JPWO2022056324A5 - - Google Patents
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- Publication number
- JPWO2022056324A5 JPWO2022056324A5 JP2023516057A JP2023516057A JPWO2022056324A5 JP WO2022056324 A5 JPWO2022056324 A5 JP WO2022056324A5 JP 2023516057 A JP2023516057 A JP 2023516057A JP 2023516057 A JP2023516057 A JP 2023516057A JP WO2022056324 A5 JPWO2022056324 A5 JP WO2022056324A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- sequence
- endonuclease
- engineered nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 150000007523 nucleic acids Chemical class 0.000 claims 21
- 102000004533 Endonucleases Human genes 0.000 claims 18
- 108010042407 Endonucleases Proteins 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 229920002477 rna polymer Polymers 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 claims 1
- 102000055025 Adenosine deaminases Human genes 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 1
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 230000030648 nucleus localization Effects 0.000 claims 1
- 238000010845 search algorithm Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063077057P | 2020-09-11 | 2020-09-11 | |
| US63/077,057 | 2020-09-11 | ||
| US202163222351P | 2021-07-15 | 2021-07-15 | |
| US63/222,351 | 2021-07-15 | ||
| PCT/US2021/049962 WO2022056324A1 (en) | 2020-09-11 | 2021-09-10 | Base editing enzymes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023540797A JP2023540797A (ja) | 2023-09-26 |
| JP2023540797A5 JP2023540797A5 (https=) | 2024-09-13 |
| JPWO2022056324A5 true JPWO2022056324A5 (https=) | 2024-09-13 |
Family
ID=80629930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023516057A Pending JP2023540797A (ja) | 2020-09-11 | 2021-09-10 | 塩基編集酵素 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US12286654B2 (https=) |
| EP (1) | EP4211234A4 (https=) |
| JP (1) | JP2023540797A (https=) |
| KR (1) | KR20230062873A (https=) |
| AU (1) | AU2021339819A1 (https=) |
| CA (1) | CA3192224A1 (https=) |
| GB (1) | GB2605340B (https=) |
| MX (1) | MX2023002913A (https=) |
| WO (1) | WO2022056324A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| CN121555430A (zh) | 2018-05-11 | 2026-02-24 | 比姆医疗股份有限公司 | 使用可编程碱基编辑器系统取代病原性氨基酸的方法 |
| KR20210055733A (ko) | 2018-09-07 | 2021-05-17 | 빔 테라퓨틱스, 인크. | 핵염기 편집 시스템을 전달하기 위한 조성물 및 방법 |
| EP3850088A4 (en) | 2018-09-07 | 2023-07-19 | Beam Therapeutics, Inc. | Compositions and methods for improving base editing |
| WO2020168122A1 (en) | 2019-02-13 | 2020-08-20 | Beam Therapeutics Inc. | Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| GB2617658B (en) | 2020-03-06 | 2024-04-17 | Metagenomi Inc | Class II, type V CRISPR systems |
| GB2608292B (en) * | 2020-03-31 | 2024-02-14 | Metagenomi Inc | Class II, type II CRISPR systems |
| CA3192224A1 (en) | 2020-09-11 | 2022-03-17 | Jyun-Liang LIN | Base editing enzymes |
| AU2021347359A1 (en) | 2020-09-25 | 2023-05-18 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| BR112023014719A2 (pt) * | 2021-01-22 | 2023-12-05 | Metagenomi Inc | Novas nucleases quiméricas e manipuladas |
| CA3225082A1 (en) | 2021-08-27 | 2023-03-02 | Brian C. Thomas | Enzymes with ruvc domains |
| AU2022380842A1 (en) * | 2021-11-05 | 2024-05-23 | Metagenomi Therapeutics, Inc. | Base editing enzymes |
