JPWO2022226584A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022226584A5 JPWO2022226584A5 JP2024508815A JP2024508815A JPWO2022226584A5 JP WO2022226584 A5 JPWO2022226584 A5 JP WO2022226584A5 JP 2024508815 A JP2024508815 A JP 2024508815A JP 2024508815 A JP2024508815 A JP 2024508815A JP WO2022226584 A5 JPWO2022226584 A5 JP WO2022226584A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- set forth
- cancer
- sequence set
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical group 0.000 claims description 70
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims description 49
- 210000004027 cell Anatomy 0.000 claims description 36
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 27
- 238000006467 substitution reaction Methods 0.000 claims description 24
- -1 ICOS Proteins 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 claims description 18
- 201000011510 cancer Diseases 0.000 claims description 18
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims description 16
- 108091008324 binding proteins Proteins 0.000 claims description 16
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims description 13
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 13
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 13
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 13
- 102100024263 CD160 antigen Human genes 0.000 claims description 12
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims description 12
- 102100032816 Integrin alpha-6 Human genes 0.000 claims description 12
- 230000002018 overexpression Effects 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 11
- 108020004707 nucleic acids Proteins 0.000 claims description 11
- 150000007523 nucleic acids Chemical class 0.000 claims description 11
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims description 10
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims description 10
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 10
- 102100032818 Integrin alpha-4 Human genes 0.000 claims description 10
- 102100025390 Integrin beta-2 Human genes 0.000 claims description 10
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 10
- 230000000139 costimulatory effect Effects 0.000 claims description 10
- 230000011664 signaling Effects 0.000 claims description 10
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims description 9
- 239000012642 immune effector Substances 0.000 claims description 9
- 229940121354 immunomodulator Drugs 0.000 claims description 9
- 101001078158 Homo sapiens Integrin alpha-1 Proteins 0.000 claims description 8
- 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 claims description 8
- 101001035237 Homo sapiens Integrin alpha-D Proteins 0.000 claims description 8
- 101001046687 Homo sapiens Integrin alpha-E Proteins 0.000 claims description 8
- 101000633786 Homo sapiens SLAM family member 6 Proteins 0.000 claims description 8
- 101000633780 Homo sapiens Signaling lymphocytic activation molecule Proteins 0.000 claims description 8
- 102100025323 Integrin alpha-1 Human genes 0.000 claims description 8
- 102100039904 Integrin alpha-D Human genes 0.000 claims description 8
- 102100022341 Integrin alpha-E Human genes 0.000 claims description 8
- 102100022297 Integrin alpha-X Human genes 0.000 claims description 8
- 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 claims description 8
- 102100029197 SLAM family member 6 Human genes 0.000 claims description 8
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims description 8
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 8
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 8
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 7
- 102100022338 Integrin alpha-M Human genes 0.000 claims description 7
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 7
- 239000000427 antigen Substances 0.000 claims description 7
- 102000036639 antigens Human genes 0.000 claims description 7
- 108091007433 antigens Proteins 0.000 claims description 7
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 6
- 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 claims description 6
- 102100025304 Integrin beta-1 Human genes 0.000 claims description 6
- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 claims description 6
- 102100027744 Semaphorin-4D Human genes 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- 206010009944 Colon cancer Diseases 0.000 claims description 5
- 208000032612 Glial tumor Diseases 0.000 claims description 5
- 206010018338 Glioma Diseases 0.000 claims description 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 206010033128 Ovarian cancer Diseases 0.000 claims description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 5
- 201000005202 lung cancer Diseases 0.000 claims description 5
- 208000020816 lung neoplasm Diseases 0.000 claims description 5
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 4
- 108010056102 CD100 antigen Proteins 0.000 claims description 4
- 108010017009 CD11b Antigen Proteins 0.000 claims description 4
- 102100027207 CD27 antigen Human genes 0.000 claims description 4
- 101150013553 CD40 gene Proteins 0.000 claims description 4
- 108010062802 CD66 antigens Proteins 0.000 claims description 4
- 102100027217 CD82 antigen Human genes 0.000 claims description 4
- 101710139831 CD82 antigen Proteins 0.000 claims description 4
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 claims description 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 4
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 4
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 4
- 101001046683 Homo sapiens Integrin alpha-L Proteins 0.000 claims description 4
- 101001046668 Homo sapiens Integrin alpha-X Proteins 0.000 claims description 4
- 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 claims description 4
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims description 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 4
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims description 4
- 101000873418 Homo sapiens P-selectin glycoprotein ligand 1 Proteins 0.000 claims description 4
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 claims description 4
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims description 4
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims description 4
