JPWO2022159758A5 - - Google Patents
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- Publication number
- JPWO2022159758A5 JPWO2022159758A5 JP2023544203A JP2023544203A JPWO2022159758A5 JP WO2022159758 A5 JPWO2022159758 A5 JP WO2022159758A5 JP 2023544203 A JP2023544203 A JP 2023544203A JP 2023544203 A JP2023544203 A JP 2023544203A JP WO2022159758 A5 JPWO2022159758 A5 JP WO2022159758A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- endonuclease
- seq
- fusion
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163140620P | 2021-01-22 | 2021-01-22 | |
| US63/140,620 | 2021-01-22 | ||
| US202163237484P | 2021-08-26 | 2021-08-26 | |
| US63/237,484 | 2021-08-26 | ||
| PCT/US2022/013396 WO2022159758A1 (en) | 2021-01-22 | 2022-01-21 | Novel engineered and chimeric nucleases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024504981A JP2024504981A (ja) | 2024-02-02 |
| JP2024504981A5 JP2024504981A5 (https=) | 2025-01-27 |
| JPWO2022159758A5 true JPWO2022159758A5 (https=) | 2025-01-27 |
Family
ID=82549895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023544203A Pending JP2024504981A (ja) | 2021-01-22 | 2022-01-21 | 新規の操作されたヌクレアーゼおよびキメラヌクレアーゼ |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230416710A1 (https=) |
| EP (1) | EP4281554A4 (https=) |
| JP (1) | JP2024504981A (https=) |
| KR (1) | KR20230134543A (https=) |
| AU (1) | AU2022210762A1 (https=) |
| BR (1) | BR112023014719A2 (https=) |
| CA (1) | CA3205865A1 (https=) |
| GB (1) | GB2610711B (https=) |
| MX (1) | MX2023008629A (https=) |
| WO (1) | WO2022159758A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2617658B (en) | 2020-03-06 | 2024-04-17 | Metagenomi Inc | Class II, type V CRISPR systems |
| CA3225082A1 (en) * | 2021-08-27 | 2023-03-02 | Brian C. Thomas | Enzymes with ruvc domains |
| WO2023178115A2 (en) * | 2022-03-14 | 2023-09-21 | Metagenomi, Inc. | Engineered and chimeric nucleases |
| CN119546757A (zh) | 2022-05-25 | 2025-02-28 | 宏基因组学公司 | 肝酶表达的补充 |
| WO2023240076A1 (en) | 2022-06-07 | 2023-12-14 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of pcsk9 |
| EP4562138A2 (en) * | 2022-07-29 | 2025-06-04 | Metagenomi, Inc. | Class ii, type v crispr systems |
| WO2024156085A1 (en) * | 2023-01-27 | 2024-08-02 | Syngenta Crop Protection Ag | Mb2cas12a variants with enhanced efficiency |
| KR20250153814A (ko) * | 2023-03-01 | 2025-10-27 | 메타지노미, 인크. | Ruvc 도메인을 갖는 효소 |
| AU2024339645A1 (en) * | 2023-09-13 | 2026-04-23 | Metagenomi Therapeutics, Inc. | Engineered and chimeric nucleases |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3363902B1 (en) * | 2012-12-06 | 2019-11-27 | Sigma Aldrich Co. LLC | Crispr-based genome modification and regulation |
| US9963689B2 (en) * | 2013-12-31 | 2018-05-08 | The Regents Of The University Of California | Cas9 crystals and methods of use thereof |
| WO2016205759A1 (en) * | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation |
| JP2020536502A (ja) * | 2017-09-07 | 2020-12-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 遺伝子操作のためのヌクレアーゼシステム |
| US12365888B2 (en) * | 2018-12-14 | 2025-07-22 | Pioneer Hi-Bred International, Inc. | CRISPR-Cas systems for genome editing |
| AU2020223370B2 (en) * | 2019-02-14 | 2023-04-20 | Metagenomi Therapeutics, Inc. | Enzymes with RuvC domains |
| US10913941B2 (en) * | 2019-02-14 | 2021-02-09 | Metagenomi Ip Technologies, Llc | Enzymes with RuvC domains |
| KR20230021657A (ko) * | 2020-05-08 | 2023-02-14 | 메타지노미, 인크. | Ruvc 도메인을 포함하는 효소 |
| CA3192224A1 (en) * | 2020-09-11 | 2022-03-17 | Jyun-Liang LIN | Base editing enzymes |
| BR112023018948A2 (pt) * | 2021-03-19 | 2023-10-17 | Metagenomi Inc | Edição multiplex com enzimas cas |
| AU2022380842A1 (en) * | 2021-11-05 | 2024-05-23 | Metagenomi Therapeutics, Inc. | Base editing enzymes |
-
2022
- 2022-01-21 BR BR112023014719A patent/BR112023014719A2/pt unknown
- 2022-01-21 KR KR1020237028011A patent/KR20230134543A/ko active Pending
- 2022-01-21 AU AU2022210762A patent/AU2022210762A1/en active Pending
- 2022-01-21 JP JP2023544203A patent/JP2024504981A/ja active Pending
- 2022-01-21 GB GB2215621.0A patent/GB2610711B/en active Active
- 2022-01-21 EP EP22743281.2A patent/EP4281554A4/en active Pending
- 2022-01-21 WO PCT/US2022/013396 patent/WO2022159758A1/en not_active Ceased
- 2022-01-21 MX MX2023008629A patent/MX2023008629A/es unknown
- 2022-01-21 CA CA3205865A patent/CA3205865A1/en active Pending
- 2022-11-17 US US18/056,629 patent/US20230416710A1/en active Pending
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