JPWO2022223954A5 - - Google Patents
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- Publication number
- JPWO2022223954A5 JPWO2022223954A5 JP2023564038A JP2023564038A JPWO2022223954A5 JP WO2022223954 A5 JPWO2022223954 A5 JP WO2022223954A5 JP 2023564038 A JP2023564038 A JP 2023564038A JP 2023564038 A JP2023564038 A JP 2023564038A JP WO2022223954 A5 JPWO2022223954 A5 JP WO2022223954A5
- Authority
- JP
- Japan
- Prior art keywords
- aav
- host cell
- care element
- nucleic acid
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000702421 Dependoparvovirus Species 0.000 claims 31
- 210000004027 cell Anatomy 0.000 claims 27
- 239000002773 nucleotide Substances 0.000 claims 22
- 125000003729 nucleotide group Chemical group 0.000 claims 22
- 108020004707 nucleic acids Proteins 0.000 claims 20
- 102000039446 nucleic acids Human genes 0.000 claims 20
- 150000007523 nucleic acids Chemical class 0.000 claims 20
- 238000000034 method Methods 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 16
- 101150066583 rep gene Proteins 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 9
- 101150044789 Cap gene Proteins 0.000 claims 7
- 230000003612 virological effect Effects 0.000 claims 7
- 238000012258 culturing Methods 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 5
- 241000701161 unidentified adenovirus Species 0.000 claims 5
- 230000003321 amplification Effects 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 239000013612 plasmid Substances 0.000 claims 4
- 241000702423 Adeno-associated virus - 2 Species 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 101710199711 Early E1A protein Proteins 0.000 claims 2
- 102100021244 Integral membrane protein GPR180 Human genes 0.000 claims 2
- 108700019146 Transgenes Proteins 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 108010024878 Adenovirus E1A Proteins Proteins 0.000 claims 1
- 108091033409 CRISPR Proteins 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 108091027544 Subgenomic mRNA Proteins 0.000 claims 1
- 108700005077 Viral Genes Proteins 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2105581.9 | 2021-04-19 | ||
| GBGB2105581.9A GB202105581D0 (en) | 2021-04-19 | 2021-04-19 | DNA amplification method |
| GB2110922.8 | 2021-07-29 | ||
| GBGB2110922.8A GB202110922D0 (en) | 2021-07-29 | 2021-07-29 | DNA amplification method |
| GBGB2113603.1A GB202113603D0 (en) | 2021-09-23 | 2021-09-23 | DNA amplification method |
| GB2113603.1 | 2021-09-23 | ||
| GB2116571.7 | 2021-11-17 | ||
| GBGB2116571.7A GB202116571D0 (en) | 2021-11-17 | 2021-11-17 | Dna amplification method |
| PCT/GB2022/050957 WO2022223954A1 (en) | 2021-04-19 | 2022-04-14 | Dna amplification method using care elements |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024517104A JP2024517104A (ja) | 2024-04-19 |
| JP2024517104A5 JP2024517104A5 (https=) | 2025-04-21 |
| JPWO2022223954A5 true JPWO2022223954A5 (https=) | 2025-04-21 |
Family
ID=81386652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023564038A Pending JP2024517104A (ja) | 2021-04-19 | 2022-04-14 | Ｃａｒｅエレメントを用いたｄｎａ増幅方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20250066811A1 (https=) |
| EP (1) | EP4326881A1 (https=) |
| JP (1) | JP2024517104A (https=) |
| WO (1) | WO2022223954A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201901571D0 (en) | 2019-02-05 | 2019-03-27 | Oxford Genetics Ltd | Inducible AAV sysyem |
| AU2022373653A1 (en) | 2021-10-18 | 2024-05-02 | Regeneron Pharmaceuticals, Inc. | Eukaryotic cells comprising adenovirus-associated virus polynucleotides |
| CN119842820A (zh) * | 2023-10-16 | 2025-04-18 | 深圳市深研生物科技有限公司 | 用于生产重组腺相关病毒载体的方法及包装/生产细胞 |
| WO2026073032A1 (en) * | 2024-09-27 | 2026-04-02 | Shape Therapeutics Inc. | Constructs for improved aav production |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002240890A1 (en) | 2000-12-07 | 2002-06-18 | Universite De Nantes | Inducible highly productive raav packaging cell-lines |
| US7972593B2 (en) * | 2004-06-10 | 2011-07-05 | Saint Louis University | Delivery of therapeutic agents to the bone |
| US9523132B2 (en) * | 2013-03-15 | 2016-12-20 | Ut-Battelle, Llc | Rapid and highly fieldable viral diagnostic |
| CN110892064A (zh) | 2017-07-25 | 2020-03-17 | 牛津遗传学有限公司 | 腺病毒载体 |
-
2022
- 2022-04-14 WO PCT/GB2022/050957 patent/WO2022223954A1/en not_active Ceased
- 2022-04-14 EP EP22718764.8A patent/EP4326881A1/en active Pending
- 2022-04-14 US US18/553,948 patent/US20250066811A1/en active Pending
- 2022-04-14 JP JP2023564038A patent/JP2024517104A/ja active Pending
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