JPWO2022232025A5 - - Google Patents
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- Publication number
- JPWO2022232025A5 JPWO2022232025A5 JP2023565387A JP2023565387A JPWO2022232025A5 JP WO2022232025 A5 JPWO2022232025 A5 JP WO2022232025A5 JP 2023565387 A JP2023565387 A JP 2023565387A JP 2023565387 A JP2023565387 A JP 2023565387A JP WO2022232025 A5 JPWO2022232025 A5 JP WO2022232025A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- compound
- alkyl
- group
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 39
- 229910052736 halogen Inorganic materials 0.000 claims 24
- 150000002367 halogens Chemical group 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 229910052805 deuterium Inorganic materials 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 10
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 8
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 8
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 8
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 150000001721 carbon Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 208000001573 Cataplexy Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 201000003631 narcolepsy Diseases 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000004306 triazinyl group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163179616P | 2021-04-26 | 2021-04-26 | |
| US63/179,616 | 2021-04-26 | ||
| PCT/US2022/026144 WO2022232025A1 (en) | 2021-04-26 | 2022-04-25 | Substituted amide macrocyclic compounds with orexin-2 receptor agonist activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024516633A JP2024516633A (ja) | 2024-04-16 |
| JPWO2022232025A5 true JPWO2022232025A5 (https=) | 2024-11-27 |
| JP2024516633A5 JP2024516633A5 (https=) | 2024-11-27 |
Family
ID=81750587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023565387A Pending JP2024516633A (ja) | 2021-04-26 | 2022-04-25 | オレキシン－２受容体アゴニスト活性を有する置換されるアミド大環状化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240124485A1 (https=) |
| EP (1) | EP4329877B1 (https=) |
| JP (1) | JP2024516633A (https=) |
| CN (1) | CN117440955A (https=) |
| AU (1) | AU2022267220A1 (https=) |
| CA (1) | CA3215210A1 (https=) |
| ES (1) | ES3062687T3 (https=) |
| WO (1) | WO2022232025A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4622712A1 (en) * | 2022-11-23 | 2025-10-01 | Vertex Pharmaceuticals Incorporated | Substituted macrocyclic amine modulators of orexin receptor 2 |
| KR20250139869A (ko) | 2023-01-31 | 2025-09-23 | 재즈 파마슈티칼즈 아일랜드 리미티드 | 거대환식 오렉신 수용체 효능제 및 이의 용도 |
| PE20252742A1 (es) | 2023-03-16 | 2025-12-05 | Takeda Pharmaceuticals Co | Compuestos heterociclicos macrociclicos y sus usos |
| IL324946A (en) | 2023-06-01 | 2026-01-01 | H Lundbeck As | Spiro-macrocyclic orexin 2 receptor agonists |
| WO2025096445A1 (en) | 2023-10-30 | 2025-05-08 | Alkermes, Inc. | Synthesis of intermediates for the preparation of macrocyclic compounds |
| WO2025124698A1 (en) | 2023-12-12 | 2025-06-19 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
| TW202542165A (zh) | 2023-12-19 | 2025-11-01 | 瑞士商愛杜西亞製藥有限公司 | 大環食慾素激動劑 |
| WO2026017128A1 (zh) * | 2024-07-17 | 2026-01-22 | 江苏恩华药业股份有限公司 | 作为食欲素受体激动剂的环烯烃衍生物及其组合物和用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1542A (en) * | 1999-04-30 | 2006-01-31 | Pfizer Prod Inc | Glucocorticoid receptor modulators. |
| EP2038255A2 (en) * | 2006-06-16 | 2009-03-25 | High Point Pharmaceuticals, LLC | Pharmaceutical use of substituted piperidine carboxamides |
| US8258163B2 (en) | 2008-06-04 | 2012-09-04 | Board Of Regents, The University Of Texas System | Small-molecule agonists for type-2 orexin receptor |
| JP5635991B2 (ja) * | 2008-10-30 | 2014-12-03 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | イソニコチンアミドオレキシン受容体アンタゴニスト |
| NZ592705A (en) * | 2008-12-10 | 2013-02-22 | Achillion Pharmaceuticals Inc | 4-amino-4-oxobutanoyl peptide cyclic analogues, inhibitors of viral replication |
| WO2014198880A1 (en) | 2013-06-14 | 2014-12-18 | Ferrer Internacional, S.A. | 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity |
| WO2015048091A1 (en) | 2013-09-24 | 2015-04-02 | The Board Of Regents Of The University Of Texas System | Orexin-control of bone formation and loss |
| EP3068783B1 (en) | 2013-11-15 | 2020-09-23 | The Board of Trustees of the Leland Stanford Junior University | Agonists of hypocretin receptor 2 for use for treating heart failure |
| PE20161064A1 (es) | 2013-12-12 | 2016-10-28 | Univ Tsukuba | Derivado de sulfonamida o sales de adicion de acido farmaceuticamente aceptables del mismo |
| WO2015147240A1 (ja) | 2014-03-28 | 2015-10-01 | 国立大学法人筑波大学 | 敗血症の予防治療剤 |
| LT3984994T (lt) * | 2016-02-04 | 2024-10-10 | Takeda Pharmaceutical Company Limited | Pakeistas piperidino junginys kaip 2 tipo oreksino agonistas narkolepsijai gydyti |
| US11059780B2 (en) * | 2017-03-08 | 2021-07-13 | Takeda Pharmaceutical Company Limited | Substituted pyrrolidine compound and use thereof |
| US10428023B2 (en) | 2017-08-03 | 2019-10-01 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| EA039459B1 (ru) * | 2017-12-25 | 2022-01-28 | Такеда Фармасьютикал Компани Лимитед | Гетероциклическое соединение и его применение в качестве средства для лечения заболеваний, связанных с рецептором орексина 2 типа |
| JP7339250B2 (ja) * | 2018-06-29 | 2023-09-05 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| US12312332B2 (en) * | 2019-08-08 | 2025-05-27 | Merck Sharp & Dohme Llc | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
| EP4065585B1 (en) * | 2019-11-25 | 2025-08-20 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| US12006330B2 (en) * | 2020-12-21 | 2024-06-11 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
-
2022
- 2022-04-25 CN CN202280038386.8A patent/CN117440955A/zh active Pending
- 2022-04-25 ES ES22724964T patent/ES3062687T3/es active Active
- 2022-04-25 AU AU2022267220A patent/AU2022267220A1/en active Pending
- 2022-04-25 JP JP2023565387A patent/JP2024516633A/ja active Pending
- 2022-04-25 CA CA3215210A patent/CA3215210A1/en active Pending
- 2022-04-25 EP EP22724964.6A patent/EP4329877B1/en active Active
- 2022-04-25 WO PCT/US2022/026144 patent/WO2022232025A1/en not_active Ceased
-
2023
- 2023-10-03 US US18/376,020 patent/US20240124485A1/en active Pending
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