JPWO2022103960A5 - - Google Patents
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- Publication number
- JPWO2022103960A5 JPWO2022103960A5 JP2023528356A JP2023528356A JPWO2022103960A5 JP WO2022103960 A5 JPWO2022103960 A5 JP WO2022103960A5 JP 2023528356 A JP2023528356 A JP 2023528356A JP 2023528356 A JP2023528356 A JP 2023528356A JP WO2022103960 A5 JPWO2022103960 A5 JP WO2022103960A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- haloalkyl
- heterocycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 27
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims 15
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 13
- 229910052805 deuterium Inorganic materials 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 9
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- -1 C 1 -C 6 aminoalkyl Chemical group 0.000 claims 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 5
- 125000004103 aminoalkyl group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063113557P | 2020-11-13 | 2020-11-13 | |
| US202063113555P | 2020-11-13 | 2020-11-13 | |
| US63/113,557 | 2020-11-13 | ||
| US63/113,555 | 2020-11-13 | ||
| US202163170855P | 2021-04-05 | 2021-04-05 | |
| US63/170,855 | 2021-04-05 | ||
| US202163225282P | 2021-07-23 | 2021-07-23 | |
| US63/225,282 | 2021-07-23 | ||
| PCT/US2021/058978 WO2022103960A1 (en) | 2020-11-13 | 2021-11-11 | Dichlorophenol hsd17b13 inhibitors and uses thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023549494A JP2023549494A (ja) | 2023-11-27 |
| JPWO2022103960A5 true JPWO2022103960A5 (https=) | 2024-10-23 |
| JP2023549494A5 JP2023549494A5 (https=) | 2024-10-23 |
| JP7605984B2 JP7605984B2 (ja) | 2024-12-24 |
Family
ID=81602609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023528356A Active JP7605984B2 (ja) | 2020-11-13 | 2021-11-11 | ジクロロフェノールｈｓｄ１７ｂ１３阻害剤およびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11827619B2 (https=) |
| EP (1) | EP4244210A4 (https=) |
| JP (1) | JP7605984B2 (https=) |
| KR (1) | KR102852264B1 (https=) |
| CN (1) | CN116670118B (https=) |
| AU (1) | AU2021377248B2 (https=) |
| CA (1) | CA3198024A1 (https=) |
| IL (1) | IL302764A (https=) |
| MX (1) | MX2023005550A (https=) |
| TW (1) | TWI893238B (https=) |
| WO (1) | WO2022103960A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116670118B (zh) | 2020-11-13 | 2026-02-06 | 伊尼制药公司 | 二氯苯酚hsd17b13抑制剂及其用途 |
| EP4320111A4 (en) * | 2021-04-05 | 2025-03-12 | Inipharm, Inc. | HYDROXYPYRIDINE-TYPE HSD17B13 INHIBITORS AND USES THEREOF |
| JP2025503953A (ja) * | 2022-01-26 | 2025-02-06 | イニファーム，インク． | ２－置換チアゾールｈｓｄ１７ｂ１３阻害剤およびその使用 |
| DK4514782T3 (da) | 2022-05-19 | 2025-12-15 | Astrazeneca Ab | Heteroaromatiske amidoforbindelser, der er nyttige ved behandling af leversygdomme |
| WO2025024682A1 (en) * | 2023-07-26 | 2025-01-30 | Inipharm, Inc. | Methods of using dichlorophenol hsd17b13 inhibitors |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2694711A (en) | 1952-12-02 | 1954-11-16 | American Cyanamid Co | Quinazolone antimalarial compounds |
