JPWO2022147442A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022147442A5 JPWO2022147442A5 JP2023539809A JP2023539809A JPWO2022147442A5 JP WO2022147442 A5 JPWO2022147442 A5 JP WO2022147442A5 JP 2023539809 A JP2023539809 A JP 2023539809A JP 2023539809 A JP2023539809 A JP 2023539809A JP WO2022147442 A5 JPWO2022147442 A5 JP WO2022147442A5
- Authority
- JP
- Japan
- Prior art keywords
- aac
- formulation
- cells
- aacs
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims description 91
- 239000000203 mixture Substances 0.000 claims description 91
- 239000008194 pharmaceutical composition Substances 0.000 claims description 65
- 210000004027 cell Anatomy 0.000 claims description 50
- 101150095491 AACS gene Proteins 0.000 claims description 45
- 239000000427 antigen Substances 0.000 claims description 45
- 102000036639 antigens Human genes 0.000 claims description 45
- 108091007433 antigens Proteins 0.000 claims description 45
- 239000002671 adjuvant Substances 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 34
- 239000012595 freezing medium Substances 0.000 claims description 31
- 238000007710 freezing Methods 0.000 claims description 19
- 230000008014 freezing Effects 0.000 claims description 19
- 210000000948 non-nucleated cell Anatomy 0.000 claims description 18
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 16
- 238000010257 thawing Methods 0.000 claims description 16
- 230000003247 decreasing effect Effects 0.000 claims description 7
- 102000000412 Annexin Human genes 0.000 claims description 6
- 108050008874 Annexin Proteins 0.000 claims description 6
- 238000005119 centrifugation Methods 0.000 claims description 6
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 claims description 4
- 239000000556 agonist Substances 0.000 claims description 4
- 239000006285 cell suspension Substances 0.000 claims description 4
- 239000002158 endotoxin Substances 0.000 claims description 4
- 210000003743 erythrocyte Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000010186 staining Methods 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 108090000672 Annexin A5 Proteins 0.000 claims description 2
- 102000004121 Annexin A5 Human genes 0.000 claims description 2
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims description 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims description 2
- 102000006992 Interferon-alpha Human genes 0.000 claims description 2
- 108010047761 Interferon-alpha Proteins 0.000 claims description 2
- 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 claims description 2
- 229940044606 RIG-I agonist Drugs 0.000 claims description 2
- 229940044665 STING agonist Drugs 0.000 claims description 2
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims description 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims description 2
- 229940115272 polyinosinic:polycytidylic acid Drugs 0.000 claims description 2
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 241000701806 Human papillomavirus Species 0.000 description 6
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 241000341655 Human papillomavirus type 16 Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063131457P | 2020-12-29 | 2020-12-29 | |
| US63/131,457 | 2020-12-29 | ||
| PCT/US2021/073142 WO2022147442A1 (en) | 2020-12-29 | 2021-12-28 | Formulations of activating antigen carriers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024503277A JP2024503277A (ja) | 2024-01-25 |
| JP2024503277A5 JP2024503277A5 (https=) | 2024-12-25 |
| JPWO2022147442A5 true JPWO2022147442A5 (https=) | 2024-12-25 |
Family
ID=80123528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023539809A Pending JP2024503277A (ja) | 2020-12-29 | 2021-12-28 | 活性化抗原担体の製剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220233676A1 (https=) |
| EP (1) | EP4271407A1 (https=) |
| JP (1) | JP2024503277A (https=) |
| CN (1) | CN116847880A (https=) |
| CA (1) | CA3203709A1 (https=) |
| WO (1) | WO2022147442A1 (https=) |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770478B2 (en) * | 2000-02-10 | 2004-08-03 | The Regents Of The University Of California | Erythrocytic cells and method for preserving cells |
