JPWO2022173667A5 - - Google Patents
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- Publication number
- JPWO2022173667A5 JPWO2022173667A5 JP2023547812A JP2023547812A JPWO2022173667A5 JP WO2022173667 A5 JPWO2022173667 A5 JP WO2022173667A5 JP 2023547812 A JP2023547812 A JP 2023547812A JP 2023547812 A JP2023547812 A JP 2023547812A JP WO2022173667 A5 JPWO2022173667 A5 JP WO2022173667A5
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- JP
- Japan
- Prior art keywords
- compound
- lipid
- group
- hydrolysis
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 45
- 150000002632 lipids Chemical class 0.000 claims 21
- 230000007062 hydrolysis Effects 0.000 claims 12
- 238000006460 hydrolysis reaction Methods 0.000 claims 12
- OQQOAWVKVDAJOI-VWLOTQADSA-N 1,2-dilauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCCCCCC OQQOAWVKVDAJOI-VWLOTQADSA-N 0.000 claims 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 8
- 230000002209 hydrophobic effect Effects 0.000 claims 7
- 125000005647 linker group Chemical group 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 5
- JFBCSFJKETUREV-LJAQVGFWSA-N 1,2-ditetradecanoyl-sn-glycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCCCCCCCC JFBCSFJKETUREV-LJAQVGFWSA-N 0.000 claims 4
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 4
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 4
- 150000001408 amides Chemical class 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 4
- 229920001400 block copolymer Polymers 0.000 claims 4
- 150000007942 carboxylates Chemical class 0.000 claims 4
- 125000005265 dialkylamine group Chemical group 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 4
- 150000002313 glycerolipids Chemical class 0.000 claims 4
- 150000003904 phospholipids Chemical class 0.000 claims 4
- 229920005604 random copolymer Polymers 0.000 claims 4
- 150000003852 triazoles Chemical class 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 239000003999 initiator Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 229910052796 boron Inorganic materials 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000012038 nucleophile Substances 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 125000002355 alkine group Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163147470P | 2021-02-09 | 2021-02-09 | |
| US63/147,470 | 2021-02-09 | ||
| US17/665,190 US12233132B2 (en) | 2021-02-09 | 2022-02-04 | Polyoxazoline-lipid conjugates and lipid nanoparticles and pharmaceutical compositions including same |
| US17/665,190 | 2022-02-04 | ||
| PCT/US2022/015314 WO2022173667A1 (en) | 2021-02-09 | 2022-02-04 | Polyoxazoline-lipid conjugates and lipid nanoparticles and pharmaceutical compositions including same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024505723A JP2024505723A (ja) | 2024-02-07 |
| JPWO2022173667A5 true JPWO2022173667A5 (https=) | 2025-03-06 |
| JP2024505723A5 JP2024505723A5 (https=) | 2025-03-06 |
Family
ID=82703446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023547812A Pending JP2024505723A (ja) | 2021-02-09 | 2022-02-04 | ポリオキサゾリン－脂質コンジュゲート並びにそれらを含む脂質ナノ粒子及び医薬組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12233132B2 (https=) |
| EP (1) | EP4291242A4 (https=) |
| JP (1) | JP2024505723A (https=) |
| KR (1) | KR20230144574A (https=) |
| CN (1) | CN117098558A (https=) |
| AU (1) | AU2022219902A1 (https=) |
| CA (1) | CA3206128A1 (https=) |
| IL (1) | IL304773A (https=) |
| WO (1) | WO2022173667A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023031392A2 (en) | 2021-09-03 | 2023-03-09 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine |
| MX2024002726A (es) | 2021-09-03 | 2024-03-20 | CureVac SE | Nuevas nanoparticulas lipidicas para la administracion de acidos nucleicos. |
| WO2023073228A1 (en) | 2021-10-29 | 2023-05-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| CN118900701A (zh) * | 2022-01-31 | 2024-11-05 | 盖纳万科学有限公司 | 聚(烷基噁唑啉)-脂质缀合物及含有聚(烷基噁唑啉)-脂质缀合物的脂质颗粒 |
