|
DE3788058T2
(de)
|
1986-08-28 |
1994-04-21 |
Teijin Ltd |
Zelltoxischer antikörperkomplex und verfahren zu seiner herstellung.
|
|
MD1367C2
(ro)
|
1992-11-13 |
2000-11-30 |
Idec Pharmaceuticals Corporation |
Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom.
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
WO2001091798A2
(en)
|
2000-06-01 |
2001-12-06 |
Universite Catholique De Louvain |
Tumor activated prodrug compounds
|
|
DE60129695T2
(de)
|
2000-06-29 |
2008-06-05 |
Merck Patent Gmbh |
Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme
|
|
ATE513563T1
(de)
|
2000-10-09 |
2011-07-15 |
Isis Innovation |
Therapeutische und toleranz-induzierende antikörper
|
|
US7465790B2
(en)
|
2000-10-09 |
2008-12-16 |
Isis Innovation, Inc. |
Therapeutic antibodies
|
|
US6942853B2
(en)
|
2001-01-09 |
2005-09-13 |
Queen Mary And Westfield College |
Latent fusion protein
|
|
US20040109855A1
(en)
|
2002-07-23 |
2004-06-10 |
Herman Waldmann |
Therapeutic antibodies with reduced side effect
|
|
US8809504B2
(en)
|
2002-09-03 |
2014-08-19 |
Vit Lauermann |
Inhibitor which is deactivatable by a reagent produced by a target cell
|
|
US20060024272A1
(en)
|
2004-07-29 |
2006-02-02 |
Large Scale Biology Corporation |
C-terminally truncated interferon
|
|
MX2007014889A
(es)
|
2005-05-26 |
2008-02-19 |
Schering Corp |
Fusion de interferon-inmunoglobulina g.
|
|
JP2009529522A
(ja)
|
2006-03-10 |
2009-08-20 |
ディアト |
酵素で切断可能なリンカーを介して抗体に複合された抗癌剤
|
|
CA2697032C
(en)
|
2007-08-22 |
2021-09-14 |
The Regents Of The University Of California |
Activatable binding polypeptides and methods of identification and use thereof
|
|
WO2009079837A1
(en)
|
2007-12-18 |
2009-07-02 |
Hangzhou Jiuyuan Gene Engineering Co., Ltd. |
A pharmaceutical formulation containing recombinant human serum albumin-interferon alpha fusion protein
|
|
US20100189651A1
(en)
|
2009-01-12 |
2010-07-29 |
Cytomx Therapeutics, Llc |
Modified antibody compositions, methods of making and using thereof
|
|
JP5861223B2
(ja)
|
2009-02-23 |
2016-02-16 |
サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. |
プロタンパク質およびその使用方法
|
|
EP2553101A4
(en)
|
2010-04-02 |
2013-09-04 |
Univ Rochester |
PROTEASE-ACTIVATED CYTOKINES
|
|
HRP20150664T1
(hr)
|
2010-12-03 |
2015-07-31 |
Adamed Sp. Z O.O. |
Antikancerogeni fuzijski protein
|
|
HRP20200470T1
(hr)
|
2011-01-18 |
2020-10-02 |
Bioniz, Llc |
Pripravci za modulaciju aktivnosti gama-c-citokina
|
|
EA201892619A1
(ru)
|
2011-04-29 |
2019-04-30 |
Роше Гликарт Аг |
Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
|
|
US9487590B2
(en)
|
2012-09-25 |
2016-11-08 |
Cytomx Therapeutics, Inc. |
Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
|
|
CA2925106C
(en)
|
2013-09-25 |
2023-11-14 |
Cytomx Therapeutics, Inc. |
Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
|
|
IL270562B
(en)
|
2014-01-31 |
2022-08-01 |
Cytomx Therapeutics Inc |
Polypeptide substrates that activate matriptase and u-plasminogen and other cleavable groups, preparations containing them and their uses
|
|
GB201411506D0
(en)
|
2014-06-27 |
2014-08-13 |
Univ London Queen Mary |
Modified latency associated protein construct
|
|
RS59340B1
(sr)
|
2014-11-06 |
2019-10-31 |
Hoffmann La Roche |
Varijante fc regiona sa modifikovanim vezivanjem za fcrn i metode upotrebe
|
|
MA41374A
(fr)
|
2015-01-20 |
2017-11-28 |
Cytomx Therapeutics Inc |
Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
|
|
JP2019518786A