| US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| DE19642451A1 (de) | 1996-10-15 | 1998-04-16 | Merck Patent Gmbh | Aminothiophencarbonsäureamide |
| WO2004085382A1 (ja) | 2003-03-27 | 2004-10-07 | Kirin Beer Kabushiki Kaisha | 生体内リン輸送を阻害する化合物およびそれを含んでなる医薬 |
| WO2006008545A2 (en) | 2004-07-22 | 2006-01-26 | Astex Therapeutics Limited | Thiazole and isothiazole derivatives as protein kinase inhibitors |
| US20070010537A1 (en) | 2004-08-20 | 2007-01-11 | Kazumasa Hamamura | Fused pyramidine derivative and use thereof |
| EP1896476A2 (en) | 2005-06-28 | 2008-03-12 | Orchid Research Laboratories Limited | Novel pyrazolopyrimidinone derivatives |
| GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
| CN101287728A (zh) | 2005-08-17 | 2008-10-15 | 先灵公司 | 新的高亲和力噻吩基和呋喃基激酶配体 |
| DK2428513T3 (en) | 2006-09-26 | 2017-08-21 | Celgene Corp | 5-substituted quinazolinone derivatives as anti-cancer agents |
| US20080255161A1 (en) * | 2007-04-11 | 2008-10-16 | Dmitry Koltun | 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS |
| US8703768B2 (en) | 2010-06-09 | 2014-04-22 | Hoffmann-La Roche Inc. | Nitrogen containing heteroaryl compounds |
| US20120165330A1 (en) * | 2010-12-22 | 2012-06-28 | Sirtris Pharmaceuticals, Inc. | Quinazolinone and related analogs as sirtuin modulators |
| CN103288771B (zh) | 2012-02-29 | 2014-12-03 | 中国中化股份有限公司 | 异噻唑类化合物及其作为杀菌剂的用途 |
| WO2013165606A1 (en) | 2012-05-04 | 2013-11-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulators of the relaxin receptor 1 |
| CA2935495C (en) | 2013-01-14 | 2021-04-20 | Deuterx, Llc | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
| CN105524053B (zh) | 2014-10-19 | 2020-06-05 | 广东东阳光药业有限公司 | 四氢苯并噻吩化合物 |
| EP3804725A3 (en) | 2014-11-17 | 2021-07-07 | Rhode Island Hospital | Nanomaterial compositions, synthesis, and assembly |
| DK3356345T3 (da) | 2015-09-30 | 2024-02-12 | Max Planck Gesellschaft | Heteroaryl-derivater som sepiapterin-reduktase-inhibitorer |
| EP3404024B1 (en) | 2016-01-14 | 2020-11-18 | Kangpu Biopharmaceuticals, Ltd. | Quinazolinone derivative, preparation method therefor, pharmaceutical composition, and applications |
| KR101870968B1 (ko) | 2016-02-02 | 2018-06-25 | 부산대학교 산학협력단 | Ppar, fxr 및 ampk 활성화 효능을 갖는 신규 티오펜 화합물 또는 이의 약제학적으로 허용 가능한 염 및 이의 의학적 용도 |
| SI3497091T1 (sl) | 2016-08-15 | 2020-11-30 | Eli Lilly And Company | Kondenzirani derivati tiofena uporabni kot inhibitorji NAPI-IIB |
| TWI762634B (zh) | 2017-05-05 | 2022-05-01 | 大陸商上海赫普化醫藥技術有限公司 | 胺基-芳基-苯甲醯胺化合物及其使用方法 |
| BR112020015743A2 (pt) | 2018-02-08 | 2020-12-15 | Enyo Pharma | Derivados de tiofeno não fundido e seus usos |
| AU2019240214A1 (en) | 2018-03-21 | 2020-09-17 | Ionis Pharmaceuticals, Inc. | Modulation of HSD17B13 expression |