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims description 4
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims description 4
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims description 4
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims description 4
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 4
- 101000679857 Homo sapiens Tumor necrosis factor receptor superfamily member 3 Proteins 0.000 claims description 4
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 4
- 102100022339 Integrin alpha-L Human genes 0.000 claims description 4
- 108010041100 Integrin alpha6 Proteins 0.000 claims description 4
- 108010030465 Integrin alpha6beta1 Proteins 0.000 claims description 4
- 102100033016 Integrin beta-7 Human genes 0.000 claims description 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 4
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 4
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims description 4
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 4
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims description 4
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims description 4
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims description 4
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims description 4
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims description 4
- 101710141230 Natural killer cell receptor 2B4 Proteins 0.000 claims description 4
- 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 102100026066 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Human genes 0.000 claims description 4
- 108010025832 RANK Ligand Proteins 0.000 claims description 4
- 102000014128 RANK Ligand Human genes 0.000 claims description 4
- 206010038389 Renal cancer Diseases 0.000 claims description 4
- 102100029216 SLAM family member 5 Human genes 0.000 claims description 4
- 102100029198 SLAM family member 7 Human genes 0.000 claims description 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims description 4
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 4
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims description 4
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims description 4
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 4
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims description 4
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims description 4
- 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 claims description 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 4
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 4
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 4
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 4
- 208000009956 adenocarcinoma Diseases 0.000 claims description 4
- 201000010881 cervical cancer Diseases 0.000 claims description 4
- 206010017758 gastric cancer Diseases 0.000 claims description 4
- 201000010536 head and neck cancer Diseases 0.000 claims description 4
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 4
- 230000003834 intracellular effect Effects 0.000 claims description 4
- 201000010982 kidney cancer Diseases 0.000 claims description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 201000002528 pancreatic cancer Diseases 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 4
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims description 3
- 239000002773 nucleotide Substances 0.000 claims description 3
- 125000003729 nucleotide group Chemical group 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims description 2
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 2
- 102100038077 CD226 antigen Human genes 0.000 claims description 2
- 102100038078 CD276 antigen Human genes 0.000 claims description 2
- 101710185679 CD276 antigen Proteins 0.000 claims description 2
- 102100035793 CD83 antigen Human genes 0.000 claims description 2
- 102100037904 CD9 antigen Human genes 0.000 claims description 2
- 102100027816 Cytotoxic and regulatory T-cell molecule Human genes 0.000 claims description 2
- 241000702421 Dependoparvovirus Species 0.000 claims description 2
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims description 2
- 101000585551 Equus caballus Pregnancy-associated glycoprotein Proteins 0.000 claims description 2
- 108010021468 Fc gamma receptor IIA Proteins 0.000 claims description 2
- 102100022086 GRB2-related adapter protein 2 Human genes 0.000 claims description 2
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims description 2
- 102100022132 High affinity immunoglobulin epsilon receptor subunit gamma Human genes 0.000 claims description 2
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims description 2
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 2
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims description 2
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims description 2
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims description 2
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims description 2
- 101000900690 Homo sapiens GRB2-related adapter protein 2 Proteins 0.000 claims description 2
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims description 2
- 101000824104 Homo sapiens High affinity immunoglobulin epsilon receptor subunit gamma Proteins 0.000 claims description 2
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims description 2
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 claims description 2
- 101000945339 Homo sapiens Killer cell immunoglobulin-like receptor 2DS2 Proteins 0.000 claims description 2
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims description 2
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims description 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims description 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims description 2
- 101001090688 Homo sapiens Lymphocyte cytosolic protein 2 Proteins 0.000 claims description 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 2
- 101001124867 Homo sapiens Peroxiredoxin-1 Proteins 0.000 claims description 2
- 101000692259 Homo sapiens Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Proteins 0.000 claims description 2
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims description 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 2
