JPWO2023028534A5 - - Google Patents
Info
- Publication number
- JPWO2023028534A5 JPWO2023028534A5 JP2024513053A JP2024513053A JPWO2023028534A5 JP WO2023028534 A5 JPWO2023028534 A5 JP WO2023028534A5 JP 2024513053 A JP2024513053 A JP 2024513053A JP 2024513053 A JP2024513053 A JP 2024513053A JP WO2023028534 A5 JPWO2023028534 A5 JP WO2023028534A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- phenol
- trifluoromethyl
- methylpiperidin
- triazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163237049P | 2021-08-25 | 2021-08-25 | |
| US63/237,049 | 2021-08-25 | ||
| US202263311463P | 2022-02-18 | 2022-02-18 | |
| US63/311,463 | 2022-02-18 | ||
| PCT/US2022/075421 WO2023028534A1 (en) | 2021-08-25 | 2022-08-24 | Inhibitors of nlrp3 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024534162A JP2024534162A (ja) | 2024-09-18 |
| JP2024534162A5 JP2024534162A5 (https=) | 2025-09-02 |
| JPWO2023028534A5 true JPWO2023028534A5 (https=) | 2025-09-02 |
Family
ID=83438923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024513053A Pending JP2024534162A (ja) | 2021-08-25 | 2022-08-24 | Ｎｌｒｐ３の阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20240262806A1 (https=) |
| EP (1) | EP4392414A1 (https=) |
| JP (1) | JP2024534162A (https=) |
| KR (1) | KR20240069714A (https=) |
| AU (1) | AU2022334474A1 (https=) |
| CA (1) | CA3229539A1 (https=) |
| CL (1) | CL2024000552A1 (https=) |
| CO (1) | CO2024001922A2 (https=) |
| CR (1) | CR20240093A (https=) |
| EC (1) | ECSP24014832A (https=) |
| IL (1) | IL310992A (https=) |
| MX (1) | MX2024002342A (https=) |
| PE (1) | PE20241727A1 (https=) |
| WO (1) | WO2023028534A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| MX2024000984A (es) * | 2021-07-21 | 2024-06-19 | Nico Therapeutics Inc | Compuesto de piridazina anilado. |
| CN118302417A (zh) * | 2021-08-25 | 2024-07-05 | Ptc医疗公司 | Nlrp3抑制剂 |
| US20240391881A1 (en) * | 2021-09-30 | 2024-11-28 | Origiant Pharmaceutical Co., Ltd. | Pharmaceutical use and preparation method for substituted heteroaryl phthalazine derivative |
| WO2023088856A1 (en) | 2021-11-17 | 2023-05-25 | F. Hoffmann-La Roche Ag | Heterocyclic nlrp3 inhibitors |
| EP4493556A4 (en) * | 2022-03-15 | 2026-03-18 | Zomagen Biosciences Ltd | NLRP3 MODULATORS |
| CN119137121A (zh) * | 2022-03-25 | 2024-12-13 | 万特斯治疗美国公司 | 可用作NLRP3衍生物的吡啶并-[3,4-d]哒嗪胺衍生物 |
| EP4499646A4 (en) * | 2022-03-31 | 2026-03-18 | Hangzhou Highlightll Pharmaceutical Co Ltd | NLRP3 Inflammasome Inhibitors |
| WO2024006559A1 (en) * | 2022-07-01 | 2024-01-04 | Neumora Therapeutics, Inc. | Modulators of nlrp3 inflammasome and related products and methods |
| EP4554945A1 (en) * | 2022-07-14 | 2025-05-21 | AC Immune SA | Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway |
| GEAP202516743A (en) * | 2022-09-23 | 2025-08-11 | Merck Sharp & Dohme Llc | Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3 |
| JP2025023868A (ja) * | 2022-09-23 | 2025-02-17 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｎｏｄ様受容体タンパク質３の阻害剤として有用なフタラジン誘導体 |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| WO2024094185A1 (zh) * | 2022-11-04 | 2024-05-10 | 药捷安康(南京)科技股份有限公司 | Nlrp3炎症小体抑制剂及其应用 |
| CN120379995A (zh) * | 2022-12-27 | 2025-07-25 | 正大天晴药业集团股份有限公司 | 一种哒嗪稠芳环化合物及其用途 |
| KR20250106322A (ko) * | 2022-12-28 | 2025-07-09 | 장춘 진사이언스 파마슈티컬 씨오., 엘티디. | 피리다진계 nlrp3 억제제 화합물, 약학 조성물 및 이의 제조 방법과 용도 |
| KR20250134147A (ko) * | 2023-01-31 | 2025-09-09 | 얀센 파마슈티카 엔브이 | NLRP3 억제제로서의 피롤로[1,2-d][1,2,4]트리아진 및 피라졸로[1,5-d] [1,2,4]트리아진 |
| CN120957980A (zh) * | 2023-01-31 | 2025-11-14 | 詹森药业有限公司 | 作为nlrp3抑制剂的2-(哒嗪-3-基)-5-(三氟甲基)苯酚 |
| US20240360151A1 (en) * | 2023-03-14 | 2024-10-31 | Sanofi | Pyridazine compounds, their preparation, and their therapeutic uses |
