JPWO2021248038A5 - - Google Patents
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- Publication number
- JPWO2021248038A5 JPWO2021248038A5 JP2022574541A JP2022574541A JPWO2021248038A5 JP WO2021248038 A5 JPWO2021248038 A5 JP WO2021248038A5 JP 2022574541 A JP2022574541 A JP 2022574541A JP 2022574541 A JP2022574541 A JP 2022574541A JP WO2021248038 A5 JPWO2021248038 A5 JP WO2021248038A5
- Authority
- JP
- Japan
- Prior art keywords
- dnaj
- alpha
- group
- fusion protein
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108020001507 fusion proteins Proteins 0.000 claims 17
- 102000037865 fusion proteins Human genes 0.000 claims 17
- 102000003802 alpha-Synuclein Human genes 0.000 claims 15
- 108090000185 alpha-Synuclein Proteins 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 101710101803 DNA-binding protein J Proteins 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 210000000234 capsid Anatomy 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 230000003612 virological effect Effects 0.000 claims 4
- 208000032859 Synucleinopathies Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 241000702423 Adeno-associated virus - 2 Species 0.000 claims 2
- 241001634120 Adeno-associated virus - 5 Species 0.000 claims 2
- 241001164825 Adeno-associated virus - 8 Species 0.000 claims 2
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 230000001426 cardiotropic effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 1
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 1
- 241001655883 Adeno-associated virus - 1 Species 0.000 claims 1
- 241000202702 Adeno-associated virus - 3 Species 0.000 claims 1
- 241000580270 Adeno-associated virus - 4 Species 0.000 claims 1
- 241000972680 Adeno-associated virus - 6 Species 0.000 claims 1
- 241001164823 Adeno-associated virus - 7 Species 0.000 claims 1
- 241000649045 Adeno-associated virus 10 Species 0.000 claims 1
- 241000649046 Adeno-associated virus 11 Species 0.000 claims 1
- 241000649047 Adeno-associated virus 12 Species 0.000 claims 1
- 241000710929 Alphavirus Species 0.000 claims 1
- 241000711404 Avian avulavirus 1 Species 0.000 claims 1
- 102100026031 Beta-glucuronidase Human genes 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 102100034114 DnaJ homolog subfamily C member 14 Human genes 0.000 claims 1
- 238000012286 ELISA Assay Methods 0.000 claims 1
- 241000710831 Flavivirus Species 0.000 claims 1
- 108700028146 Genetic Enhancer Elements Proteins 0.000 claims 1
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 claims 1
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 claims 1
- 101000933465 Homo sapiens Beta-glucuronidase Proteins 0.000 claims 1
- 101000870166 Homo sapiens DnaJ homolog subfamily C member 14 Proteins 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 201000005505 Measles Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 102000006890 Methyl-CpG-Binding Protein 2 Human genes 0.000 claims 1
- 108010072388 Methyl-CpG-Binding Protein 2 Proteins 0.000 claims 1
- 208000001089 Multiple system atrophy Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108091034057 RNA (poly(A)) Proteins 0.000 claims 1
- 241000702263 Reovirus sp. Species 0.000 claims 1
- 102000001435 Synapsin Human genes 0.000 claims 1
- 108050009621 Synapsin Proteins 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 210000000805 cytoplasm Anatomy 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 208000009091 myxoma Diseases 0.000 claims 1
- 230000003372 organotropic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063035297P | 2020-06-05 | 2020-06-05 | |
| US63/035,297 | 2020-06-05 | ||
| PCT/US2021/035958 WO2021248038A1 (en) | 2020-06-05 | 2021-06-04 | Compositions and methods for the treatment of synucleinopathies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023529371A JP2023529371A (ja) | 2023-07-10 |
| JPWO2021248038A5 true JPWO2021248038A5 (https=) | 2024-06-10 |
| JP2023529371A5 JP2023529371A5 (https=) | 2024-06-10 |
Family