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims description 2
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims description 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 2
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims description 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims description 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 2
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 claims description 2
- 102100033630 Killer cell immunoglobulin-like receptor 2DS2 Human genes 0.000 claims description 2
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims description 2
- 102100024032 Linker for activation of T-cells family member 1 Human genes 0.000 claims description 2
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims description 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims description 2
- 102100034709 Lymphocyte cytosolic protein 2 Human genes 0.000 claims description 2
- 101001043810 Macaca fascicularis Interleukin-7 receptor subunit alpha Proteins 0.000 claims description 2
- 101100236305 Mus musculus Ly9 gene Proteins 0.000 claims description 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 2
- 108091008874 T cell receptors Proteins 0.000 claims description 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 2
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims description 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 2
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims description 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 2
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims description 2
- 108010072917 class-I restricted T cell-associated molecule Proteins 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 230000001177 retroviral effect Effects 0.000 claims description 2
- 241000701161 unidentified adenovirus Species 0.000 claims description 2
- 102000023732 binding proteins Human genes 0.000 claims 4
- 101100341510 Mus musculus Itgal gene Proteins 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- 230000014509 gene expression Effects 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 101000980827 Homo sapiens T-cell surface glycoprotein CD1a Proteins 0.000 description 1
- 101000716149 Homo sapiens T-cell surface glycoprotein CD1b Proteins 0.000 description 1
- 101000716124 Homo sapiens T-cell surface glycoprotein CD1c Proteins 0.000 description 1
- 102000049772 Interleukin-16 Human genes 0.000 description 1
- 101800003050 Interleukin-16 Proteins 0.000 description 1
- 102000013691 Interleukin-17 Human genes 0.000 description 1
- 108050003558 Interleukin-17 Proteins 0.000 description 1
- 208000000172 Medulloblastoma Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021901226A AU2021901226A0 (en) | 2021-04-26 | EGFRvIII BINDING PROTEINS II | |
| AU2021901227A AU2021901227A0 (en) | 2021-04-26 | EGFRvIII BINDING PROTEINS I | |
| AU2021901227 | 2021-04-26 | ||
| AU2021901226 | 2021-04-26 | ||
| PCT/AU2022/050379 WO2022226584A1 (en) | 2021-04-26 | 2022-04-26 | EGFRvIII BINDING PROTEINS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024516748A JP2024516748A (ja) | 2024-04-16 |
| JPWO2022226584A5 true JPWO2022226584A5 (https=) | 2025-04-22 |
| JP2024516748A5 JP2024516748A5 (https=) | 2025-04-22 |
Family
ID=83846542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024508815A Pending JP2024516748A (ja) | 2021-04-26 | 2022-04-26 | EGFRvIII結合タンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240207407A1 (https=) |
| EP (1) | EP4330285A4 (https=) |
| JP (1) | JP2024516748A (https=) |
| AU (1) | AU2022267410A1 (https=) |
| WO (1) | WO2022226584A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240005794A (ko) * | 2021-05-18 | 2024-01-12 | 쑤저우 카노바 바이오파마슈티컬 컴퍼니 리미티드 | 항 pd-1 폴리펩티드 및 그의 용도 |
| AU2024360934A1 (en) * | 2023-10-13 | 2026-04-09 | The General Hospital Corporation | Treating glioblastoma using car-t cell therapy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2958943T3 (da) * | 2013-02-20 | 2019-12-09 | Univ Pennsylvania | Behandling af cancer ved anvendelse af humaniseret anti-EGFRvIII kimær antigenreceptor |
| TWI731535B (zh) * | 2014-03-21 | 2021-06-21 | 美商艾伯維有限公司 | 抗-egfr抗體及抗體藥物結合物 |
| MX2017001229A (es) * | 2014-07-29 | 2017-05-01 | Pfizer | Receptores de antigenos quimericos especificos de egfrviii para inmunoterapia de cancer. |
| WO2020172553A1 (en) * | 2019-02-22 | 2020-08-27 | Novartis Ag | Combination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors |
| KR20210148228A (ko) * | 2019-03-27 | 2021-12-07 | 내셔날 리서치 카운실 오브 캐나다 | 항-EGFRvIII 항체 및 그의 항원-결합 단편 |
-
2022
- 2022-04-26 EP EP22794091.3A patent/EP4330285A4/en active Pending
- 2022-04-26 WO PCT/AU2022/050379 patent/WO2022226584A1/en not_active Ceased
- 2022-04-26 JP JP2024508815A patent/JP2024516748A/ja active Pending
- 2022-04-26 AU AU2022267410A patent/AU2022267410A1/en not_active Abandoned
- 2022-04-26 US US18/288,475 patent/US20240207407A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021520788A5 (https=) | ||
| JP2021000103A5 (https=) | ||
| RU2017105161A (ru) | Лечение рака с использованием химерного антигенного рецептора cll-1 | |
| RU2017105160A (ru) | Лечение рака с помощью химерного антигенного рецептора к cd33 | |
| JPWO2016028896A5 (https=) | ||
| CA3032581A1 (en) | Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule | |
| JP2017524367A5 (https=) | ||
| JP2017522879A5 (https=) | ||
| JP7527641B2 (ja) | スイッチ分子及びスイッチャブルキメラ抗原受容体 | |
| RU2017108903A (ru) | Химерный антигенный рецептор (car) против cd123 для использования в лечении злокачественных опухолей | |
| RU2017105065A (ru) | Лечение злокачественного новообразования с использованием гуманизированного химерного антигенного рецептора против всма | |
| JPWO2020180591A5 (https=) | ||
| IL298326A (en) | Anti-her2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same | |
| US20220396635A1 (en) | Trivalent binding molecules | |
| JPWO2019200007A5 (https=) | ||
| JP2021530233A5 (https=) | ||
| JPWO2021173985A5 (https=) | ||
| JPWO2021061778A5 (https=) | ||
| US20250051443A1 (en) | Anti-cd3 monoclonal antibodies and therapeutic constructs | |
| US20240156962A1 (en) | Bcma-targeted car-t cell therapy of multiple myeloma | |
| JPWO2019245991A5 (https=) | ||
| CN118510814A (zh) | 一种嵌合抗原受体及其应用 | |
| JPWO2022226584A5 (https=) | ||
| JPWO2023068382A5 (https=) | ||
| WO2023185256A1 (zh) | 特异性结合cd7的抗体及其在制备嵌合抗原受体中的应用 |