JPWO2022218290A5 - - Google Patents
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- Publication number
- JPWO2022218290A5 JPWO2022218290A5 JP2023562533A JP2023562533A JPWO2022218290A5 JP WO2022218290 A5 JPWO2022218290 A5 JP WO2022218290A5 JP 2023562533 A JP2023562533 A JP 2023562533A JP 2023562533 A JP2023562533 A JP 2023562533A JP WO2022218290 A5 JPWO2022218290 A5 JP WO2022218290A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- nucleotide
- acid molecule
- electrical signal
- segment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims description 108
- 102000039446 nucleic acids Human genes 0.000 claims description 108
- 108020004707 nucleic acids Proteins 0.000 claims description 108
- 239000002773 nucleotide Substances 0.000 claims description 108
- 125000003729 nucleotide group Chemical group 0.000 claims description 108
- 238000000034 method Methods 0.000 claims description 102
- 239000000523 sample Substances 0.000 claims description 62
- 230000004048 modification Effects 0.000 claims description 46
- 238000012986 modification Methods 0.000 claims description 46
- 230000011987 methylation Effects 0.000 claims description 24
- 238000007069 methylation reaction Methods 0.000 claims description 24
- 230000001605 fetal effect Effects 0.000 claims description 18
- 230000008774 maternal effect Effects 0.000 claims description 12
- 239000012472 biological sample Substances 0.000 claims description 4
- 210000003754 fetus Anatomy 0.000 claims description 4
- 230000005856 abnormality Effects 0.000 claims description 2
- 230000003647 oxidation Effects 0.000 claims description 2
- 238000007254 oxidation reaction Methods 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163173728P | 2021-04-12 | 2021-04-12 | |
| US63/173,728 | 2021-04-12 | ||
| PCT/CN2022/086260 WO2022218290A1 (en) | 2021-04-12 | 2022-04-12 | Base modification analysis using electrical signals |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024516365A JP2024516365A (ja) | 2024-04-15 |
| JP2024516365A5 JP2024516365A5 (https=) | 2025-04-08 |
| JPWO2022218290A5 true JPWO2022218290A5 (https=) | 2025-04-08 |
Family
ID=83509521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023562533A Pending JP2024516365A (ja) | 2021-04-12 | 2022-04-12 | 電気信号を使用する塩基修飾分析 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220328135A1 (https=) |
| EP (1) | EP4323539A4 (https=) |
| JP (1) | JP2024516365A (https=) |
| KR (1) | KR20240007159A (https=) |
| CN (1) | CN117545855A (https=) |
| AU (1) | AU2022258155A1 (https=) |
| CA (1) | CA3215066A1 (https=) |
| IL (1) | IL307398A (https=) |
| TW (1) | TW202305818A (https=) |
| WO (1) | WO2022218290A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112481363B (zh) * | 2020-03-09 | 2024-05-28 | 南京大学 | 突变Aerolysin单体在检测RNA碱基序列及RNA修饰方面的应用 |
| CN115620809B (zh) * | 2022-12-16 | 2023-04-07 | 北京齐碳科技有限公司 | 纳米孔测序数据分析方法、装置以及存储介质和应用 |
| US20240203530A1 (en) * | 2022-12-16 | 2024-06-20 | Centre For Novostics | Machine learning techniques to determine base methylations |
| JPWO2024247764A1 (https=) * | 2023-05-30 | 2024-12-05 | ||
| CN117831630B (zh) * | 2024-03-05 | 2024-05-17 | 北京普译生物科技有限公司 | 为碱基识别模型构建训练数据集的方法、装置及电子设备 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002318336A1 (en) * | 2001-06-08 | 2002-12-23 | U.S. Genomics, Inc. | Methods and products for analyzing nucleic acids based on methylation status |
| WO2008047234A1 (en) * | 2006-10-18 | 2008-04-24 | Epigenomics Ag | A molecule for providing a standard for the quantitative analysis of the methylation status of a nucleic acid |
| WO2008070144A2 (en) * | 2006-12-06 | 2008-06-12 | Duke University | Imprinted genes and disease |
| US9238836B2 (en) * | 2012-03-30 | 2016-01-19 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing modified nucleic acids |
| CA2995422A1 (en) * | 2015-08-12 | 2017-02-16 | The Chinese University Of Hong Kong | Single-molecule sequencing of plasma dna |
| GB201819378D0 (en) * | 2018-11-28 | 2019-01-09 | Oxford Nanopore Tech Ltd | Analysis of nanopore signal using a machine-learning technique |
| WO2020236995A1 (en) * | 2019-05-22 | 2020-11-26 | Icahn School Of Medicine At Mount Sinai | Method for de novo detection, identification and fine mapping of multiple forms of nucleic acid modifications |
| TWI752593B (zh) * | 2019-08-16 | 2022-01-11 | 香港中文大學 | 核酸鹼基修飾的測定 |
-
2022
- 2022-04-12 US US17/719,166 patent/US20220328135A1/en active Pending
- 2022-04-12 EP EP22787514.3A patent/EP4323539A4/en not_active Withdrawn
- 2022-04-12 CN CN202280037190.7A patent/CN117545855A/zh active Pending
- 2022-04-12 WO PCT/CN2022/086260 patent/WO2022218290A1/en not_active Ceased
- 2022-04-12 IL IL307398A patent/IL307398A/en unknown
- 2022-04-12 AU AU2022258155A patent/AU2022258155A1/en not_active Abandoned
- 2022-04-12 KR KR1020237038839A patent/KR20240007159A/ko active Pending
- 2022-04-12 JP JP2023562533A patent/JP2024516365A/ja active Pending
- 2022-04-12 CA CA3215066A patent/CA3215066A1/en active Pending
- 2022-04-12 TW TW111113903A patent/TW202305818A/zh unknown
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