| WO2005072523A2 (en) * | 2004-02-02 | 2005-08-11 | I.M.T. Interface Multigrad Technology Ltd. | Biological material and methods and solutions for preservation thereof |
| ES2482192T3 (es) * | 2007-05-31 | 2014-08-01 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Vacunación intradérmica del péptido de HPV |
| CN107058101B (zh) | 2011-10-17 | 2021-06-01 | 麻省理工学院 | 细胞内传递 |
| EP3033184B1 (en) | 2013-08-16 | 2021-03-31 | Massachusetts Institute of Technology | Selective delivery of material to cells |
| ES2865825T3 (es) * | 2014-04-01 | 2021-10-18 | Rubius Therapeutics Inc | Procedimientos y composiciones para inmunomodulación |
| JP7523203B2 (ja) * | 2014-10-31 | 2024-07-26 | マサチューセッツ インスティテュート オブ テクノロジー | 生体分子の免疫細胞への送達 |
| SG10201912910PA (en) | 2015-07-09 | 2020-02-27 | Massachusetts Inst Technology | Delivery of materials to anucleate cells |
| ES2930017T3 (es) | 2015-09-04 | 2022-12-05 | Sqz Biotechnologies Co | Suministro intracelular de biomoléculas mediado por una superficie con poros |
| CN108779475A (zh) * | 2016-01-12 | 2018-11-09 | Sqz生物技术公司 | 复合物的细胞内递送 |
| JP7602702B2 (ja) | 2016-05-03 | 2024-12-19 | ステムセル テクノロジーズ カナダ インコーポレーテッド | 寛容性を誘導するための生体分子の細胞内送達 |
| KR102490952B1 (ko) | 2016-05-03 | 2023-01-19 | 에스큐지 바이오테크놀로지스 컴퍼니 | 관용을 유도하는 생체분자의 세포내 전달 |
| EP3765068A2 (en) | 2018-03-12 | 2021-01-20 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to modify immune response |
| US12599656B2 (en) | 2018-03-12 | 2026-04-14 | Stemcell Technologies Canada Inc. | Methods for treating HPV-associated diseases |
| KR20210070338A (ko) | 2018-10-04 | 2021-06-14 | 에스큐지 바이오테크놀로지스 컴퍼니 | 항원 제시 세포 기능을 증진시키기 위한 생체분자의 세포내 전달 |
| WO2020154696A1 (en) | 2019-01-25 | 2020-07-30 | Sqz Biotechnologies Company | Anucleate cell-derived vaccines |
| CA3131701A1 (en) | 2019-02-28 | 2020-09-03 | Sqz Biotechnologies Company | Delivery of biomolecules to pbmcs to modify an immune response |
| EP4188425B1 (en) * | 2020-07-29 | 2025-05-14 | Stemcell Technologies Canada Inc. | Methods to stimulate immune responses to mutant ras using anucleate cells |
-
2021
- 2021-12-28 US US17/563,780 patent/US20220233676A1/en active Pending
- 2021-12-28 CN CN202180094095.6A patent/CN116847880A/zh active Pending
- 2021-12-28 WO PCT/US2021/073142 patent/WO2022147442A1/en not_active Ceased
- 2021-12-28 JP JP2023539809A patent/JP2024503277A/ja active Pending
- 2021-12-28 CA CA3203709A patent/CA3203709A1/en active Pending
- 2021-12-28 EP EP21851939.5A patent/EP4271407A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Scotti et al. | Flock house virus: a Nodavirus isolated from Costelytra zealandica (White)(Coleoptera: Scarabaeida) | |
| US20220411823A1 (en) | Platelets transfected by exogenous genetic material and platelet microparticles obtained by said transfected platelets, method for the preparation and uses thereof | |
| CN110804586B (zh) | 一种临床级人诱导多能干细胞源间充质干细胞的制备方法及试剂盒 | |
| McGuckin et al. | Embryonic-like stem cells from umbilical cord blood and potential for neural modeling | |
| RU2012130928A (ru) | Способ культивирования адгезионных клеток | |
| CA2423038A1 (en) | Live vaccine and method of manufacture | |
| CN103275925A (zh) | 鳜鱼脑细胞系的构建方法 | |
| KR20100087705A (ko) | 인간 탯줄로부터 전구 세포를 분리하고 보존하기 위한 최적화되고 규정된 방법 | |
| CN110862968A (zh) | Map3k8基因敲除pk-15细胞系的构建方法及其应用 | |
| CN109628373B (zh) | 一种收获三维微载体上的细胞的方法 | |
| CN110583622A (zh) | 一种t细胞无血清冻存液及其使用方法 | |
| JP7397493B2 (ja) | 治療用途のための樹状細胞のｉｎ ｖｉｔｒｏ分化および成熟のための方法 | |
| US20220073868A1 (en) | Systems and methods for culturing cells in suspension | |
| CN115466711A (zh) | 一种获得无病毒细胞系的方法及其所获得的无病毒细胞系 | |
| JPWO2022147442A5 (https=) | ||
| CN117327647A (zh) | 一种高纯度Muse细胞的培养方法 | |
| JP6563145B2 (ja) | 不死化汗腺筋上皮細胞 | |
| RU2230784C2 (ru) | Способ получения клеток млекопитающих для использования в производстве вирусов | |
| US20230241123A1 (en) | Pluripotent stem cell and derivative thereof | |
| CN103421839B (zh) | 瓜类褪绿黄化病毒侵染性载体的构建方法 | |
| CN111235150B (zh) | 用于抑制非洲猪瘟病毒复制的shRNA及其用途 | |
| CN102899316B (zh) | 磷硫酰化dna的酶促合成方法 | |
| CN112980767B (zh) | 一种无诺达病毒的单克隆昆虫细胞系及其应用 | |
| JPWO2022147017A5 (https=) | ||
| Armitage et al. | High-Yield Monocyte, Macrophage, and Dendritic Cell Differentiation from Induced Pluripotent Stem Cells |