 조성물 및 방법 |
-
2022
- 2022-08-29 US US18/687,695 patent/US20240384001A1/en active Pending
- 2022-08-29 EP EP22863407.7A patent/EP4397686A4/en active Pending
- 2022-08-29 CN CN202211041811.7A patent/CN116063500A/zh active Pending
- 2022-08-29 JP JP2024513196A patent/JP2024534847A/ja active Pending
- 2022-08-29 WO PCT/CN2022/115590 patent/WO2023030272A1/zh not_active Ceased
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