JPWO2022051583A5 - - Google Patents
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- JPWO2022051583A5 JPWO2022051583A5 JP2023515095A JP2023515095A JPWO2022051583A5 JP WO2022051583 A5 JPWO2022051583 A5 JP WO2022051583A5 JP 2023515095 A JP2023515095 A JP 2023515095A JP 2023515095 A JP2023515095 A JP 2023515095A JP WO2022051583 A5 JPWO2022051583 A5 JP WO2022051583A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- alkenyl
- compound according
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063074220P | 2020-09-03 | 2020-09-03 | |
| US63/074,220 | 2020-09-03 | ||
| PCT/US2021/049003 WO2022051583A1 (en) | 2020-09-03 | 2021-09-03 | Medium- or macro-cyclic benzyl-substituted heterocycle derivatives and their uses as orexin-2 receptor agonists |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023540350A JP2023540350A (ja) | 2023-09-22 |
| JPWO2022051583A5 true JPWO2022051583A5 (https=) | 2024-10-02 |
| JP2023540350A5 JP2023540350A5 (https=) | 2024-10-02 |
| JP7811578B2 JP7811578B2 (ja) | 2026-02-05 |
Family
ID=78078371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023515095A Active JP7811578B2 (ja) | 2020-09-03 | 2021-09-03 | 中環状または大環状ベンジル置換複素環誘導体およびオレキシン－２受容体アゴニストとしてのそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230331720A1 (https=) |
| EP (1) | EP4208465A1 (https=) |
| JP (1) | JP7811578B2 (https=) |
| CN (1) | CN116635393A (https=) |
| TW (1) | TW202227433A (https=) |
| WO (1) | WO2022051583A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4065585B1 (en) | 2019-11-25 | 2025-08-20 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| CN116583502A (zh) | 2020-09-03 | 2023-08-11 | 欧瑞夏治疗有限公司 | 二环-杂环衍生物及其作为食欲素-2受体激动剂的用途 |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| US12006330B2 (en) | 2020-12-21 | 2024-06-11 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| AU2022280804A1 (en) * | 2021-05-26 | 2023-11-30 | Alkermes, Inc. | Substituted carbamate macrocyclic compounds and related methods of treatment |
| JP2025507852A (ja) * | 2022-03-01 | 2025-03-21 | センテッサ ファーマシューティカルズ （ユーケー） リミテッド | 中環状または大環状ベンジル置換複素環誘導体および関連の使用 |
| IL316468A (en) * | 2022-04-22 | 2024-12-01 | Teijin Pharma Ltd | The aftermath of oxazepine |
| CN114716319B (zh) * | 2022-04-28 | 2024-03-26 | 浙江工业大学 | 一种联芳氧基烯酸酯类化合物的合成方法 |
| WO2024075825A1 (ja) * | 2022-10-07 | 2024-04-11 | キッセイ薬品工業株式会社 | シクロペンタン化合物 |
| EP4611745A1 (en) | 2022-10-31 | 2025-09-10 | Takeda Pharmaceutical Company Limited | Dosing of orexin type 2 receptor agonists |
| PE20252742A1 (es) | 2023-03-16 | 2025-12-05 | Takeda Pharmaceuticals Co | Compuestos heterociclicos macrociclicos y sus usos |
| IL324946A (en) | 2023-06-01 | 2026-01-01 | H Lundbeck As | Spiro-macrocyclic orexin 2 receptor agonists |
| EP4719397A1 (en) | 2023-06-02 | 2026-04-08 | Takeda Pharmaceutical Company Limited | Use of an orexin 2 receptor agonist for improving respiratory function during sleep |
| TW202535890A (zh) * | 2023-10-20 | 2025-09-16 | 日商帝人製藥股份有限公司 | 氧氮呯衍生物之結晶或其溶劑合物之結晶 |
| WO2025124698A1 (en) | 2023-12-12 | 2025-06-19 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
| TW202542165A (zh) | 2023-12-19 | 2025-11-01 | 瑞士商愛杜西亞製藥有限公司 | 大環食慾素激動劑 |
| WO2025229493A1 (en) | 2024-04-29 | 2025-11-06 | Takeda Pharmaceutical Company Limited | Dosing of orexin type 2 receptor agonists |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| PE20081229A1 (es) * | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| US10428023B2 (en) | 2017-08-03 | 2019-10-01 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| JP7253640B2 (ja) * | 2019-01-31 | 2023-04-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| EP4065585B1 (en) * | 2019-11-25 | 2025-08-20 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
-
2021
- 2021-09-03 JP JP2023515095A patent/JP7811578B2/ja active Active
- 2021-09-03 CN CN202180074185.9A patent/CN116635393A/zh active Pending
- 2021-09-03 TW TW110132882A patent/TW202227433A/zh unknown
- 2021-09-03 EP EP21786656.5A patent/EP4208465A1/en active Pending
- 2021-09-03 US US18/024,236 patent/US20230331720A1/en active Pending
- 2021-09-03 WO PCT/US2021/049003 patent/WO2022051583A1/en not_active Ceased
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