|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
ATE164852T1
(de)
|
1990-01-24 |
1998-04-15 |
Douglas I Buckley |
Glp-1-analoga verwendbar in der diabetesbehandlung
|
|
US5869602A
(en)
|
1995-03-17 |
1999-02-09 |
Novo Nordisk A/S |
Peptide derivatives
|
|
US6268343B1
(en)
|
1996-08-30 |
2001-07-31 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
|
US7235627B2
(en)
|
1996-08-30 |
2007-06-26 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
|
US6458924B2
(en)
|
1996-08-30 |
2002-10-01 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
|
IL128332A0
(en)
*
|
1996-08-30 |
2000-01-31 |
Novo Nordisk As |
GLP-1 derivatives
|
|
UA65549C2
(uk)
|
1996-11-05 |
2004-04-15 |
Елі Ліллі Енд Компані |
Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
|
|
WO1998030575A1
(en)
|
1997-01-08 |
1998-07-16 |
Proligo Llc |
Bioconjugation of macromolecules
|
|
JP2003522099A
(ja)
|
1998-02-27 |
2003-07-22 |
ノボ ノルディスク アクティーゼルスカブ |
遅延作用プロファイルを有するglp−1のglp−1誘導体及びエキセンジン
|
|
EP1061946B1
(en)
|
1998-02-27 |
2004-04-28 |
Novo Nordisk A/S |
Glp-1 derivatives with helix-content exceeding 25 %, forming partially structured micellar-like aggregates
|
|
EP1062240B1
(en)
|
1998-02-27 |
2010-04-28 |
Novo Nordisk A/S |
N-terminally modified glp-1 derivatives
|
|
AU2610599A
(en)
|
1998-02-27 |
1999-09-15 |
Novo Nordisk A/S |
N-terminally truncated glp-1 derivatives
|
|
JP2002512175A
(ja)
|
1998-02-27 |
2002-04-23 |
ノボ ノルディスク アクティーゼルスカブ |
Glp−1類似体の誘導体類
|
|
AU5027299A
(en)
|
1998-07-31 |
2000-02-28 |
Novo Nordisk A/S |
Use of glp-1 and analogues for preventing type ii diabetes
|
|
US6444788B1
(en)
|
1999-03-15 |
2002-09-03 |
Novo Nordisk A/S |
Ion exchange chromatography of GLP-1, analogs and derivatives thereof
|
|
WO2001053480A1
(en)
*
|
2000-01-24 |
2001-07-26 |
Sangamo Biosciences, Inc. |
Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules
|
|
BR0116024A
(pt)
*
|
2000-12-07 |
2005-12-13 |
Lilly Co Eli |
Proteìna de fusão heteróloga e uso da mesma
|
|
US7083970B2
(en)
|
2001-04-19 |
2006-08-01 |
The Scripps Research Institute |
Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
JP5275566B2
(ja)
|
2003-06-18 |
2013-08-28 |
ザ スクリプス リサーチ インスティチュート |
反応性非天然アミノ酸遺伝コード付加
|
|
CN100444898C
(zh)
|
2003-09-19 |
2008-12-24 |
诺沃挪第克公司 |
治疗肽的清蛋白结合型衍生物
|
|
KR101241862B1
(ko)
|
2003-09-19 |
2013-03-13 |
노보 노르디스크 에이/에스 |
신규 glp-1 유도체
|
|
US7498298B2
(en)
|
2003-11-06 |
2009-03-03 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
|
MXPA06006745A
(es)
|
2003-12-18 |
2006-08-18 |
Novo Nordisk As |
Compuestos glp-1 novedosos.
