JPWO2022235557A5 - - Google Patents
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- Publication number
- JPWO2022235557A5 JPWO2022235557A5 JP2023564664A JP2023564664A JPWO2022235557A5 JP WO2022235557 A5 JPWO2022235557 A5 JP WO2022235557A5 JP 2023564664 A JP2023564664 A JP 2023564664A JP 2023564664 A JP2023564664 A JP 2023564664A JP WO2022235557 A5 JPWO2022235557 A5 JP WO2022235557A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- metabolic disorder
- lactoyl
- amino acid
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 19
- 208000030159 metabolic disease Diseases 0.000 claims 8
- -1 N-lactoyl amino Chemical group 0.000 claims 6
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 2
- 210000000577 adipose tissue Anatomy 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 230000037406 food intake Effects 0.000 claims 2
- 235000012631 food intake Nutrition 0.000 claims 2
- 230000014101 glucose homeostasis Effects 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 230000036470 plasma concentration Effects 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- IIRJJZHHNGABMQ-WPRPVWTQSA-N N-[(S)-lactoyl]-L-phenylalanine Chemical compound C[C@H](O)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 IIRJJZHHNGABMQ-WPRPVWTQSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000037081 physical activity Effects 0.000 claims 1
- 238000011477 surgical intervention Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163183868P | 2021-05-04 | 2021-05-04 | |
| US63/183,868 | 2021-05-04 | ||
| PCT/US2022/027261 WO2022235557A1 (en) | 2021-05-04 | 2022-05-02 | Lactoyl amino acids for the treatment of metabolic disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024516969A JP2024516969A (ja) | 2024-04-18 |
| JP2024516969A5 JP2024516969A5 (https=) | 2025-04-24 |
| JPWO2022235557A5 true JPWO2022235557A5 (https=) | 2025-04-24 |
Family
ID=83932803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023564664A Pending JP2024516969A (ja) | 2021-05-04 | 2022-05-02 | 代謝性疾患の治療のためのラクトイルアミノ酸 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240189266A1 (https=) |
| EP (1) | EP4313297A4 (https=) |
| JP (1) | JP2024516969A (https=) |
| KR (1) | KR20240006050A (https=) |
| CN (1) | CN117769414A (https=) |
| AU (1) | AU2022271191A1 (https=) |
| WO (1) | WO2022235557A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240122888A1 (en) * | 2022-10-03 | 2024-04-18 | Transdermal Biotechnology, Inc. | Systems and methods for delivery of phenylalanine and lactate |
| CN116035217B (zh) * | 2022-12-23 | 2023-08-04 | 暨南大学 | 一种具有减肥减脂作用的组合物与应用 |
| WO2024192165A1 (en) * | 2023-03-14 | 2024-09-19 | The Board Of Trustees Of The Leland Stanford Junior University | N-beta-hydroxybutyryl-amino acids and related compositions and methods |
| WO2025072489A2 (en) * | 2023-09-27 | 2025-04-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Analogues of n-lactoyl-phenylalanine, methods of synthesis, and methods of use |
| WO2025184353A1 (en) * | 2024-03-01 | 2025-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating metabolic disorders |
| CN118795011B (zh) * | 2024-06-28 | 2025-01-21 | 合肥工业大学 | 一种用于细胞代谢产物n-l-乳酰-l-苯丙氨酸的快速检测方法 |
| CN119350175B (zh) * | 2024-10-15 | 2026-03-17 | 广东药科大学 | 一类新型酰基苯丙氨酸衍生物、其制备方法及其作为药物的用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159146A (zh) * | 1995-07-26 | 1997-09-10 | 弗门尼舍有限公司 | 风味产品及其制备方法 |
| AU719332B2 (en) * | 1995-09-19 | 2000-05-04 | Cellular Sciences, Inc. | Method and composition for treating mammalian diseases caused by inflammatory response |
| WO2012054528A2 (en) * | 2010-10-19 | 2012-04-26 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
-
2022
- 2022-05-02 WO PCT/US2022/027261 patent/WO2022235557A1/en not_active Ceased
- 2022-05-02 AU AU2022271191A patent/AU2022271191A1/en active Pending
- 2022-05-02 EP EP22799358.1A patent/EP4313297A4/en active Pending
- 2022-05-02 JP JP2023564664A patent/JP2024516969A/ja active Pending
- 2022-05-02 CN CN202280034413.4A patent/CN117769414A/zh active Pending
- 2022-05-02 US US18/286,516 patent/US20240189266A1/en active Pending
- 2022-05-02 KR KR1020237041490A patent/KR20240006050A/ko active Pending
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