| CA3110520A1 (en) | 2018-08-24 | 2020-02-27 | Terns, Inc. | Thyroid hormone receptor beta agonist compounds |
| EP3994125B1 (en) | 2019-07-02 | 2025-12-24 | Regeneron Pharmaceuticals, Inc. | Modulators of hsd17b13 and methods of use thereof |
| WO2021211974A1 (en) | 2020-04-18 | 2021-10-21 | Inipharm, Inc. | Hsd17b13 inhibitors and uses thereof |
| WO2022020714A1 (en) | 2020-07-24 | 2022-01-27 | Inipharm, Inc. | Thiophene hsd17b13 inhibitors and uses thereof |
| EP4185380A4 (en) | 2020-07-24 | 2024-08-21 | Inipharm, Inc. | Quinazolinone hsd17b13 inhibitors and uses thereof |
| EP4192448A1 (en) | 2020-08-05 | 2023-06-14 | ENYO Pharma | Thiophen compounds for use in the treatment of renal fibrosis |
| WO2022040324A1 (en) | 2020-08-18 | 2022-02-24 | Metrea Biosciences, Inc. | COMPOUNDS AND METHODS OF MODULATING 17β-ΗYDROXYSTEROID DEHYDROGENASE TYPE 13 |
| IL301768A (en) | 2020-09-30 | 2023-05-01 | Fl2022 001 Inc | Hsd17b13 inhibitors and uses thereof |
| US20240083853A1 (en) | 2020-09-30 | 2024-03-14 | Fl2022-001, Inc. | Hsd17b13 inhibitors and uses thereof |
| CA3194376A1 (en) | 2020-09-30 | 2022-04-07 | Andrew R. Hudson | Hsd17b13 inhibitors and uses thereof |
| US20230416802A1 (en) | 2020-11-06 | 2023-12-28 | Inipharm, Inc. | Specific substrates and products of hsd17b13 as markers of liver disease and biomarkers for liver disease treatment |
| CN116670118B (zh) | 2020-11-13 | 2026-02-06 | 伊尼制药公司 | 二氯苯酚hsd17b13抑制剂及其用途 |
| WO2022216627A1 (en) | 2021-04-05 | 2022-10-13 | Inipharm, Inc. | Thiazole/isothiazole hsd17b13 inhibitors and uses thereof |
| EP4320111A4 (en) | 2021-04-05 | 2025-03-12 | Inipharm, Inc. | HYDROXYPYRIDINE-TYPE HSD17B13 INHIBITORS AND USES THEREOF |
| CN118103038A (zh) | 2021-08-20 | 2024-05-28 | 英安塔制药有限公司 | 17β-羟基类固醇脱氢酶13型抑制剂及其使用方法 |
| JP2025503953A (ja) | 2022-01-26 | 2025-02-06 | イニファーム，インク． | ２－置換チアゾールｈｓｄ１７ｂ１３阻害剤およびその使用 |
| JP2025523357A (ja) | 2022-06-09 | 2025-07-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｈｓｄ１７ｂ１３阻害剤 |
-
2021
- 2021-11-11 CN CN202180090470.XA patent/CN116670118B/zh active Active
- 2021-11-11 JP JP2023528356A patent/JP7605984B2/ja active Active
- 2021-11-11 KR KR1020237019074A patent/KR102852264B1/ko active Active
- 2021-11-11 CA CA3198024A patent/CA3198024A1/en active Pending
- 2021-11-11 EP EP21892809.1A patent/EP4244210A4/en active Pending
- 2021-11-11 IL IL302764A patent/IL302764A/en unknown
- 2021-11-11 TW TW110142108A patent/TWI893238B/zh active
- 2021-11-11 MX MX2023005550A patent/MX2023005550A/es unknown
- 2021-11-11 AU AU2021377248A patent/AU2021377248B2/en active Active
- 2021-11-11 WO PCT/US2021/058978 patent/WO2022103960A1/en not_active Ceased
-
2023
- 2023-05-10 US US18/315,138 patent/US11827619B2/en active Active
- 2023-10-02 US US18/479,578 patent/US12227489B2/en active Active
-
2025
- 2025-01-08 US US19/013,234 patent/US20250376457A1/en active Pending
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