|
|
JP2007537142A
(ja)
|
2003-12-18 |
2007-12-20 |
ノボ ノルディスク アクティーゼルスカブ |
アルブミン様物質に結合した新規のglp−1類似物
|
|
KR101699142B1
(ko)
|
2004-06-18 |
2017-01-23 |
암브룩스, 인코포레이티드 |
신규 항원-결합 폴리펩티드 및 이의 용도
|
|
KR101270829B1
(ko)
|
2004-09-23 |
2013-06-07 |
제넨테크, 인크. |
시스테인 유전자조작 항체 및 접합체
|
|
US7893017B2
(en)
|
2004-10-07 |
2011-02-22 |
Novo Nordisk A/S |
Protracted GLP-1 compounds
|
|
TWI372629B
(en)
*
|
2005-03-18 |
2012-09-21 |
Novo Nordisk As |
Acylated glp-1 compounds
|
|
JP5755398B2
(ja)
|
2005-03-18 |
2015-07-29 |
ノヴォ ノルディスク アー/エス |
伸長されたglp−1化合物
|
|
CN101379075B
(zh)
|
2006-02-08 |
2013-05-15 |
隆萨股份公司 |
类胰高血糖素肽的合成
|
|
EP1996937A4
(en)
|
2006-03-06 |
2009-04-08 |
Amunix Inc |
GENETIC PACKS AND USES THEREOF
|
|
EP2444499A3
(en)
|
2006-05-02 |
2012-05-09 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
ATE502114T1
(de)
|
2007-06-21 |
2011-04-15 |
Univ Muenchen Tech |
Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität
|
|
US8933197B2
(en)
|
2007-08-15 |
2015-01-13 |
Amunix Operating Inc. |
Compositions comprising modified biologically active polypeptides
|
|
US20100261637A1
(en)
|
2007-09-05 |
2010-10-14 |
Novo Nordisk A/S |
Peptides derivatized with a-b-c-d- and their therapeutical use
|
|
EP2190872B1
(en)
|
2007-09-05 |
2018-03-14 |
Novo Nordisk A/S |
Glucagon-like peptide-1 derivatives and their pharmaceutical use
|
|
WO2009030774A1
(en)
|
2007-09-05 |
2009-03-12 |
Novo Nordisk A/S |
Truncated glp-1 derivatives and their therapeutical use
|
|
US20100317057A1
(en)
|
2007-12-28 |
2010-12-16 |
Novo Nordisk A/S |
Semi-recombinant preparation of glp-1 analogues
|
|
US8637647B2
(en)
|
2008-09-12 |
2014-01-28 |
Novo Nordisk A/S |
Method of acylating a peptide or protein
|
|
CA2748314C
(en)
|
2009-02-03 |
2018-10-02 |
Amunix Operating Inc. |
Extended recombinant polypeptides and compositions comprising same
|
|
JP5839597B2
(ja)
|
2009-06-08 |
2016-01-06 |
アムニクス オペレーティング インコーポレイテッド |
グルコース調節ポリペプチド並びにその作成及び使用方法
|
|
EP2512518A1
(en)
*
|
2009-12-16 |
2012-10-24 |
Novo Nordisk A/S |
Glp-1 receptor agonist compounds with a modified n-terminus
|
|
US20110312881A1
(en)
|
2009-12-21 |
2011-12-22 |
Amunix, Inc. |
Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases
|
|
EP2552967A4
(en)
|
2010-04-02 |
2014-10-08 |
Amunix Operating Inc |
BINDING FUSION PROTEINS, BINDING FUSION PROTEIN MEDICINAL CONJUGATES, XTEN MEDICAMENT CONJUGATES, AND METHOD FOR THEIR PREPARATION AND USE
|
|
EA023925B1
(ru)
*
|
2010-04-27 |
2016-07-29 |
Зилэнд Фарма А/С |
Пептидные конъюгаты агонистов рецептора glp-1 и их применение
|
|
TW201203798A
(en)
|
2010-07-01 |
2012-01-16 |
Tricore Corp |
Tray sealant filling fixture for spindle motor and the sealant filling method
|
|
EP2637698B1
(en)
|
2010-11-09 |
2022-04-20 |
Novo Nordisk A/S |
Double-acylated glp-1 derivatives
|
|
RU2602601C2
(ru)
*
|
2011-04-12 |
2016-11-20 |
Ново Нордиск А/С |
Дважды ацилированные производные glp-1
|
|
CN102786590A
(zh)
*
|
2011-05-19 |
2012-11-21 |
江苏豪森药业股份有限公司 |
分枝型peg修饰的glp-1类似物及其可药用盐
|
|
EP2753642B8
(en)
|
2011-09-06 |
2017-12-13 |
Novo Nordisk A/S |
Glp-1 derivatives
|
|
EP2755675B1
(en)
|
2011-09-12 |
2018-06-06 |
Amunix Operating Inc. |
Glucagon-like peptide-2 compositions and methods of making and using same
|
|
BR112014020694A2
(pt)
|
2012-02-15 |
2018-05-08 |
Amunix Operating Inc. |
proteína de fusão do fator viii compreendendo polipeptídeo do fator viii fusionado a polipeptí-deo recombinante estendido (xten) e seu método de fabricação, ácido nucleico, vetores, célula hospedeira, bem como composição farmacêutica e seu uso no tratamento de coagulopatia, episódio de hemorragia e hemofilia a
|
|
CN117462693A
(zh)
|
2012-02-27 |
