JPWO2022094348A5 - - Google Patents
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- Publication number
- JPWO2022094348A5 JPWO2022094348A5 JP2023526200A JP2023526200A JPWO2022094348A5 JP WO2022094348 A5 JPWO2022094348 A5 JP WO2022094348A5 JP 2023526200 A JP2023526200 A JP 2023526200A JP 2023526200 A JP2023526200 A JP 2023526200A JP WO2022094348 A5 JPWO2022094348 A5 JP WO2022094348A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- endogenous gene
- chain
- transgene
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108090000623 proteins and genes Proteins 0.000 claims description 87
- 210000004027 cell Anatomy 0.000 claims description 76
- 108700019146 Transgenes Proteins 0.000 claims description 41
- 150000007523 nucleic acids Chemical class 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 27
- 102000039446 nucleic acids Human genes 0.000 claims description 27
- 108020004707 nucleic acids Proteins 0.000 claims description 27
- 108020005004 Guide RNA Proteins 0.000 claims description 26
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 24
- 101710163270 Nuclease Proteins 0.000 claims description 22
- 238000003780 insertion Methods 0.000 claims description 21
- 230000037431 insertion Effects 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 20
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 claims description 18
- 102100029452 T cell receptor alpha chain constant Human genes 0.000 claims description 15
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 12
- 229920001184 polypeptide Polymers 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 101150050925 ATP5PB gene Proteins 0.000 claims description 6
- 102000007469 Actins Human genes 0.000 claims description 6
- 108010085238 Actins Proteins 0.000 claims description 6
- 102100026031 Beta-glucuronidase Human genes 0.000 claims description 6
- 101100447432 Danio rerio gapdh-2 gene Proteins 0.000 claims description 6
- 101150112014 Gapdh gene Proteins 0.000 claims description 6
- 101150001754 Gusb gene Proteins 0.000 claims description 6
- 108010020382 Hepatocyte Nuclear Factor 1-alpha Proteins 0.000 claims description 6
- 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 claims description 6
- 101000933465 Homo sapiens Beta-glucuronidase Proteins 0.000 claims description 6
- 101001128090 Homo sapiens Homeobox protein NANOG Proteins 0.000 claims description 6
- 101150003028 Hprt1 gene Proteins 0.000 claims description 6
- 102000018251 Hypoxanthine Phosphoribosyltransferase Human genes 0.000 claims description 6
- 108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 claims description 6
- 102100031827 Myeloid zinc finger 1 Human genes 0.000 claims description 6
- 102000055601 Nanog Homeobox Human genes 0.000 claims description 6
- 101150056612 PPIA gene Proteins 0.000 claims description 6
- 102100034539 Peptidyl-prolyl cis-trans isomerase A Human genes 0.000 claims description 6
- 101710111198 Peptidyl-prolyl cis-trans isomerase A Proteins 0.000 claims description 6
- 102000011755 Phosphoglycerate Kinase Human genes 0.000 claims description 6
- 101710150336 Protein Rex Proteins 0.000 claims description 6
- 101150005678 RPS18 gene Proteins 0.000 claims description 6
- 101710191487 T cell receptor alpha chain constant Proteins 0.000 claims description 6
- 102000006467 TATA-Box Binding Protein Human genes 0.000 claims description 6
- 108010044281 TATA-Box Binding Protein Proteins 0.000 claims description 6
- 101150095461 Tfrc gene Proteins 0.000 claims description 6
- 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 claims description 6
- 102000007238 Transferrin Receptors Human genes 0.000 claims description 6
- 108010033576 Transferrin Receptors Proteins 0.000 claims description 6
- 108091000117 Tyrosine 3-Monooxygenase Proteins 0.000 claims description 6
- 102000048218 Tyrosine 3-monooxygenases Human genes 0.000 claims description 6
- 101710160552 Zinc finger protein 42 Proteins 0.000 claims description 6
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims description 6
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims description 6
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims description 6
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims description 6
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims description 6
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims description 6
- 210000002865 immune cell Anatomy 0.000 claims description 6
- 230000002438 mitochondrial effect Effects 0.000 claims description 6
- 101150079312 pgk1 gene Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 230000008685 targeting Effects 0.000 claims description 6
- 101150076297 ywhaz gene Proteins 0.000 claims description 6
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 5
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 108091033409 CRISPR Proteins 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 230000003612 virological effect Effects 0.000 claims description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
- 108091028113 Trans-activating crRNA Proteins 0.000 claims description 2
- 238000004520 electroporation Methods 0.000 claims description 2
- 108700026220 vif Genes Proteins 0.000 claims description 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 5
- 102000002278 Ribosomal Proteins Human genes 0.000 claims 5
- 108010000605 Ribosomal Proteins Proteins 0.000 claims 5
- 102000020233 phosphotransferase Human genes 0.000 claims 5
- 101000945093 Homo sapiens Ribosomal protein S6 kinase alpha-4 Proteins 0.000 claims 2
- 102100033644 Ribosomal protein S6 kinase alpha-4 Human genes 0.000 claims 2
- 102000004296 ribosomal protein S18 Human genes 0.000 claims 2
- 108090000842 ribosomal protein S18 Proteins 0.000 claims 2
- 102100039980 40S ribosomal protein S18 Human genes 0.000 claims 1
- 102000004271 Tryptophan 5-monooxygenases Human genes 0.000 claims 1
- 108090000885 Tryptophan 5-monooxygenases Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063107401P | 2020-10-29 | 2020-10-29 | |
| US63/107,401 | 2020-10-29 | ||
| PCT/US2021/057457 WO2022094348A1 (en) | 2020-10-29 | 2021-10-29 | Compositions and methods of genomic modification of cells and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023548478A JP2023548478A (ja) | 2023-11-17 |
| JP2023548478A5 JP2023548478A5 (https=) | 2024-11-05 |
| JPWO2022094348A5 true JPWO2022094348A5 (https=) | 2024-11-05 |
Family
ID=81384376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023526200A Pending JP2023548478A (ja) | 2020-10-29 | 2021-10-29 | 細胞のゲノム改変用組成物及び方法ならびにその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230365997A1 (https=) |
| EP (1) | EP4236969A4 (https=) |
| JP (1) | JP2023548478A (https=) |
| CN (1) | CN116490606A (https=) |
| WO (1) | WO2022094348A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116784280B (zh) * | 2023-08-10 | 2025-08-19 | 广东药康生物科技有限公司 | 一种tfrc人源化小鼠模型的构建方法及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210020873A (ko) * | 2018-04-05 | 2021-02-24 | 주노 쎄러퓨티크스 인코퍼레이티드 | 재조합 수용체를 발현하는 τ 세포, 관련 폴리뉴클레오티드 및 방법 |
| CN113840920A (zh) * | 2019-03-14 | 2021-12-24 | 加利福尼亚大学董事会 | 合并的敲入筛选和在内源基因座控制下共表达的异源多肽 |
-
2021
- 2021-10-29 CN CN202180078424.8A patent/CN116490606A/zh active Pending
- 2021-10-29 EP EP21887679.5A patent/EP4236969A4/en active Pending
- 2021-10-29 WO PCT/US2021/057457 patent/WO2022094348A1/en not_active Ceased
- 2021-10-29 JP JP2023526200A patent/JP2023548478A/ja active Pending
-
2023
- 2023-04-27 US US18/308,481 patent/US20230365997A1/en active Pending
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