JPWO2022026767A5 - - Google Patents

Info

Publication number

JPWO2022026767A5

JPWO2022026767A5 JP2023504814A JP2023504814A JPWO2022026767A5 JP WO2022026767 A5 JPWO2022026767 A5 JP WO2022026767A5 JP 2023504814 A JP2023504814 A JP 2023504814A JP 2023504814 A JP2023504814 A JP 2023504814A JP WO2022026767 A5 JPWO2022026767 A5 JP WO2022026767A5

Authority

JP

Japan

Prior art keywords

atogepant

reduction

days

results

baseline

Prior art date

2024-08-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims description 44
• QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 claims description 43
• 229940070146 atogepant Drugs 0.000 claims description 43
• 208000019695 Migraine disease Diseases 0.000 claims description 28
• 206010027599 migraine Diseases 0.000 claims description 28
• 230000037396 body weight Effects 0.000 claims description 13
• 238000011282 treatment Methods 0.000 claims description 8
• 238000011321 prophylaxis Methods 0.000 claims description 7
• 150000003839 salts Chemical class 0.000 claims description 7
• 239000003814 drug Substances 0.000 claims description 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000000694 effects Effects 0.000 description 11
• 230000003449 preventive effect Effects 0.000 description 7
• 230000004580 weight loss Effects 0.000 description 7
• 206010019233 Headaches Diseases 0.000 description 4
• 231100000869 headache Toxicity 0.000 description 4
• 230000001154 acute effect Effects 0.000 description 3
• 229940079593 drug Drugs 0.000 description 3
• KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 description 1
• 238000005452 bending Methods 0.000 description 1
• 230000003247 decreasing effect Effects 0.000 description 1
• 230000006735 deficit Effects 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 230000037081 physical activity Effects 0.000 description 1
• 238000002203 pretreatment Methods 0.000 description 1
• 229960004394 topiramate Drugs 0.000 description 1