JPWO2022046942A5 - - Google Patents

Info

Publication number

JPWO2022046942A5

JPWO2022046942A5 JP2023513407A JP2023513407A JPWO2022046942A5 JP WO2022046942 A5 JPWO2022046942 A5 JP WO2022046942A5 JP 2023513407 A JP2023513407 A JP 2023513407A JP 2023513407 A JP2023513407 A JP 2023513407A JP WO2022046942 A5 JPWO2022046942 A5 JP WO2022046942A5

Authority

JP

Japan

Prior art keywords

antibody

antigen

pharmaceutical composition

administration

amino acid

Prior art date

2024-07-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000427 antigen Substances 0.000 claims 19
• 102000036639 antigens Human genes 0.000 claims 19
• 108091007433 antigens Proteins 0.000 claims 19
• 239000008194 pharmaceutical composition Substances 0.000 claims 19
• 229920001184 polypeptide Polymers 0.000 claims 12
• 102000004196 processed proteins & peptides Human genes 0.000 claims 12
• 108090000765 processed proteins & peptides Proteins 0.000 claims 12
• 150000001413 amino acids Chemical group 0.000 claims 10
• 239000012634 fragment Substances 0.000 claims 7
• 238000000034 method Methods 0.000 claims 6
• 208000021386 Sjogren Syndrome Diseases 0.000 claims 4
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 4
• 239000002260 anti-inflammatory agent Substances 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 230000002519 immonomodulatory effect Effects 0.000 claims 4
• 229960003444 immunosuppressant agent Drugs 0.000 claims 4
• 230000001861 immunosuppressant effect Effects 0.000 claims 4
• 239000003018 immunosuppressive agent Substances 0.000 claims 4
• 238000001990 intravenous administration Methods 0.000 claims 4
• 238000007920 subcutaneous administration Methods 0.000 claims 4
• QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 3
• 229930006000 Sucrose Natural products 0.000 claims 2
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 229960003330 pentetic acid Drugs 0.000 claims 2
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
• 229920000053 polysorbate 80 Polymers 0.000 claims 2
• 229940068968 polysorbate 80 Drugs 0.000 claims 2
• 239000005720 sucrose Substances 0.000 claims 2
• 230000003442 weekly effect Effects 0.000 claims 2
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical group OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
• 239000004475 Arginine Chemical group 0.000 claims 1
• 101100099884 Homo sapiens CD40 gene Proteins 0.000 claims 1
• 102000009490 IgG Receptors Human genes 0.000 claims 1
• 108010073807 IgG Receptors Proteins 0.000 claims 1
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical group NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical group C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
• 239000004472 Lysine Substances 0.000 claims 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Chemical group OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Chemical group C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
• 235000004279 alanine Nutrition 0.000 claims 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical group OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1