JPWO2022047186A5 - - Google Patents
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- Publication number
- JPWO2022047186A5 JPWO2022047186A5 JP2023514021A JP2023514021A JPWO2022047186A5 JP WO2022047186 A5 JPWO2022047186 A5 JP WO2022047186A5 JP 2023514021 A JP2023514021 A JP 2023514021A JP 2023514021 A JP2023514021 A JP 2023514021A JP WO2022047186 A5 JPWO2022047186 A5 JP WO2022047186A5
- Authority
- JP
- Japan
- Prior art keywords
- ras
- kras
- protein
- sample
- nras
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063071694P | 2020-08-28 | 2020-08-28 | |
| US63/071,694 | 2020-08-28 | ||
| US202063117080P | 2020-11-23 | 2020-11-23 | |
| US63/117,080 | 2020-11-23 | ||
| US202163160120P | 2021-03-12 | 2021-03-12 | |
| US63/160,120 | 2021-03-12 | ||
| PCT/US2021/047998 WO2022047186A1 (en) | 2020-08-28 | 2021-08-27 | Target engagement assay for ras proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023540934A JP2023540934A (ja) | 2023-09-27 |
| JPWO2022047186A5 true JPWO2022047186A5 (https=) | 2024-09-03 |
| JP2023540934A5 JP2023540934A5 (https=) | 2024-09-03 |
Family
ID=77914456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023514021A Pending JP2023540934A (ja) | 2020-08-28 | 2021-08-27 | Ｒａｓタンパク質のターゲットエンゲージメントアッセイ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220064696A1 (https=) |
| EP (1) | EP4204808A1 (https=) |
| JP (1) | JP2023540934A (https=) |
| CN (1) | CN116391129A (https=) |
| WO (1) | WO2022047186A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210006356A (ko) | 2018-04-04 | 2021-01-18 | 아비나스 오퍼레이션스, 인코포레이티드 | 단백질분해 조절제 및 연관된 사용 방법 |
| CN121419983A (zh) | 2023-01-26 | 2026-01-27 | 阿尔维纳斯运营股份有限公司 | 基于小脑蛋白的kras降解protac及其相关用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4812409A (en) | 1986-01-31 | 1989-03-14 | Eastman Kodak Company | Hydrolyzable fluorescent substrates and analytical determinations using same |
| US4810636A (en) | 1986-12-09 | 1989-03-07 | Miles Inc. | Chromogenic acridinone enzyme substrates |
| US6162931A (en) | 1996-04-12 | 2000-12-19 | Molecular Probes, Inc. | Fluorinated xanthene derivatives |
| US7429472B2 (en) | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
| EP1594962B1 (en) | 2003-01-31 | 2014-08-27 | Promega Corporation | Covalent tethering of functional groups to proteins |
| US7425436B2 (en) | 2004-07-30 | 2008-09-16 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
| WO2008118445A1 (en) | 2007-03-26 | 2008-10-02 | Promega Corporation | Methods to quench light from optical reactions |
| GB0905840D0 (en) | 2009-04-06 | 2009-05-20 | Sagentia Ltd | Apparatus and methods |
| ES2795287T3 (es) | 2009-05-01 | 2020-11-23 | Promega Corp | Luciferasas de Oplophorus sintéticas con mayor emisión de luz |
| JP5677041B2 (ja) | 2009-11-11 | 2015-02-25 | 株式会社ニデック | 眼科装置 |
| SG10202103336SA (en) | 2010-11-02 | 2021-04-29 | Promega Corp | Novel coelenterazine substrates and methods of use |
| GB201103631D0 (en) * | 2011-03-03 | 2011-04-13 | Univ Leeds | Identification of candidate therapeutics |
| JP5751030B2 (ja) | 2011-06-03 | 2015-07-22 | ソニー株式会社 | 表示制御装置、表示制御方法、及びプログラム |
| WO2013078244A1 (en) | 2011-11-21 | 2013-05-30 | Promega Corporation | Carboxy x rhodamine analogs |
| US20140099654A1 (en) | 2012-09-26 | 2014-04-10 | Promega Corporation | Real-time monitoring |
| KR102292431B1 (ko) | 2012-12-12 | 2021-08-20 | 프로메가 코포레이션 | 세포내 생물발광 공명 에너지 전이를 이용하여 생물활성제에 의한 세포 표적 결합의 인식 |
| US10067149B2 (en) * | 2012-12-12 | 2018-09-04 | Promega Corporation | Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer |
| ES2926463T3 (es) | 2013-03-15 | 2022-10-26 | Promega Corp | Activación de la bioluminiscencia mediante complementación estructural |
| JP2018533939A (ja) * | 2015-10-19 | 2018-11-22 | アラクセス ファーマ エルエルシー | Ｒａｓの阻害剤をスクリーニングするための方法 |
| JP7092677B2 (ja) | 2016-02-15 | 2022-06-28 | プロメガ コーポレイション | セレンテラジン類似体 |
| JP7212612B2 (ja) | 2016-07-28 | 2023-01-25 | プロメガ コーポレイション | セレンテラジン類縁体 |
| WO2019173683A1 (en) * | 2018-03-08 | 2019-09-12 | Stc. Unm | Discovery of novel molecules and repurposed drugs for ras family gtpases |
| WO2019241438A2 (en) | 2018-06-12 | 2019-12-19 | Promega Corporation | Multipartite luciferase |
-
2021
- 2021-08-27 EP EP21777898.4A patent/EP4204808A1/en active Pending
- 2021-08-27 WO PCT/US2021/047998 patent/WO2022047186A1/en not_active Ceased
- 2021-08-27 US US17/459,502 patent/US20220064696A1/en active Pending
- 2021-08-27 JP JP2023514021A patent/JP2023540934A/ja active Pending
- 2021-08-27 CN CN202180074299.3A patent/CN116391129A/zh active Pending
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