JPWO2022140252A5 - - Google Patents

Info

Publication number

JPWO2022140252A5

JPWO2022140252A5 JP2023537357A JP2023537357A JPWO2022140252A5 JP WO2022140252 A5 JPWO2022140252 A5 JP WO2022140252A5 JP 2023537357 A JP2023537357 A JP 2023537357A JP 2023537357 A JP2023537357 A JP 2023537357A JP WO2022140252 A5 JPWO2022140252 A5 JP WO2022140252A5

Authority

JP

Japan

Prior art keywords

optionally substituted

sulfur

nitrogen

oxygen

membered

Prior art date

2024-12-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 50
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 50
• 125000005842 heteroatom Chemical group 0.000 claims 50
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 50
• 229910052757 nitrogen Inorganic materials 0.000 claims 50
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 50
• 239000001301 oxygen Chemical group 0.000 claims 50
• 229910052760 oxygen Inorganic materials 0.000 claims 50
• 239000011593 sulfur Chemical group 0.000 claims 50
• 229910052717 sulfur Inorganic materials 0.000 claims 50
• 125000000623 heterocyclic group Chemical group 0.000 claims 32
• 239000001257 hydrogen Substances 0.000 claims 29
• 229910052739 hydrogen Inorganic materials 0.000 claims 29
• 125000002723 alicyclic group Chemical group 0.000 claims 27
• 125000001931 aliphatic group Chemical group 0.000 claims 24
• 125000005466 alkylenyl group Chemical group 0.000 claims 24
• 150000001875 compounds Chemical class 0.000 claims 21
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
• -1 1-adamantyl Chemical group 0.000 claims 16
• 238000000034 method Methods 0.000 claims 16
• 150000002431 hydrogen Chemical class 0.000 claims 15
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
• 125000004429 atom Chemical group 0.000 claims 13
• 239000008194 pharmaceutical composition Substances 0.000 claims 13
• 239000003795 chemical substances by application Substances 0.000 claims 12
• 230000000069 prophylactic effect Effects 0.000 claims 12
• 150000003839 salts Chemical class 0.000 claims 12
• 230000001225 therapeutic effect Effects 0.000 claims 12
• 150000001204 N-oxides Chemical class 0.000 claims 9
• 210000004027 cell Anatomy 0.000 claims 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
• 125000003670 adamantan-2-yl group Chemical group [H]C1([H])C(C2([H])[H])([H])C([H])([H])C3([H])C([*])([H])C1([H])C([H])([H])C2([H])C3([H])[H] 0.000 claims 6
• 125000002619 bicyclic group Chemical group 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 4
• 150000002632 lipids Chemical class 0.000 claims 3
• 210000004962 mammalian cell Anatomy 0.000 claims 3
• 108020004999 messenger RNA Proteins 0.000 claims 3
• 210000000056 organ Anatomy 0.000 claims 3
• 230000003393 splenic effect Effects 0.000 claims 3
• 208000035475 disorder Diseases 0.000 claims 2
• 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 210000001616 monocyte Anatomy 0.000 claims 2
• 239000002105 nanoparticle Substances 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• 229930182558 Sterol Natural products 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 230000033289 adaptive immune response Effects 0.000 claims 1
• 210000003719 b-lymphocyte Anatomy 0.000 claims 1
• 210000001185 bone marrow Anatomy 0.000 claims 1
• 210000002798 bone marrow cell Anatomy 0.000 claims 1
• 210000003169 central nervous system Anatomy 0.000 claims 1
• 210000002064 heart cell Anatomy 0.000 claims 1
• 210000003494 hepatocyte Anatomy 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 210000002865 immune cell Anatomy 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 210000003292 kidney cell Anatomy 0.000 claims 1
• 210000005229 liver cell Anatomy 0.000 claims 1
• 210000000663 muscle cell Anatomy 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 150000003904 phospholipids Chemical class 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 210000004989 spleen cell Anatomy 0.000 claims 1
• 150000003432 sterols Chemical class 0.000 claims 1
• 235000003702 sterols Nutrition 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 238000002255 vaccination Methods 0.000 claims 1