JPWO2022250731A5 - - Google Patents
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- Publication number
- JPWO2022250731A5 JPWO2022250731A5 JP2023572709A JP2023572709A JPWO2022250731A5 JP WO2022250731 A5 JPWO2022250731 A5 JP WO2022250731A5 JP 2023572709 A JP2023572709 A JP 2023572709A JP 2023572709 A JP2023572709 A JP 2023572709A JP WO2022250731 A5 JPWO2022250731 A5 JP WO2022250731A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- phosphodiesterase inhibitor
- water
- soluble solvent
- organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 24
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 11
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000003021 water soluble solvent Substances 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000004721 Polyphenylene oxide Substances 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- 229920000570 polyether Polymers 0.000 claims 4
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 201000001881 impotence Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000003125 aqueous solvent Substances 0.000 claims 2
- 125000005456 glyceride group Chemical group 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims 2
- 239000008118 PEG 6000 Substances 0.000 claims 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims 1
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical group CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000013011 aqueous formulation Substances 0.000 claims 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims 1
- 229960002401 calcium lactate Drugs 0.000 claims 1
- 239000001527 calcium lactate Substances 0.000 claims 1
- 235000011086 calcium lactate Nutrition 0.000 claims 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 1
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims 1
- 230000004907 flux Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000002850 nasal mucosa Anatomy 0.000 claims 1
- 229960003310 sildenafil Drugs 0.000 claims 1
- 229960000835 tadalafil Drugs 0.000 claims 1
- IEHKWSGCTWLXFU-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C([C]4C=CC=CC4=N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 IEHKWSGCTWLXFU-IIBYNOLFSA-N 0.000 claims 1
- 229960002381 vardenafil Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063029881P | 2020-05-26 | 2020-05-26 | |
| USPCT/US2021/034334 | 2021-05-26 | ||
| PCT/US2021/034334 WO2021242913A1 (en) | 2020-05-26 | 2021-05-26 | Formulations and methods for treating erectile dysfunction |
| PCT/US2021/061488 WO2022250731A1 (en) | 2020-05-26 | 2021-12-01 | Formulations and methods for treating erectile dysfunction |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024521765A JP2024521765A (ja) | 2024-06-04 |
| JPWO2022250731A5 true JPWO2022250731A5 (https=) | 2024-12-10 |
| JP2024521765A5 JP2024521765A5 (https=) | 2024-12-10 |
Family
ID=78722740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023572709A Pending JP2024521765A (ja) | 2020-05-26 | 2021-12-01 | 勃起不全を治療するための製剤および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240216383A1 (https=) |
| EP (1) | EP4157449A4 (https=) |
| JP (1) | JP2024521765A (https=) |
| KR (1) | KR20240013128A (https=) |
| CN (1) | CN116568289A (https=) |
| AU (1) | AU2021280285A1 (https=) |
| BR (1) | BR112022024098A2 (https=) |
| CA (1) | CA3179630A1 (https=) |
| IL (1) | IL298432A (https=) |
| WO (2) | WO2021242913A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL247528B1 (pl) * | 2023-04-08 | 2025-07-21 | Sativa Med Spolka Akcyjna | Płynna kompozycja inhibitorów fosfodiesterazy typu 5 (PDE-5), sposób jej wytwarzania oraz jej zastosowanie do leczenia zaburzeń erekcji |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2391968A1 (en) * | 1999-11-18 | 2001-05-25 | Natco Pharma Limited | An improved pharmaceutical composition for treating male erectile dysfunction |
| DE10118306A1 (de) * | 2001-04-12 | 2002-10-17 | Bayer Ag | Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation |
| DE102004023069A1 (de) * | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
| US20060051413A1 (en) * | 2004-09-08 | 2006-03-09 | Chow Sing S M | Method of enhancing absorptions of transmucosal administration formulations |
| DE102005009240A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
| DE102005009241A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit kontrollierter Bioverfügbarkeit |
| US20060207596A1 (en) * | 2005-03-18 | 2006-09-21 | Fairfield Clinical Trials, Llc | Device and method for delivery of combination nasal medication |
| US8911751B2 (en) * | 2005-10-11 | 2014-12-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions for nasal delivery |
| MX2010004265A (es) * | 2007-10-19 | 2010-07-28 | Innozen Inc | Composicion para administrar un ingrediente activo y metodo para hacer y usar el mismo. |
| GB2497933B (en) * | 2011-12-21 | 2014-12-24 | Londonpharma Ltd | Drug delivery technology |
| US20140271847A1 (en) * | 2013-03-13 | 2014-09-18 | SatisPharma, LLC | Formulations and methods for rapid penile erections |
| US20170014417A1 (en) * | 2015-07-14 | 2017-01-19 | Lipp Life Sciences Llc | Pharmaceutical administration system for the transdermal application of vardenafil |
| CN111655229A (zh) * | 2017-12-20 | 2020-09-11 | 卡里亚制药控股有限公司 | 包含伐地那非的薄膜制剂、其制备方法及其用途 |
| US11648197B2 (en) * | 2018-06-28 | 2023-05-16 | Arx, Llc | Dispensing method for producing dissolvable unit dose film constructs |
-
2021
- 2021-05-26 IL IL298432A patent/IL298432A/en unknown
- 2021-05-26 AU AU2021280285A patent/AU2021280285A1/en active Pending
- 2021-05-26 BR BR112022024098A patent/BR112022024098A2/pt unknown
- 2021-05-26 WO PCT/US2021/034334 patent/WO2021242913A1/en not_active Ceased
- 2021-05-26 EP EP21811862.8A patent/EP4157449A4/en active Pending
- 2021-05-26 CA CA3179630A patent/CA3179630A1/en active Pending
- 2021-12-01 WO PCT/US2021/061488 patent/WO2022250731A1/en not_active Ceased
- 2021-12-01 US US17/999,826 patent/US20240216383A1/en active Pending
- 2021-12-01 KR KR1020237040722A patent/KR20240013128A/ko active Pending
- 2021-12-01 CN CN202180076999.6A patent/CN116568289A/zh active Pending
- 2021-12-01 JP JP2023572709A patent/JP2024521765A/ja active Pending
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