JPWO2022064399A5 - - Google Patents

Info

Publication number

JPWO2022064399A5

JPWO2022064399A5 JP2023518177A JP2023518177A JPWO2022064399A5 JP WO2022064399 A5 JPWO2022064399 A5 JP WO2022064399A5 JP 2023518177 A JP2023518177 A JP 2023518177A JP 2023518177 A JP2023518177 A JP 2023518177A JP WO2022064399 A5 JPWO2022064399 A5 JP WO2022064399A5

Authority

JP

Japan

Prior art keywords

weeks

antigen

binding fragment

administered

item

Prior art date

2024-10-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 238000000034 method Methods 0.000 claims description 78
• 239000000427 antigen Substances 0.000 claims description 71
• 102000036639 antigens Human genes 0.000 claims description 71
• 108091007433 antigens Proteins 0.000 claims description 71
• 239000012634 fragment Substances 0.000 claims description 71
• 206010028980 Neoplasm Diseases 0.000 claims description 38
• 229940059392 oleclumab Drugs 0.000 claims description 37
• 229950009791 durvalumab Drugs 0.000 claims description 26
• 238000010186 staining Methods 0.000 claims description 26
• 238000003364 immunohistochemistry Methods 0.000 claims description 17
• 229960005277 gemcitabine Drugs 0.000 claims description 12
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 12
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 12
• 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims description 11
• 230000001394 metastastic effect Effects 0.000 claims description 9
• 206010061289 metastatic neoplasm Diseases 0.000 claims description 9
• 108010058566 130-nm albumin-bound paclitaxel Proteins 0.000 claims description 7
• 229960001592 paclitaxel Drugs 0.000 claims description 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• 201000011510 cancer Diseases 0.000 claims 4
• 239000012829 chemotherapy agent Substances 0.000 claims 4
• 238000002512 chemotherapy Methods 0.000 description 35
• 230000002401 inhibitory effect Effects 0.000 description 9
• 230000004614 tumor growth Effects 0.000 description 8
• 102100022464 5'-nucleotidase Human genes 0.000 description 7
• 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 description 7
• 101100112922 Candida albicans CDR3 gene Proteins 0.000 description 4
• 125000003275 alpha amino acid group Chemical group 0.000 description 4
• 238000012986 modification Methods 0.000 description 2
• 230000004048 modification Effects 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 1
• 206010052747 Adenocarcinoma pancreas Diseases 0.000 description 1
• VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 1
• 235000008191 folinic acid Nutrition 0.000 description 1
• 239000011672 folinic acid Substances 0.000 description 1
• 230000012010 growth Effects 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 229960001691 leucovorin Drugs 0.000 description 1
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
• 229960001756 oxaliplatin Drugs 0.000 description 1
• 201000002094 pancreatic adenocarcinoma Diseases 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1