(ja)
|
2016-05-06 |
2019-07-04 |
牧林 王 |
インターロイキンの組み合せ及びその使用
|
|
CN110214147A
(zh)
|
2016-10-14 |
2019-09-06 |
Xencor股份有限公司 |
IL15/IL15Rα异源二聚体FC-融合蛋白
|
|
CN111050803A
(zh)
*
|
2017-06-20 |
2020-04-21 |
德克萨斯大学系统董事会 |
用于治疗癌症的干扰素前药
|
|
CA3287794A1
(en)
|
2017-10-14 |
2025-10-27 |
Cytomx Therapeutics, Inc. |
Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof
|
|
CA3081539A1
(en)
|
2017-11-08 |
2019-05-16 |
Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd. |
Conjugates of biomolecule and use thereof
|
|
CN111954680B
(zh)
|
2017-11-10 |
2024-03-15 |
新加坡科技研究局 |
IL2Rβ/共同γ链抗体
|
|
EP3727146A4
(en)
|
2017-12-19 |
2021-10-06 |
Blaze Bioscience, Inc. |
TUMOR HOMING AND CELL-PENETANT PEPTIDE IMMUNO-ONCOLOGY AGENT COMPLEX AND METHOD OF USE
|
|
WO2020113403A1
(en)
|
2018-12-04 |
2020-06-11 |
Beijing Percans Oncology Co. Ltd. |
Cytokine fusion proteins
|
|
WO2019173832A2
(en)
|
2018-03-09 |
2019-09-12 |
AskGene Pharma, Inc. |
Novel cytokine prodrugs
|
|
CA3100005A1
(en)
|
2018-05-14 |
2019-11-21 |
Werewolf Therapeutics, Inc. |
Activatable cytokine polypeptides and methods of use thereof
|
|
AU2019271148B9
(en)
|
2018-05-14 |
2025-05-29 |
Werewolf Therapeutics, Inc. |
Activatable interleukin-2 polypeptides and methods of use thereof
|
|
US20210130430A1
(en)
|
2018-05-14 |
2021-05-06 |
Werewolf Therapeutics, Inc. |
Activatable cytokine polypeptides and methods of use thereof
|
|
WO2019230868A1
(ja)
|
2018-05-30 |
2019-12-05 |
中外製薬株式会社 |
単ドメイン抗体含有リガンド結合分子
|
|
US12030721B2
(en)
|
2018-06-21 |
2024-07-09 |
Tgw Logistics Group Gmbh |
Storage and order picking system and method for picking ordered articles from a hanging bag and another load aid
|
|
EP3810624A4
(en)
|
2018-06-22 |
2022-07-06 |
Cugene Inc. |
Cytokine-based bioactivatable drugs and methods of uses thereof
|
|
US12459980B2
(en)
|
2018-07-25 |
2025-11-04 |
AskGene Pharma, Inc. |
IL-21 prodrugs and methods of use thereof
|
|
CN112867503A
(zh)
|
2018-08-24 |
2021-05-28 |
希望之城 |
掩蔽的细胞因子缀合物
|
|
CN120463822A
(zh)
|
2018-09-27 |
2025-08-12 |
西里欧发展公司 |
掩蔽型细胞因子多肽
|
|
JP2022502443A
(ja)
|
2018-09-28 |
2022-01-11 |
ピエール、ファーブル、メディカマン |
癌の処置のための新規な免疫サイトカイン
|
|
AU2019366956B2
(en)
|
2018-10-23 |
2025-10-30 |
Dragonfly Therapeutics, Inc. |
Heterodimeric Fc-fused proteins
|
|
MY205459A
(en)
|
2018-12-06 |
2024-10-22 |
Cytomx Therapeutics Inc |
Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof
|
|
AU2019395266A1
(en)
|
2018-12-14 |
2021-06-17 |
Proviva Therapeutics (Hong Kong) Limited |
IL-15 compositions and methods of use thereof
|
|
WO2020214690A1
(en)
|
2019-04-15 |
2020-10-22 |
Qwixel Therapeutics |
Fusion protein composition(s) comprising targeted masked type i interferons (ifna and ifnb) and an antibody against tumor antigen, for use in the treatment of cancer
|
|
KR20220023988A
(ko)
|
2019-05-14 |
2022-03-03 |
웨어울프 세라퓨틱스, 인크. |
분리 모이어티 및 이의 사용 방법
|
|
JP2022533254A
(ja)
|
2019-05-24 |
2022-07-21 |
プロヴィヴァ セラピューティクス （ホン コン） リミテッド |
Ｉｌ－２組成物およびその使用方法
|
|
CN114127277A
(zh)
|
2019-06-05 |
2022-03-01 |
中外制药株式会社 |
蛋白酶底物和包含蛋白酶切割序列的多肽
|
|
KR20220020879A
(ko)
|
2019-06-12 |
2022-02-21 |
에스크진 파마, 아이엔씨. |
새로운 il-15 프로드럭 및 이를 사용하는 방법
|
|
CA3146156A1
(en)
|
2019-07-12 |
2021-01-21 |
Proviva Therapeutics (Hong Kong) Limited |
Il-2 compositions and methods of use thereof
|
|
MX2022000991A
(es)
|
2019-07-25 |
2022-05-24 |
Univ Chicago |
Composiciones y metodos que comprenden agentes terapeuticos activados por proteasa.