| AU2023425729A1 (en) * | 2023-01-20 | 2025-07-17 | Serina Therapeutics (Al), Inc. | Targeting of antigen-presenting cells by nanoparticles containing polyoxazoline-lipid conjugates |
| KR20250153298A (ko) | 2023-03-08 | 2025-10-24 | 큐어백 에스이 | 핵산 전달을 위한 신규의 지질 나노입자 제형 |
| WO2024192291A1 (en) | 2023-03-15 | 2024-09-19 | Renagade Therapeutics Management Inc. | Delivery of gene editing systems and methods of use thereof |
| EP4680595A2 (en) | 2023-03-15 | 2026-01-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| IL324725A (en) * | 2023-06-15 | 2026-01-01 | Serina Therapeutics Al Inc | Poly(oxazoline) conjugates with pendant cationic groups and lipid nanoparticles and polyplexes comprising them |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025137256A1 (en) * | 2023-12-20 | 2025-06-26 | Wu Nian | Polyoxazoline-carbohydrate-lipid conjugates |
| WO2025134071A1 (en) | 2023-12-22 | 2025-06-26 | Sanofi | Malic and glutaric acid based ionizable lipids |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025196065A1 (en) | 2024-03-20 | 2025-09-25 | Sanofi | Novel homocysteine based lipids and their use for delivery of nucleic acids |
| WO2025257084A1 (en) * | 2024-06-10 | 2025-12-18 | Isar Bioscience Gmbh | Lipid composition |
| WO2026008743A1 (en) | 2024-07-02 | 2026-01-08 | Sanofi Pasteur Inc. | Water-soluble polyanionic polymer as adjuvant for carrier-formulated nucleic acid |
| WO2026053147A1 (en) | 2024-09-05 | 2026-03-12 | Sanofi Pasteur Inc. | Helper lipids and lnp compositions comprising same |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| JP2602544B2 (ja) * | 1989-03-20 | 1997-04-23 | 花王株式会社 | 新規オリゴマー、その製法および用途 |
| US5395619A (en) * | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| JPH08286313A (ja) * | 1995-04-14 | 1996-11-01 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| US20020001614A1 (en) * | 2000-02-10 | 2002-01-03 | Kent Jorgensen | Lipid-based drug delivery systems containing phospholipase A2 degradable lipid derivatives and the therapeutic uses thereof |
| KR101508621B1 (ko) | 2007-02-28 | 2015-04-07 | 세리나 쎄라퓨틱스, 인코포레이티드 | 활성화된 폴리옥사졸린 및 이를 포함하는 조성물 |
| US8088884B2 (en) | 2007-09-27 | 2012-01-03 | Serina Therapeutics, Inc. | Multi-armed forms of activated polyoxazoline and methods of synthesis thereof |
| US8110651B2 (en) | 2008-01-11 | 2012-02-07 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
| US8101706B2 (en) | 2008-01-11 | 2012-01-24 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
| JP5642673B2 (ja) * | 2008-07-10 | 2014-12-17 | セリナ・セラピユーテイツクス・インコーポレーテツド | 不活性末端基を有するポリオキサゾリン類、保護された開始基から調製されるポリオキサゾリン類及び関連化合物 |
| US20110313017A1 (en) * | 2010-01-13 | 2011-12-22 | Protiva Biotherapeutics, Inc. | Snalp formulations containing polyoxazoline-dialkyloxypropyl conjugates |
| SG186085A1 (en) * | 2010-06-03 | 2013-01-30 | Alnylam Pharmaceuticals Inc | Biodegradable lipids for the delivery of active agents |
| PT3970742T (pt) * | 2010-08-31 | 2022-06-27 | Glaxosmithkline Biologicals Sa | Lipossomas peguilados para entrega de arn codificador de imunogénio |
| US8383093B1 (en) | 2011-11-01 | 2013-02-26 | Serina Therapeutics, Inc. | Subcutaneous delivery of poly(oxazoline) conjugates |
| US12485181B2 (en) * | 2019-06-28 | 2025-12-02 | Serina Therapeutics (Al), Inc. | Polyoxazoline-drug conjugates with novel pharmacokinetic properties |
-
2022
- 2022-02-04 CN CN202280026034.0A patent/CN117098558A/zh active Pending
- 2022-02-04 CA CA3206128A patent/CA3206128A1/en active Pending
- 2022-02-04 US US17/665,190 patent/US12233132B2/en active Active
- 2022-02-04 JP JP2023547812A patent/JP2024505723A/ja active Pending
- 2022-02-04 WO PCT/US2022/015314 patent/WO2022173667A1/en not_active Ceased
- 2022-02-04 KR KR1020237030341A patent/KR20230144574A/ko active Pending
- 2022-02-04 AU AU2022219902A patent/AU2022219902A1/en active Pending
- 2022-02-04 EP EP22753169.6A patent/EP4291242A4/en active Pending
-
2023
- 2023-07-26 IL IL304773A patent/IL304773A/en unknown
- 2023-11-07 US US18/387,528 patent/US20240108750A1/en active Pending
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