| CN120659791A (zh) * | 2023-04-17 | 2025-09-16 | 上海拓界生物医药科技有限公司 | 稠合哒嗪类衍生物及其用途 |
| AU2024280075A1 (en) | 2023-06-02 | 2025-12-11 | Merck Sharp & Dohme Llc | 5,6-Unsaturated Bicyclic Heterocycles Useful as Inhibitors of Nod-Like Receptor Protein 3 |
| WO2025006681A2 (en) * | 2023-06-27 | 2025-01-02 | Viva Star Biosciences (Us) Inc. | Substituted pyridazine compounds as inhibitors of nlrp3 activity and therapeutic uses thereof |
| WO2025133307A1 (en) * | 2023-12-22 | 2025-06-26 | Ac Immune Sa | Heterocyclic modulators of the nlrp3 inflammasome pathway |
| WO2025146160A1 (zh) * | 2024-01-05 | 2025-07-10 | 北京普祺医药科技股份有限公司 | 杂环化合物及其药物组合物 |
| WO2025153532A1 (en) | 2024-01-16 | 2025-07-24 | NodThera Limited | Nlrp3 inhibitors and glp-1 agonists combination therapies |
| WO2025153624A1 (en) * | 2024-01-17 | 2025-07-24 | Ac Immune Sa | Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway |
| WO2025153625A1 (en) * | 2024-01-17 | 2025-07-24 | Ac Immune Sa | Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway |
| WO2026002229A1 (zh) * | 2024-06-28 | 2026-01-02 | 长春金赛药业有限责任公司 | 一种nlrp3抑制剂化合物及其制备方法和应用 |
| WO2026047040A1 (en) * | 2024-08-28 | 2026-03-05 | Sanofi | Pyridazine compounds, their preparation, and their therapeutic uses |
| WO2026057747A1 (en) | 2024-09-11 | 2026-03-19 | Ac Immune Sa | Therapeutic use of nlrp3 inflammasome pathway inhibitor compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9919957D0 (en) * | 1999-08-23 | 1999-10-27 | Merck Sharp & Dohme | Therapeutic agents |
| JPWO2006075638A1 (ja) | 2005-01-14 | 2008-06-12 | 大日本住友製薬株式会社 | 新規ヘテロアリール誘導体 |
| WO2009035568A1 (en) * | 2007-09-07 | 2009-03-19 | Amgen Inc. | Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling |
| WO2018080216A1 (en) * | 2016-10-28 | 2018-05-03 | Daewoong Pharmaceutical Co., Ltd. | Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same |
| JP7649257B2 (ja) | 2019-05-13 | 2025-03-19 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| UY38687A (es) * | 2019-05-17 | 2023-05-15 | Novartis Ag | Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso |
| CN114174282A (zh) | 2019-05-29 | 2022-03-11 | 南京明德新药研发有限公司 | 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用 |
| CN116390914A (zh) * | 2020-12-25 | 2023-07-04 | 上海拓界生物医药科技有限公司 | 一类含哒嗪的化合物及其医药用途 |
| US11319319B1 (en) * | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| US20240327413A1 (en) | 2021-06-29 | 2024-10-03 | Zomagen Biosciences Ltd | Nlrp3 modulators |
| HRP20251513T1 (hr) | 2021-07-02 | 2026-01-02 | Astrazeneca Ab | Inhibitori inflamasoma nlrp3 |
| MX2024000984A (es) | 2021-07-21 | 2024-06-19 | Nico Therapeutics Inc | Compuesto de piridazina anilado. |
-
2022
- 2022-08-24 IL IL310992A patent/IL310992A/en unknown
- 2022-08-24 KR KR1020247005965A patent/KR20240069714A/ko active Pending
- 2022-08-24 MX MX2024002342A patent/MX2024002342A/es unknown
- 2022-08-24 CA CA3229539A patent/CA3229539A1/en active Pending
- 2022-08-24 JP JP2024513053A patent/JP2024534162A/ja active Pending
- 2022-08-24 WO PCT/US2022/075421 patent/WO2023028534A1/en not_active Ceased
- 2022-08-24 CR CR20240093A patent/CR20240093A/es unknown
- 2022-08-24 PE PE2024000299A patent/PE20241727A1/es unknown
- 2022-08-24 US US18/256,099 patent/US20240262806A1/en active Pending
- 2022-08-24 AU AU2022334474A patent/AU2022334474A1/en active Pending
- 2022-08-24 EP EP22777142.5A patent/EP4392414A1/en active Pending
-
2024
- 2024-02-22 CL CL2024000552A patent/CL2024000552A1/es unknown
- 2024-02-22 CO CONC2024/0001922A patent/CO2024001922A2/es unknown
- 2024-02-23 EC ECSENADI202414832A patent/ECSP24014832A/es unknown
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