JPWO2022192346A5 - - Google Patents
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- JPWO2022192346A5 JPWO2022192346A5 JP2023555231A JP2023555231A JPWO2022192346A5 JP WO2022192346 A5 JPWO2022192346 A5 JP WO2022192346A5 JP 2023555231 A JP2023555231 A JP 2023555231A JP 2023555231 A JP2023555231 A JP 2023555231A JP WO2022192346 A5 JPWO2022192346 A5 JP WO2022192346A5
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- JP
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- Prior art keywords
- domain
- pharmaceutical composition
- receptor
- orthogonal
- intracellular signaling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 34
- 239000000427 antigen Substances 0.000 claims 26
- 102000036639 antigens Human genes 0.000 claims 26
- 108091007433 antigens Proteins 0.000 claims 26
- 230000004068 intracellular signaling Effects 0.000 claims 26
- 108091008874 T cell receptors Proteins 0.000 claims 22
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 22
- 102000003675 cytokine receptors Human genes 0.000 claims 20
- 108010057085 cytokine receptors Proteins 0.000 claims 20
- 206010028980 Neoplasm Diseases 0.000 claims 14
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 11
- 101001055219 Homo sapiens Interleukin-9 receptor Proteins 0.000 claims 8
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 8
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 8
- 102100026244 Interleukin-9 receptor Human genes 0.000 claims 8
- 210000002865 immune cell Anatomy 0.000 claims 8
- 230000003834 intracellular effect Effects 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 6
- 230000000174 oncolytic effect Effects 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 4
- 102100026094 C-type lectin domain family 12 member A Human genes 0.000 claims 4
- 102100038078 CD276 antigen Human genes 0.000 claims 4
- 101710185679 CD276 antigen Proteins 0.000 claims 4
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 4
- 102000000588 Interleukin-2 Human genes 0.000 claims 4
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 4
- 102000002698 KIR Receptors Human genes 0.000 claims 4
- 108010043610 KIR Receptors Proteins 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 201000002528 pancreatic cancer Diseases 0.000 claims 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 4
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 2
- 101100279855 Arabidopsis thaliana EPFL5 gene Proteins 0.000 claims 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 101150031358 COLEC10 gene Proteins 0.000 claims 2
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 2
- 102100025466 Carcinoembryonic antigen-related cell adhesion molecule 3 Human genes 0.000 claims 2
- 101100044298 Drosophila melanogaster fand gene Proteins 0.000 claims 2
- 101150064015 FAS gene Proteins 0.000 claims 2
- 108010087819 Fc receptors Proteins 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 2
- 229930186217 Glycolipid Natural products 0.000 claims 2
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 2
- 101000912622 Homo sapiens C-type lectin domain family 12 member A Proteins 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
- 101100496086 Homo sapiens CLEC12A gene Proteins 0.000 claims 2
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 2
- 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 claims 2
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 2
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 2
- 101000960952 Homo sapiens Interleukin-1 receptor accessory protein Proteins 0.000 claims 2
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 2
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 2
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 2
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 2
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 2
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 2
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 2
- -1 ICOS Proteins 0.000 claims 2
- 108010073807 IgG Receptors Proteins 0.000 claims 2
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 2
- 102100022339 Integrin alpha-L Human genes 0.000 claims 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 2
- 102100039880 Interleukin-1 receptor accessory protein Human genes 0.000 claims 2
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 101150028321 Lck gene Proteins 0.000 claims 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 2
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 2
- 102000003735 Mesothelin Human genes 0.000 claims 2
- 108090000015 Mesothelin Proteins 0.000 claims 2
- 102100034256 Mucin-1 Human genes 0.000 claims 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 2
- 102000007399 Nuclear hormone receptor Human genes 0.000 claims 2
- 101100335198 Pneumocystis carinii fol1 gene Proteins 0.000 claims 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 2
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 2
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 2
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims 2
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims 2
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 2
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 102000052547 Wnt-1 Human genes 0.000 claims 2
- 108700020987 Wnt-1 Proteins 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 108091007930 cytoplasmic receptors Proteins 0.000 claims 2
- 210000005220 cytoplasmic tail Anatomy 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims 2
- 102000006815 folate receptor Human genes 0.000 claims 2
- 108020005243 folate receptor Proteins 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- 108010008486 gp100 Melanoma Antigen Proteins 0.000 claims 2
- 102000007192 gp100 Melanoma Antigen Human genes 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 230000002601 intratumoral effect Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 238000012737 microarray-based gene expression Methods 0.000 claims 2
- 238000012243 multiplex automated genomic engineering Methods 0.000 claims 2
- 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000032258 transport Effects 0.000 claims 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163158671P | 2021-03-09 | 2021-03-09 | |
| US63/158,671 | 2021-03-09 | ||
| PCT/US2022/019479 WO2022192346A1 (en) | 2021-03-09 | 2022-03-09 | Selective stimulation of t cells in solid tumors using oncolytic viral delivery of orthogonal il-2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024509917A JP2024509917A (ja) | 2024-03-05 |
| JP2024509917A5 JP2024509917A5 (https=) | 2025-03-12 |
| JPWO2022192346A5 true JPWO2022192346A5 (https=) | 2025-03-12 |
Family
ID=83227027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023555231A Pending JP2024509917A (ja) | 2021-03-09 | 2022-03-09 | 腫瘍溶解性ウイルスによる直交性ｉｌ－２の送達を用いた、固形腫瘍におけるｔ細胞の選択的刺激方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240299541A1 (https=) |
| EP (1) | EP4305054A4 (https=) |
| JP (1) | JP2024509917A (https=) |
| CN (1) | CN117377682A (https=) |
| WO (1) | WO2022192346A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023044457A1 (en) | 2021-09-17 | 2023-03-23 | Parker Institute For Cancer Immunotherapy | Switch receptors using il-9 signaling domains |
| US20230265147A1 (en) * | 2021-09-17 | 2023-08-24 | The Trustees Of The University Of Pennsylvania | Interleukin-9 Signaling in Chimeric Antigen Receptor (CAR) Immune Cells |
| EP4554611A1 (en) * | 2022-07-15 | 2025-05-21 | The Regents Of The University Of California | Il-9r signaling compositions and methods |
| CN120225568A (zh) * | 2022-12-27 | 2025-06-27 | 广州瑞风生物科技有限公司 | 一种融合蛋白及其应用 |
| WO2025085721A1 (en) * | 2023-10-18 | 2025-04-24 | Memorial Sloan-Kettering Cancer Center | Chimeric receptors and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102739782B1 (ko) * | 2015-09-11 | 2024-12-09 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 생물학적으로 관련된 직교 사이토카인/수용체 쌍 |
| EP3746116A1 (en) * | 2018-01-31 | 2020-12-09 | Novartis AG | Combination therapy using a chimeric antigen receptor |
| AU2020219246A1 (en) * | 2019-02-08 | 2021-08-19 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Chimeric cytokine receptors |
| CN115996746A (zh) * | 2020-04-06 | 2023-04-21 | 辛德凯因股份有限公司 | 经基因组修饰以表达正交受体的人免疫细胞 |
-
2022
- 2022-03-09 CN CN202280033752.0A patent/CN117377682A/zh active Pending
- 2022-03-09 EP EP22767860.4A patent/EP4305054A4/en active Pending
- 2022-03-09 JP JP2023555231A patent/JP2024509917A/ja active Pending
- 2022-03-09 US US18/549,503 patent/US20240299541A1/en active Pending
- 2022-03-09 WO PCT/US2022/019479 patent/WO2022192346A1/en not_active Ceased
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