JPWO2022109398A5 - - Google Patents
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- Publication number
- JPWO2022109398A5 JPWO2022109398A5 JP2023530843A JP2023530843A JPWO2022109398A5 JP WO2022109398 A5 JPWO2022109398 A5 JP WO2022109398A5 JP 2023530843 A JP2023530843 A JP 2023530843A JP 2023530843 A JP2023530843 A JP 2023530843A JP WO2022109398 A5 JPWO2022109398 A5 JP WO2022109398A5
- Authority
- JP
- Japan
- Prior art keywords
- antisense strand
- nucleotides
- dsrna
- sense strand
- strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063117005P | 2020-11-23 | 2020-11-23 | |
| US63/117,005 | 2020-11-23 | ||
| PCT/US2021/060356 WO2022109398A1 (en) | 2020-11-23 | 2021-11-22 | Oligonucleotides for dgat2 modulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023550485A JP2023550485A (ja) | 2023-12-01 |
| JPWO2022109398A5 true JPWO2022109398A5 (https=) | 2024-11-29 |
| JP2023550485A5 JP2023550485A5 (https=) | 2024-11-29 |
Family
ID=81709762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023530843A Pending JP2023550485A (ja) | 2020-11-23 | 2021-11-22 | Ｄｇａｔ２調節のためのオリゴヌクレオチド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220228141A1 (https=) |
| EP (1) | EP4247391A4 (https=) |
| JP (1) | JP2023550485A (https=) |
| AU (1) | AU2021382621A1 (https=) |
| WO (1) | WO2022109398A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3277811B1 (en) | 2015-04-03 | 2020-12-23 | University of Massachusetts | Fully stabilized asymmetric sirna |
| US10633653B2 (en) | 2015-08-14 | 2020-04-28 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| WO2017132669A1 (en) | 2016-01-31 | 2017-08-03 | University Of Massachusetts | Branched oligonucleotides |
| CA3033368A1 (en) | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
| JP7406793B2 (ja) | 2017-06-23 | 2023-12-28 | ユニバーシティー オブ マサチューセッツ | ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法 |
| JP7627042B2 (ja) | 2018-08-23 | 2025-02-05 | ユニバーシティー オブ マサチューセッツ | Ｏ－メチルリッチ完全安定化オリゴヌクレオチド |
| CN113614232A (zh) | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
| MX2022001710A (es) | 2019-08-09 | 2022-05-10 | Univ Massachusetts | Oligonucleótidos modificados químicamente dirigidos a los snp. |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| WO2021242883A1 (en) | 2020-05-26 | 2021-12-02 | University Of Massachusetts | Synthetic oligonucleotides having regions of block and cluster modifications |
| CN116600817A (zh) * | 2020-07-16 | 2023-08-15 | 马萨诸塞大学 | 用于组织特异性递送的缀合寡核苷酸 |
| AU2022299169A1 (en) | 2021-06-23 | 2024-02-08 | Beth Israel Deaconess Medical Center, Inc. | Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders |
| WO2024228030A2 (en) * | 2023-05-04 | 2024-11-07 | Argonaute RNA Limited | Dual silencing |
| EP4705458A2 (en) * | 2023-05-04 | 2026-03-11 | Argonaute RNA Limited | Dual silencing |
| EP4712982A1 (en) * | 2023-05-17 | 2026-03-25 | University of Massachusetts | Oligonucleotides for dgat2, fasn, opn, and nox4 modulations |
| WO2024245151A1 (zh) * | 2023-05-26 | 2024-12-05 | 维亚臻生物技术（苏州）有限公司 | 一种用于代谢疾病的双链核苷酸化合物及其应用 |
| AU2024321098A1 (en) * | 2023-08-09 | 2026-03-19 | Beijing Foyou Pharma Co., Ltd | Sirna for inhibiting dgat2 gene expression, sirna conjugate or prodrug and pharmaceutical composition thereof, and use thereof |
| WO2025040139A1 (zh) * | 2023-08-23 | 2025-02-27 | 云合智药（苏州）生物科技有限公司 | 用于抑制二酰甘油-O-酰基转移酶2表达的RNAi剂及其应用 |
| CN117257764A (zh) * | 2023-09-26 | 2023-12-22 | 中国药科大学 | 一种脂滴衍生的核酸药物递送系统及其制备方法和应用 |
| CN121825964A (zh) * | 2023-12-26 | 2026-04-10 | 苏州吉玛基因股份有限公司 | 用于抑制DGAT2的siRNA及其修饰物与应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1455815A4 (en) * | 2001-12-19 | 2006-11-02 | Millennium Pharm Inc | MEMBERS OF THE DIACYLGLYCEROL-ACYLTRANSFERASES FAMILY 2 (DGAT2) AND USES THEREOF |
| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| US20190270995A1 (en) * | 2002-11-14 | 2019-09-05 | Thermo Fisher Scientific Inc. | Methods and Compositions for Selecting siRNA of Improved Functionality |
| US7825235B2 (en) * | 2003-08-18 | 2010-11-02 | Isis Pharmaceuticals, Inc. | Modulation of diacylglycerol acyltransferase 2 expression |
| KR102486617B1 (ko) * | 2013-05-22 | 2023-01-12 | 알닐람 파마슈티칼스 인코포레이티드 | Ｔｍｐｒｓｓ6 조성물 및 이의 사용 방법 |
| PT3277815T (pt) * | 2015-04-03 | 2021-11-11 | Beth Israel Deaconess Medical Ct Inc | Compostos de oligonucleótidos para o tratamento de pré-eclâmpsia e outros distúrbios angiogénicos |
| CA2991894A1 (en) * | 2015-07-10 | 2017-01-19 | Ionis Pharmaceuticals, Inc. | Modulators of diacyglycerol acyltransferase 2 (dgat2) |
| CN115175685B (zh) * | 2019-12-09 | 2024-12-13 | 艾姆皮瑞克公司 | 用于治疗血管生成素样4(angptl4)相关疾病的寡核苷酸 |
| TW202221120A (zh) * | 2020-08-04 | 2022-06-01 | 美商黛瑟納製藥公司 | 用於治療代謝症候群之組成物及方法 |
-
2021
- 2021-11-22 JP JP2023530843A patent/JP2023550485A/ja active Pending
- 2021-11-22 WO PCT/US2021/060356 patent/WO2022109398A1/en not_active Ceased
- 2021-11-22 EP EP21895761.1A patent/EP4247391A4/en active Pending
- 2021-11-22 US US17/532,636 patent/US20220228141A1/en active Pending
- 2021-11-22 AU AU2021382621A patent/AU2021382621A1/en active Pending
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