2024-01-30 |
阿穆尼克斯运营公司 |
Xten缀合组合物和制造其的方法
|
|
JP6254146B2
(ja)
|
2012-03-27 |
2017-12-27 |
エヌジーエム バイオファーマシューティカルス,インコーポレーテッド |
代謝障害を治療するための組成物および方法
|
|
ES2629735T3
(es)
|
2012-05-08 |
2017-08-14 |
Novo Nordisk A/S |
Derivados de GLP-1 doblemente acilados
|
|
JP6250034B2
(ja)
|
2012-05-08 |
2017-12-20 |
ノヴォ ノルディスク アー/エス |
二重アシル化されたglp−1誘導体
|
|
KR20150021072A
(ko)
|
2012-06-05 |
2015-02-27 |
아뮤닉스 오퍼레이팅 인코포레이티드 |
성장 호르몬 결핍의 치료에 있어서 hgh-xten 융합 단백질 및 이의 용도
|
|
HRP20200007T1
(hr)
|
2012-07-11 |
2020-03-20 |
Bioverativ Therapeutics Inc. |
Kompleks proteina faktora viii s xten i von willebrandovim faktorom, te njegova uporaba
|
|
US20150273069A1
(en)
|
2012-10-17 |
2015-10-01 |
Novo Nordisk A/S |
Fatty acid acylated amino acids for oral peptide delivery
|
|
HK1216617A1
(zh)
|
2013-03-11 |
2016-11-25 |
Amunix Operating Inc. |
用人生长激素类似物治疗小儿生长激素缺乏症
|
|
KR20160021183A
(ko)
|
2013-06-20 |
2016-02-24 |
노보 노르디스크 에이/에스 |
Glp-1 유도체 및 그것의 용도
|
|
WO2015000942A1
(en)
|
2013-07-04 |
2015-01-08 |
Novo Nordisk A/S |
Derivatives of glp-1 like peptides, and uses thereof
|
|
US10548953B2
(en)
|
2013-08-14 |
2020-02-04 |
Bioverativ Therapeutics Inc. |
Factor VIII-XTEN fusions and uses thereof
|
|
US10266577B2
(en)
*
|
2013-08-15 |
2019-04-23 |
Novo Nordisk A/S |
GLP-1 derivatives, and uses thereof
|
|
US10689429B2
(en)
|
2014-04-07 |
2020-06-23 |
Novo Nordisk A/S |
Double-acylated GLP-1 compounds
|
|
MX2017006016A
(es)
|
2014-11-11 |
2017-06-19 |
Amunix Operating Inc |
Composiciones conjugadas de xten direccionadas y metodos para producir las mismas.
|
|
JP6730278B2
(ja)
|
2014-11-27 |
2020-07-29 |
ノヴォ ノルディスク アー/エス |
Glp−1誘導体及びその使用
|
|
WO2016097108A1
(en)
|
2014-12-17 |
2016-06-23 |
Novo Nordisk A/S |
Glp-1 derivatives and uses thereof
|
|
JO3575B1
(ar)
*
|
2015-01-09 |
2020-07-05 |
Lilly Co Eli |
مركبات مساعد مشترك من gip وglp-1
|
|
WO2016131893A1
(en)
*
|
2015-02-18 |
2016-08-25 |
Medimmune Limited |
Incretin fusion polypeptides
|
|
JP6983075B2
(ja)
*
|
2015-06-02 |
2021-12-17 |
ノヴォ ノルディスク アー/エス |
極性の組換え延長部を有するインスリン
|
|
IL319047A
(en)
|
2015-08-28 |
2025-04-01 |
Amunix Operating Inc |
Chimeric polypeptide composition and methods for its preparation and use
|
|
EP3368556B1
(en)
*
|
2015-10-28 |
2024-04-10 |
Tufts University |
Novel polypeptides with improved proteolytic stability, and methods of preparing and using same
|
|
WO2017116204A1
(ko)
|
2015-12-31 |
2017-07-06 |
한미약품 주식회사 |
글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체
|
|
AR107560A1
(es)
|
2016-02-24 |
2018-05-09 |
Lilly Co Eli |
Compuesto que disminuye la glucosa en la sangre
|
|
WO2017149070A1
(en)
|
2016-03-03 |
2017-09-08 |
Novo Nordisk A/S |
Glp-1 derivatives and uses thereof
|
|
EP3463424A1
(en)
*
|
2016-06-02 |
2019-04-10 |
Indiana University Research & Technology Corporation |
Glucagon-like peptide-1-t3 conjugates
|
|
TWI710377B
(zh)
|
2017-05-23 |
2020-11-21 |
丹麥商諾佛 儂迪克股份有限公司 |
Mic-1化合物及其用途
|
|
EP3655427A1
(en)
|
2017-07-19 |
2020-05-27 |
Novo Nordisk A/S |
Bifunctional compounds
|
|
CN110386974B
(zh)
*
|
2018-04-19 |
2022-12-09 |
杭州先为达生物科技有限公司 |
Glp-1衍生物及其治疗用途
|
|
US11780900B2
(en)
*
|
2018-04-25 |
2023-10-10 |
Janssen Sciences Ireland Unlimited Company |
Glucagon like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof
|
|
TW202028229A
(zh)
|
2018-10-05 |
2020-08-01 |
丹麥商諾佛 儂迪克股份有限公司 |
包含胰島素肽及egf(a)肽之雙功能化合物
|
|
MX2021012277A
(es)
|
2019-04-11 |
2021-11-12 |
Jiangsu Hansoh Pharmaceutical Group Co Ltd |
Agonista multireceptor y uso medico del mismo.
|
|
CN115260313B
(zh)
*
|
2019-12-31 |
2023-07-18 |
北京质肽生物医药科技有限公司 |
Glp-1和gdf15的融合蛋白以及其缀合物
|
|
CN114729060B
(zh)
*
|
2020-09-30 |
2022-11-25 |
北京质肽生物医药科技有限公司 |
多肽缀合物和使用方法
|