|
|
EP4004026A4
(en)
|
2019-07-25 |
2023-11-15 |
Trutino Biosciences Inc. |
IL-2 CYTOKINE PRODRUGS WITH A CLAVEABLE LINKER
|
|
CA3148505A1
(en)
|
2019-08-12 |
2021-02-18 |
AskGene Pharma, Inc. |
Novel il-2 fusion molecules
|
|
US20220289822A1
(en)
|
2019-08-21 |
2022-09-15 |
AskGene Pharma, Inc. |
Novel il-21 prodrugs and methods of use thereof
|
|
US20220356221A1
(en)
|
2019-09-28 |
2022-11-10 |
AskGene Pharma, Inc. |
Cytokine prodrugs and dual-prodrugs
|
|
BR112022009110A2
(pt)
|
2019-11-14 |
2022-07-26 |
Werewolf Therapeutics Inc |
Polipeptídeos de citocina ativáveis e métodos de uso destes
|
|
CN115315434A
(zh)
|
2019-12-05 |
2022-11-08 |
免疫靶向有限公司 |
白细胞介素15融合蛋白和前药及其组合物和方法
|
|
MX2022007202A
(es)
|
2019-12-13 |
2022-10-07 |
Cugene Inc |
Fármacos bioactivables a base de citocinas y metodos de uso de los mismos.
|
|
BR112022012112A2
(pt)
|
2019-12-20 |
2022-09-06 |
Regeneron Pharma |
Agonistas de il2 e métodos de uso dos mesmos
|
|
US20240043489A1
(en)
|
2020-01-15 |
2024-02-08 |
Trutino Biosciences Inc. |
Cytokine Prodrugs Comprising a Cleavable Linker
|
|
JP7773991B2
(ja)
|
2020-03-23 |
2025-11-20 |
ザイムワークス ビーシー インコーポレイテッド |
マスクされたｉｌ１２融合タンパク質及びその使用方法
|
|
WO2021202354A1
(en)
|
2020-03-30 |
2021-10-07 |
Proviva Therapeutics (Hong Kong) Limited |
Il-2/il-15 compositions and methods of use thereof
|
|
JP7735306B2
(ja)
|
2020-04-01 |
2025-09-08 |
エクシリオ デベロップメント， インコーポレイテッド |
マスクされたｉｌ－２サイトカイン及びその切断産物
|
|
IL296911A
(en)
|
2020-04-01 |
2022-12-01 |
Xilio Dev Inc |
Masked il-15 cytokines and their cleavage products
|
|
AU2021248919A1
(en)
*
|
2020-04-01 |
2022-10-13 |
Xilio Development, Inc. |
Masked IL-12 cytokines and their cleavage products
|
|
AU2021254283B2
(en)
|
2020-04-10 |
2025-12-11 |
Cytomx Therapeutics, Inc. |
Activatable cytokine constructs and related compositions and methods
|
|
US11597753B2
(en)
|
2020-04-30 |
2023-03-07 |
Immune Targeting, Inc. |
Activatable IL2 composition and methods of use
|
|
JP2023526428A
(ja)
|
2020-05-19 |
2023-06-21 |
ウェアウルフ セラピューティクス， インコーポレイテッド |
活性化可能なｉｌ－１２ポリペプチド及びその使用方法
|