ID=76708439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022574541A Pending JP2023529371A (ja) | 2020-06-05 | 2021-06-04 | シヌクレイノパチーの処置のための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230234997A1 (https=) |
| EP (1) | EP4161953A1 (https=) |
| JP (1) | JP2023529371A (https=) |
| CN (1) | CN116096737A (https=) |
| CA (1) | CA3183251A1 (https=) |
| WO (1) | WO2021248038A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116590342B (zh) * | 2023-05-11 | 2026-04-03 | 普递瑞(上海)医药有限公司 | 一种aav载体及其应用 |
| WO2024229777A1 (zh) * | 2023-05-11 | 2024-11-14 | 深圳先进技术研究院 | 一种aav载体及其应用 |
| CN117402251B (zh) * | 2023-12-15 | 2024-02-23 | 中国医学科学院基础医学研究所 | 一种抗小g蛋白rbj的抗体及其应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8918616D0 (en) | 1989-08-15 | 1989-09-27 | Univ Glasgow | Herpes simplex virus type 1 mutant |
| US5804413A (en) | 1992-07-31 | 1998-09-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus strains for gene transfer |
| GB9415319D0 (en) | 1994-07-29 | 1994-09-21 | Medical Res Council | HSV viral vector |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| AU8605598A (en) | 1997-07-31 | 1999-02-22 | University Of Pittsburgh | Targeted hsv vectors |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| EP1082413B1 (en) | 1998-05-28 | 2008-07-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Aav5 vector and uses thereof |
| CN1246532A (zh) * | 1998-08-31 | 2000-03-08 | 复旦大学 | 人热休克关联蛋白编码序列、其编码的多肽及制备方法 |
| NZ522840A (en) | 2000-06-01 | 2004-12-24 | Univ North Carolina | A parvovirus vector that carries a duplexed genome resulting in co-packaging of strands of plus and minus polarity tethered together |
| JP2004502781A (ja) | 2000-07-07 | 2004-01-29 | パナシア ファーマシューティカルズ インコーポレーテッド | 神経組織の損傷を予防するため、およびα−シヌクレイン疾患を処置するための方法 |
| AU2002248297A1 (en) | 2001-01-05 | 2002-07-16 | Children's Hospital, Inc. | Aav2 vectors and methods |
| NZ532635A (en) | 2001-11-13 | 2007-05-31 | Univ Pennsylvania | A method of identifying unknown adeno-associated virus (AAV) sequences and a kit for the method |
| DK2359869T3 (en) | 2001-12-17 | 2019-04-15 | Univ Pennsylvania | Sequences of adeno-associated virus (AAV) serotype 8, vectors containing these, and uses thereof |
| CN1856576B (zh) | 2003-09-30 | 2011-05-04 | 宾夕法尼亚州立大学托管会 | 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用 |
| EP1828390B1 (en) | 2004-12-15 | 2012-06-13 | The University Of North Carolina At Chapel Hill | Chimeric vectors |
| US20110201686A1 (en) * | 2006-06-23 | 2011-08-18 | Yousef Al-Abed | Inhibitors of ASS and Synuclein Aggregation |
| EP2396343B1 (en) | 2009-02-11 | 2017-05-17 | The University of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| ES2683695T3 (es) | 2010-01-12 | 2018-09-27 | The University Of North Carolina At Chapel Hill | Repeticiones terminales invertidas restrictivas para vectores virales |
| CA2788682C (en) | 2010-02-05 | 2019-03-05 | The University Of North Carolina At Chapel Hill | Compositions and methods for enhanced parvovirus transduction |
| WO2014053879A1 (en) | 2012-10-04 | 2014-04-10 | Centre National De La Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
| JP6345688B2 (ja) * | 2012-12-05 | 2018-06-20 | ソラ・バイオサイエンシズ・エルエルシー | タンパク質発現増強ポリペプチド |
| US11390899B2 (en) * | 2016-09-26 | 2022-07-19 | SOLA Biosciences, LLC | Cell-associated secretion-enhancing fusion proteins |
| US12162929B2 (en) * | 2018-02-19 | 2024-12-10 | New York University | Alpha-synuclein single domain antibodies |
| WO2021138582A1 (en) * | 2019-12-31 | 2021-07-08 | The Johns Hopkins University | Fusion proteins and methods of use thereof |
-
2021
- 2021-06-04 CN CN202180058141.7A patent/CN116096737A/zh active Pending
- 2021-06-04 US US18/007,978 patent/US20230234997A1/en active Pending
- 2021-06-04 EP EP21736438.9A patent/EP4161953A1/en active Pending
- 2021-06-04 JP JP2022574541A patent/JP2023529371A/ja active Pending
- 2021-06-04 WO PCT/US2021/035958 patent/WO2021248038A1/en not_active Ceased
- 2021-06-04 CA CA3183251A patent/CA3183251A1/en active Pending
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