JPWO2022232638A5 - - Google Patents
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- Publication number
- JPWO2022232638A5 JPWO2022232638A5 JP2023562936A JP2023562936A JPWO2022232638A5 JP WO2022232638 A5 JPWO2022232638 A5 JP WO2022232638A5 JP 2023562936 A JP2023562936 A JP 2023562936A JP 2023562936 A JP2023562936 A JP 2023562936A JP WO2022232638 A5 JPWO2022232638 A5 JP WO2022232638A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- nuclease system
- engineered nuclease
- engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101710163270 Nuclease Proteins 0.000 claims 24
- 150000007523 nucleic acids Chemical group 0.000 claims 14
- 102000004533 Endonucleases Human genes 0.000 claims 12
- 108010042407 Endonucleases Proteins 0.000 claims 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229920002477 rna polymer Polymers 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 101001000998 Homo sapiens Protein phosphatase 1 regulatory subunit 12C Proteins 0.000 claims 1
- 102100035620 Protein phosphatase 1 regulatory subunit 12C Human genes 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163182438P | 2021-04-30 | 2021-04-30 | |
| US63/182,438 | 2021-04-30 | ||
| PCT/US2022/027124 WO2022232638A2 (en) | 2021-04-30 | 2022-04-29 | Enzymes with ruvc domains |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024517607A JP2024517607A (ja) | 2024-04-23 |
| JPWO2022232638A5 true JPWO2022232638A5 (https=) | 2025-05-01 |
| JP2024517607A5 JP2024517607A5 (https=) | 2025-05-01 |
Family
ID=83847352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023562936A Pending JP2024517607A (ja) | 2021-04-30 | 2022-04-29 | Ｒｕｖｃドメインを有する酵素 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240110167A1 (https=) |
| EP (1) | EP4330386A4 (https=) |
| JP (1) | JP2024517607A (https=) |
| KR (1) | KR20240004618A (https=) |
| CN (1) | CN117203332A (https=) |
| AU (1) | AU2022264921A1 (https=) |
| BR (1) | BR112023022270A2 (https=) |
| CA (1) | CA3214222A1 (https=) |
| MX (1) | MX2023012606A (https=) |
| WO (1) | WO2022232638A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3225082A1 (en) | 2021-08-27 | 2023-03-02 | Brian C. Thomas | Enzymes with ruvc domains |
| MX2024006257A (es) | 2021-11-24 | 2024-07-29 | Metagenomi Inc | Sistemas de endonucleasas. |
| AU2024339645A1 (en) * | 2023-09-13 | 2026-04-23 | Metagenomi Therapeutics, Inc. | Engineered and chimeric nucleases |
| WO2025106934A1 (en) * | 2023-11-16 | 2025-05-22 | Metagenomi, Inc. | Enzymes with ruvc domains |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2894684A1 (en) * | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of improved crispr-cas systems, methods and enzyme compositions for sequence manipulation in eukaryotes |
| US9234213B2 (en) * | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| AU2018240515B2 (en) * | 2017-03-24 | 2024-07-25 | CureVac SE | Nucleic acids encoding CRISPR-associated proteins and uses thereof |
| KR20200124702A (ko) * | 2018-02-23 | 2020-11-03 | 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 | 신규한 cas9 오르소로그 |
| AU2020223370B2 (en) * | 2019-02-14 | 2023-04-20 | Metagenomi Therapeutics, Inc. | Enzymes with RuvC domains |
| US10913941B2 (en) * | 2019-02-14 | 2021-02-09 | Metagenomi Ip Technologies, Llc | Enzymes with RuvC domains |
-
2022
- 2022-04-29 WO PCT/US2022/027124 patent/WO2022232638A2/en not_active Ceased
- 2022-04-29 AU AU2022264921A patent/AU2022264921A1/en active Pending
- 2022-04-29 CA CA3214222A patent/CA3214222A1/en active Pending
- 2022-04-29 MX MX2023012606A patent/MX2023012606A/es unknown
- 2022-04-29 JP JP2023562936A patent/JP2024517607A/ja active Pending
- 2022-04-29 CN CN202280030364.7A patent/CN117203332A/zh active Pending
- 2022-04-29 EP EP22796888.0A patent/EP4330386A4/en active Pending
- 2022-04-29 BR BR112023022270A patent/BR112023022270A2/pt unknown
- 2022-04-29 KR KR1020237040583A patent/KR20240004618A/ko active Pending
-
2023
- 2023-10-17 US US18/488,520 patent/US20240110167A1/en active Pending
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