| MX2024006257A (es) | 2021-11-24 | 2024-07-29 | Metagenomi Inc | Sistemas de endonucleasas. |
| CN121241133A (zh) * | 2023-03-31 | 2025-12-30 | 阿伯生物技术公司 | Crispr核酸酶多肽和包含此类crispr核酸酶多肽的基因编辑系统 |
| WO2025003344A1 (en) * | 2023-06-28 | 2025-01-02 | Alia Therapeutics Srl | Type ii cas proteins and applications thereof |
| WO2025106894A1 (en) * | 2023-11-15 | 2025-05-22 | Profluent Bio Inc. | Adenine deaminases and compositions, systems, and methods thereof |
| WO2025240372A1 (en) * | 2024-05-13 | 2025-11-20 | Metagenomi, Inc. | Compositions and methods for editing t cells |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102547316B1 (ko) * | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11192929B2 (en) | 2016-12-08 | 2021-12-07 | Regents Of The University Of Minnesota | Site-specific DNA base editing using modified APOBEC enzymes |
| EP3572525A4 (en) | 2017-01-17 | 2020-09-30 | Institute for Basic Science | PROCEDURE FOR IDENTIFYING AN OFF-TARGET BASIC EDITING SITE BY BREAKING A SINGLE DNA STRAND |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| KR102758434B1 (ko) * | 2017-03-30 | 2025-01-21 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 게놈 편집에 의한 엑손 스키핑 유도 방법 |
| US9982279B1 (en) * | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| AU2018290843B2 (en) * | 2017-06-26 | 2025-04-24 | Massachusetts Institute Of Technology | CRISPR/Cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing |
| JP2021506251A (ja) * | 2017-12-14 | 2021-02-22 | クリスパー セラピューティクス アーゲー | 新規ｒｎａプログラム可能エンドヌクレアーゼ系、ならびにゲノム編集および他の適用におけるその使用 |
| US11946040B2 (en) * | 2019-02-04 | 2024-04-02 | The General Hospital Corporation | Adenine DNA base editor variants with reduced off-target RNA editing |
| US20220298494A1 (en) | 2019-02-14 | 2022-09-22 | Metagenomi Ip Technologies, Llc | Enzymes with ruvc domains |
| AU2020223370B2 (en) | 2019-02-14 | 2023-04-20 | Metagenomi Therapeutics, Inc. | Enzymes with RuvC domains |
| WO2021097118A1 (en) | 2019-11-12 | 2021-05-20 | The Broad Institute, Inc. | Small type ii cas proteins and methods of use thereof |
| GB2608292B (en) * | 2020-03-31 | 2024-02-14 | Metagenomi Inc | Class II, type II CRISPR systems |
| GB2700205B (en) | 2020-09-11 | 2026-04-15 | Metagenomi Therapeutics Inc | Base editing enzymes |
| CA3192224A1 (en) | 2020-09-11 | 2022-03-17 | Jyun-Liang LIN | Base editing enzymes |
| AU2022380842A1 (en) * | 2021-11-05 | 2024-05-23 | Metagenomi Therapeutics, Inc. | Base editing enzymes |
-
2021
- 2021-09-10 CA CA3192224A patent/CA3192224A1/en active Pending
- 2021-09-10 GB GB2209534.3A patent/GB2605340B/en active Active
- 2021-09-10 MX MX2023002913A patent/MX2023002913A/es unknown
- 2021-09-10 JP JP2023516057A patent/JP2023540797A/ja active Pending
- 2021-09-10 EP EP21867718.5A patent/EP4211234A4/en active Pending
- 2021-09-10 AU AU2021339819A patent/AU2021339819A1/en active Pending
- 2021-09-10 KR KR1020237012244A patent/KR20230062873A/ko active Pending
- 2021-09-10 WO PCT/US2021/049962 patent/WO2022056324A1/en not_active Ceased
-
2022
- 2022-06-15 US US17/841,082 patent/US12286654B2/en active Active
-
2023
- 2023-03-07 US US18/180,009 patent/US20230348876A1/en active Pending
- 2023-05-31 US US18/326,440 patent/US20230374482A1/en active Pending
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