JPWO2022162471A5 - - Google Patents
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- JPWO2022162471A5 JPWO2022162471A5 JP2023544649A JP2023544649A JPWO2022162471A5 JP WO2022162471 A5 JPWO2022162471 A5 JP WO2022162471A5 JP 2023544649 A JP2023544649 A JP 2023544649A JP 2023544649 A JP2023544649 A JP 2023544649A JP WO2022162471 A5 JPWO2022162471 A5 JP WO2022162471A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- cycloalkyl
- heterocycloalkyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 111
- 125000000217 alkyl group Chemical group 0.000 claims 59
- 229910052736 halogen Inorganic materials 0.000 claims 43
- 150000002367 halogens Chemical class 0.000 claims 43
- 125000000753 cycloalkyl group Chemical group 0.000 claims 36
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 36
- 229910005965 SO 2 Inorganic materials 0.000 claims 33
- 125000003342 alkenyl group Chemical group 0.000 claims 24
- 125000000304 alkynyl group Chemical group 0.000 claims 24
- 125000004103 aminoalkyl group Chemical group 0.000 claims 17
- 125000003282 alkyl amino group Chemical group 0.000 claims 16
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 16
- 125000003710 aryl alkyl group Chemical group 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 16
- 125000001072 heteroaryl group Chemical group 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- -1 C(O)-alkyl Chemical group 0.000 claims 9
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 9
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- XCUAIINAJCDIPM-XVFCMESISA-N N(4)-hydroxycytidine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=NO)C=C1 XCUAIINAJCDIPM-XVFCMESISA-N 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 229910020008 S(O) Inorganic materials 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004806 ferroptosis Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 208000012268 mitochondrial disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163142333P | 2021-01-27 | 2021-01-27 | |
| US63/142,333 | 2021-01-27 | ||
| PCT/IB2022/000049 WO2022162471A1 (en) | 2021-01-27 | 2022-01-27 | Urolithin derivatives and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024503753A JP2024503753A (ja) | 2024-01-26 |
| JPWO2022162471A5 true JPWO2022162471A5 (https=) | 2025-01-31 |
| JP2024503753A5 JP2024503753A5 (https=) | 2025-01-31 |
Family
ID=80595402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023544649A Pending JP2024503753A (ja) | 2021-01-27 | 2022-01-27 | ウロリチン誘導体及びその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11820751B2 (https=) |
| EP (1) | EP4284781A1 (https=) |
| JP (1) | JP2024503753A (https=) |
| KR (1) | KR20230153533A (https=) |
| CN (1) | CN117015530A (https=) |
| AU (1) | AU2022212883A1 (https=) |
| BR (1) | BR112023014973A2 (https=) |
| CA (1) | CA3206062A1 (https=) |
| IL (1) | IL304680A (https=) |
| MX (1) | MX2023008677A (https=) |
| WO (1) | WO2022162471A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022143864A1 (zh) * | 2020-12-31 | 2022-07-07 | 江苏先声药业有限公司 | 三环类化合物及用途 |
| CA3206062A1 (en) | 2021-01-27 | 2022-08-04 | Said Oumouch | Urolithin derivatives and methods of use thereof |
| WO2023228994A1 (ja) * | 2022-05-25 | 2023-11-30 | 株式会社ダイセル | Ｓｉｒｔ３遺伝子発現増強用組成物 |
| US20240139149A1 (en) * | 2022-07-27 | 2024-05-02 | Vandria Sa | Therapeutic uses of urolithin derivatives |
| CN119948002A (zh) * | 2022-07-27 | 2025-05-06 | 范徳利亚股份公司 | 尿石素衍生物和治疗用途 |
| WO2024119140A1 (en) | 2022-12-01 | 2024-06-06 | Massachusetts Institute Of Technology | Cleavable comonomer strategy for accelerating removal of gel nail polish |
| EP4712958A2 (en) * | 2023-05-18 | 2026-03-25 | Vandria SA | Use of urolithin derivatives in the treatment of amyotrophic lateral sclerosis |
| CN116715649A (zh) * | 2023-06-07 | 2023-09-08 | 武汉大学人民医院（湖北省人民医院） | 肝癌药四碳链环己亚胺甲基尿石素a及其制备方法和应用 |
| CN116715650A (zh) * | 2023-06-07 | 2023-09-08 | 武汉大学人民医院（湖北省人民医院） | 尿石素类衍生物及其制备方法和应用 |
| CN119661547A (zh) * | 2023-09-20 | 2025-03-21 | 科辉智药(深圳)新药研究中心有限公司 | 作为sarm1酶活性抑制剂的三环吡啶类化合物及其应用 |
| CN121318904A (zh) * | 2024-07-12 | 2026-01-13 | 深圳市翰林生物医药科技有限公司 | 用于改善线粒体功能、防治衰老和线粒体相关疾病的化合物及其制备方法和应用 |
| CN119504692A (zh) * | 2024-11-21 | 2025-02-25 | 常州大学 | 磷酸二酯酶2抑制剂的3,8-二羟基-6H-苯并[c]色烯-6-酮类8位羟基醚化衍生物及其应用 |
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| CA3206062A1 (en) | 2021-01-27 | 2022-08-04 | Said Oumouch | Urolithin derivatives and methods of use thereof |
| CN119948002A (zh) | 2022-07-27 | 2025-05-06 | 范徳利亚股份公司 | 尿石素衍生物和治疗用途 |
| US20240139149A1 (en) | 2022-07-27 | 2024-05-02 | Vandria Sa | Therapeutic uses of urolithin derivatives |
| EP4712958A2 (en) | 2023-05-18 | 2026-03-25 | Vandria SA | Use of urolithin derivatives in the treatment of amyotrophic lateral sclerosis |
-
2022
- 2022-01-27 CA CA3206062A patent/CA3206062A1/en active Pending
- 2022-01-27 AU AU2022212883A patent/AU2022212883A1/en active Pending
- 2022-01-27 KR KR1020237028804A patent/KR20230153533A/ko active Pending
- 2022-01-27 JP JP2023544649A patent/JP2024503753A/ja active Pending
- 2022-01-27 EP EP22706901.0A patent/EP4284781A1/en active Pending
- 2022-01-27 MX MX2023008677A patent/MX2023008677A/es unknown
- 2022-01-27 WO PCT/IB2022/000049 patent/WO2022162471A1/en not_active Ceased
- 2022-01-27 BR BR112023014973A patent/BR112023014973A2/pt unknown
- 2022-01-27 CN CN202280022588.3A patent/CN117015530A/zh active Pending
- 2022-01-27 US US17/586,294 patent/US11820751B2/en active Active
-
2023
- 2023-07-24 IL IL304680A patent/IL304680A/en unknown
- 2023-11-16 US US18/511,612 patent/US12473269B2/en active Active
- 2023-11-16 US US18/511,627 patent/US12358884B2/en active Active
- 2023-11-16 US US18/511,586 patent/US12351567B2/en active Active
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